pyPESTO: Getting started

This notebook takes you through the first steps to get started with pyPESTO.

pyPESTO logo

pyPESTO is a python package for parameter inference, offering a unified interface to various optimization and sampling methods. pyPESTO is highly modular and customizable, e.g. with respect to objective function definition and employed inference algorithms.

[1]:
import os.path

import amici

# import matplotlib and increase image resolution
import matplotlib as mpl
import numpy as np
import petab

import pypesto
import pypesto.optimize as optimize
import pypesto.petab
import pypesto.visualize as visualize

mpl.rcParams['figure.dpi'] = 300

1. Objective Definition

PyPESTO allows the definition of a custom objectives, as well as offers support for objectives defined in the PEtab format.

Custom Objective Definition

You can define an objective via a python function. Also providing an analytical gradient (and potentiall also a hessian) improves the performance of Gradient/Hessian-based optimizers. When acessing parameter uncertainties via profile-likelihoods/sampling, pyPESTO interprets the objective function as the negative-log-likelihood/negative-log-posterior.

[2]:
# define objective function
def f(x: np.array):
    return x[0] ** 2 + x[1] ** 2


# define gradient
def grad(x: np.array):
    return 2 * x


# define objective
custom_objective = pypesto.Objective(fun=f, grad=grad)

Define lower and upper parameter bounds and create an optimization problem.

[3]:
# define optimization bounds
lb = np.array([-10, -10])
ub = np.array([10, 10])

# create problem
custom_problem = pypesto.Problem(objective=custom_objective, lb=lb, ub=ub)

Now choose an optimizer to perform the optimization. minimize uses multi-start optimization, meaning that the optimzation is run n_start times from different initial values, in case the problem contians multiple local optima (which of course is not the case for this toy problem).

[4]:
# choose optimizer
optimizer = optimize.ScipyOptimizer()

# do the optimization
result_custom_problem = optimize.minimize(
    problem=custom_problem, optimizer=optimizer, n_starts=10
)
100%|██████████████████████████████████████████| 10/10 [00:00<00:00, 496.47it/s]

result_custom_problem.optimize_result now stores a list, that contains the results and meta data of the individual optimizer runs (ordered by function value).

[5]:
# E.g. The best model fit was obtained by the following optimization run:
result_custom_problem.optimize_result.list[0]
[5]:
{'id': '0',
 'x': array([0., 0.]),
 'fval': 0.0,
 'grad': array([0., 0.]),
 'hess': None,
 'res': None,
 'sres': None,
 'n_fval': 4,
 'n_grad': 4,
 'n_hess': 0,
 'n_res': 0,
 'n_sres': 0,
 'x0': array([0.6901338 , 7.17776654]),
 'fval0': 51.996617134691896,
 'history': <pypesto.history.base.CountHistory at 0x12d86aaa0>,
 'exitflag': 0,
 'time': 0.007859945297241211,
 'message': 'CONVERGENCE: NORM_OF_PROJECTED_GRADIENT_<=_PGTOL',
 'optimizer': "<ScipyOptimizer method=L-BFGS-B options={'maxfun': 1000, 'disp': False}>"}
[6]:
# Objective function values of the different optimizer runs:
result_custom_problem.optimize_result.get_for_key('fval')
[6]:
[0.0,
 0.0,
 0.0,
 0.0,
 0.0,
 7.523163845262637e-37,
 1.504632769052528e-36,
 1.5046327690525307e-36,
 3.0562853121379475e-36,
 3.1973446342366133e-36]

Problem Definition via PEtab

Background on PEtab

pyPESTO logo

PyPESTO supports the PEtab standard. PEtab is a data format for specifying parameter estimation problems in systems biology.

A PEtab problem consist of an SBML file, defining the model topology and a set of .tsv files, defining experimental conditions, observables, measurements and parameters (and their optimization bounds, scale, priors…). All files, that make up a PEtab problem, can be structured in a .yaml file. The pypesto.Objective comming from a PEtab problem corresponds to the negative-log-likelihood/negative-log-posterior disrtibution of the parameters.

For more details on PEtab, the interested reader is refered to PEtab’s format definition, for examples, the reader is refered to the PEtab benchmark collection. The Model from Böhm et al. JProteomRes 2014 is part of the benchmark collection and will be used as the running example throughout this notebook.

PyPESTO provides an interface to the model simulation tool AMICI for the simulation of Ordinary Differential Equation (ODE) models specified in the SBML format.

Basic Model Import and Optimization

The first step is to import a PEtab problem and create a pypesto.problem object:

[7]:
%%capture
# directory of the PEtab problem
petab_yaml = './boehm_JProteomeRes2014/boehm_JProteomeRes2014.yaml'

importer = pypesto.petab.PetabImporter.from_yaml(petab_yaml)
problem = importer.create_problem()

Next, we choose an optimizer to perform the multi start optimization.

[8]:
%%time
%%capture

# choose optimizer
optimizer = optimize.ScipyOptimizer()

# do the optimization
result = optimize.minimize(problem=problem,
                           optimizer=optimizer,
                           n_starts=10)
2023-02-17 16:01:22.984 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 158.494 and h = 1.34133e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:22.986 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 158.494: AMICI failed to integrate the forward problem
2023-02-17 16:01:23.022 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 158.494 and h = 1.34133e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:23.023 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 158.494: AMICI failed to integrate the forward problem
2023-02-17 16:01:23.045 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 158.494 and h = 1.34133e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:23.046 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 158.494: AMICI failed to integrate the forward problem
CPU times: user 15 s, sys: 476 ms, total: 15.5 s
Wall time: 15.4 s

result.optimize_result contains a list with the ordered optimization results.

[9]:
# E.g. best model fit was obtained by the following optimization run:
result.optimize_result.list[0]
[9]:
{'id': '3',
 'x': array([-1.56904695, -5.        , -2.20985861, -1.78591646,  5.        ,
         4.19769784,  0.693     ,  0.58567634,  0.81886181,  0.49859024,
         0.107     ]),
 'fval': 138.2219738778035,
 'grad': array([ 1.02808139e-02,  5.53588489e-02,  2.03115656e-04,  1.00993749e-02,
        -4.41596715e-05, -9.26213990e-03,             nan,  2.11437217e-03,
         2.50708689e-03, -3.97887714e-04,             nan]),
 'hess': None,
 'res': None,
 'sres': None,
 'n_fval': 191,
 'n_grad': 191,
 'n_hess': 0,
 'n_res': 0,
 'n_sres': 0,
 'x0': array([ 2.1608791 , -2.88363288, -4.61132422,  1.82016484, -1.49529658,
        -1.08670354,  0.693     , -3.8208997 ,  2.23962013,  0.32443793,
         0.107     ]),
 'fval0': 1950794339021.3562,
 'history': <pypesto.history.base.CountHistory at 0x12da5b430>,
 'exitflag': 0,
 'time': 2.9797539710998535,
 'message': 'CONVERGENCE: REL_REDUCTION_OF_F_<=_FACTR*EPSMCH',
 'optimizer': "<ScipyOptimizer method=L-BFGS-B options={'maxfun': 1000, 'disp': False}>"}
[10]:
# Objective function values of the different optimizer runs:
result.optimize_result.get_for_key('fval')
[10]:
[138.2219738778035,
 149.58788363739558,
 149.58968254433313,
 150.06701061933796,
 158.809924925096,
 171.13435267913164,
 233.09982603500364,
 249.74596437461332,
 249.74599739701642,
 249.74599747333608]

2. Optimizer Choice

PyPESTO provides a unified interface to a variety of optimizers of different types:

  • All scipy optimizer (optimize.ScipyOptimizer(method=<method_name>))

    • function-value or least-squares-based optimizers

    • gradient or hessian-based optimizers

  • IpOpt (optimize.IpoptOptimizer())

    • Interior point method

  • Dlib (optimize.DlibOptimizer(options={'maxiter': <max. number of iterations>}))

    • Global optimizer

    • Gradient free

  • FIDES (optimize.FidesOptimizer())

    • Interior Trust Region optimizer

  • Particle Swarm (optimize.PyswarmOptimizer())

    • Particle swarm algorithm

    • Gradient free

  • CMA-ES (optimize.CmaesOptimizer())

    • Covariance Matrix Adaptation Evolution Strategy

    • Evolutionary Algorithm

[11]:
optimizer_scipy_lbfgsb = optimize.ScipyOptimizer(method='L-BFGS-B')
optimizer_scipy_powell = optimize.ScipyOptimizer(method='Powell')

optimizer_fides = optimize.FidesOptimizer()
optimizer_pyswarm = optimize.PyswarmOptimizer()

The following performs 100 multi-start runs with different optimizers in order to compare their performance.

Note: dlib and pyswarm need to be installed for this section to run. Furthermore the computation time is in the order of minutes, so you might want to skip the excecution and jump to the section on large scale models.

[12]:
%%time
%%capture --no-display
n_starts = 100

# Due to run time we already use parallelization.
# This will be introduced in more detail later.
engine = pypesto.engine.MultiProcessEngine()
history_options = pypesto.HistoryOptions(trace_record=True)

# Scipy: L-BFGS-B
result_lbfgsb = optimize.minimize(problem=problem,
                                  optimizer=optimizer_scipy_lbfgsb,
                                  engine=engine,
                                  history_options=history_options,
                                  n_starts=n_starts)

# Scipy: Powell
result_powell = optimize.minimize(problem=problem,
                              optimizer=optimizer_scipy_powell,
                              engine=engine,
                              history_options=history_options,
                              n_starts=n_starts)

# Fides
result_fides = optimize.minimize(problem=problem,
                                optimizer=optimizer_fides,
                                engine=engine,
                                history_options=history_options,
                                n_starts=n_starts)


# PySwarm
result_pyswarm = optimize.minimize(problem=problem,
                                   optimizer=optimizer_pyswarm,
                                   engine=engine,
                                   history_options=history_options,
                                   n_starts=n_starts)
Engine set up to use up to 8 processes in total. The number was automatically determined and might not be appropriate on some systems.
Performing parallel task execution on 8 processes.
2023-02-17 16:01:41.379 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 98.8572 and h = 1.56563e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:41.379 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 98.8572: AMICI failed to integrate the forward problem
2023-02-17 16:01:41.408 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 98.8572 and h = 1.56563e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:41.408 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 98.8572: AMICI failed to integrate the forward problem
2023-02-17 16:01:42.689 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.945 and h = 2.71313e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:42.690 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.945: AMICI failed to integrate the forward problem
2023-02-17 16:01:42.903 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.945 and h = 2.71313e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:42.904 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.945: AMICI failed to integrate the forward problem
2023-02-17 16:01:43.010 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.945 and h = 2.71313e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:43.010 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.945: AMICI failed to integrate the forward problem
2023-02-17 16:01:43.595 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 51.0716 and h = 3.63082e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:43.595 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 51.0716: AMICI failed to integrate the forward problem
2023-02-17 16:01:43.628 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 51.0716 and h = 3.63082e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:43.628 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 51.0716: AMICI failed to integrate the forward problem
2023-02-17 16:01:50.278 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:TOO_MUCH_WORK] AMICI ERROR: in module CVODES in function CVode : At t = 76.964, mxstep steps taken before reaching tout.
2023-02-17 16:01:50.278 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 76.964: AMICI failed to integrate the forward problem
2023-02-17 16:01:50.564 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 140.591 and h = 1.97937e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:50.565 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 140.591: AMICI failed to integrate the forward problem
2023-02-17 16:01:51.675 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 167.379 and h = 7.66589e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:51.676 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 167.379: AMICI failed to integrate the forward problem
2023-02-17 16:01:51.735 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 167.379 and h = 7.66589e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:51.736 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 167.379: AMICI failed to integrate the forward problem
2023-02-17 16:01:55.008 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 188.834 and h = 3.15716e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:01:55.009 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 188.834: AMICI failed to integrate the forward problem
2023-02-17 16:02:00.240 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.6972 and h = 1.45985e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:00.240 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.6972: AMICI failed to integrate the forward problem
2023-02-17 16:02:00.294 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.6972 and h = 1.45985e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:00.294 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.6972: AMICI failed to integrate the forward problem
2023-02-17 16:02:07.377 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 169.229 and h = 1.90001e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:07.378 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 169.229: AMICI failed to integrate the forward problem
2023-02-17 16:02:07.511 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 169.229 and h = 1.90001e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:07.512 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 169.229: AMICI failed to integrate the forward problem
2023-02-17 16:02:08.616 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 92.2863 and h = 1.84593e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:08.616 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 92.2863: AMICI failed to integrate the forward problem
2023-02-17 16:02:08.718 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 118.037 and h = 2.126e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:08.718 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 118.037: AMICI failed to integrate the forward problem
2023-02-17 16:02:08.830 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 118.037 and h = 2.126e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:08.831 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 118.037: AMICI failed to integrate the forward problem
2023-02-17 16:02:08.900 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 118.037 and h = 2.126e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:08.900 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 118.037: AMICI failed to integrate the forward problem
2023-02-17 16:02:12.500 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 138.745 and h = 1.31331e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:12.500 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 138.745: AMICI failed to integrate the forward problem
2023-02-17 16:02:12.732 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 138.745 and h = 1.31331e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:12.732 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 138.745: AMICI failed to integrate the forward problem
2023-02-17 16:02:12.830 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 138.745 and h = 1.31331e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:12.830 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 138.745: AMICI failed to integrate the forward problem
2023-02-17 16:02:13.480 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.825 and h = 1.87415e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:13.480 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.825: AMICI failed to integrate the forward problem
2023-02-17 16:02:13.674 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.825 and h = 1.87415e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:13.674 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.825: AMICI failed to integrate the forward problem
2023-02-17 16:02:13.761 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.825 and h = 1.87415e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:13.761 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.825: AMICI failed to integrate the forward problem
2023-02-17 16:02:15.776 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 168.782 and h = 3.21943e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:15.776 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 168.782: AMICI failed to integrate the forward problem
2023-02-17 16:02:16.578 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 168.806 and h = 2.98398e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:16.578 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 168.806: AMICI failed to integrate the forward problem
2023-02-17 16:02:18.407 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.788 and h = 1.37128e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:18.407 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.788: AMICI failed to integrate the forward problem
2023-02-17 16:02:18.474 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.788 and h = 1.37128e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:18.474 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.788: AMICI failed to integrate the forward problem
2023-02-17 16:02:18.529 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.788 and h = 1.37128e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:18.530 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.788: AMICI failed to integrate the forward problem
2023-02-17 16:02:20.019 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 150.727 and h = 1.41441e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:20.020 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 150.727: AMICI failed to integrate the forward problem
2023-02-17 16:02:20.112 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 150.727 and h = 1.41441e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:20.113 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 150.727: AMICI failed to integrate the forward problem
2023-02-17 16:02:22.871 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 66.7204 and h = 1.90309e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:22.871 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 66.7204: AMICI failed to integrate the forward problem
2023-02-17 16:02:27.514 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 13.8788 and h = 2.73008e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:27.514 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 13.8788: AMICI failed to integrate the forward problem
2023-02-17 16:02:27.582 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 13.8788 and h = 2.73008e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:27.583 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 13.8788: AMICI failed to integrate the forward problem
2023-02-17 16:02:27.608 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 13.8788 and h = 2.73008e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:27.608 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 13.8788: AMICI failed to integrate the forward problem
2023-02-17 16:02:27.889 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 221.347 and h = 4.88446e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:27.889 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 221.347: AMICI failed to integrate the forward problem
2023-02-17 16:02:28.730 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 97.978 and h = 2.09287e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:28.730 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 97.978: AMICI failed to integrate the forward problem
2023-02-17 16:02:28.807 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 97.978 and h = 2.09287e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:28.807 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 97.978: AMICI failed to integrate the forward problem
2023-02-17 16:02:28.886 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 97.978 and h = 2.09287e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:02:28.886 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 97.978: AMICI failed to integrate the forward problem
Performing parallel task execution on 8 processes.
Performing parallel task execution on 8 processes.
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +2.27E+04 |    NaN   |    NaN   | 1.0E+00 | 9.5E+04 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +9.53E+12 |    NaN   |    NaN   | 1.0E+00 | 4.4E+13 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +7.39E+13 |    NaN   |    NaN   | 1.0E+00 | 3.4E+14 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +3.54E+08 |    NaN   |    NaN   | 1.0E+00 | 1.6E+09 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +4.33E+02 |    NaN   |    NaN   | 1.0E+00 | 6.4E+01 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +3.21E+11 |    NaN   |    NaN   | 1.0E+00 | 1.4E+12 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +4.32E+02 |    NaN   |    NaN   | 1.0E+00 | 6.4E+01 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)     0| +8.98E+11 |    NaN   |    NaN   | 1.0E+00 | 4.1E+12 |   NaN   | NaN |1
2023-02-17 16:05:05 fides(INFO)     1| +9.31E+02 | -2.2E+04 | +1.3E-01 | 1.0E+00 | 9.5E+04 | 2.2E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     1| +9.41E+06 | -9.5E+12 | +8.5E-02 | 1.0E+00 | 4.4E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     1| +4.70E+04 | -3.5E+08 | +1.0E-01 | 1.0E+00 | 1.6E+09 | 2.7E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +3.88E+02 | -5.4E+02 | +9.0E-01 | 2.5E-01 | 3.0E+03 | 4.7E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     1| +3.05E+02 | -1.3E+02 | +5.0E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +1.79E+06 | -7.6E+06 | +8.9E-01 | 2.5E-01 | 3.6E+07 | 6.2E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     3| +3.04E+02 | -8.4E+01 | +8.9E-01 | 5.0E-01 | 4.8E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     1| +2.34E+11 | -7.4E+13 | +8.4E-02 | 1.0E+00 | 3.4E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +8.13E+03 | -3.9E+04 | +9.0E-01 | 2.5E-01 | 2.1E+05 | 5.8E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     1| +7.96E+09 | -3.1E+11 | +9.3E-02 | 1.0E+00 | 1.4E+12 | 2.9E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     1| +3.05E+02 | -1.3E+02 | +5.4E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     3| +2.78E+05 | -1.5E+06 | +9.0E-01 | 5.0E-01 | 6.2E+06 | 1.1E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     4| +2.73E+02 | -3.2E+01 | +5.6E-01 | 1.0E+00 | 7.5E+01 | 2.5E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +3.48E+10 | -2.0E+11 | +8.9E-01 | 2.5E-01 | 1.1E+12 | 6.6E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     3| +1.52E+03 | -6.6E+03 | +9.0E-01 | 5.0E-01 | 3.3E+04 | 1.2E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     4| +4.37E+04 | -2.3E+05 | +9.0E-01 | 1.0E+00 | 9.6E+05 | 1.1E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +2.58E+02 | -4.7E+01 | +8.8E-01 | 1.0E+00 | 2.3E+02 | 2.2E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     5| +2.51E+02 | -2.2E+01 | +7.0E-01 | 1.0E+00 | 9.4E+01 | 2.0E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +1.20E+09 | -6.8E+09 | +8.9E-01 | 2.5E-01 | 3.7E+10 | 6.8E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     1| +2.58E+08 | -9.0E+11 | +8.9E-02 | 1.0E+00 | 4.1E+12 | 2.9E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +2.68E+02 | -3.7E+01 | +8.8E-01 | 1.0E+00 | 1.9E+02 | 2.8E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     6| +2.51E+02 | +3.1E+00 | -1.3E+00 | 1.0E+00 | 1.7E+01 | 2.6E+00 |  2d |0
2023-02-17 16:05:05 fides(INFO)     3| +5.19E+09 | -3.0E+10 | +8.9E-01 | 5.0E-01 | 1.6E+11 | 7.6E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     4| +4.18E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 5.3E+03 | 1.8E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     5| +7.03E+03 | -3.7E+04 | +9.0E-01 | 1.0E+00 | 1.5E+05 | 1.2E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     7| +2.51E+02 | +3.2E+00 | -1.3E+00 | 2.5E-01 | 1.7E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:05 fides(INFO)     3| +2.58E+02 | +1.6E+02 | -1.0E+01 | 2.0E+00 | 3.8E+01 | 4.1E+00 |  2d |0
2023-02-17 16:05:05 fides(INFO)     6| +1.28E+03 | -5.8E+03 | +9.0E-01 | 1.0E+00 | 2.4E+04 | 1.2E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     8| +2.50E+02 | -1.1E+00 | +5.2E-01 | 6.2E-02 | 1.7E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     5| +2.63E+02 | -1.5E+02 | +8.8E-01 | 1.0E+00 | 8.2E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     4| +7.78E+08 | -4.4E+09 | +8.9E-01 | 5.0E-01 | 2.4E+10 | 7.4E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     3| +1.81E+08 | -1.0E+09 | +8.9E-01 | 5.0E-01 | 5.5E+09 | 1.3E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     3| +2.68E+02 | +2.9E+06 | -2.2E+05 | 2.0E+00 | 3.7E+01 | 5.2E+00 |  2d |0
2023-02-17 16:05:05 fides(INFO)     5| +1.17E+08 | -6.6E+08 | +8.9E-01 | 5.0E-01 | 3.6E+09 | 7.4E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     9| +2.50E+02 | -4.6E-02 | +2.0E-01 | 6.2E-02 | 6.5E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     7| +3.80E+02 | -9.0E+02 | +9.0E-01 | 1.0E+00 | 3.8E+03 | 1.3E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     2| +3.93E+07 | -2.2E+08 | +8.9E-01 | 2.5E-01 | 1.2E+09 | 6.3E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     6| +2.32E+02 | -3.1E+01 | +1.4E+00 | 2.0E+00 | 1.1E+02 | 4.0E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     4| +2.58E+02 | +1.6E+02 | -9.3E+00 | 5.0E-01 | 3.8E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:05 fides(INFO)     6| +1.77E+07 | -9.9E+07 | +8.9E-01 | 5.0E-01 | 5.4E+08 | 7.3E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)    10| +2.50E+02 | -5.6E-02 | +4.5E-01 | 1.6E-02 | 4.6E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:05 fides(INFO)     4| +2.76E+07 | -1.5E+08 | +8.9E-01 | 1.0E+00 | 8.3E+08 | 1.0E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     8| +2.56E+02 | -1.2E+02 | +8.7E-01 | 1.0E+00 | 5.9E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)    11| +2.50E+02 | -2.1E-03 | +8.3E-02 | 1.6E-02 | 2.1E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:05 fides(INFO)     4| +2.68E+02 | +8.2E+01 | -3.8E+00 | 5.0E-01 | 3.7E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:05 fides(INFO)     5| +2.50E+02 | -8.2E+00 | +7.7E-01 | 1.2E-01 | 3.8E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     7| +2.32E+02 | +2.8E+03 | -8.1E+01 | 4.0E+00 | 4.5E+01 | 1.1E+01 |  2d |0
2023-02-17 16:05:05 fides(INFO)     7| +2.70E+06 | -1.5E+07 | +8.9E-01 | 5.0E-01 | 8.2E+07 | 7.3E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)    12| +2.50E+02 | -9.9E-03 | +7.0E-01 | 3.9E-03 | 1.8E+00 | 1.0E-02 |  2d |1
2023-02-17 16:05:05 fides(INFO)     9| +2.32E+02 | -2.4E+01 | +1.6E+00 | 2.0E+00 | 7.0E+01 | 3.8E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)     5| +4.23E+06 | -2.3E+07 | +8.9E-01 | 1.0E+00 | 1.3E+08 | 9.6E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     8| +4.12E+05 | -2.3E+06 | +8.9E-01 | 5.0E-01 | 1.2E+07 | 7.2E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)    13| +2.50E+02 | -3.6E-05 | +2.6E-01 | 3.9E-03 | 1.3E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:05 fides(INFO)     8| +2.32E+02 | +2.5E+02 | -9.6E+00 | 1.0E+00 | 4.5E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:05 fides(INFO)     5| +2.57E+02 | -1.1E+01 | +9.5E-01 | 1.2E-01 | 3.7E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)    14| +2.50E+02 | -3.8E-05 | +2.8E-01 | 3.9E-03 | 1.3E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:05 fides(INFO)     6| +2.50E+02 | +3.5E-01 | -5.0E-01 | 2.5E-01 | 1.0E+01 | 5.8E-01 |  2d |0
2023-02-17 16:05:05 fides(INFO)     9| +6.25E+04 | -3.5E+05 | +9.0E-01 | 5.0E-01 | 1.9E+06 | 7.0E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     3| +5.97E+06 | -3.3E+07 | +8.9E-01 | 5.0E-01 | 1.8E+08 | 1.1E+00 |  2d |1
2023-02-17 16:05:05 fides(INFO)    15| +2.50E+02 | -3.7E-05 | +2.8E-01 | 3.9E-03 | 1.3E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)    10| +2.32E+02 | +1.0E+03 | -3.9E+01 | 4.0E+00 | 4.2E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:05 fides(INFO)     9| +2.22E+02 | -9.9E+00 | +4.0E-01 | 2.5E-01 | 4.5E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     6| +6.50E+05 | -3.6E+06 | +9.0E-01 | 1.0E+00 | 1.9E+07 | 9.1E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)     6| +2.57E+02 | +3.5E+00 | -4.3E-01 | 2.5E-01 | 3.0E+01 | 6.5E-01 |  2d |0
2023-02-17 16:05:05 fides(INFO)     7| +2.50E+02 | +3.5E-01 | -5.0E-01 | 6.2E-02 | 1.0E+01 | 1.6E-01 |  2d |0
2023-02-17 16:05:05 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:05 fides(INFO)    10| +9.71E+03 | -5.3E+04 | +9.0E-01 | 5.0E-01 | 2.9E+05 | 5.7E-01 |  2d |1
2023-02-17 16:05:05 fides(INFO)    16| +2.50E+02 | -3.9E-05 | +2.9E-01 | 3.9E-03 | 1.3E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)     7| +9.99E+04 | -5.5E+05 | +9.0E-01 | 1.0E+00 | 3.0E+06 | 9.0E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +2.50E+02 | -3.8E-05 | +2.9E-01 | 3.9E-03 | 1.3E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    10| +2.18E+02 | -4.7E+00 | +6.3E-01 | 2.5E-01 | 4.8E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    11| +2.32E+02 | +1.1E+02 | -5.5E+00 | 1.0E+00 | 4.2E+01 | 2.8E+00 |  2d |0
2023-02-17 16:05:06 fides(INFO)    11| +1.61E+03 | -8.1E+03 | +9.1E-01 | 1.0E+00 | 4.4E+04 | 5.1E-01 | trr |1
2023-02-17 16:05:06 fides(INFO)     8| +2.50E+02 | -2.9E-01 | +8.4E-01 | 1.6E-02 | 1.0E+01 | 3.9E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)     7| +2.53E+02 | -4.3E+00 | +9.3E-01 | 6.2E-02 | 3.0E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    18| +2.50E+02 | -4.0E-05 | +3.0E-01 | 3.9E-03 | 1.3E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    12| +2.28E+02 | -4.3E+00 | +1.7E-01 | 2.5E-01 | 4.2E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    19| +2.50E+02 | -3.9E-05 | +3.0E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    12| +4.30E+02 | -1.2E+03 | +9.0E-01 | 1.0E+00 | 6.6E+03 | 2.7E+00 | trr |1
2023-02-17 16:05:06 fides(INFO)    11| +2.17E+02 | -6.0E-01 | +6.6E-02 | 2.5E-01 | 2.1E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    13| +2.23E+02 | -5.2E+00 | +8.6E-01 | 6.2E-02 | 6.5E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)     8| +2.51E+02 | -1.4E+00 | +2.2E-01 | 1.2E-01 | 2.3E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)     9| +2.50E+02 | +2.2E-02 | -1.7E-01 | 3.1E-02 | 4.7E+00 | 7.6E-02 |  2d |0
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +2.50E+02 | -4.1E-05 | +3.1E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)     4| +9.12E+05 | -5.1E+06 | +8.9E-01 | 5.0E-01 | 2.7E+07 | 1.0E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    21| +2.50E+02 | -4.0E-05 | +3.1E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    13| +2.35E+02 | -1.9E+02 | +9.3E-01 | 1.0E+00 | 1.0E+03 | 1.7E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    14| +2.20E+02 | -2.3E+00 | +5.9E-01 | 1.2E-01 | 3.3E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)     8| +1.53E+04 | -8.5E+04 | +9.0E-01 | 1.0E+00 | 4.6E+05 | 8.7E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    12| +2.14E+02 | -3.4E+00 | +8.3E-01 | 6.2E-02 | 4.6E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    22| +2.50E+02 | -4.2E-05 | +3.3E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    10| +2.50E+02 | -6.0E-02 | +8.0E-01 | 7.8E-03 | 4.7E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)     9| +2.50E+02 | -1.0E+00 | +8.3E-01 | 3.1E-02 | 2.5E+01 | 6.1E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    15| +2.20E+02 | +3.1E-01 | -1.7E-01 | 1.2E-01 | 1.9E+01 | 3.1E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    23| +2.50E+02 | -4.1E-05 | +3.3E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    13| +2.12E+02 | -2.0E+00 | +7.7E-01 | 1.2E-01 | 2.1E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    11| +2.50E+02 | +4.3E-04 | -2.9E-02 | 1.6E-02 | 1.7E+00 | 3.7E-02 |  2d |0
2023-02-17 16:05:06 fides(INFO)    24| +2.50E+02 | -4.3E-05 | +3.4E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    10| +2.50E+02 | -1.5E-01 | +3.2E-01 | 6.2E-02 | 9.9E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    14| +2.14E+02 | -2.1E+01 | +7.7E-01 | 2.0E+00 | 1.4E+02 | 5.9E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    16| +2.19E+02 | -9.2E-01 | +8.5E-01 | 3.1E-02 | 1.9E+01 | 7.4E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    25| +2.50E+02 | -4.2E-05 | +3.4E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    14| +2.09E+02 | -2.5E+00 | +6.5E-01 | 2.5E-01 | 1.6E+01 | 5.6E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)     5| +1.41E+05 | -7.7E+05 | +9.0E-01 | 5.0E-01 | 4.2E+06 | 9.9E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    12| +2.50E+02 | -8.0E-03 | +6.8E-01 | 3.9E-03 | 1.7E+00 | 9.4E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    26| +2.50E+02 | -4.4E-05 | +3.5E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)     9| +2.47E+03 | -1.3E+04 | +9.1E-01 | 1.0E+00 | 7.0E+04 | 8.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +2.18E+02 | -1.1E+00 | +9.1E-01 | 6.2E-02 | 1.5E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    11| +2.50E+02 | +2.9E-02 | -1.4E-01 | 6.2E-02 | 5.7E+00 | 1.7E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    27| +2.50E+02 | -4.3E-05 | +3.5E-01 | 3.9E-03 | 1.2E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    15| +2.14E+02 | +1.2E+04 | -3.9E+02 | 4.0E+00 | 5.8E+01 | 9.7E+00 | trr |0
2023-02-17 16:05:06 fides(INFO)    15| +2.02E+02 | -7.4E+00 | +1.0E+00 | 2.5E-01 | 2.9E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    28| +2.50E+02 | -4.5E-05 | +3.7E-01 | 3.9E-03 | 1.2E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    18| +2.17E+02 | -1.3E+00 | +7.6E-01 | 1.2E-01 | 1.7E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    29| +2.50E+02 | -4.5E-05 | +3.7E-01 | 3.9E-03 | 1.1E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    13| +2.50E+02 | -1.0E-04 | +1.0E-01 | 3.9E-03 | 4.0E-01 | 8.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    12| +2.50E+02 | -1.1E-01 | +6.3E-01 | 1.6E-02 | 5.7E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    30| +2.50E+02 | -4.6E-05 | +3.8E-01 | 3.9E-03 | 1.1E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    19| +2.17E+02 | +3.8E-01 | -2.1E-01 | 2.5E-01 | 1.7E+01 | 7.0E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)     6| +2.19E+04 | -1.2E+05 | +9.0E-01 | 5.0E-01 | 6.4E+05 | 9.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    16| +1.88E+02 | -1.3E+01 | +1.8E-01 | 5.0E-01 | 2.3E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    16| +2.14E+02 | +3.6E+01 | -2.8E+00 | 9.1E-01 | 5.8E+01 | 2.4E+00 |  2d |0
2023-02-17 16:05:06 fides(INFO)    14| +2.50E+02 | -4.0E-04 | +5.9E-01 | 9.8E-04 | 3.7E-01 | 2.6E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    31| +2.50E+02 | -4.6E-05 | +3.8E-01 | 3.9E-03 | 1.1E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    13| +2.50E+02 | -5.0E-03 | +7.3E-01 | 1.6E-02 | 5.3E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +2.16E+02 | -9.1E-01 | +5.2E-01 | 6.2E-02 | 1.7E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    10| +5.65E+02 | -1.9E+03 | +9.0E-01 | 1.0E+00 | 1.1E+04 | 2.7E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    32| +2.50E+02 | -4.8E-05 | +3.9E-01 | 3.9E-03 | 1.1E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +1.62E+02 | -2.6E+01 | +9.5E-01 | 1.2E-01 | 2.4E+02 | 2.3E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    21| +2.15E+02 | -7.3E-01 | +7.1E-01 | 6.2E-02 | 1.6E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    15| +2.50E+02 | -1.8E-05 | +4.9E-01 | 9.8E-04 | 6.0E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    33| +2.50E+02 | -8.5E-05 | +1.0E+00 | 3.9E-03 | 1.1E-01 | 9.7E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    14| +2.50E+02 | -4.5E-03 | +6.8E-01 | 1.6E-02 | 5.8E-01 | 4.3E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    34| +2.50E+02 | +3.0E-03 | -1.3E+01 | 7.8E-03 | 3.4E-02 | 2.0E-02 |  2d |0
2023-02-17 16:05:06 fides(INFO)     7| +3.57E+03 | -1.8E+04 | +9.0E-01 | 5.0E-01 | 9.9E+04 | 9.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    22| +2.15E+02 | -2.4E-01 | +2.6E-01 | 6.2E-02 | 1.2E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    35| +2.50E+02 | +1.1E-03 | -1.0E+01 | 2.0E-03 | 3.4E-02 | 5.0E-03 |  2d |0
2023-02-17 16:05:06 fides(INFO)    16| +2.50E+02 | -1.7E-05 | +5.1E-01 | 9.8E-04 | 5.5E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    18| +1.51E+02 | -1.2E+01 | +7.1E-01 | 2.5E-01 | 5.4E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    36| +2.50E+02 | +7.4E-05 | -2.0E+00 | 4.9E-04 | 3.4E-02 | 1.2E-03 |  2d |0
2023-02-17 16:05:06 fides(INFO)    11| +2.58E+02 | -3.1E+02 | +9.3E-01 | 2.0E+00 | 1.7E+03 | 2.0E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +2.02E+02 | -1.2E+01 | +9.9E-01 | 2.3E-01 | 5.8E+01 | 4.9E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    15| +2.50E+02 | -4.3E-03 | +6.5E-01 | 1.6E-02 | 6.2E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)     8| +7.19E+02 | -2.9E+03 | +8.9E-01 | 1.0E+00 | 1.5E+04 | 1.5E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    23| +2.14E+02 | -7.2E-01 | +6.0E-01 | 6.2E-02 | 1.9E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    37| +2.50E+02 | -3.1E-06 | +3.0E-01 | 1.2E-04 | 3.4E-02 | 3.1E-04 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +2.50E+02 | -1.8E-05 | +5.4E-01 | 9.8E-04 | 5.4E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    12| +2.04E+02 | -5.3E+01 | +9.2E-01 | 2.0E+00 | 2.4E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    19| +1.49E+02 | -1.5E+00 | +8.9E-01 | 2.5E-01 | 2.9E+01 | 3.8E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    38| +2.50E+02 | -2.7E-06 | +1.0E+00 | 1.2E-04 | 1.9E-02 | 3.0E-04 |  2d |1
2023-02-17 16:05:06 fides(INFO)    24| +2.14E+02 | -1.0E-01 | +1.3E-01 | 6.2E-02 | 1.1E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    39| +2.50E+02 | -5.2E-06 | +1.0E+00 | 2.4E-04 | 8.2E-03 | 6.3E-04 |  2d |1
2023-02-17 16:05:06 fides(INFO)    16| +2.50E+02 | -3.8E-03 | +6.2E-01 | 1.6E-02 | 6.2E-01 | 4.3E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    18| +2.50E+02 | -1.7E-05 | +5.6E-01 | 9.8E-04 | 5.0E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    25| +2.14E+02 | -3.8E-01 | +9.0E-01 | 1.6E-02 | 1.8E+01 | 2.9E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)     9| +3.47E+02 | -3.7E+02 | +6.6E-01 | 2.0E+00 | 2.4E+03 | 1.5E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    40| +2.50E+02 | -9.1E-06 | +1.0E+00 | 4.9E-04 | 8.8E-03 | 1.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +1.48E+02 | -1.0E+00 | +6.6E-01 | 5.0E-01 | 3.8E+01 | 7.0E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    41| +2.50E+02 | -1.9E-05 | +1.0E+00 | 9.8E-04 | 8.3E-03 | 2.5E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    18| +1.89E+02 | -1.2E+01 | +7.6E-02 | 4.6E-01 | 3.2E+01 | 9.3E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +2.50E+02 | -3.6E-03 | +6.1E-01 | 1.6E-02 | 6.4E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    13| +2.04E+02 | +7.8E+03 | -4.7E+02 | 2.0E+00 | 5.1E+01 | 4.2E+00 | trr |0
2023-02-17 16:05:06 fides(INFO)    19| +2.50E+02 | -1.8E-05 | +5.8E-01 | 9.8E-04 | 4.9E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    42| +2.50E+02 | -3.8E-05 | +1.0E+00 | 2.0E-03 | 1.1E-02 | 5.1E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    26| +2.14E+02 | -3.5E-01 | +7.6E-01 | 3.1E-02 | 1.3E+01 | 5.3E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    43| +2.50E+02 | -7.6E-05 | +1.0E+00 | 3.9E-03 | 1.0E-02 | 1.0E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    21| +1.48E+02 | +3.6E+01 | -1.4E+01 | 5.0E-01 | 2.5E+01 | 7.9E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    14| +1.72E+02 | -3.2E+01 | +8.5E-01 | 5.0E-01 | 5.1E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    10| +2.01E+02 | -1.5E+02 | +9.0E-01 | 2.0E+00 | 5.2E+02 | 1.8E+00 | trr |1
2023-02-17 16:05:06 fides(INFO)    18| +2.50E+02 | -3.2E-03 | +5.8E-01 | 1.6E-02 | 6.2E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +2.50E+02 | -1.7E-05 | +5.9E-01 | 9.8E-04 | 4.7E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    44| +2.50E+02 | -1.6E-04 | +1.0E+00 | 7.8E-03 | 1.4E-02 | 2.0E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    27| +2.13E+02 | -3.5E-01 | +6.8E-01 | 6.2E-02 | 8.4E+00 | 1.0E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    45| +2.50E+02 | -3.3E-04 | +1.0E+00 | 1.6E-02 | 2.7E-02 | 4.0E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    15| +1.72E+02 | +4.5E+03 | -2.0E+02 | 1.0E+00 | 1.3E+02 | 1.8E+00 |  2d |0
2023-02-17 16:05:06 fides(INFO)    28| +2.13E+02 | -2.6E-01 | +4.4E-01 | 6.2E-02 | 1.3E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    22| +1.48E+02 | +4.0E-01 | -4.6E-01 | 1.2E-01 | 2.5E+01 | 2.0E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    46| +2.50E+02 | -7.3E-04 | +1.1E+00 | 3.1E-02 | 5.6E-02 | 8.1E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    21| +2.50E+02 | -1.8E-05 | +6.2E-01 | 9.8E-04 | 4.6E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    19| +2.50E+02 | -3.1E-03 | +5.7E-01 | 1.6E-02 | 6.4E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    19| +1.68E+02 | -2.1E+01 | +9.8E-01 | 1.1E-01 | 2.5E+02 | 1.9E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    47| +2.50E+02 | -1.8E-03 | +1.2E+00 | 6.2E-02 | 1.1E-01 | 1.6E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    16| +1.60E+02 | -1.3E+01 | +5.5E-01 | 2.4E-01 | 1.3E+02 | 4.4E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    29| +2.13E+02 | +1.7E-02 | -5.8E-02 | 6.2E-02 | 8.9E+00 | 1.6E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    23| +1.48E+02 | -2.2E-01 | +7.3E-01 | 3.1E-02 | 2.5E+01 | 5.0E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    48| +2.50E+02 | -6.0E-03 | +1.5E+00 | 1.2E-01 | 2.2E-01 | 3.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    11| +2.01E+02 | +7.6E+02 | -3.3E+01 | 2.0E+00 | 1.3E+02 | 2.0E+00 |  2d |0
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +2.50E+02 | -2.7E-03 | +5.5E-01 | 1.6E-02 | 6.1E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    22| +2.50E+02 | -1.8E-05 | +6.2E-01 | 9.8E-04 | 4.4E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    49| +2.50E+02 | -3.3E-02 | +2.1E+00 | 2.5E-01 | 4.4E-01 | 6.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    30| +2.13E+02 | -2.1E-01 | +8.2E-01 | 1.6E-02 | 8.9E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +1.53E+02 | -6.8E+00 | +9.6E-01 | 2.4E-01 | 1.9E+02 | 8.8E-02 | trr |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06.633 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.235 and h = 2.73909e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:06.633 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.235: AMICI failed to integrate the forward problem
2023-02-17 16:05:06 fides(INFO)    50| +2.49E+02 | -5.0E-01 | +3.7E+00 | 5.0E-01 | 8.0E-01 | 1.2E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    24| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-02 | 1.1E+01 | 3.9E-02 |  2d |0
2023-02-17 16:05:06 fides(INFO)    23| +2.50E+02 | -1.8E-05 | +6.4E-01 | 9.8E-04 | 4.4E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    31| +2.13E+02 | -1.5E-01 | +7.0E-01 | 3.1E-02 | 6.6E+00 | 5.6E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    21| +2.50E+02 | -2.6E-03 | +5.4E-01 | 1.6E-02 | 6.2E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    18| +1.50E+02 | -3.2E+00 | +7.8E-01 | 2.4E-01 | 5.5E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    12| +1.89E+02 | -1.2E+01 | +5.5E-01 | 3.2E-01 | 1.3E+02 | 5.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    51| +2.37E+02 | -1.2E+01 | +4.4E+00 | 1.0E+00 | 1.3E+00 | 2.2E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    32| +2.13E+02 | -1.4E-01 | +5.8E-01 | 3.1E-02 | 8.4E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    25| +1.48E+02 | -5.5E-02 | +9.5E-01 | 7.8E-03 | 1.1E+01 | 1.1E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    24| +2.50E+02 | -1.8E-05 | +6.4E-01 | 9.8E-04 | 4.3E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    19| +1.50E+02 | +5.4E+01 | -1.2E+01 | 4.7E-01 | 6.5E+01 | 7.7E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +1.59E+02 | -8.8E+00 | +8.0E-01 | 2.3E-01 | 4.5E+01 | 4.3E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    22| +2.50E+02 | -2.3E-03 | +5.2E-01 | 1.6E-02 | 5.9E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    13| +1.82E+02 | -6.7E+00 | +9.3E-01 | 3.2E-01 | 1.2E+02 | 6.3E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    33| +2.12E+02 | -6.5E-02 | +3.0E-01 | 3.1E-02 | 6.3E+00 | 7.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    52| +2.28E+02 | -9.6E+00 | +5.7E-01 | 2.0E+00 | 3.1E+01 | 2.9E+00 | trr |1
2023-02-17 16:05:06 fides(INFO)    25| +2.50E+02 | -1.8E-05 | +6.5E-01 | 9.8E-04 | 4.3E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    26| +1.48E+02 | -4.0E-02 | +9.3E-01 | 1.6E-02 | 1.3E+01 | 1.9E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +1.49E+02 | -3.2E-01 | +1.4E-01 | 1.2E-01 | 6.5E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    53| +2.28E+02 | +4.7E+03 | -1.9E+02 | 2.0E+00 | 4.1E+01 | 3.2E+00 | trr |0
2023-02-17 16:05:06 fides(INFO)    34| +2.12E+02 | -1.4E-01 | +5.3E-01 | 3.1E-02 | 8.8E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    14| +1.82E+02 | -8.6E-01 | -1.3E-01 | 6.4E-01 | 3.2E+01 | 1.0E+00 |  2d |0
2023-02-17 16:05:06 fides(INFO)    23| +2.50E+02 | -2.2E-03 | +5.2E-01 | 1.6E-02 | 6.0E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    26| +2.50E+02 | -1.8E-05 | +6.5E-01 | 9.8E-04 | 4.2E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    27| +1.48E+02 | -4.3E-02 | +9.2E-01 | 3.1E-02 | 7.4E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    35| +2.12E+02 | -4.9E-02 | +2.7E-01 | 3.1E-02 | 5.7E+00 | 7.5E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    21| +1.49E+02 | -5.4E-01 | +9.3E-01 | 2.9E-02 | 3.9E+01 | 3.6E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    27| +2.50E+02 | -1.8E-05 | +6.6E-01 | 9.8E-04 | 4.2E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    24| +2.50E+02 | -2.0E-03 | +4.9E-01 | 1.6E-02 | 5.7E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    54| +2.21E+02 | -6.9E+00 | +2.5E-01 | 3.2E-01 | 4.1E+01 | 8.2E-01 | trr |1
2023-02-17 16:05:06 fides(INFO)    15| +1.79E+02 | -2.9E+00 | +9.5E-01 | 1.6E-01 | 3.2E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    36| +2.12E+02 | -1.2E-01 | +5.0E-01 | 3.1E-02 | 8.1E+00 | 6.4E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    28| +1.48E+02 | -5.0E-02 | +9.3E-01 | 6.2E-02 | 8.9E+00 | 7.0E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    22| +1.48E+02 | -4.9E-01 | +6.7E-01 | 5.9E-02 | 3.5E+01 | 6.7E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    28| +2.50E+02 | -1.8E-05 | +6.6E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    25| +2.50E+02 | -1.9E-03 | +5.0E-01 | 1.6E-02 | 5.8E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    55| +2.14E+02 | -6.7E+00 | +8.1E-01 | 8.0E-02 | 7.1E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:06.818 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.0543 and h = 1.00881e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:06.818 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.0543: AMICI failed to integrate the forward problem
2023-02-17 16:05:06 fides(INFO)    37| +2.12E+02 | -4.5E-02 | +2.6E-01 | 3.1E-02 | 5.3E+00 | 7.8E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    23| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.9E-02 | 2.9E+01 | 5.4E-02 |  2d |0
2023-02-17 16:05:06.820 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.802 and h = 3.01856e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:06.820 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.802: AMICI failed to integrate the forward problem
2023-02-17 16:05:06 fides(INFO)    29| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 5.5E+00 | 1.4E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    16| +1.76E+02 | -2.8E+00 | +1.0E+00 | 3.2E-01 | 5.7E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    21| +1.55E+02 | -4.4E+00 | +1.1E+00 | 4.6E-01 | 1.3E+02 | 3.2E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    29| +2.50E+02 | -1.9E-05 | +6.7E-01 | 9.8E-04 | 4.2E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    38| +2.12E+02 | -1.0E-01 | +4.8E-01 | 3.1E-02 | 7.4E+00 | 6.7E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    56| +2.13E+02 | -1.4E+00 | +8.9E-01 | 1.6E-01 | 2.1E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    26| +2.50E+02 | -1.7E-03 | +4.7E-01 | 1.6E-02 | 5.5E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    30| +1.48E+02 | -3.0E-02 | +9.2E-01 | 3.1E-02 | 5.5E+00 | 3.5E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    24| +1.48E+02 | -1.3E-01 | +9.5E-01 | 1.5E-02 | 2.9E+01 | 1.5E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    17| +1.76E+02 | +5.8E+00 | -1.0E+00 | 6.4E-01 | 3.4E+01 | 9.5E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    39| +2.12E+02 | -4.6E-02 | +2.9E-01 | 3.1E-02 | 4.9E+00 | 8.0E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    30| +2.50E+02 | -1.8E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    25| +1.48E+02 | -1.4E-01 | +9.7E-01 | 2.9E-02 | 2.0E+01 | 2.8E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    57| +2.13E+02 | -1.6E-01 | +8.3E-02 | 3.2E-01 | 9.5E+00 | 6.0E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    27| +2.50E+02 | -1.6E-03 | +4.7E-01 | 1.6E-02 | 5.6E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    31| +1.48E+02 | -4.1E-02 | +9.4E-01 | 6.2E-02 | 8.6E+00 | 6.7E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    18| +1.72E+02 | -4.7E+00 | +1.0E+00 | 1.6E-01 | 3.4E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    40| +2.12E+02 | -9.2E-02 | +4.9E-01 | 3.1E-02 | 6.6E+00 | 7.1E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    31| +2.50E+02 | -1.9E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    26| +1.48E+02 | -1.3E-01 | +9.2E-01 | 5.9E-02 | 2.0E+01 | 5.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    58| +2.12E+02 | -1.1E+00 | +9.4E-01 | 8.0E-02 | 1.6E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    32| +1.48E+02 | -6.2E-02 | +9.3E-01 | 1.2E-01 | 3.4E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    28| +2.50E+02 | -1.4E-03 | +4.4E-01 | 1.6E-02 | 5.3E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    19| +1.69E+02 | -3.0E+00 | +9.6E-01 | 3.2E-01 | 7.8E+01 | 4.5E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    41| +2.12E+02 | -5.1E-02 | +3.6E-01 | 3.1E-02 | 4.5E+00 | 8.1E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    32| +2.50E+02 | -1.8E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    22| +1.55E+02 | -6.0E-02 | +2.0E-01 | 4.6E-01 | 1.6E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:06 fides(INFO)    59| +2.11E+02 | -8.6E-02 | +4.5E-01 | 1.6E-01 | 3.0E+00 | 3.4E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    33| +1.48E+02 | -5.6E-02 | +5.5E-01 | 2.5E-01 | 7.0E+00 | 2.5E-01 |  2d |1
2023-02-17 16:05:06 fides(INFO)    27| +1.48E+02 | -1.5E-01 | +8.3E-01 | 1.2E-01 | 1.2E+01 | 9.0E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)    42| +2.12E+02 | -8.7E-02 | +5.3E-01 | 3.1E-02 | 5.9E+00 | 7.5E-02 |  2d |1
2023-02-17 16:05:06.973 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 191.433 and h = 1.57281e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:06.973 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 191.433: AMICI failed to integrate the forward problem
2023-02-17 16:05:06 fides(INFO)    29| +2.50E+02 | -1.3E-03 | +4.5E-01 | 1.6E-02 | 5.4E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:06 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:06 fides(INFO)    20| +1.69E+02 | +0.0E+00 | +0.0E+00 | 6.4E-01 | 3.8E+01 | 9.4E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    33| +2.50E+02 | -1.9E-05 | +6.8E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:06 fides(INFO)    34| +1.48E+02 | +1.4E-01 | -7.5E-01 | 2.5E-01 | 3.6E+00 | 2.2E-01 |  2d |0
2023-02-17 16:05:06 fides(INFO)    43| +2.12E+02 | -6.0E-02 | +4.7E-01 | 3.1E-02 | 4.0E+00 | 8.3E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    60| +2.11E+02 | -4.1E-01 | +1.6E+00 | 1.6E-01 | 4.8E+00 | 4.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    28| +1.48E+02 | +1.2E+00 | -3.6E+00 | 2.4E-01 | 1.1E+01 | 2.9E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    21| +1.64E+02 | -4.6E+00 | +8.6E-01 | 1.6E-01 | 3.8E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    30| +2.50E+02 | -1.2E-03 | +4.2E-01 | 1.6E-02 | 5.1E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    34| +2.50E+02 | -1.9E-05 | +6.7E-01 | 9.8E-04 | 4.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    44| +2.12E+02 | -8.8E-02 | +6.1E-01 | 3.1E-02 | 5.1E+00 | 7.8E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    35| +1.48E+02 | -5.7E-03 | +4.7E-02 | 6.2E-02 | 3.6E+00 | 6.5E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    22| +1.62E+02 | -2.0E+00 | +9.1E-01 | 3.2E-01 | 9.0E+01 | 8.9E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    29| +1.48E+02 | -2.4E-02 | +2.0E-01 | 5.9E-02 | 1.1E+01 | 7.3E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    61| +2.10E+02 | -1.3E+00 | +1.6E+00 | 3.2E-01 | 4.7E+00 | 8.3E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    31| +2.50E+02 | -1.1E-03 | +4.2E-01 | 1.6E-02 | 5.2E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    35| +2.50E+02 | -2.6E-05 | +1.0E+00 | 9.8E-04 | 4.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    45| +2.12E+02 | -7.4E-02 | +6.0E-01 | 3.1E-02 | 3.6E+00 | 8.4E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    36| +1.48E+02 | -3.6E-02 | +9.2E-01 | 1.6E-02 | 1.2E+01 | 1.7E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    30| +1.48E+02 | -5.9E-02 | +6.2E-01 | 1.5E-02 | 7.1E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    23| +1.62E+02 | +6.4E+01 | -1.0E+01 | 6.4E-01 | 2.8E+01 | 7.8E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    62| +2.10E+02 | +3.8E+01 | -2.7E+01 | 6.4E-01 | 8.3E+00 | 1.7E+00 |  2d |0
2023-02-17 16:05:07 fides(INFO)    46| +2.11E+02 | -9.7E-02 | +7.2E-01 | 3.1E-02 | 4.4E+00 | 8.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    36| +2.50E+02 | -4.4E-05 | +1.0E+00 | 2.0E-03 | 1.3E-02 | 4.9E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    32| +2.50E+02 | -9.9E-04 | +3.9E-01 | 1.6E-02 | 5.0E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    23| +1.55E+02 | -1.6E-01 | +9.6E-01 | 1.1E-01 | 3.5E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    37| +1.48E+02 | -1.9E-02 | +6.6E-01 | 3.1E-02 | 2.4E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    31| +1.48E+02 | -2.2E-02 | +9.5E-01 | 1.5E-02 | 1.2E+01 | 1.3E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    47| +2.11E+02 | -9.3E-02 | +7.4E-01 | 3.1E-02 | 3.2E+00 | 8.5E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    24| +1.60E+02 | -1.6E+00 | +4.6E-01 | 1.6E-01 | 2.8E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    37| +2.50E+02 | -5.0E-05 | +5.4E-01 | 3.9E-03 | 3.3E-02 | 9.7E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    38| +1.48E+02 | -6.6E-03 | +9.5E-01 | 3.1E-02 | 2.7E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    63| +2.10E+02 | -1.7E-02 | -1.9E-02 | 1.6E-01 | 8.3E+00 | 4.2E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    48| +2.11E+02 | -1.2E-01 | +8.2E-01 | 3.1E-02 | 3.8E+00 | 8.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    33| +2.50E+02 | -9.9E-05 | +5.5E-02 | 1.6E-02 | 5.1E-01 | 4.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    32| +1.48E+02 | -1.0E-02 | +8.3E-01 | 2.9E-02 | 1.9E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    25| +1.59E+02 | -8.2E-01 | +9.2E-01 | 1.6E-01 | 7.7E+01 | 4.9E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    49| +2.11E+02 | -2.5E-01 | +9.9E-01 | 6.2E-02 | 2.9E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    38| +2.50E+02 | -1.4E-04 | +1.0E+00 | 3.9E-03 | 1.3E-01 | 9.4E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    39| +1.48E+02 | -9.5E-03 | +9.5E-01 | 6.2E-02 | 9.8E-01 | 5.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    64| +2.09E+02 | -2.9E-01 | +1.1E+00 | 4.0E-02 | 8.3E+00 | 1.0E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    33| +1.48E+02 | -1.6E-02 | +9.3E-01 | 5.9E-02 | 3.7E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    26| +1.59E+02 | +1.4E+00 | -9.1E-01 | 3.2E-01 | 1.4E+01 | 3.0E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    34| +2.50E+02 | -1.6E-03 | +5.5E-01 | 3.9E-03 | 7.6E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    39| +2.50E+02 | -1.9E-04 | +1.0E+00 | 7.8E-03 | 3.9E-02 | 1.9E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    50| +2.10E+02 | -8.2E-01 | +1.3E+00 | 1.2E-01 | 4.2E+00 | 3.4E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    40| +1.48E+02 | -1.5E-02 | +9.6E-01 | 1.2E-01 | 1.4E+00 | 9.6E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    65| +2.09E+02 | -2.2E-03 | -4.0E-03 | 8.0E-02 | 2.7E+00 | 2.1E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    34| +1.48E+02 | -8.3E-03 | +3.8E-01 | 1.2E-01 | 1.5E+00 | 9.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    40| +2.50E+02 | -4.0E-04 | +1.0E+00 | 1.6E-02 | 3.2E-02 | 3.8E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    51| +2.06E+02 | -4.2E+00 | +1.9E+00 | 2.5E-01 | 5.5E+00 | 6.6E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    27| +1.59E+02 | -2.9E-01 | +3.6E-01 | 8.0E-02 | 1.4E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    35| +2.50E+02 | -5.5E-04 | +1.0E+00 | 3.9E-03 | 3.4E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    24| +1.55E+02 | -5.3E-02 | +8.6E-01 | 2.3E-01 | 9.3E+00 | 6.8E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    41| +1.48E+02 | -1.7E-02 | +8.2E-01 | 2.5E-01 | 7.1E-01 | 1.8E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    66| +2.09E+02 | -6.0E-02 | +9.2E-01 | 2.0E-02 | 2.7E+00 | 5.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    35| +1.48E+02 | +1.5E-01 | -2.0E+00 | 1.2E-01 | 2.4E+00 | 8.4E-02 |  2d |0
2023-02-17 16:05:07 fides(INFO)    28| +1.59E+02 | -2.9E-01 | +9.1E-01 | 8.0E-02 | 4.7E+01 | 1.3E-01 | trr |1
2023-02-17 16:05:07 fides(INFO)    41| +2.50E+02 | -9.0E-04 | +1.1E+00 | 3.1E-02 | 7.0E-02 | 7.5E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    42| +1.48E+02 | +1.8E-01 | -6.0E+00 | 5.0E-01 | 1.3E+00 | 2.7E-01 | trr |0
2023-02-17 16:05:07 fides(INFO)    52| +1.82E+02 | -2.4E+01 | +1.6E+00 | 5.0E-01 | 1.7E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:07 fides(INFO)    36| +2.50E+02 | -4.2E-04 | +9.5E-01 | 7.8E-03 | 3.5E-02 | 2.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    36| +1.48E+02 | -7.1E-03 | +2.8E-01 | 2.9E-02 | 2.4E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    42| +2.50E+02 | -2.3E-03 | +1.2E+00 | 6.2E-02 | 1.4E-01 | 1.5E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    29| +1.59E+02 | -5.4E-02 | +6.6E-01 | 8.0E-02 | 7.8E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:07.368 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.2556 and h = 1.10609e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:07.368 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.2556: AMICI failed to integrate the forward problem
2023-02-17 16:05:07 fides(INFO)    43| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 1.3E+00 | 6.7E-02 |  2d |0
2023-02-17 16:05:07 fides(INFO)    67| +2.09E+02 | +1.3E-02 | -3.3E-01 | 4.0E-02 | 8.9E-01 | 1.0E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    53| +1.82E+02 | +4.1E+01 | -3.7E+00 | 1.0E+00 | 4.0E+01 | 2.1E+00 |  2d |0
2023-02-17 16:05:07 fides(INFO)    37| +2.50E+02 | -7.0E-04 | +7.1E-01 | 1.6E-02 | 1.1E-01 | 4.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    37| +1.48E+02 | -5.7E-03 | +5.0E-01 | 2.9E-02 | 4.8E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    30| +1.59E+02 | -1.4E-02 | +6.0E-01 | 8.0E-02 | 6.5E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    43| +2.50E+02 | -8.0E-03 | +1.6E+00 | 1.2E-01 | 2.9E-01 | 3.0E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    25| +1.55E+02 | -5.3E-02 | +1.1E+00 | 4.6E-01 | 1.1E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:07 fides(INFO)    44| +1.48E+02 | -2.9E-03 | +7.2E-01 | 3.1E-02 | 1.3E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    54| +1.75E+02 | -7.0E+00 | +3.9E-01 | 2.5E-01 | 4.0E+01 | 5.9E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    68| +2.09E+02 | -1.2E-02 | +8.8E-01 | 1.0E-02 | 8.9E-01 | 2.7E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    38| +1.48E+02 | -1.7E-03 | +3.0E-01 | 2.9E-02 | 1.1E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    38| +2.50E+02 | -9.7E-04 | +1.0E+00 | 1.6E-02 | 2.7E-01 | 4.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    31| +1.59E+02 | -2.1E-03 | +1.1E-01 | 8.0E-02 | 4.2E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    44| +2.50E+02 | -5.1E-02 | +2.4E+00 | 2.5E-01 | 5.9E-01 | 5.8E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    45| +1.48E+02 | -1.6E-03 | +9.8E-01 | 3.1E-02 | 1.4E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    55| +1.65E+02 | -9.7E+00 | +1.1E+00 | 2.5E-01 | 9.5E+01 | 7.4E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    39| +1.48E+02 | -2.7E-03 | +3.8E-01 | 2.9E-02 | 3.2E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    26| +1.55E+02 | +2.1E+01 | -4.1E+02 | 9.1E-01 | 5.1E+00 | 2.4E+00 |  2d |0
2023-02-17 16:05:07 fides(INFO)    45| +2.49E+02 | -1.0E+00 | +4.7E+00 | 5.0E-01 | 1.3E+00 | 1.1E+00 |  2d |1
2023-02-17 16:05:07 fides(INFO)    32| +1.59E+02 | -7.8E-03 | +7.2E-01 | 2.0E-02 | 4.0E+00 | 7.6E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    39| +2.50E+02 | -1.3E-03 | +1.0E+00 | 3.1E-02 | 4.4E-02 | 8.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    69| +2.09E+02 | -7.3E-03 | +9.6E-01 | 2.0E-02 | 6.9E-01 | 4.8E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    46| +1.48E+02 | -2.4E-03 | +9.7E-01 | 6.2E-02 | 4.0E-01 | 3.5E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    40| +1.48E+02 | +4.8E-04 | -1.0E-01 | 2.9E-02 | 8.6E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:07 fides(INFO)    56| +1.51E+02 | -1.4E+01 | +1.1E+00 | 5.0E-01 | 5.4E+01 | 9.6E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    33| +1.59E+02 | -2.3E-03 | +8.5E-01 | 2.0E-02 | 2.5E+00 | 4.6E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    70| +2.09E+02 | +9.4E-03 | -7.8E-01 | 4.0E-02 | 4.6E-01 | 1.0E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    47| +1.48E+02 | -3.0E-03 | +8.2E-01 | 1.2E-01 | 7.2E-01 | 6.8E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    40| +2.50E+02 | -1.9E-03 | +9.5E-01 | 6.2E-02 | 4.8E-02 | 1.6E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    41| +1.48E+02 | -8.9E-04 | +4.3E-01 | 7.4E-03 | 8.6E-01 | 4.6E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    57| +1.51E+02 | +6.8E+00 | -1.5E+00 | 1.0E+00 | 6.2E+01 | 1.0E+00 | trr |0
2023-02-17 16:05:07 fides(INFO)    27| +1.55E+02 | -5.3E-02 | +1.4E+00 | 2.3E-01 | 5.1E+00 | 6.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    34| +1.59E+02 | -1.0E-03 | +7.6E-01 | 4.0E-02 | 1.4E+00 | 6.6E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    48| +1.48E+02 | +1.4E-02 | -2.2E+00 | 2.5E-01 | 5.3E-01 | 1.0E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    71| +2.09E+02 | -1.4E-03 | +3.6E-01 | 1.0E-02 | 4.6E-01 | 2.5E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    41| +2.50E+02 | -2.2E-03 | +1.1E+00 | 1.2E-01 | 1.9E-01 | 3.3E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    42| +1.48E+02 | -1.1E-03 | +9.4E-01 | 7.4E-03 | 2.7E+00 | 4.6E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    58| +1.49E+02 | -2.4E+00 | +9.7E-01 | 1.5E-01 | 6.2E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    35| +1.59E+02 | -7.6E-04 | +5.0E-01 | 8.0E-02 | 1.5E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    59| +1.49E+02 | +1.9E+00 | -1.2E+00 | 3.1E-01 | 1.5E+01 | 4.2E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    46| +2.30E+02 | -1.9E+01 | +3.6E+00 | 1.0E+00 | 6.0E+00 | 2.2E+00 |  2d |1
2023-02-17 16:05:07 fides(INFO)    28| +1.55E+02 | +9.0E-01 | -9.7E+00 | 4.6E-01 | 8.2E+00 | 1.2E+00 |  2d |0
2023-02-17 16:05:07 fides(INFO)    49| +1.48E+02 | -5.8E-04 | +2.4E-01 | 6.2E-02 | 5.3E-01 | 2.5E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    43| +1.48E+02 | -5.3E-04 | +9.8E-01 | 1.5E-02 | 3.1E-01 | 7.5E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    36| +1.59E+02 | +3.0E-03 | -1.1E+00 | 8.0E-02 | 9.1E-01 | 1.4E-02 |  2d |0
2023-02-17 16:05:07 fides(INFO)    72| +2.09E+02 | -3.3E-03 | +1.0E+00 | 1.0E-02 | 6.9E-01 | 2.6E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    42| +2.50E+02 | -8.4E-04 | +1.4E+00 | 2.5E-01 | 1.8E-01 | 2.4E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    50| +1.48E+02 | -1.0E-03 | +7.4E-01 | 1.6E-02 | 1.3E+00 | 1.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    44| +1.48E+02 | -7.2E-04 | +9.3E-01 | 2.9E-02 | 7.2E-01 | 1.4E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    60| +1.48E+02 | -4.6E-01 | +4.5E-01 | 7.7E-02 | 1.5E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    43| +2.50E+02 | -3.8E-04 | +1.3E+00 | 2.5E-01 | 4.7E-02 | 2.6E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    37| +1.59E+02 | -5.2E-04 | +5.3E-01 | 2.0E-02 | 9.1E-01 | 3.6E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    73| +2.09E+02 | -3.0E-03 | +6.9E-01 | 2.0E-02 | 2.2E-01 | 5.2E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    51| +1.48E+02 | -2.7E-04 | +8.9E-01 | 1.6E-02 | 2.4E-01 | 7.4E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    45| +1.48E+02 | -7.6E-04 | +7.2E-01 | 5.9E-02 | 2.6E-01 | 2.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    29| +1.55E+02 | -6.0E-02 | +1.2E+00 | 1.1E-01 | 8.2E+00 | 2.9E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    61| +1.48E+02 | -2.5E-01 | +4.8E-01 | 7.7E-02 | 4.9E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    44| +2.50E+02 | -2.1E-04 | +1.2E+00 | 2.5E-01 | 8.0E-02 | 2.7E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    38| +1.59E+02 | -1.2E-04 | +8.9E-01 | 2.0E-02 | 7.5E-01 | 2.0E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    46| +1.48E+02 | +3.8E-03 | -1.7E+00 | 5.9E-02 | 5.2E-01 | 4.3E-02 |  2d |0
2023-02-17 16:05:07 fides(INFO)    74| +2.09E+02 | -6.2E-03 | +1.2E+00 | 2.0E-02 | 6.9E-01 | 5.3E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    52| +1.48E+02 | -3.5E-04 | +9.2E-01 | 3.1E-02 | 1.1E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    47| +2.24E+02 | -6.0E+00 | +5.9E-01 | 2.0E+00 | 5.6E+01 | 8.2E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    62| +1.48E+02 | +6.5E-02 | -1.4E-01 | 7.7E-02 | 1.1E+01 | 1.0E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    39| +1.59E+02 | -8.4E-05 | +7.5E-01 | 4.0E-02 | 3.7E-01 | 3.7E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    45| +2.50E+02 | -8.4E-05 | +1.4E+00 | 2.5E-01 | 5.6E-02 | 2.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    47| +1.48E+02 | -2.8E-04 | +4.1E-01 | 1.5E-02 | 5.2E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    53| +1.48E+02 | -5.6E-04 | +9.9E-01 | 6.2E-02 | 3.4E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    63| +1.48E+02 | -1.3E-01 | +7.3E-01 | 1.9E-02 | 1.1E+01 | 3.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    75| +2.09E+02 | -1.1E-02 | +1.0E+00 | 4.0E-02 | 2.8E-01 | 1.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    30| +1.54E+02 | -9.4E-02 | +5.4E-01 | 2.3E-01 | 4.2E+00 | 5.6E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    46| +2.50E+02 | -4.5E-05 | +1.4E+00 | 2.5E-01 | 1.1E-02 | 2.4E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    48| +1.48E+02 | -1.2E-04 | +4.9E-01 | 1.5E-02 | 2.5E-01 | 2.6E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    40| +1.59E+02 | +1.3E-04 | -9.4E-01 | 8.0E-02 | 3.1E-01 | 6.6E-03 |  2d |0
2023-02-17 16:05:07 fides(INFO)    54| +1.48E+02 | -6.1E-04 | +9.0E-01 | 1.2E-01 | 1.0E-01 | 4.4E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    64| +1.48E+02 | -4.6E-02 | +9.2E-01 | 1.9E-02 | 1.4E+01 | 2.1E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    76| +2.09E+02 | -2.8E-02 | +1.2E+00 | 8.0E-02 | 4.1E-01 | 2.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    41| +1.59E+02 | -3.6E-05 | +6.4E-01 | 2.0E-02 | 3.1E-01 | 1.7E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    31| +1.54E+02 | -8.5E-02 | +1.3E-01 | 2.3E-01 | 2.8E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    49| +1.48E+02 | -9.6E-05 | +5.4E-01 | 1.5E-02 | 3.0E-01 | 7.1E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    47| +2.50E+02 | -2.1E-05 | +1.4E+00 | 2.5E-01 | 5.0E-03 | 2.3E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    55| +1.48E+02 | +2.3E-03 | -4.7E+00 | 2.5E-01 | 2.3E-01 | 5.3E-02 | trr |0
2023-02-17 16:05:07 fides(INFO)    65| +1.48E+02 | -3.8E-02 | +9.3E-01 | 3.8E-02 | 5.5E+00 | 4.6E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    77| +2.09E+02 | -9.8E-02 | +1.6E+00 | 1.6E-01 | 8.6E-01 | 4.3E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    42| +1.59E+02 | -2.2E-05 | +6.9E-01 | 2.0E-02 | 2.2E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    50| +1.48E+02 | -4.4E-05 | +3.1E-01 | 1.5E-02 | 1.5E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    48| +2.50E+02 | -1.0E-05 | +1.4E+00 | 2.5E-01 | 2.5E-03 | 2.2E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    56| +1.48E+02 | -3.8E-05 | +1.7E-01 | 5.7E-02 | 2.3E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    78| +2.08E+02 | -7.3E-01 | +2.7E+00 | 3.2E-01 | 1.7E+00 | 8.5E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    66| +1.48E+02 | -5.2E-02 | +8.7E-01 | 7.7E-02 | 5.7E+00 | 8.5E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    43| +1.59E+02 | -9.7E-06 | +4.7E-01 | 2.0E-02 | 1.7E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:07.915 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.426 and h = 1.34871e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:07.915 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.426: AMICI failed to integrate the forward problem
2023-02-17 16:05:07 fides(INFO)    32| +1.54E+02 | -1.2E-01 | +9.6E-01 | 5.7E-02 | 2.8E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    51| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.5E-02 | 4.5E-01 | 7.8E-03 |  2d |0
2023-02-17 16:05:07 fides(INFO)    49| +2.50E+02 | -4.6E-06 | +1.4E+00 | 2.5E-01 | 2.9E-04 | 2.1E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    79| +2.05E+02 | -3.5E+00 | +9.6E-01 | 6.4E-01 | 3.7E+00 | 1.7E+00 |  2d |1
2023-02-17 16:05:07 fides(INFO)    67| +1.48E+02 | +1.3E-01 | -2.0E+00 | 1.5E-01 | 2.4E+00 | 2.0E-01 |  2d |0
2023-02-17 16:05:07 fides(INFO)    57| +1.48E+02 | -1.2E-04 | +4.9E-01 | 1.4E-02 | 1.8E-01 | 6.2E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    44| +1.59E+02 | -6.2E-06 | +3.7E-01 | 2.0E-02 | 1.3E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    52| +1.48E+02 | -6.5E-05 | +8.6E-01 | 3.7E-03 | 4.5E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    50| +2.50E+02 | -2.0E-06 | +1.4E+00 | 2.5E-01 | 2.6E-04 | 1.9E-01 |  2d |1
2023-02-17 16:05:07 fides(WARNING) Stopping as function difference 2.03E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:07 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:07 fides(INFO)    80| +2.02E+02 | -2.6E+00 | +6.2E-01 | 1.3E+00 | 4.4E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:07 fides(INFO)    68| +1.48E+02 | -8.2E-03 | +3.9E-01 | 3.8E-02 | 2.4E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:07 fides(INFO)    58| +1.48E+02 | -2.3E-05 | +9.1E-01 | 1.4E-02 | 1.8E-01 | 2.9E-03 |  2d |1
2023-02-17 16:05:07 fides(INFO)    45| +1.59E+02 | +7.7E-08 | -4.1E-03 | 2.0E-02 | 1.1E-01 | 1.1E-03 |  2d |0
2023-02-17 16:05:08 fides(INFO)    33| +1.54E+02 | -4.6E-02 | +8.8E-01 | 1.1E-01 | 1.0E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    48| +2.24E+02 | +2.3E+02 | -8.9E+00 | 2.0E+00 | 5.0E+01 | 1.9E+00 |  2d |0
2023-02-17 16:05:08 fides(INFO)    53| +1.48E+02 | -3.0E-05 | +7.3E-01 | 7.4E-03 | 6.1E-02 | 2.8E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    69| +1.48E+02 | +2.3E-02 | -5.4E-01 | 3.8E-02 | 2.7E+00 | 3.7E-02 |  2d |0
2023-02-17 16:05:08 fides(INFO)    59| +1.48E+02 | -2.8E-05 | +8.9E-01 | 2.8E-02 | 5.1E-02 | 6.1E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    81| +2.02E+02 | +6.9E+01 | -1.0E+01 | 1.3E+00 | 2.2E+01 | 3.0E+00 | trr |0
2023-02-17 16:05:08 fides(INFO)    46| +1.59E+02 | -3.8E-06 | +5.6E-01 | 5.0E-03 | 1.1E-01 | 2.9E-04 |  2d |1
2023-02-17 16:05:08 fides(INFO)    54| +1.48E+02 | -2.2E-05 | +1.0E+00 | 7.4E-03 | 5.7E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    70| +1.48E+02 | -6.9E-03 | +3.8E-01 | 9.6E-03 | 2.7E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    60| +1.48E+02 | -3.5E-05 | +8.4E-01 | 5.7E-02 | 6.1E-02 | 1.1E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    55| +1.48E+02 | -3.6E-05 | +1.0E+00 | 1.5E-02 | 7.9E-02 | 3.4E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    47| +1.59E+02 | -4.3E-07 | +2.7E-01 | 5.0E-03 | 7.0E-02 | 2.3E-04 |  2d |1
2023-02-17 16:05:08 fides(WARNING) Stopping as function difference 4.32E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:08 fides(INFO)    82| +1.96E+02 | -6.6E+00 | +1.8E+00 | 2.7E-01 | 2.2E+01 | 7.7E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    34| +1.54E+02 | -4.9E-02 | +8.7E-01 | 2.3E-01 | 1.1E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    61| +1.48E+02 | +5.0E-04 | -5.9E+00 | 1.1E-01 | 3.8E-02 | 2.3E-02 |  2d |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)     0| +2.03E+13 |    NaN   |    NaN   | 1.0E+00 | 6.9E+13 |   NaN   | NaN |1
2023-02-17 16:05:08 fides(INFO)    71| +1.48E+02 | -6.8E-03 | +8.7E-01 | 9.6E-03 | 6.0E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    56| +1.48E+02 | -4.2E-05 | +8.9E-01 | 2.9E-02 | 4.2E-02 | 6.0E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)     1| +1.32E+10 | -2.0E+13 | +1.1E-01 | 1.0E+00 | 6.9E+13 | 3.1E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    83| +1.96E+02 | +5.1E+00 | -6.2E-01 | 5.3E-01 | 2.9E+01 | 1.5E+00 | trr |0
2023-02-17 16:05:08 fides(INFO)    62| +1.48E+02 | +3.7E-06 | -1.1E-01 | 2.8E-02 | 3.8E-02 | 5.8E-03 |  2d |0
2023-02-17 16:05:08 fides(INFO)    72| +1.48E+02 | -3.8E-03 | +8.6E-01 | 1.9E-02 | 6.6E-01 | 2.2E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    57| +1.48E+02 | -2.8E-05 | +8.4E-01 | 5.9E-02 | 5.8E-02 | 1.0E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    84| +1.89E+02 | -6.6E+00 | +1.5E+00 | 1.3E-01 | 2.9E+01 | 3.6E-01 | trr |1
2023-02-17 16:05:08 fides(INFO)    49| +2.01E+02 | -2.3E+01 | +1.1E+00 | 2.3E-01 | 5.0E+01 | 5.4E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    63| +1.48E+02 | -8.8E-06 | +9.8E-01 | 7.1E-03 | 3.8E-02 | 1.5E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)     2| +2.14E+09 | -1.1E+10 | +8.8E-01 | 2.5E-01 | 6.1E+10 | 7.1E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    35| +1.54E+02 | -2.3E-02 | +7.8E-01 | 4.6E-01 | 4.4E+00 | 7.8E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    73| +1.48E+02 | -6.8E-03 | +8.8E-01 | 3.8E-02 | 6.9E-01 | 3.7E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    58| +1.48E+02 | +4.4E-04 | -1.3E+01 | 1.2E-01 | 3.7E-02 | 7.8E-03 | trr |0
2023-02-17 16:05:08 fides(INFO)    64| +1.48E+02 | -3.3E-06 | +6.2E-01 | 1.4E-02 | 3.8E-02 | 2.2E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    85| +1.82E+02 | -7.5E+00 | +7.6E-01 | 2.7E-01 | 3.2E+01 | 7.2E-01 | trr |1
2023-02-17 16:05:08 fides(INFO)     3| +3.18E+08 | -1.8E+09 | +8.9E-01 | 5.0E-01 | 9.3E+09 | 1.1E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    74| +1.48E+02 | +3.8E-03 | -4.3E-01 | 7.7E-02 | 7.3E-01 | 8.7E-02 |  2d |0
2023-02-17 16:05:08 fides(INFO)    36| +1.54E+02 | -1.3E-02 | +9.2E-01 | 9.1E-01 | 4.6E+00 | 1.3E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)     0| +3.89E+02 |    NaN   |    NaN   | 1.0E+00 | 6.4E+01 |   NaN   | NaN |1
2023-02-17 16:05:08 fides(INFO)    59| +1.48E+02 | +1.6E-05 | -1.0E+00 | 9.9E-03 | 3.7E-02 | 2.0E-03 |  2d |0
2023-02-17 16:05:08 fides(INFO)    65| +1.48E+02 | -4.5E-06 | +1.1E+00 | 1.4E-02 | 2.3E-02 | 2.0E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)     4| +4.57E+07 | -2.7E+08 | +9.0E-01 | 5.0E-01 | 1.4E+09 | 1.0E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    75| +1.48E+02 | -2.0E-03 | +7.1E-01 | 1.9E-02 | 7.3E-01 | 2.2E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    37| +1.54E+02 | +6.1E-02 | -6.0E+00 | 1.8E+00 | 5.8E-01 | 7.5E-01 | trr |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    60| +1.48E+02 | -1.4E-06 | +3.2E-01 | 2.5E-03 | 3.7E-02 | 4.9E-04 |  2d |1
2023-02-17 16:05:08 fides(WARNING) Stopping as function difference 1.44E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:08 fides(INFO)    86| +1.82E+02 | +1.8E+02 | -8.8E+00 | 5.3E-01 | 4.6E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:08 fides(INFO)     1| +2.62E+02 | -1.3E+02 | +6.5E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)     5| +6.32E+06 | -3.9E+07 | +9.0E-01 | 5.0E-01 | 2.0E+08 | 7.9E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    76| +1.48E+02 | +7.0E-04 | -1.9E-01 | 1.9E-02 | 4.9E-01 | 1.7E-02 |  2d |0
2023-02-17 16:05:08 fides(INFO)    66| +1.48E+02 | -7.6E-06 | +1.3E+00 | 2.8E-02 | 3.3E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)     2| +2.38E+02 | -2.4E+01 | +6.8E-01 | 1.0E+00 | 8.7E+01 | 2.5E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    38| +1.54E+02 | -2.1E-03 | +5.7E-01 | 2.0E-01 | 5.8E-01 | 1.9E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)     6| +9.04E+05 | -5.4E+06 | +9.0E-01 | 5.0E-01 | 2.9E+07 | 6.6E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    67| +1.48E+02 | +3.6E-06 | -4.7E-01 | 5.7E-02 | 1.7E-02 | 6.1E-03 |  2d |0
2023-02-17 16:05:08 fides(INFO)    77| +1.48E+02 | +4.7E-04 | -2.3E-01 | 4.8E-03 | 4.9E-01 | 7.5E-03 |  2d |0
2023-02-17 16:05:08 fides(INFO)    87| +1.73E+02 | -8.4E+00 | +7.9E-01 | 1.3E-01 | 4.6E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)     3| +2.38E+02 | -1.7E+01 | -3.4E-01 | 1.0E+00 | 5.5E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:08 fides(INFO)     7| +1.32E+05 | -7.7E+05 | +8.9E-01 | 5.0E-01 | 4.4E+06 | 6.3E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    78| +1.48E+02 | -5.8E-04 | +5.9E-01 | 1.2E-03 | 4.9E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    68| +1.48E+02 | -2.4E-08 | +8.8E-03 | 1.4E-02 | 1.7E-02 | 1.5E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    39| +1.54E+02 | -5.8E-04 | +8.9E-01 | 2.0E-01 | 5.2E-01 | 1.6E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    88| +1.66E+02 | -7.4E+00 | +7.2E-01 | 2.7E-01 | 2.7E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    69| +1.48E+02 | +4.0E-07 | -4.9E-01 | 3.5E-03 | 3.4E-02 | 4.3E-04 |  2d |0
2023-02-17 16:05:08 fides(INFO)     4| +2.19E+02 | -1.9E+01 | +9.9E-01 | 2.5E-01 | 5.5E+01 | 6.6E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)     8| +1.97E+04 | -1.1E+05 | +8.9E-01 | 5.0E-01 | 6.9E+05 | 6.3E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    50| +2.01E+02 | +1.3E+02 | -4.8E+00 | 4.5E-01 | 5.6E+01 | 9.4E-01 |  2d |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    40| +1.54E+02 | -8.3E-04 | +1.0E+00 | 3.9E-01 | 2.3E-01 | 2.9E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    79| +1.48E+02 | -2.7E-04 | +9.7E-01 | 1.2E-03 | 1.1E+00 | 1.3E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)     0| +1.94E+12 |    NaN   |    NaN   | 1.0E+00 | 8.9E+12 |   NaN   | NaN |1
2023-02-17 16:05:08 fides(INFO)    89| +1.66E+02 | +8.5E+01 | -5.9E+00 | 2.7E-01 | 5.0E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:08 fides(INFO)     5| +2.19E+02 | +1.6E+02 | -7.7E+00 | 5.0E-01 | 4.4E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    70| +1.48E+02 | -4.4E-06 | +1.4E+01 | 8.9E-04 | 3.4E-02 | 1.1E-04 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    80| +1.48E+02 | -2.5E-04 | +9.9E-01 | 2.4E-03 | 2.0E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)     9| +3.04E+03 | -1.7E+04 | +8.9E-01 | 5.0E-01 | 1.1E+05 | 6.3E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    41| +1.54E+02 | +1.7E-03 | -1.6E+00 | 7.9E-01 | 3.7E-01 | 2.5E-01 | trr |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    90| +1.66E+02 | +5.9E+00 | -1.0E+00 | 6.7E-02 | 5.0E+01 | 1.7E-01 |  2d |0
2023-02-17 16:05:08 fides(INFO)     6| +2.09E+02 | -1.0E+01 | +9.3E-01 | 1.2E-01 | 4.4E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    81| +1.48E+02 | -4.5E-04 | +9.7E-01 | 4.8E-03 | 2.9E-01 | 4.9E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)     1| +2.04E+06 | -1.9E+12 | +8.7E-02 | 1.0E+00 | 8.9E+12 | 3.0E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    71| +1.48E+02 | +4.6E-06 | -1.4E+01 | 1.8E-03 | 8.1E-03 | 2.1E-04 |  2d |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    10| +5.75E+02 | -2.5E+03 | +8.8E-01 | 5.0E-01 | 1.7E+04 | 6.3E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)     7| +2.06E+02 | -2.8E+00 | +2.6E-01 | 2.5E-01 | 3.2E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    82| +1.48E+02 | -8.1E-04 | +9.6E-01 | 9.6E-03 | 2.3E-01 | 9.4E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)     2| +3.17E+05 | -1.7E+06 | +9.0E-01 | 2.5E-01 | 9.4E+06 | 6.5E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    42| +1.54E+02 | -3.0E-04 | +6.2E-01 | 1.2E-01 | 3.7E-01 | 6.1E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    72| +1.48E+02 | +5.3E-06 | -4.8E+01 | 4.4E-04 | 8.1E-03 | 5.4E-05 |  2d |0
2023-02-17 16:05:08 fides(INFO)    91| +1.65E+02 | -1.1E+00 | +5.7E-01 | 1.7E-02 | 5.0E+01 | 4.3E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    11| +2.11E+02 | -3.6E+02 | +8.6E-01 | 5.0E-01 | 2.9E+03 | 8.6E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)     8| +1.96E+02 | -1.0E+01 | +9.7E-01 | 2.5E-01 | 7.1E+01 | 6.2E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)     3| +4.97E+04 | -2.7E+05 | +9.0E-01 | 5.0E-01 | 1.5E+06 | 1.3E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    43| +1.54E+02 | -2.9E-04 | +8.4E-01 | 1.2E-01 | 1.3E-01 | 5.3E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    83| +1.48E+02 | -1.4E-03 | +9.8E-01 | 1.9E-02 | 3.5E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    73| +1.48E+02 | +2.9E-06 | -5.4E+01 | 1.1E-04 | 8.1E-03 | 1.6E-05 |  2d |0
2023-02-17 16:05:08 fides(INFO)    12| +1.67E+02 | -4.4E+01 | +6.4E-01 | 1.0E+00 | 5.1E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)     4| +8.02E+03 | -4.2E+04 | +9.0E-01 | 1.0E+00 | 2.3E+05 | 1.1E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    51| +1.95E+02 | -6.1E+00 | +6.2E-01 | 1.1E-01 | 5.6E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)     9| +1.84E+02 | -1.1E+01 | +1.1E+00 | 5.0E-01 | 4.1E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    92| +1.64E+02 | -7.7E-01 | +9.9E-01 | 1.7E-02 | 3.9E+01 | 3.0E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    74| +1.48E+02 | +3.8E-06 | -9.6E+01 | 2.8E-05 | 8.1E-03 | 9.6E-06 |  2d |0
2023-02-17 16:05:08 fides(INFO)    84| +1.48E+02 | -1.8E-03 | +9.3E-01 | 3.8E-02 | 2.1E-01 | 3.4E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    44| +1.54E+02 | -1.1E-04 | +2.8E-01 | 2.4E-01 | 5.9E-01 | 9.0E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)     5| +1.46E+03 | -6.6E+03 | +9.0E-01 | 1.0E+00 | 3.6E+04 | 1.1E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    10| +1.76E+02 | -8.0E+00 | +3.6E-01 | 1.0E+00 | 2.6E+01 | 1.9E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    13| +1.50E+02 | -1.6E+01 | +9.1E-01 | 1.0E+00 | 2.6E+02 | 2.7E+00 | trr |1
2023-02-17 16:05:08 fides(INFO)    75| +1.48E+02 | +5.2E-06 | -1.4E+02 | 6.9E-06 | 8.1E-03 | 8.9E-06 |  2d |0
2023-02-17 16:05:08 fides(INFO)    85| +1.48E+02 | +6.0E-04 | -4.5E-01 | 7.7E-02 | 3.3E-01 | 4.5E-02 | trr |0
2023-02-17 16:05:08 fides(INFO)    93| +1.63E+02 | -1.2E+00 | +9.0E-01 | 3.3E-02 | 3.3E+01 | 6.8E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)     6| +4.22E+02 | -1.0E+03 | +9.0E-01 | 1.0E+00 | 5.7E+03 | 2.9E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    45| +1.54E+02 | +7.4E-03 | -4.7E+00 | 2.4E-01 | 1.0E-01 | 7.6E-02 | trr |0
2023-02-17 16:05:08 fides(INFO)    14| +1.49E+02 | -1.1E+00 | +2.7E-01 | 1.0E+00 | 9.6E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    86| +1.48E+02 | -4.6E-04 | +7.7E-01 | 1.8E-02 | 3.3E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)     7| +2.66E+02 | -1.6E+02 | +8.9E-01 | 2.0E+00 | 9.1E+02 | 4.8E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    11| +1.72E+02 | -4.6E+00 | +7.7E-01 | 1.0E+00 | 6.3E+01 | 1.7E+00 |  2d |1
2023-02-17 16:05:08 fides(INFO)    46| +1.54E+02 | -2.6E-04 | +4.0E-01 | 5.1E-02 | 1.0E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    76| +1.48E+02 | +5.5E-06 | -2.1E+02 | 1.7E-06 | 8.1E-03 | 4.5E-06 |  2d |0
2023-02-17 16:05:08 fides(INFO)    15| +1.49E+02 | +1.4E+02 | -2.4E+01 | 1.0E+00 | 6.2E+01 | 1.5E+00 |  2d |0
2023-02-17 16:05:08 fides(INFO)     8| +2.37E+02 | -2.8E+01 | +1.0E+00 | 4.0E+00 | 1.3E+02 | 4.8E+00 | trr |1
2023-02-17 16:05:08 fides(INFO)    94| +1.62E+02 | -1.2E+00 | +8.0E-01 | 6.7E-02 | 3.7E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    87| +1.48E+02 | +1.7E-03 | -1.5E+00 | 3.6E-02 | 1.5E-01 | 3.7E-02 |  2d |0
2023-02-17 16:05:08 fides(INFO)    52| +1.93E+02 | -1.5E+00 | +8.0E-01 | 1.1E-01 | 2.1E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    16| +1.49E+02 | -4.9E-01 | +1.1E-01 | 2.5E-01 | 6.2E+01 | 3.8E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    12| +1.71E+02 | -4.6E-01 | +7.5E-01 | 2.0E+00 | 1.8E+01 | 2.8E+00 | trr |1
2023-02-17 16:05:08 fides(INFO)    77| +1.48E+02 | +1.5E-06 | -1.9E+02 | 4.3E-07 | 8.1E-03 | 1.1E-06 |  2d |0
2023-02-17 16:05:08 fides(INFO)     9| +2.37E+02 | +2.0E+02 | -1.2E+01 | 4.0E+00 | 3.2E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:08 fides(INFO)    47| +1.54E+02 | -9.5E-05 | +4.3E-01 | 5.1E-02 | 4.2E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    88| +1.48E+02 | -1.6E-04 | +4.8E-01 | 9.0E-03 | 1.5E-01 | 9.1E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    95| +1.62E+02 | +4.1E-01 | -4.3E-01 | 1.3E-01 | 2.2E+01 | 2.9E-01 |  2d |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    10| +2.37E+02 | +3.3E+01 | -3.9E+00 | 1.0E+00 | 3.2E+01 | 2.9E+00 |  2d |0
2023-02-17 16:05:08 fides(INFO)    78| +1.48E+02 | +4.2E-06 | -2.0E+03 | 1.1E-07 | 8.1E-03 | 2.8E-07 |  2d |0
2023-02-17 16:05:08 fides(INFO)    89| +1.48E+02 | -1.0E-04 | +3.4E-01 | 9.0E-03 | 2.2E-01 | 2.8E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    17| +1.48E+02 | -5.8E-01 | +9.5E-01 | 6.2E-02 | 6.4E+01 | 8.1E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    13| +1.71E+02 | -1.2E-02 | +9.5E-02 | 2.0E+00 | 7.1E+00 | 3.1E-01 | trr |1
2023-02-17 16:05:08 fides(INFO)    11| +2.37E+02 | +9.4E+00 | -9.6E-01 | 2.5E-01 | 3.2E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:08 fides(INFO)    48| +1.54E+02 | -4.6E-05 | +3.6E-01 | 5.1E-02 | 7.2E-02 | 1.0E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    96| +1.61E+02 | -5.5E-01 | +1.0E+00 | 3.3E-02 | 2.2E+01 | 7.3E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    12| +2.34E+02 | -3.9E+00 | +8.6E-01 | 6.2E-02 | 3.2E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    79| +1.48E+02 | +2.5E-06 | -4.6E+03 | 2.7E-08 | 8.1E-03 | 7.0E-08 |  2d |0
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    90| +1.48E+02 | -9.1E-05 | +2.6E-01 | 9.0E-03 | 2.6E-01 | 9.4E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    18| +1.48E+02 | -3.9E-01 | +6.1E-01 | 1.2E-01 | 3.1E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    13| +2.33E+02 | -5.2E-01 | +1.1E-01 | 1.2E-01 | 2.0E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    49| +1.54E+02 | -1.1E-05 | +7.9E-02 | 5.1E-02 | 1.5E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    14| +1.71E+02 | -4.8E-02 | +5.8E-01 | 1.4E-01 | 4.7E+00 | 6.7E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    97| +1.60E+02 | -1.0E+00 | +7.6E-01 | 6.7E-02 | 1.9E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    80| +1.48E+02 | +4.0E-07 | -3.0E+03 | 6.8E-09 | 8.1E-03 | 1.7E-08 |  2d |0
2023-02-17 16:05:08 fides(INFO)    19| +1.48E+02 | -2.0E-01 | +9.2E-01 | 1.2E-01 | 3.9E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    91| +1.48E+02 | +1.0E-04 | -2.6E-01 | 9.0E-03 | 2.1E-01 | 3.6E-03 |  2d |0
2023-02-17 16:05:08 fides(INFO)    14| +2.31E+02 | -1.8E+00 | +9.2E-01 | 3.1E-02 | 4.1E+01 | 5.6E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)    53| +1.91E+02 | -2.0E+00 | +1.2E+00 | 2.3E-01 | 1.0E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    50| +1.54E+02 | -6.4E-05 | +7.1E-01 | 1.3E-02 | 5.9E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    81| +1.48E+02 | -4.6E-07 | +1.4E+04 | 1.7E-09 | 8.1E-03 | 4.4E-09 |  2d |1
2023-02-17 16:05:08 fides(WARNING) Stopping as function difference 4.61E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:08 fides(INFO)    92| +1.48E+02 | -7.7E-05 | +6.3E-01 | 2.3E-03 | 2.1E-01 | 1.0E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    15| +2.29E+02 | -2.0E+00 | +8.6E-01 | 6.2E-02 | 2.9E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    15| +1.71E+02 | -8.8E-03 | +8.3E-01 | 1.4E-01 | 5.9E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:08 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:08 fides(INFO)    20| +1.48E+02 | -6.9E-02 | +8.0E-01 | 2.5E-01 | 1.2E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    98| +1.60E+02 | +2.9E+00 | -9.3E-01 | 1.3E-01 | 4.1E+01 | 3.4E-01 |  2d |0
2023-02-17 16:05:08 fides(INFO)    16| +2.26E+02 | -3.5E+00 | +1.2E+00 | 1.2E-01 | 1.8E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:08 fides(INFO)    51| +1.54E+02 | -1.5E-05 | +9.4E-01 | 1.3E-02 | 1.8E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    93| +1.48E+02 | -3.0E-05 | +8.5E-01 | 2.3E-03 | 3.7E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:08 fides(INFO)    21| +1.48E+02 | +2.4E-01 | -2.3E+00 | 4.9E-01 | 1.1E+01 | 5.1E-01 |  2d |0
2023-02-17 16:05:08 fides(INFO)    17| +2.21E+02 | -4.4E+00 | +1.1E+00 | 2.5E-01 | 1.8E+01 | 4.9E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    99| +1.60E+02 | -4.3E-01 | +3.8E-01 | 3.3E-02 | 4.1E+01 | 8.6E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    16| +1.71E+02 | -2.1E-03 | +9.9E-01 | 2.8E-01 | 1.2E+00 | 7.2E-02 | trr |1
2023-02-17 16:05:09 fides(INFO)    94| +1.48E+02 | -3.9E-05 | +9.9E-01 | 4.5E-03 | 6.3E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    18| +2.18E+02 | -3.2E+00 | +5.1E-01 | 5.0E-01 | 2.6E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    52| +1.54E+02 | -1.8E-05 | +1.1E+00 | 2.5E-02 | 3.4E-02 | 2.5E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    22| +1.48E+02 | -1.8E-02 | +4.4E-01 | 1.2E-01 | 1.1E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)   100| +1.59E+02 | -4.9E-01 | +1.0E+00 | 3.3E-02 | 2.8E+01 | 6.9E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    95| +1.48E+02 | -4.2E-05 | +6.7E-01 | 9.0E-03 | 1.9E-01 | 5.7E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    19| +1.98E+02 | -2.0E+01 | +1.5E+00 | 5.0E-01 | 4.0E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    17| +1.71E+02 | -4.8E-05 | +3.4E-01 | 5.6E-01 | 4.9E-01 | 5.5E-03 | trr |1
2023-02-17 16:05:09 fides(INFO)    53| +1.54E+02 | -2.5E-05 | +1.2E+00 | 5.1E-02 | 9.4E-02 | 4.2E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)     0| +5.85E+12 |    NaN   |    NaN   | 1.0E+00 | 2.7E+13 |   NaN   | NaN |1
2023-02-17 16:05:09 fides(INFO)    54| +1.91E+02 | -4.2E+00 | -3.0E-01 | 4.5E-01 | 2.5E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:09 fides(INFO)    23| +1.48E+02 | -7.8E-03 | +1.9E-01 | 1.2E-01 | 5.9E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   101| +1.59E+02 | -2.4E-01 | +4.7E-01 | 6.7E-02 | 8.2E+00 | 1.4E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    96| +1.48E+02 | +5.6E-05 | -5.8E-01 | 9.0E-03 | 8.7E-02 | 1.7E-03 |  2d |0
2023-02-17 16:05:09 fides(INFO)    18| +1.71E+02 | -3.1E-06 | +3.2E-02 | 5.6E-01 | 1.8E-01 | 6.7E-03 | trr |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    20| +1.98E+02 | +1.9E+03 | -4.7E+01 | 1.0E+00 | 3.7E+01 | 2.1E+00 | trr |0
2023-02-17 16:05:09 fides(INFO)     1| +1.05E+07 | -5.9E+12 | +8.3E-02 | 1.0E+00 | 2.7E+13 | 3.1E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    24| +1.48E+02 | -1.7E-02 | +8.1E-01 | 3.1E-02 | 9.3E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    54| +1.54E+02 | -9.9E-07 | +5.9E-02 | 1.0E-01 | 2.7E-02 | 4.2E-03 | trr |1
2023-02-17 16:05:09 fides(INFO)    97| +1.48E+02 | -1.2E-05 | +3.4E-01 | 2.3E-03 | 8.7E-02 | 6.5E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)     2| +2.00E+06 | -8.5E+06 | +9.1E-01 | 2.5E-01 | 3.6E+07 | 6.6E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    21| +1.79E+02 | -1.9E+01 | +9.5E-01 | 2.5E-01 | 3.7E+01 | 5.7E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    25| +1.48E+02 | -3.3E-03 | +5.9E-01 | 6.2E-02 | 2.4E+00 | 5.4E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   102| +1.59E+02 | +7.1E-01 | -1.5E+00 | 6.7E-02 | 6.6E+00 | 1.5E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)    19| +1.71E+02 | -3.2E-05 | +3.8E-01 | 1.9E-03 | 1.9E-01 | 5.1E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    55| +1.54E+02 | +5.1E-04 | -4.1E+00 | 1.2E-02 | 3.0E-02 | 1.8E-02 | trr |0
2023-02-17 16:05:09 fides(INFO)    22| +1.79E+02 | -1.4E+01 | -3.3E-02 | 5.0E-01 | 8.4E+01 | 9.2E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)    98| +1.48E+02 | -2.4E-05 | +9.6E-01 | 2.3E-03 | 3.0E-01 | 1.5E-03 |  2d |1
2023-02-17 16:05:09.201 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 117.386 and h = 3.00881e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:09.202 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 117.386: AMICI failed to integrate the forward problem
2023-02-17 16:05:09 fides(INFO)   103| +1.59E+02 | +0.0E+00 | +0.0E+00 | 1.7E-02 | 6.6E+00 | 3.7E-02 |  2d |0
2023-02-17 16:05:09 fides(INFO)    26| +1.48E+02 | -1.6E-03 | +9.3E-01 | 6.2E-02 | 2.6E+00 | 5.1E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    20| +1.71E+02 | -8.8E-06 | +3.9E-01 | 1.9E-03 | 1.4E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)     3| +3.31E+05 | -1.7E+06 | +9.0E-01 | 5.0E-01 | 6.6E+06 | 1.4E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    99| +1.48E+02 | -7.5E-06 | +5.8E-01 | 4.5E-03 | 3.6E-02 | 1.8E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    23| +1.68E+02 | -1.2E+01 | +1.0E+00 | 1.2E-01 | 8.4E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    56| +1.54E+02 | -1.4E-05 | +2.6E-01 | 2.1E-03 | 3.0E-02 | 4.4E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)     4| +5.18E+04 | -2.8E+05 | +9.0E-01 | 1.0E+00 | 1.1E+06 | 1.2E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    27| +1.48E+02 | -1.6E-03 | +9.7E-01 | 1.2E-01 | 1.6E+00 | 9.8E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   104| +1.59E+02 | -3.3E-02 | +6.8E-01 | 4.2E-03 | 6.6E+00 | 9.7E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    21| +1.71E+02 | -2.4E-07 | +2.8E-02 | 1.9E-03 | 7.6E-02 | 1.8E-03 | trr |1
2023-02-17 16:05:09 fides(INFO)     5| +8.31E+03 | -4.4E+04 | +9.0E-01 | 1.0E+00 | 1.7E+05 | 1.2E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    24| +1.61E+02 | -7.0E+00 | +6.1E-01 | 2.5E-01 | 6.1E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)   100| +1.48E+02 | -1.2E-05 | +1.2E+00 | 4.5E-03 | 3.0E-02 | 1.5E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    55| +1.89E+02 | -2.8E+00 | +9.3E-01 | 1.1E-01 | 2.5E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    57| +1.54E+02 | +6.2E-06 | -2.1E-01 | 2.1E-03 | 2.9E-02 | 4.2E-03 |  2d |0
2023-02-17 16:05:09 fides(INFO)     6| +1.47E+03 | -6.8E+03 | +9.0E-01 | 1.0E+00 | 2.7E+04 | 1.4E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    25| +1.53E+02 | -7.2E+00 | +4.6E-01 | 2.5E-01 | 1.7E+02 | 3.7E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    28| +1.48E+02 | -1.2E-03 | +8.4E-01 | 2.5E-01 | 1.8E+00 | 1.8E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   105| +1.59E+02 | -3.4E-02 | +8.9E-01 | 4.2E-03 | 9.4E+00 | 7.8E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)   101| +1.48E+02 | -1.4E-05 | +9.8E-01 | 9.0E-03 | 3.3E-02 | 3.1E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    22| +1.71E+02 | -3.9E-07 | +1.5E-01 | 1.7E-04 | 5.9E-02 | 2.3E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)     7| +4.09E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 4.3E+03 | 1.5E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    58| +1.54E+02 | -6.8E-06 | +7.5E-01 | 5.4E-04 | 2.9E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    29| +1.48E+02 | +1.7E-02 | -6.6E+00 | 4.9E-01 | 7.7E-01 | 2.9E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)    26| +1.49E+02 | -4.5E+00 | +9.6E-01 | 2.5E-01 | 2.1E+02 | 7.9E-01 | trr |1
2023-02-17 16:05:09 fides(INFO)   102| +1.48E+02 | +7.9E-06 | -5.8E-01 | 1.8E-02 | 2.0E-02 | 3.0E-03 |  2d |0
2023-02-17 16:05:09 fides(INFO)     8| +2.59E+02 | -1.5E+02 | +8.7E-01 | 1.0E+00 | 6.6E+02 | 2.2E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    23| +1.71E+02 | -1.8E-06 | +3.0E+00 | 4.2E-05 | 2.8E-02 | 6.1E-05 |  2d |1
2023-02-17 16:05:09 fides(INFO)   106| +1.59E+02 | -4.6E-02 | +8.4E-01 | 8.3E-03 | 4.3E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)     9| +2.39E+02 | -2.0E+01 | +1.1E+00 | 2.0E+00 | 8.1E+01 | 4.0E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    59| +1.54E+02 | -2.1E-06 | +6.9E-01 | 5.4E-04 | 1.7E-02 | 7.1E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    30| +1.48E+02 | +3.6E-04 | -3.1E-01 | 1.2E-01 | 7.7E-01 | 7.3E-02 |  2d |0
2023-02-17 16:05:09 fides(INFO)    27| +1.48E+02 | -9.4E-01 | +6.7E-01 | 5.0E-01 | 3.8E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   103| +1.48E+02 | -7.8E-06 | +1.5E+00 | 4.5E-03 | 2.0E-02 | 7.5E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)   107| +1.59E+02 | -1.9E-02 | +7.9E-01 | 1.7E-02 | 5.2E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    31| +1.48E+02 | -3.0E-04 | +6.1E-01 | 3.1E-02 | 7.7E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    24| +1.71E+02 | -6.3E-07 | +1.2E+00 | 8.3E-05 | 1.9E-02 | 1.1E-04 |  2d |1
2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 6.33E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    60| +1.54E+02 | -2.3E-06 | +1.2E+00 | 5.4E-04 | 1.2E-02 | 3.3E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    10| +2.39E+02 | +2.5E+02 | -1.2E+01 | 4.0E+00 | 3.4E+01 | 1.1E+01 | trr |0
2023-02-17 16:05:09 fides(INFO)   104| +1.48E+02 | +1.9E-05 | -1.6E+00 | 9.0E-03 | 4.3E-02 | 3.8E-03 |  2d |0
2023-02-17 16:05:09 fides(INFO)    28| +1.48E+02 | -1.4E-02 | -3.5E-01 | 5.0E-01 | 2.5E+01 | 1.5E+00 |  2d |0
2023-02-17 16:05:09 fides(INFO)    11| +2.39E+02 | +6.1E+01 | -5.4E+00 | 1.0E+00 | 3.4E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:09 fides(INFO)    32| +1.48E+02 | -2.0E-04 | +9.4E-01 | 3.1E-02 | 1.1E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    56| +1.77E+02 | -1.2E+01 | +1.8E+00 | 2.3E-01 | 3.2E+01 | 6.2E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   108| +1.59E+02 | +3.5E-02 | -1.2E+00 | 3.3E-02 | 2.7E+00 | 3.5E-02 |  2d |0
2023-02-17 16:05:09 fides(INFO)   105| +1.48E+02 | +7.4E-06 | -2.0E+00 | 2.3E-03 | 4.3E-02 | 9.6E-04 |  2d |0
2023-02-17 16:05:09 fides(INFO)    29| +1.48E+02 | -1.7E-01 | +9.4E-01 | 1.2E-01 | 2.5E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    12| +2.39E+02 | +6.7E+00 | -6.1E-01 | 2.5E-01 | 3.4E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)    61| +1.54E+02 | -2.1E-06 | +1.1E+00 | 1.1E-03 | 4.2E-02 | 3.3E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)    33| +1.48E+02 | -1.4E-04 | +9.7E-01 | 6.2E-02 | 4.4E-01 | 3.4E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    13| +2.35E+02 | -4.3E+00 | +8.8E-01 | 6.2E-02 | 3.4E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   106| +1.48E+02 | +4.3E-06 | -3.8E+00 | 5.6E-04 | 4.3E-02 | 2.4E-04 |  2d |0
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    30| +1.48E+02 | -9.7E-02 | +3.7E-01 | 2.5E-01 | 9.0E+00 | 7.1E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    62| +1.54E+02 | -7.0E-07 | +4.7E-01 | 2.1E-03 | 6.9E-03 | 9.2E-04 | trr |1
2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 6.97E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:09 fides(INFO)   109| +1.59E+02 | -9.5E-03 | +7.2E-01 | 8.3E-03 | 2.7E+00 | 8.9E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    34| +1.48E+02 | -1.1E-04 | +8.6E-01 | 1.2E-01 | 6.1E-01 | 6.5E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    14| +2.34E+02 | -8.2E-01 | +1.7E-01 | 1.2E-01 | 2.2E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   107| +1.48E+02 | +4.4E-06 | -9.6E+00 | 1.4E-04 | 4.3E-02 | 6.1E-05 |  2d |0
2023-02-17 16:05:09 fides(INFO)    31| +1.48E+02 | +7.1E-02 | -5.0E-01 | 2.5E-01 | 1.9E+01 | 2.3E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)     0| +9.19E+02 |    NaN   |    NaN   | 1.0E+00 | 3.1E+03 |   NaN   | NaN |1
2023-02-17 16:05:09 fides(INFO)    15| +2.32E+02 | -1.8E+00 | +9.2E-01 | 3.1E-02 | 3.8E+01 | 5.6E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)   110| +1.59E+02 | -2.8E-03 | +6.2E-01 | 8.3E-03 | 1.0E+00 | 7.6E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    35| +1.48E+02 | +3.6E-04 | -2.0E+00 | 2.5E-01 | 2.4E-01 | 1.1E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)    32| +1.48E+02 | -5.4E-02 | +7.6E-01 | 6.2E-02 | 1.9E+01 | 5.8E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   108| +1.48E+02 | +4.9E-06 | -1.7E+01 | 3.5E-05 | 4.3E-02 | 1.9E-05 |  2d |0
2023-02-17 16:05:09 fides(INFO)     1| +2.87E+02 | -6.3E+02 | +1.3E-01 | 1.0E+00 | 3.1E+03 | 2.0E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    16| +2.30E+02 | -2.0E+00 | +8.7E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    36| +1.48E+02 | -2.7E-05 | +3.7E-01 | 6.2E-02 | 2.4E-01 | 2.8E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   111| +1.59E+02 | -1.7E-03 | +8.1E-01 | 8.3E-03 | 2.8E+00 | 5.1E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)     2| +2.61E+02 | -2.7E+01 | +8.9E-01 | 2.5E-01 | 7.8E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   109| +1.48E+02 | +6.0E-06 | -2.5E+01 | 8.8E-06 | 4.3E-02 | 1.1E-05 |  2d |0
2023-02-17 16:05:09 fides(INFO)    17| +2.27E+02 | -3.5E+00 | +1.2E+00 | 1.2E-01 | 1.8E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    33| +1.48E+02 | -2.7E-02 | +7.8E-01 | 1.2E-01 | 4.4E+00 | 9.6E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    37| +1.48E+02 | -1.3E-05 | +1.2E-01 | 6.2E-02 | 3.6E-01 | 2.7E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    18| +2.22E+02 | -4.9E+00 | +1.2E+00 | 2.5E-01 | 1.9E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)     3| +2.61E+02 | +3.7E+02 | -1.9E+01 | 5.0E-01 | 3.3E+01 | 1.4E+00 |  2d |0
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)     0| +6.60E+12 |    NaN   |    NaN   | 1.0E+00 | 2.2E+13 |   NaN   | NaN |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)   110| +1.48E+02 | +6.7E-06 | -4.9E+01 | 2.2E-06 | 4.3E-02 | 4.0E-06 |  2d |0
2023-02-17 16:05:09 fides(INFO)   112| +1.59E+02 | -8.3E-05 | +4.7E-01 | 8.3E-03 | 6.4E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    34| +1.48E+02 | +2.1E-02 | -6.9E-01 | 2.5E-01 | 9.4E+00 | 1.9E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)     4| +2.51E+02 | -9.4E+00 | +8.8E-01 | 1.2E-01 | 3.3E+01 | 3.4E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    38| +1.48E+02 | -3.1E-05 | +5.7E-01 | 1.5E-02 | 1.8E-01 | 6.2E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)    19| +2.21E+02 | -1.2E+00 | +4.9E-02 | 5.0E-01 | 2.1E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:09.703 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0069 and h = 1.38872e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:09.703 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0069: AMICI failed to integrate the forward problem
2023-02-17 16:05:09 fides(INFO)   111| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.5E-07 | 4.3E-02 | 1.0E-06 |  2d |0
2023-02-17 16:05:09 fides(INFO)    57| +1.77E+02 | +1.4E+02 | -6.5E+00 | 4.5E-01 | 4.1E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:09 fides(INFO)    35| +1.48E+02 | -1.2E-02 | +7.4E-01 | 6.2E-02 | 9.4E+00 | 4.6E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   113| +1.59E+02 | -4.1E-05 | +8.5E-01 | 8.3E-03 | 1.7E-01 | 9.7E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)     5| +2.51E+02 | +8.2E+00 | -2.3E+00 | 2.5E-01 | 1.9E+01 | 6.8E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    20| +2.13E+02 | -7.3E+00 | +7.8E-01 | 1.2E-01 | 6.6E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)     1| +2.56E+09 | -6.6E+12 | +1.1E-01 | 1.0E+00 | 2.2E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    39| +1.48E+02 | -1.4E-05 | +9.5E-01 | 1.5E-02 | 3.3E-01 | 6.0E-03 |  2d |1
2023-02-17 16:05:09 fides(INFO)   112| +1.48E+02 | +7.4E-06 | -7.0E+02 | 1.4E-07 | 4.3E-02 | 2.5E-07 |  2d |0
2023-02-17 16:05:09 fides(INFO)    36| +1.48E+02 | -2.9E-03 | +6.1E-01 | 6.2E-02 | 1.9E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)     6| +2.50E+02 | -1.6E+00 | +6.5E-01 | 6.2E-02 | 1.9E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    21| +2.05E+02 | -8.7E+00 | +1.3E+00 | 2.5E-01 | 1.8E+01 | 5.7E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)     2| +4.81E+08 | -2.1E+09 | +8.8E-01 | 2.5E-01 | 9.3E+09 | 6.6E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   114| +1.59E+02 | -2.4E-06 | +5.2E-01 | 8.3E-03 | 4.1E-02 | 6.8E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    40| +1.48E+02 | -7.4E-06 | +5.9E-01 | 3.1E-02 | 8.1E-02 | 1.2E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   113| +1.48E+02 | +5.8E-06 | -2.2E+03 | 3.4E-08 | 4.3E-02 | 6.2E-08 |  2d |0
2023-02-17 16:05:09 fides(INFO)     7| +2.50E+02 | -1.4E-03 | +6.7E-02 | 6.2E-02 | 1.8E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)    37| +1.48E+02 | -2.2E-03 | +6.4E-01 | 6.2E-02 | 3.6E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    22| +1.94E+02 | -1.1E+01 | +9.7E-01 | 5.0E-01 | 3.2E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)     3| +7.29E+07 | -4.1E+08 | +8.9E-01 | 5.0E-01 | 1.6E+09 | 1.0E+00 |  2d |1
2023-02-17 16:05:09 fides(INFO)    41| +1.48E+02 | -5.0E-06 | +1.0E+00 | 3.1E-02 | 1.6E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   115| +1.59E+02 | -1.3E-06 | +2.0E+00 | 8.3E-03 | 1.1E-02 | 5.1E-04 |  2d |1
2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 1.35E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:09 fides(INFO)   114| +1.48E+02 | +4.0E-06 | -6.1E+03 | 8.6E-09 | 4.3E-02 | 1.6E-08 |  2d |0
2023-02-17 16:05:09 fides(INFO)    38| +1.48E+02 | -7.8E-04 | +5.2E-01 | 6.2E-02 | 1.0E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)     8| +2.50E+02 | +9.3E-04 | -6.0E-02 | 1.6E-02 | 1.6E+00 | 4.3E-02 |  2d |0
2023-02-17 16:05:09 fides(INFO)     4| +1.11E+07 | -6.2E+07 | +8.9E-01 | 5.0E-01 | 2.4E+08 | 1.0E+00 |  2d |1
2023-02-17 16:05:09.842 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0854 and h = 2.28973e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:09.842 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0854: AMICI failed to integrate the forward problem
2023-02-17 16:05:09 fides(INFO)    42| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 3.1E-02 | 2.1E-02 |  2d |0
2023-02-17 16:05:09 fides(INFO)    23| +1.94E+02 | +8.6E+00 | -1.9E+00 | 1.0E+00 | 4.2E+01 | 2.5E+00 |  2d |0
2023-02-17 16:05:09 fides(INFO)     9| +2.50E+02 | -8.1E-03 | +6.5E-01 | 3.9E-03 | 1.6E+00 | 1.0E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)     5| +1.70E+06 | -9.4E+06 | +9.0E-01 | 5.0E-01 | 3.6E+07 | 9.7E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   115| +1.48E+02 | +6.4E-06 | -3.9E+04 | 2.1E-09 | 4.3E-02 | 3.9E-09 |  2d |0
2023-02-17 16:05:09 fides(INFO)    39| +1.48E+02 | -5.9E-04 | +5.2E-01 | 6.2E-02 | 1.7E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    43| +1.48E+02 | -1.3E-06 | +1.2E+00 | 1.5E-02 | 3.1E-02 | 5.4E-03 |  2d |1
2023-02-17 16:05:09 fides(WARNING) Stopping as function difference 1.27E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    10| +2.50E+02 | -1.5E-07 | +5.2E-03 | 3.9E-03 | 6.7E-02 | 1.1E-02 |  2d |1
2023-02-17 16:05:09.892 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.732 and h = 3.21785e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:09.892 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.732: AMICI failed to integrate the forward problem
2023-02-17 16:05:09 fides(INFO)   116| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.4E-10 | 4.3E-02 | 9.8E-10 |  2d |0
2023-02-17 16:05:09.895 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 123.347 and h = 8.2092e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:09.895 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 123.347: AMICI failed to integrate the forward problem
2023-02-17 16:05:09 fides(INFO)    24| +1.94E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 4.2E+01 | 5.8E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)    40| +1.48E+02 | -2.6E-04 | +3.5E-01 | 6.2E-02 | 6.7E-01 | 3.3E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    11| +2.50E+02 | +3.9E-08 | -1.6E-03 | 9.8E-04 | 6.7E-02 | 2.7E-03 |  2d |0
2023-02-17 16:05:09.925 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 147.013 and h = 1.79811e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:09.925 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 147.013: AMICI failed to integrate the forward problem
2023-02-17 16:05:09 fides(INFO)    25| +1.94E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 4.2E+01 | 1.4E-01 |  2d |0
2023-02-17 16:05:09 fides(INFO)    58| +1.71E+02 | -5.8E+00 | +6.8E-01 | 1.1E-01 | 4.1E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)     6| +2.63E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 5.5E+06 | 9.5E-01 |  2d |1
2023-02-17 16:05:09 fides(INFO)   117| +1.48E+02 | +2.3E-06 | -2.2E+05 | 1.3E-10 | 4.3E-02 | 2.4E-10 |  2d |0
2023-02-17 16:05:09 fides(INFO)    41| +1.48E+02 | -1.8E-04 | +2.6E-01 | 6.2E-02 | 9.3E-01 | 3.1E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)    12| +2.50E+02 | -8.1E-06 | +3.2E-01 | 2.4E-04 | 6.7E-02 | 6.4E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)    26| +1.92E+02 | -1.3E+00 | +9.9E-01 | 1.6E-02 | 4.2E+01 | 3.6E-02 |  2d |1
2023-02-17 16:05:09 fides(INFO)   118| +1.48E+02 | +2.9E-06 | -1.1E+06 | 3.4E-11 | 4.3E-02 | 6.1E-11 |  2d |0
2023-02-17 16:05:09 fides(INFO)    13| +2.50E+02 | -2.2E-06 | +2.1E-01 | 2.4E-04 | 4.2E-02 | 4.3E-04 |  2d |1
2023-02-17 16:05:09 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:09 fides(INFO)     0| +1.10E+14 |    NaN   |    NaN   | 1.0E+00 | 5.1E+14 |   NaN   | NaN |1
2023-02-17 16:05:09 fides(INFO)    42| +1.48E+02 | -2.5E-05 | +3.3E-02 | 6.2E-02 | 5.0E-01 | 3.0E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    27| +1.90E+02 | -2.4E+00 | +9.8E-01 | 3.1E-02 | 4.1E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)     0| +5.57E+12 |    NaN   |    NaN   | 1.0E+00 | 2.6E+13 |   NaN   | NaN |1
2023-02-17 16:05:10 fides(INFO)   119| +1.48E+02 | +4.2E-06 | -6.5E+06 | 8.4E-12 | 4.3E-02 | 1.5E-11 |  2d |0
2023-02-17 16:05:10 fides(INFO)     7| +4.11E+04 | -2.2E+05 | +9.0E-01 | 5.0E-01 | 8.6E+05 | 9.3E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    14| +2.50E+02 | -2.9E-06 | +7.3E-01 | 6.1E-05 | 3.2E-02 | 1.6E-04 |  2d |1
2023-02-17 16:05:10 fides(INFO)    43| +1.48E+02 | -2.6E-04 | +7.3E-01 | 1.6E-02 | 7.4E-01 | 7.1E-03 |  2d |1
2023-02-17 16:05:10 fides(INFO)     1| +1.08E+08 | -1.1E+14 | +8.2E-02 | 1.0E+00 | 5.1E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    28| +1.86E+02 | -4.3E+00 | +9.8E-01 | 6.2E-02 | 4.0E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     1| +1.50E+09 | -5.6E+12 | +8.6E-02 | 1.0E+00 | 2.6E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    15| +2.50E+02 | -1.1E-09 | +9.6E-03 | 6.1E-05 | 4.5E-03 | 1.7E-04 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)   120| +1.48E+02 | +1.6E-06 | -9.7E+06 | 2.1E-12 | 4.3E-02 | 3.8E-12 |  2d |0
2023-02-17 16:05:10 fides(INFO)     2| +2.44E+08 | -1.3E+09 | +8.9E-01 | 2.5E-01 | 6.5E+09 | 6.6E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    44| +1.48E+02 | -5.8E-05 | +8.4E-01 | 1.6E-02 | 3.6E-01 | 6.4E-03 |  2d |1
2023-02-17 16:05:10 fides(INFO)    16| +2.50E+02 | -5.9E-08 | +6.6E-01 | 1.5E-05 | 4.5E-03 | 2.7E-05 |  2d |1
2023-02-17 16:05:10 fides(WARNING) Stopping as function difference 5.90E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:10 fides(INFO)   121| +1.48E+02 | +3.6E-06 | -8.8E+07 | 5.2E-13 | 4.3E-02 | 9.5E-13 |  2d |0
2023-02-17 16:05:10 fides(INFO)    29| +1.77E+02 | -9.0E+00 | +1.1E+00 | 1.2E-01 | 4.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     3| +3.70E+07 | -2.1E+08 | +8.9E-01 | 5.0E-01 | 1.0E+09 | 1.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)     2| +1.69E+07 | -9.1E+07 | +8.9E-01 | 2.5E-01 | 3.5E+08 | 6.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    45| +1.48E+02 | -3.7E-05 | +8.4E-01 | 3.1E-02 | 3.0E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    59| +1.63E+02 | -8.4E+00 | +8.7E-01 | 1.1E-01 | 8.0E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)   122| +1.48E+02 | +3.2E-06 | -3.2E+08 | 1.3E-13 | 4.3E-02 | 2.4E-13 |  2d |0
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    30| +1.62E+02 | -1.5E+01 | +8.6E-01 | 2.5E-01 | 4.9E+01 | 5.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     4| +5.64E+06 | -3.1E+07 | +8.9E-01 | 5.0E-01 | 1.5E+08 | 1.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    46| +1.48E+02 | -4.9E-05 | +9.3E-01 | 6.2E-02 | 2.4E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)     3| +2.62E+06 | -1.4E+07 | +8.9E-01 | 5.0E-01 | 5.5E+07 | 1.5E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)   123| +1.48E+02 | +3.2E-06 | -1.3E+09 | 3.3E-14 | 4.3E-02 | 6.0E-14 |  2d |0
2023-02-17 16:05:10 fides(INFO)     8| +6.58E+03 | -3.5E+04 | +9.0E-01 | 5.0E-01 | 1.3E+05 | 9.2E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    31| +1.62E+02 | +7.2E+01 | -5.0E+00 | 5.0E-01 | 1.0E+02 | 9.7E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)     5| +8.66E+05 | -4.8E+06 | +8.9E-01 | 5.0E-01 | 2.3E+07 | 1.1E+00 |  2d |1
2023-02-17 16:05:10.187 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.882 and h = 4.14838e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:10.188 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.882: AMICI failed to integrate the forward problem
2023-02-17 16:05:10 fides(INFO)    47| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 2.7E-01 | 4.4E-02 |  2d |0
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)     0| +4.28E+11 |    NaN   |    NaN   | 1.0E+00 | 2.0E+12 |   NaN   | NaN |1
2023-02-17 16:05:10 fides(INFO)     4| +4.31E+05 | -2.2E+06 | +8.6E-01 | 1.0E+00 | 8.6E+06 | 2.8E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)   124| +1.48E+02 | +6.8E-06 | -1.1E+10 | 8.2E-15 | 4.3E-02 | 1.5E-14 |  2d |0
2023-02-17 16:05:10 fides(INFO)     6| +1.34E+05 | -7.3E+05 | +9.0E-01 | 1.0E+00 | 3.5E+06 | 1.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    32| +1.55E+02 | -7.2E+00 | +7.5E-01 | 1.2E-01 | 1.0E+02 | 2.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    48| +1.48E+02 | -1.9E-05 | +7.7E-01 | 3.1E-02 | 2.7E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)     7| +2.10E+04 | -1.1E+05 | +9.0E-01 | 1.0E+00 | 5.4E+05 | 1.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)     9| +1.18E+03 | -5.4E+03 | +9.0E-01 | 5.0E-01 | 2.1E+04 | 9.4E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)   125| +1.48E+02 | +4.5E-06 | -2.8E+10 | 2.0E-15 | 4.3E-02 | 3.7E-15 |  2d |0
2023-02-17 16:05:10 fides(INFO)     5| +6.72E+04 | -3.6E+05 | +9.0E-01 | 2.0E+00 | 1.3E+06 | 9.6E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     8| +3.45E+03 | -1.8E+04 | +9.0E-01 | 1.0E+00 | 8.5E+04 | 1.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)     1| +5.82E+05 | -4.3E+11 | +8.9E-02 | 1.0E+00 | 2.0E+12 | 2.9E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    33| +1.53E+02 | -2.2E+00 | +1.0E+00 | 1.2E-01 | 6.5E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    49| +1.48E+02 | -2.3E-05 | +8.5E-01 | 6.2E-02 | 1.5E-01 | 2.1E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)   126| +1.48E+02 | +3.8E-06 | -9.7E+10 | 5.1E-16 | 4.3E-02 | 9.3E-16 |  2d |0
2023-02-17 16:05:10 fides(WARNING) Stopping as trust region radius 1.28E-16 is smaller than machine precision.
2023-02-17 16:05:10 fides(INFO)     9| +7.11E+02 | -2.7E+03 | +9.0E-01 | 1.0E+00 | 1.3E+04 | 1.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)     2| +9.11E+04 | -4.9E+05 | +9.0E-01 | 2.5E-01 | 2.7E+06 | 6.9E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    10| +3.53E+02 | -8.3E+02 | +9.0E-01 | 5.0E-01 | 3.4E+03 | 9.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     6| +1.05E+04 | -5.7E+04 | +9.0E-01 | 2.0E+00 | 2.1E+05 | 9.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    34| +1.51E+02 | -1.9E+00 | +4.6E-01 | 2.5E-01 | 3.0E+01 | 3.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     3| +1.46E+04 | -7.6E+04 | +9.0E-01 | 5.0E-01 | 4.2E+05 | 1.4E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    50| +1.48E+02 | +2.8E-05 | -7.2E-01 | 1.2E-01 | 2.0E-01 | 3.8E-02 |  2d |0
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    10| +2.99E+02 | -4.1E+02 | +9.0E-01 | 1.0E+00 | 2.1E+03 | 1.3E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    11| +2.39E+02 | -1.1E+02 | +9.0E-01 | 1.0E+00 | 5.2E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)     4| +4.15E+03 | -1.0E+04 | +6.8E-01 | 1.0E+00 | 6.6E+04 | 1.9E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    11| +2.35E+02 | -6.4E+01 | +1.0E+00 | 1.0E+00 | 3.1E+02 | 1.9E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)     7| +1.72E+03 | -8.8E+03 | +9.1E-01 | 2.0E+00 | 3.2E+04 | 9.3E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    35| +1.50E+02 | -6.8E-01 | +2.3E-01 | 2.5E-01 | 9.0E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     5| +8.28E+02 | -3.3E+03 | +9.0E-01 | 1.0E+00 | 1.3E+04 | 2.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    51| +1.48E+02 | -1.4E-05 | +8.8E-01 | 3.1E-02 | 2.0E-01 | 9.4E-03 |  2d |1
2023-02-17 16:05:10 fides(INFO)     6| +3.15E+02 | -5.1E+02 | +9.0E-01 | 2.0E+00 | 2.1E+03 | 3.5E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    12| +2.20E+02 | -1.9E+01 | +1.1E+00 | 1.0E+00 | 6.1E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    36| +1.49E+02 | -7.8E-01 | +9.3E-01 | 6.2E-02 | 4.3E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    52| +1.48E+02 | -9.5E-07 | +6.4E-02 | 6.2E-02 | 9.3E-02 | 1.8E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    12| +2.35E+02 | +9.0E+01 | -2.0E+01 | 2.0E+00 | 2.8E+01 | 4.0E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)     8| +3.86E+02 | -1.3E+03 | +9.3E-01 | 2.0E+00 | 4.9E+03 | 8.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     7| +2.51E+02 | -6.4E+01 | +8.4E-01 | 4.0E+00 | 3.2E+02 | 2.3E+00 | trr |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    60| +1.63E+02 | +2.1E+01 | -2.5E+00 | 2.3E-01 | 3.8E+01 | 4.6E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)    13| +2.35E+02 | +2.0E+01 | -2.5E+00 | 5.0E-01 | 2.8E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)     8| +2.34E+02 | -1.7E+01 | +5.1E+00 | 4.0E+00 | 2.5E+01 | 4.2E+00 | trr |1
2023-02-17 16:05:10 fides(INFO)    53| +1.48E+02 | -5.7E-06 | +4.3E-01 | 1.6E-02 | 1.2E-01 | 4.0E-03 |  2d |1
2023-02-17 16:05:10 fides(INFO)    37| +1.48E+02 | -6.9E-01 | +6.4E-01 | 1.2E-01 | 3.2E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    14| +2.32E+02 | -3.5E+00 | +5.1E-01 | 1.2E-01 | 2.8E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    13| +2.20E+02 | +2.1E+02 | -1.3E+01 | 2.0E+00 | 3.4E+01 | 5.8E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)     0| +5.24E+12 |    NaN   |    NaN   | 1.0E+00 | 2.4E+13 |   NaN   | NaN |1
2023-02-17 16:05:10 fides(INFO)    15| +2.29E+02 | -3.1E+00 | +8.1E-01 | 1.2E-01 | 2.9E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     9| +2.06E+02 | -1.8E+02 | +1.0E+00 | 2.0E+00 | 7.0E+02 | 9.8E-01 |  2d |1
2023-02-17 16:05:10.466 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.274 and h = 2.21878e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:10.467 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.274: AMICI failed to integrate the forward problem
2023-02-17 16:05:10 fides(INFO)    54| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 6.9E-02 | 3.8E-03 |  2d |0
2023-02-17 16:05:10 fides(INFO)    38| +1.48E+02 | -3.1E-01 | +7.9E-01 | 1.2E-01 | 3.2E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    14| +2.20E+02 | +1.6E+00 | -6.3E-01 | 5.0E-01 | 3.4E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)     9| +2.34E+02 | +1.1E+04 | -3.1E+02 | 4.0E+00 | 4.9E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:10 fides(INFO)    16| +2.29E+02 | +2.5E-01 | -1.9E-01 | 2.5E-01 | 2.2E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)    55| +1.48E+02 | -5.4E-06 | +6.4E+00 | 3.9E-03 | 6.9E-02 | 9.5E-04 |  2d |1
2023-02-17 16:05:10 fides(INFO)    39| +1.48E+02 | -1.1E-01 | +1.8E-01 | 2.5E-01 | 1.5E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     1| +7.80E+10 | -5.2E+12 | +8.7E-02 | 1.0E+00 | 2.4E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    15| +2.14E+02 | -5.5E+00 | +7.8E-01 | 1.2E-01 | 3.4E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    10| +2.34E+02 | +1.5E+03 | -4.5E+01 | 1.0E+00 | 4.9E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)    17| +2.27E+02 | -1.8E+00 | +7.9E-01 | 6.2E-02 | 2.2E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    56| +1.48E+02 | +3.0E-06 | -3.9E+00 | 7.8E-03 | 5.3E-02 | 1.9E-03 |  2d |0
2023-02-17 16:05:10 fides(INFO)     2| +1.16E+10 | -6.6E+10 | +8.9E-01 | 2.5E-01 | 3.6E+11 | 7.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    40| +1.48E+02 | -2.4E-01 | +3.2E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    18| +2.23E+02 | -3.4E+00 | +1.1E+00 | 1.2E-01 | 2.1E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    10| +2.06E+02 | +2.3E+02 | -1.4E+01 | 2.0E+00 | 8.5E+01 | 5.7E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)    11| +2.17E+02 | -1.7E+01 | +6.3E-01 | 2.5E-01 | 4.9E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    16| +2.06E+02 | -8.7E+00 | +1.1E+00 | 2.5E-01 | 3.9E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    57| +1.48E+02 | +1.8E-06 | -4.1E+00 | 2.0E-03 | 5.3E-02 | 4.7E-04 |  2d |0
2023-02-17 16:05:10 fides(INFO)    19| +2.23E+02 | -8.5E-01 | +1.2E-01 | 2.5E-01 | 2.0E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    12| +2.16E+02 | -1.2E+00 | +5.0E-01 | 2.5E-01 | 2.4E+01 | 7.3E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    41| +1.48E+02 | -9.5E-02 | +7.6E-01 | 6.2E-02 | 1.2E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    17| +2.06E+02 | -3.9E+00 | -9.5E-02 | 5.0E-01 | 3.1E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)     3| +1.74E+09 | -9.9E+09 | +8.9E-01 | 5.0E-01 | 5.3E+10 | 1.4E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    13| +2.16E+02 | +5.5E-01 | -3.9E-01 | 2.5E-01 | 1.7E+01 | 7.3E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    20| +2.19E+02 | -3.7E+00 | +8.4E-01 | 6.2E-02 | 4.9E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    58| +1.48E+02 | +9.3E-07 | -2.6E+00 | 4.9E-04 | 5.3E-02 | 1.2E-04 |  2d |0
2023-02-17 16:05:10 fides(INFO)    42| +1.48E+02 | -7.8E-02 | +9.5E-01 | 1.2E-01 | 8.4E+00 | 9.7E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    11| +1.91E+02 | -1.5E+01 | +1.4E+00 | 5.0E-01 | 8.5E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    14| +2.15E+02 | -4.4E-01 | +3.1E-01 | 6.2E-02 | 1.7E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    18| +2.01E+02 | -4.8E+00 | +7.6E-01 | 1.2E-01 | 3.1E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     4| +2.61E+08 | -1.5E+09 | +8.9E-01 | 1.0E+00 | 8.0E+09 | 1.5E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    61| +1.63E+02 | -1.1E-01 | +9.7E-03 | 5.6E-02 | 3.8E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    21| +2.17E+02 | -2.3E+00 | +8.0E-01 | 1.2E-01 | 2.4E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    59| +1.48E+02 | -2.1E-08 | +6.2E-02 | 1.2E-04 | 5.3E-02 | 3.3E-05 |  2d |1
2023-02-17 16:05:10 fides(INFO)    43| +1.48E+02 | -7.0E-02 | +8.7E-01 | 2.5E-01 | 5.8E+00 | 1.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    15| +2.14E+02 | -6.6E-01 | +6.0E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     5| +3.95E+07 | -2.2E+08 | +8.9E-01 | 1.0E+00 | 1.2E+09 | 1.0E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    19| +1.95E+02 | -5.8E+00 | +6.8E-01 | 2.5E-01 | 4.1E+01 | 4.8E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    22| +2.14E+02 | -2.5E+00 | +5.9E-01 | 2.5E-01 | 1.9E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    60| +1.48E+02 | +2.8E-06 | -4.1E+00 | 3.1E-05 | 5.3E-02 | 3.5E-05 |  2d |0
2023-02-17 16:05:10 fides(INFO)    44| +1.48E+02 | +7.5E-02 | -1.7E+00 | 5.0E-01 | 3.6E+00 | 2.1E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)    12| +1.91E+02 | +4.2E+01 | -2.3E+00 | 1.0E+00 | 4.9E+01 | 2.1E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)     6| +6.00E+06 | -3.3E+07 | +8.9E-01 | 1.0E+00 | 1.8E+08 | 1.0E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    16| +2.14E+02 | -4.9E-03 | -2.0E-02 | 6.2E-02 | 1.2E+01 | 1.4E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)    23| +2.07E+02 | -6.8E+00 | +9.6E-01 | 2.5E-01 | 3.3E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    20| +1.89E+02 | -6.2E+00 | +3.7E-01 | 2.5E-01 | 3.9E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    61| +1.48E+02 | +3.0E-06 | -7.2E+00 | 7.6E-06 | 5.3E-02 | 1.3E-05 |  2d |0
2023-02-17 16:05:10 fides(INFO)    17| +2.14E+02 | -2.3E-01 | +8.6E-01 | 1.6E-02 | 1.2E+01 | 3.2E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)     7| +9.19E+05 | -5.1E+06 | +8.9E-01 | 1.0E+00 | 2.8E+07 | 9.5E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    45| +1.48E+02 | -1.3E-02 | +6.0E-01 | 1.0E-01 | 3.6E+00 | 5.3E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    62| +1.48E+02 | +2.6E-06 | -2.1E+01 | 1.9E-06 | 5.3E-02 | 3.2E-06 |  2d |0
2023-02-17 16:05:10 fides(INFO)    24| +1.82E+02 | -2.5E+01 | +1.2E+00 | 5.0E-01 | 2.5E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    18| +2.14E+02 | -3.3E-01 | +9.6E-01 | 3.1E-02 | 1.0E+01 | 4.0E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    21| +1.80E+02 | -8.9E+00 | +8.7E-01 | 2.5E-01 | 7.0E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    13| +1.78E+02 | -1.3E+01 | +7.1E-01 | 2.5E-01 | 4.9E+01 | 5.6E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)     8| +1.42E+05 | -7.8E+05 | +8.9E-01 | 1.0E+00 | 4.2E+06 | 1.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    46| +1.48E+02 | +2.7E-02 | -6.9E-01 | 1.0E-01 | 2.4E+00 | 9.6E-02 |  2d |0
2023-02-17 16:05:10.784 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 37.9918 and h = 5.00215e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:10.784 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 37.9918: AMICI failed to integrate the forward problem
2023-02-17 16:05:10 fides(INFO)    25| +1.82E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 9.0E+01 | 1.8E+00 |  2d |0
2023-02-17 16:05:10 fides(INFO)    19| +2.13E+02 | -4.8E-01 | +8.3E-01 | 6.2E-02 | 9.0E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    63| +1.48E+02 | +6.0E-06 | -1.9E+02 | 4.8E-07 | 5.3E-02 | 8.1E-07 |  2d |0
2023-02-17 16:05:10 fides(INFO)    22| +1.63E+02 | -1.7E+01 | +1.1E+00 | 5.0E-01 | 6.2E+01 | 9.6E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    47| +1.48E+02 | -6.8E-03 | +6.0E-01 | 2.5E-02 | 2.4E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)     9| +2.22E+04 | -1.2E+05 | +9.0E-01 | 1.0E+00 | 6.5E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    20| +2.13E+02 | -1.1E-01 | +2.1E-01 | 1.2E-01 | 1.1E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    26| +1.68E+02 | -1.4E+01 | +8.3E-01 | 2.5E-01 | 9.0E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    14| +1.71E+02 | -6.9E+00 | +9.9E-01 | 2.5E-01 | 1.1E+02 | 4.6E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    64| +1.48E+02 | +1.3E-06 | -1.6E+02 | 1.2E-07 | 5.3E-02 | 2.0E-07 |  2d |0
2023-02-17 16:05:10 fides(INFO)    23| +1.59E+02 | -4.3E+00 | +9.0E-01 | 1.0E+00 | 6.6E+01 | 1.7E+00 | trr |1
2023-02-17 16:05:10 fides(INFO)    48| +1.48E+02 | -3.0E-03 | +9.9E-01 | 2.5E-02 | 2.1E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    62| +1.60E+02 | -2.7E+00 | +1.0E+00 | 1.4E-02 | 1.1E+02 | 3.9E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    21| +2.13E+02 | -3.8E-01 | +7.0E-01 | 3.1E-02 | 1.2E+01 | 6.5E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    27| +1.64E+02 | -4.1E+00 | +9.1E-01 | 5.0E-01 | 7.4E+01 | 5.4E-01 | trr |1
2023-02-17 16:05:10 fides(INFO)    65| +1.48E+02 | +3.1E-06 | -1.5E+03 | 3.0E-08 | 5.3E-02 | 5.1E-08 |  2d |0
2023-02-17 16:05:10 fides(INFO)    22| +2.13E+02 | -1.9E-01 | +8.6E-01 | 3.1E-02 | 7.4E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    49| +1.48E+02 | -4.2E-03 | +9.5E-01 | 5.0E-02 | 1.8E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    10| +3.64E+03 | -1.9E+04 | +9.0E-01 | 1.0E+00 | 1.0E+05 | 1.9E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    24| +1.59E+02 | +1.6E+03 | -1.2E+02 | 1.0E+00 | 7.0E+01 | 1.8E+00 |  2d |0
2023-02-17 16:05:10.914 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.723 and h = 3.11306e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:10.914 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.723: AMICI failed to integrate the forward problem
2023-02-17 16:05:10 fides(INFO)    66| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.5E-09 | 5.3E-02 | 1.3E-08 |  2d |0
2023-02-17 16:05:10 fides(INFO)    28| +1.64E+02 | -1.6E+00 | -3.3E-01 | 5.0E-01 | 6.9E+01 | 9.0E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)    15| +1.61E+02 | -1.0E+01 | +9.0E-01 | 5.0E-01 | 7.3E+01 | 9.9E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    23| +2.13E+02 | -2.4E-02 | +8.0E-02 | 6.2E-02 | 6.5E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    50| +1.48E+02 | -5.6E-03 | +9.2E-01 | 1.0E-01 | 1.4E+00 | 4.8E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    67| +1.48E+02 | +1.9E-06 | -1.5E+04 | 1.9E-09 | 5.3E-02 | 3.2E-09 |  2d |0
2023-02-17 16:05:10 fides(INFO)    24| +2.13E+02 | -2.2E-01 | +8.3E-01 | 1.6E-02 | 1.2E+01 | 3.0E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    29| +1.59E+02 | -5.6E+00 | +8.1E-01 | 1.2E-01 | 6.9E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    11| +7.26E+02 | -2.9E+03 | +9.0E-01 | 2.0E+00 | 1.6E+04 | 1.9E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    25| +1.52E+02 | -7.0E+00 | +5.3E-01 | 2.3E-01 | 7.0E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:10 fides(INFO)    51| +1.48E+02 | +1.6E-02 | -2.0E+00 | 2.0E-01 | 1.1E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:10 fides(INFO)    16| +1.56E+02 | -4.5E+00 | +9.9E-02 | 1.0E+00 | 7.5E+01 | 2.1E+00 |  2d |1
2023-02-17 16:05:10 fides(INFO)    25| +2.12E+02 | -9.8E-02 | +5.4E-01 | 3.1E-02 | 6.8E+00 | 5.2E-02 |  2d |1
2023-02-17 16:05:10 fides(INFO)    68| +1.48E+02 | -5.6E-07 | +1.8E+04 | 4.7E-10 | 5.3E-02 | 7.9E-10 |  2d |1
2023-02-17 16:05:10 fides(WARNING) Stopping as function difference 5.55E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:10 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:10 fides(INFO)    30| +1.53E+02 | -5.5E+00 | +1.0E+00 | 2.5E-01 | 7.0E+01 | 3.5E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    26| +1.49E+02 | -2.9E+00 | +9.7E-01 | 2.3E-01 | 1.4E+02 | 3.6E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    52| +1.48E+02 | -1.2E-03 | +4.3E-01 | 5.0E-02 | 1.1E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    26| +2.12E+02 | -2.7E-02 | +1.2E-01 | 3.1E-02 | 6.2E+00 | 7.4E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    31| +1.53E+02 | +2.0E+01 | -3.2E+00 | 5.0E-01 | 5.6E+01 | 7.8E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)    12| +7.26E+02 | +9.4E+03 | -2.8E+01 | 2.0E+00 | 2.5E+03 | 3.8E+00 | trr |0
2023-02-17 16:05:11 fides(INFO)    17| +1.53E+02 | -3.1E+00 | +1.0E+00 | 2.5E-01 | 7.8E+01 | 6.2E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    63| +1.59E+02 | -1.2E+00 | +8.4E-01 | 2.8E-02 | 3.6E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    27| +1.49E+02 | +1.3E+00 | -6.9E-01 | 4.7E-01 | 3.3E+01 | 6.9E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)    53| +1.48E+02 | +1.1E-03 | -2.3E-01 | 5.0E-02 | 9.6E-01 | 1.7E-02 |  2d |0
2023-02-17 16:05:11 fides(INFO)    27| +2.12E+02 | -9.1E-02 | +9.0E-01 | 7.8E-03 | 8.7E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    32| +1.51E+02 | -2.6E+00 | +7.3E-01 | 1.2E-01 | 5.6E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    28| +2.12E+02 | -8.2E-02 | +7.4E-01 | 1.6E-02 | 6.4E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    54| +1.48E+02 | -9.9E-04 | +5.4E-01 | 1.3E-02 | 9.6E-01 | 5.0E-03 |  2d |1
2023-02-17 16:05:11.099 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 208.039 and h = 1.4974e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:11.099 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 208.039: AMICI failed to integrate the forward problem
2023-02-17 16:05:11 fides(INFO)    13| +7.26E+02 | +0.0E+00 | +0.0E+00 | 4.3E-01 | 2.5E+03 | 8.8E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)    28| +1.48E+02 | -8.3E-01 | +4.9E-01 | 1.2E-01 | 3.3E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    18| +1.53E+02 | -3.9E-01 | +1.0E+00 | 5.0E-01 | 4.0E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:11 fides(INFO)    33| +1.49E+02 | -1.2E+00 | +8.6E-01 | 1.2E-01 | 5.8E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    29| +2.12E+02 | -6.2E-02 | +8.4E-01 | 1.6E-02 | 4.5E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    55| +1.48E+02 | -7.5E-04 | +9.4E-01 | 1.3E-02 | 2.1E+00 | 5.8E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)     0| +3.71E+02 |    NaN   |    NaN   | 1.0E+00 | 1.4E+02 |   NaN   | NaN |1
2023-02-17 16:05:11.147 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 172.17 and h = 5.26904e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:11.147 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 172.17: AMICI failed to integrate the forward problem
2023-02-17 16:05:11 fides(INFO)    34| +1.49E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 3.2E+01 | 3.0E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    30| +2.12E+02 | -5.4E-02 | +4.9E-01 | 3.1E-02 | 4.9E+00 | 5.6E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    29| +1.48E+02 | -4.0E-01 | +4.6E-01 | 1.2E-01 | 4.7E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    14| +3.80E+02 | -3.5E+02 | +8.5E-01 | 1.1E-01 | 2.5E+03 | 2.3E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    19| +1.52E+02 | -8.7E-01 | +7.8E-01 | 1.0E+00 | 2.3E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:11 fides(INFO)    56| +1.48E+02 | -7.6E-04 | +9.4E-01 | 2.5E-02 | 4.2E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)     1| +3.36E+02 | -3.5E+01 | +2.1E-02 | 1.0E+00 | 1.4E+02 | 2.4E+00 |  2d |1
2023-02-17 16:05:11 fides(INFO)    31| +2.12E+02 | -8.0E-03 | +3.5E-02 | 3.1E-02 | 5.3E+00 | 7.8E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    35| +1.49E+02 | -6.2E-01 | +7.4E-01 | 6.2E-02 | 3.2E+01 | 8.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    30| +1.48E+02 | -1.2E-01 | +7.7E-01 | 1.2E-01 | 9.1E+00 | 1.6E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    57| +1.48E+02 | -4.3E-04 | +4.5E-01 | 5.0E-02 | 9.4E-01 | 2.3E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)     2| +2.85E+02 | -5.1E+01 | +9.0E-01 | 2.5E-01 | 1.8E+02 | 6.5E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    20| +1.51E+02 | -3.6E-01 | +9.9E-01 | 2.0E+00 | 3.9E+01 | 1.0E+00 | trr |1
2023-02-17 16:05:11 fides(INFO)    32| +2.12E+02 | -8.0E-02 | +8.8E-01 | 7.8E-03 | 7.6E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    15| +2.32E+02 | -1.5E+02 | +8.8E-01 | 2.1E-01 | 8.4E+02 | 4.4E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    36| +1.48E+02 | -3.6E-01 | +7.7E-01 | 6.2E-02 | 4.0E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    31| +1.48E+02 | -9.2E-02 | +9.3E-01 | 2.3E-01 | 5.5E+00 | 3.0E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    33| +2.12E+02 | -5.0E-02 | +6.1E-01 | 1.6E-02 | 5.1E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    58| +1.48E+02 | +2.6E-03 | -1.2E+00 | 5.0E-02 | 4.0E-01 | 1.5E-02 |  2d |0
2023-02-17 16:05:11 fides(INFO)    21| +1.51E+02 | +1.7E-01 | -1.2E+00 | 2.0E+00 | 4.7E+00 | 9.1E-01 | trr |0
2023-02-17 16:05:11 fides(INFO)     3| +2.67E+02 | -1.8E+01 | +1.7E-01 | 5.0E-01 | 5.6E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:11 fides(INFO)    37| +1.48E+02 | -3.0E-01 | +4.8E-01 | 1.2E-01 | 1.8E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    32| +1.48E+02 | +7.5E-03 | -8.6E-02 | 4.7E-01 | 5.0E+00 | 5.5E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)    59| +1.48E+02 | +1.5E-04 | -1.6E-01 | 1.3E-02 | 4.0E-01 | 5.0E-03 |  2d |0
2023-02-17 16:05:11 fides(INFO)    34| +2.12E+02 | -2.2E-02 | +4.2E-01 | 1.6E-02 | 3.6E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    16| +2.11E+02 | -2.1E+01 | +8.5E-01 | 4.3E-01 | 1.3E+02 | 8.6E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)     4| +2.52E+02 | -1.5E+01 | +8.1E-01 | 1.2E-01 | 1.1E+02 | 2.4E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    64| +1.57E+02 | -1.7E+00 | +8.4E-01 | 5.6E-02 | 2.9E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    22| +1.51E+02 | -9.5E-02 | +1.0E+00 | 2.3E-01 | 4.7E+00 | 1.9E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    38| +1.48E+02 | +1.0E+00 | -9.7E-01 | 1.2E-01 | 3.1E+01 | 2.2E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)    35| +2.12E+02 | -4.0E-02 | +5.6E-01 | 1.6E-02 | 4.7E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    33| +1.48E+02 | -3.1E-02 | +7.6E-01 | 1.2E-01 | 5.0E+00 | 1.4E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    60| +1.48E+02 | -3.9E-05 | +6.2E-02 | 3.1E-03 | 4.0E-01 | 3.0E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)     5| +2.52E+02 | -4.8E-02 | -2.8E-02 | 2.5E-01 | 2.8E+01 | 6.0E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)    36| +2.12E+02 | -1.6E-02 | +3.3E-01 | 1.6E-02 | 3.4E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    23| +1.51E+02 | -2.1E-01 | +1.3E+00 | 4.7E-01 | 6.5E+00 | 3.7E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    39| +1.48E+02 | -2.6E-01 | +6.8E-01 | 3.1E-02 | 3.1E+01 | 5.5E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    34| +1.48E+02 | -4.3E-02 | +6.3E-01 | 2.3E-01 | 3.8E+00 | 2.6E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    61| +1.48E+02 | -3.7E-04 | +9.5E-01 | 7.9E-04 | 1.8E+00 | 5.5E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)    37| +2.12E+02 | -3.5E-02 | +5.2E-01 | 1.6E-02 | 4.4E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)     6| +2.50E+02 | -2.0E+00 | +7.3E-01 | 6.2E-02 | 2.8E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    24| +1.51E+02 | -4.8E-01 | +1.0E+00 | 9.4E-01 | 9.9E+00 | 3.2E-01 | trr |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    40| +1.48E+02 | -5.2E-02 | +8.1E-01 | 3.1E-02 | 6.5E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    35| +1.48E+02 | +1.5E-01 | -1.1E+00 | 2.3E-01 | 6.3E+00 | 2.5E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)    62| +1.48E+02 | -3.1E-05 | +1.0E+00 | 1.6E-03 | 1.5E-01 | 6.9E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)    38| +2.12E+02 | -1.4E-02 | +2.9E-01 | 1.6E-02 | 3.2E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    17| +2.11E+02 | +1.7E+02 | -1.5E+01 | 8.5E-01 | 3.1E+01 | 1.6E+00 | trr |0
2023-02-17 16:05:11 fides(INFO)     7| +2.50E+02 | -1.8E-02 | +1.2E-01 | 6.2E-02 | 5.1E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    41| +1.48E+02 | -7.6E-02 | +9.4E-01 | 6.2E-02 | 1.3E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    25| +1.51E+02 | +4.7E-01 | -4.4E-01 | 9.4E-01 | 4.8E+01 | 3.7E-01 | trr |0
2023-02-17 16:05:11 fides(INFO)    36| +1.48E+02 | -2.2E-02 | +5.4E-01 | 5.8E-02 | 6.3E+00 | 6.3E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    39| +2.12E+02 | -3.0E-02 | +4.8E-01 | 1.6E-02 | 4.1E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)     8| +2.50E+02 | -3.2E-02 | +3.2E-01 | 1.6E-02 | 4.1E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    63| +1.48E+02 | -3.8E-05 | +9.4E-01 | 3.1E-03 | 2.3E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    42| +1.48E+02 | -5.1E-02 | +5.7E-01 | 1.2E-01 | 4.1E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    40| +2.12E+02 | -1.2E-02 | +2.7E-01 | 1.6E-02 | 3.0E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    37| +1.48E+02 | -1.1E-02 | +8.5E-01 | 5.8E-02 | 2.4E+00 | 5.6E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    26| +1.50E+02 | -4.2E-01 | +9.8E-01 | 4.7E-02 | 4.8E+01 | 3.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    64| +1.48E+02 | -5.1E-05 | +8.8E-01 | 6.3E-03 | 8.6E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    43| +1.48E+02 | +1.4E-01 | -8.1E-01 | 1.2E-01 | 5.6E+00 | 8.6E-02 |  2d |0
2023-02-17 16:05:11 fides(INFO)    18| +2.08E+02 | -3.4E+00 | +4.1E-01 | 1.6E-01 | 3.1E+01 | 3.9E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)     9| +2.50E+02 | -7.8E-03 | +1.9E-01 | 1.6E-02 | 2.7E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    41| +2.12E+02 | -2.6E-02 | +4.5E-01 | 1.6E-02 | 3.9E+00 | 3.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    65| +1.48E+02 | -7.4E-05 | +9.6E-01 | 1.3E-02 | 1.8E-01 | 4.1E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    38| +1.48E+02 | -1.4E-02 | +7.9E-01 | 1.2E-01 | 5.3E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    27| +1.50E+02 | -4.1E-01 | +8.8E-01 | 9.4E-02 | 1.3E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    65| +1.56E+02 | -1.1E+00 | +4.5E-01 | 1.1E-01 | 5.5E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    10| +2.50E+02 | -1.2E-02 | +7.4E-01 | 3.9E-03 | 2.1E+00 | 1.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    39| +1.48E+02 | -4.5E-03 | +1.6E-01 | 2.3E-01 | 1.6E+00 | 2.0E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    44| +1.48E+02 | -3.4E-02 | +5.7E-01 | 3.1E-02 | 5.6E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    42| +2.12E+02 | -1.1E-02 | +2.6E-01 | 1.6E-02 | 2.9E+00 | 4.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    66| +1.48E+02 | -1.1E-04 | +9.1E-01 | 2.5E-02 | 8.0E-02 | 6.9E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    11| +2.50E+02 | +7.2E-06 | -9.2E-03 | 3.9E-03 | 3.7E-01 | 9.9E-03 |  2d |0
2023-02-17 16:05:11 fides(INFO)    28| +1.50E+02 | -1.2E-01 | +8.3E-01 | 1.9E-01 | 1.8E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    43| +2.12E+02 | -2.3E-02 | +4.3E-01 | 1.6E-02 | 3.6E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    45| +1.48E+02 | -1.6E-02 | +8.7E-01 | 3.1E-02 | 6.4E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    19| +1.99E+02 | -8.5E+00 | +9.5E-01 | 1.6E-01 | 9.1E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    67| +1.48E+02 | -7.9E-05 | +3.8E-01 | 5.0E-02 | 2.9E-01 | 1.6E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    40| +1.48E+02 | -1.7E-02 | +3.7E-01 | 5.8E-02 | 5.5E+00 | 6.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    12| +2.50E+02 | -4.0E-04 | +5.9E-01 | 9.8E-04 | 3.7E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    29| +1.50E+02 | +5.5E-03 | -2.2E-01 | 3.8E-01 | 2.0E+00 | 9.9E-02 | trr |0
2023-02-17 16:05:11 fides(INFO)    46| +1.48E+02 | -2.2E-02 | +9.1E-01 | 6.2E-02 | 2.7E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    44| +2.12E+02 | -1.1E-02 | +2.7E-01 | 1.6E-02 | 2.7E+00 | 4.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    68| +1.48E+02 | +1.4E-03 | -1.9E+00 | 5.0E-02 | 2.0E-01 | 1.3E-02 |  2d |0
2023-02-17 16:05:11 fides(INFO)    41| +1.48E+02 | -3.0E-03 | +3.5E-01 | 5.8E-02 | 1.4E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    13| +2.50E+02 | -3.5E-08 | +1.6E-03 | 9.8E-04 | 5.8E-02 | 2.4E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    45| +2.12E+02 | -2.0E-02 | +4.1E-01 | 1.6E-02 | 3.4E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    30| +1.50E+02 | -9.2E-03 | +7.6E-01 | 3.5E-02 | 2.0E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    69| +1.48E+02 | +4.1E-05 | -1.5E-01 | 1.3E-02 | 2.0E-01 | 3.6E-03 |  2d |0
2023-02-17 16:05:11 fides(INFO)    47| +1.48E+02 | +7.5E-03 | -2.5E-01 | 1.2E-01 | 4.2E+00 | 1.1E-01 |  2d |0
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    20| +1.94E+02 | -5.8E+00 | +5.3E-01 | 3.2E-01 | 4.2E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    42| +1.48E+02 | -3.9E-03 | +6.6E-01 | 5.8E-02 | 3.8E+00 | 4.4E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    46| +2.12E+02 | -1.1E-02 | +2.8E-01 | 1.6E-02 | 2.6E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    14| +2.50E+02 | -2.2E-06 | +1.1E-01 | 2.4E-04 | 5.8E-02 | 6.4E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    70| +1.48E+02 | -2.8E-05 | +1.9E-01 | 3.1E-03 | 2.0E-01 | 1.5E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    48| +1.48E+02 | -8.3E-03 | +7.3E-01 | 3.1E-02 | 4.2E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    31| +1.50E+02 | -4.4E-03 | +8.8E-01 | 7.0E-02 | 4.0E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    43| +1.48E+02 | -1.6E-03 | +7.3E-01 | 5.8E-02 | 6.7E-01 | 3.9E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    47| +2.12E+02 | -1.8E-02 | +4.1E-01 | 1.6E-02 | 3.2E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    15| +2.50E+02 | -4.5E-06 | +9.0E-01 | 6.1E-05 | 5.1E-02 | 1.1E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)    32| +1.50E+02 | -4.5E-04 | +7.2E-01 | 1.4E-01 | 9.6E-01 | 1.2E-02 | trr |1
2023-02-17 16:05:11 fides(INFO)    49| +1.48E+02 | -7.2E-03 | +7.7E-01 | 3.1E-02 | 1.7E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    71| +1.48E+02 | -7.9E-05 | +9.3E-01 | 7.9E-04 | 8.5E-01 | 2.8E-04 |  2d |1
2023-02-17 16:05:11.838 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.1643 and h = 1.42051e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:11.838 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.1643: AMICI failed to integrate the forward problem
2023-02-17 16:05:11 fides(INFO)    44| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.8E-02 | 1.5E+00 | 3.9E-02 |  2d |0
2023-02-17 16:05:11 fides(INFO)    48| +2.12E+02 | -1.1E-02 | +3.0E-01 | 1.6E-02 | 2.5E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    50| +1.48E+02 | -4.3E-03 | +3.0E-01 | 6.2E-02 | 3.9E+00 | 5.5E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    16| +2.50E+02 | -3.0E-06 | +6.0E-01 | 1.2E-04 | 3.2E-02 | 2.2E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)    49| +2.12E+02 | -1.7E-02 | +4.2E-01 | 1.6E-02 | 3.0E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    33| +1.50E+02 | +6.5E-05 | -2.0E-01 | 1.4E-01 | 5.2E-01 | 1.0E-02 | trr |0
2023-02-17 16:05:11 fides(INFO)    72| +1.48E+02 | -5.7E-06 | +1.6E+00 | 1.6E-03 | 5.8E-02 | 3.7E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)    45| +1.48E+02 | -6.5E-04 | +9.4E-01 | 1.5E-02 | 1.5E+00 | 9.7E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    73| +1.48E+02 | -2.7E-06 | +4.9E-01 | 3.1E-03 | 5.4E-02 | 7.1E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)    66| +1.55E+02 | -8.8E-01 | +4.3E-01 | 1.1E-01 | 1.9E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    21| +1.86E+02 | -7.9E+00 | +5.9E-01 | 3.2E-01 | 1.2E+02 | 5.7E-01 |  2d |1
2023-02-17 16:05:11 fides(INFO)    17| +2.50E+02 | +1.6E-11 | -1.2E-04 | 1.2E-04 | 4.9E-03 | 3.1E-04 |  2d |0
2023-02-17 16:05:11 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:11 fides(INFO)    50| +2.12E+02 | -1.2E-02 | +3.3E-01 | 1.6E-02 | 2.3E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    51| +1.48E+02 | +1.1E-01 | -2.7E+00 | 6.2E-02 | 1.7E+00 | 5.5E-02 |  2d |0
2023-02-17 16:05:11 fides(INFO)    46| +1.48E+02 | -8.0E-04 | +9.8E-01 | 2.9E-02 | 2.7E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    34| +1.50E+02 | -1.4E-04 | +8.5E-01 | 6.2E-03 | 5.2E-01 | 2.6E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    74| +1.48E+02 | -6.6E-06 | +1.4E+00 | 3.1E-03 | 3.8E-02 | 6.7E-04 |  2d |1
2023-02-17 16:05:11 fides(INFO)    51| +2.12E+02 | -1.7E-02 | +4.4E-01 | 1.6E-02 | 2.8E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    18| +2.50E+02 | +1.6E-11 | -1.2E-04 | 3.1E-05 | 4.9E-03 | 7.8E-05 |  2d |0
2023-02-17 16:05:11 fides(INFO)    47| +1.48E+02 | -1.1E-03 | +9.0E-01 | 5.8E-02 | 7.6E-01 | 3.7E-02 |  2d |1
2023-02-17 16:05:11 fides(INFO)    52| +1.48E+02 | +3.0E-02 | -1.1E+00 | 1.6E-02 | 1.7E+00 | 3.2E-02 |  2d |0
2023-02-17 16:05:11 fides(INFO)    35| +1.50E+02 | -2.7E-05 | +5.7E-01 | 1.2E-02 | 1.4E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:11 fides(INFO)    75| +1.48E+02 | -7.1E-06 | +8.7E-01 | 6.3E-03 | 5.6E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    22| +1.82E+02 | -3.9E+00 | +9.2E-01 | 3.2E-01 | 1.2E+02 | 5.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    52| +2.12E+02 | -1.2E-02 | +3.7E-01 | 1.6E-02 | 2.2E+00 | 4.3E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    19| +2.50E+02 | -6.4E-08 | +7.9E-01 | 7.6E-06 | 4.9E-03 | 2.0E-05 |  2d |1
2023-02-17 16:05:12 fides(WARNING) Stopping as function difference 6.38E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:12 fides(INFO)    48| +1.48E+02 | -1.4E-03 | +7.4E-01 | 1.2E-01 | 3.1E-01 | 6.8E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    53| +1.48E+02 | -7.1E-03 | +6.3E-01 | 3.9E-03 | 1.7E+00 | 8.5E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    36| +1.50E+02 | -1.1E-06 | +9.1E-02 | 1.2E-02 | 1.4E-01 | 1.7E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    53| +2.12E+02 | -1.6E-02 | +4.7E-01 | 1.6E-02 | 2.6E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    76| +1.48E+02 | -1.3E-05 | +9.6E-01 | 1.3E-02 | 3.3E-02 | 2.4E-03 |  2d |1
2023-02-17 16:05:12.047 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.6153 and h = 1.60736e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:12.047 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.6153: AMICI failed to integrate the forward problem
2023-02-17 16:05:12 fides(INFO)    49| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 1.1E+00 | 6.9E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    54| +1.48E+02 | -6.0E-04 | +9.7E-01 | 3.9E-03 | 1.6E+00 | 2.4E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    23| +1.81E+02 | -1.1E+00 | +9.7E-01 | 6.3E-01 | 4.5E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    54| +2.12E+02 | -1.3E-02 | +1.0E+00 | 1.6E-02 | 2.0E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    77| +1.48E+02 | -2.3E-05 | +1.1E+00 | 2.5E-02 | 6.5E-02 | 4.5E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    37| +1.50E+02 | -4.6E-06 | +3.9E-01 | 3.1E-03 | 1.9E-02 | 1.6E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    50| +1.48E+02 | -7.1E-04 | +7.0E-01 | 2.9E-02 | 1.1E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    55| +1.48E+02 | -8.9E-04 | +9.4E-01 | 7.8E-03 | 5.8E-01 | 4.9E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    55| +2.12E+02 | -2.9E-02 | +1.0E+00 | 3.1E-02 | 1.4E+00 | 5.8E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    24| +1.81E+02 | +6.2E+00 | -4.8E+00 | 1.3E+00 | 3.3E+01 | 2.5E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)     0| +1.34E+06 |    NaN   |    NaN   | 1.0E+00 | 6.1E+06 |   NaN   | NaN |1
2023-02-17 16:05:12 fides(INFO)    78| +1.48E+02 | -1.6E-05 | +6.3E-01 | 5.0E-02 | 3.3E-02 | 7.3E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    38| +1.50E+02 | +1.1E-07 | -3.6E-02 | 3.1E-03 | 5.1E-02 | 9.7E-04 |  2d |0
2023-02-17 16:05:12 fides(INFO)    56| +1.48E+02 | -1.2E-03 | +9.6E-01 | 1.6E-02 | 1.3E+00 | 9.7E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    56| +2.12E+02 | -2.7E-02 | +1.1E+00 | 6.2E-02 | 2.3E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    51| +1.48E+02 | -2.6E-04 | +1.0E+00 | 2.9E-02 | 2.2E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)     1| +1.14E+03 | -1.3E+06 | +1.1E-01 | 1.0E+00 | 6.1E+06 | 2.4E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    25| +1.80E+02 | -3.4E-01 | +3.2E-01 | 3.2E-01 | 3.3E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    79| +1.48E+02 | +2.3E-04 | -3.5E+00 | 5.0E-02 | 4.3E-02 | 1.1E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    57| +2.11E+02 | -3.2E-02 | +2.9E-01 | 1.2E-01 | 1.1E+00 | 3.1E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    39| +1.50E+02 | -1.2E-06 | +8.9E-01 | 7.8E-04 | 5.1E-02 | 2.4E-04 |  2d |1
2023-02-17 16:05:12 fides(WARNING) Stopping as function difference 1.19E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:12 fides(INFO)     2| +4.50E+02 | -6.9E+02 | +9.0E-01 | 2.5E-01 | 3.7E+03 | 6.3E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    57| +1.48E+02 | -2.0E-03 | +9.0E-01 | 3.1E-02 | 4.0E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    52| +1.48E+02 | -4.2E-04 | +9.7E-01 | 5.8E-02 | 1.7E-01 | 2.9E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)     3| +2.97E+02 | -1.5E+02 | +9.1E-01 | 5.0E-01 | 6.1E+02 | 1.4E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    58| +2.11E+02 | -1.8E-01 | +1.4E+00 | 1.2E-01 | 6.7E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    67| +1.55E+02 | +1.3E+00 | -1.5E+00 | 1.1E-01 | 3.3E+01 | 2.9E-01 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    80| +1.48E+02 | -7.5E-07 | +3.6E-02 | 1.3E-02 | 4.3E-02 | 2.7E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    53| +1.48E+02 | -6.1E-04 | +9.6E-01 | 1.2E-01 | 2.1E-01 | 5.4E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    26| +1.79E+02 | -1.2E+00 | +8.4E-01 | 3.2E-01 | 3.8E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    58| +1.48E+02 | -6.3E-04 | +1.6E-01 | 6.2E-02 | 1.3E+00 | 4.5E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)     4| +2.51E+02 | -4.7E+01 | +7.6E-01 | 1.0E+00 | 9.8E+01 | 2.2E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    59| +2.11E+02 | -3.6E-01 | +1.2E+00 | 2.5E-01 | 2.9E+00 | 3.9E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    81| +1.48E+02 | -6.3E-06 | +8.9E-01 | 3.1E-03 | 6.2E-02 | 4.4E-04 |  2d |1
2023-02-17 16:05:12 fides(INFO)    54| +1.48E+02 | -4.3E-04 | +7.1E-01 | 2.3E-01 | 9.3E-02 | 9.5E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)     5| +2.27E+02 | -2.3E+01 | +4.0E+00 | 2.0E+00 | 2.5E+01 | 3.8E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    59| +1.48E+02 | +7.6E-03 | -9.4E-01 | 1.6E-02 | 9.2E-01 | 1.7E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    60| +2.07E+02 | -3.5E+00 | +2.6E+00 | 5.0E-01 | 2.8E+00 | 1.1E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    27| +1.79E+02 | +4.8E+00 | -5.3E+00 | 6.3E-01 | 1.9E+01 | 1.4E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)    82| +1.48E+02 | -2.3E-06 | +8.6E-01 | 6.3E-03 | 7.4E-02 | 5.6E-04 |  2d |1
2023-02-17 16:05:12 fides(INFO)    55| +1.48E+02 | +1.9E-02 | -1.2E+01 | 2.3E-01 | 2.7E-01 | 7.0E-02 | trr |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    60| +1.48E+02 | -3.8E-04 | +7.3E-02 | 3.9E-03 | 9.2E-01 | 8.3E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)     0| +9.11E+06 |    NaN   |    NaN   | 1.0E+00 | 4.2E+07 |   NaN   | NaN |1
2023-02-17 16:05:12 fides(INFO)    61| +2.07E+02 | +1.0E+02 | -8.3E+00 | 1.0E+00 | 9.9E+00 | 2.6E+00 | trr |0
2023-02-17 16:05:12 fides(INFO)     6| +2.27E+02 | +1.5E+04 | -7.0E+02 | 4.0E+00 | 4.2E+01 | 1.2E+01 | trr |0
2023-02-17 16:05:12 fides(INFO)    28| +1.79E+02 | -9.2E-02 | +1.9E-01 | 1.6E-01 | 1.9E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    83| +1.48E+02 | -9.2E-07 | +6.3E-01 | 1.3E-02 | 9.9E-03 | 1.3E-03 |  2d |1
2023-02-17 16:05:12 fides(WARNING) Stopping as function difference 9.23E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:12 fides(INFO)    56| +1.48E+02 | +5.4E-04 | -8.0E-01 | 5.7E-02 | 2.7E-01 | 1.7E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)     1| +1.64E+03 | -9.1E+06 | +1.1E-01 | 1.0E+00 | 4.2E+07 | 2.5E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    62| +2.01E+02 | -6.2E+00 | +1.4E+00 | 2.5E-01 | 9.9E+00 | 6.4E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    61| +1.48E+02 | -1.8E-03 | +9.5E-01 | 9.8E-04 | 3.9E+00 | 1.2E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)     7| +2.27E+02 | +2.6E+02 | -1.2E+01 | 1.0E+00 | 4.2E+01 | 2.6E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)    57| +1.48E+02 | -1.1E-04 | +5.4E-01 | 1.4E-02 | 2.7E-01 | 4.3E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    62| +1.48E+02 | -3.2E-04 | +8.2E-01 | 2.0E-03 | 5.3E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)     8| +2.18E+02 | -9.3E+00 | +4.2E-01 | 2.5E-01 | 4.2E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)     2| +5.48E+02 | -1.1E+03 | +9.0E-01 | 2.5E-01 | 5.9E+03 | 6.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    29| +1.79E+02 | -1.0E-01 | +9.7E-01 | 3.9E-02 | 1.9E+01 | 7.4E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    63| +1.72E+02 | -2.9E+01 | +2.0E+00 | 5.0E-01 | 3.6E+01 | 8.7E-01 | trr |1
2023-02-17 16:05:12 fides(INFO)    58| +1.48E+02 | -1.8E-05 | +1.0E+00 | 1.4E-02 | 2.9E-01 | 3.4E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)     9| +2.14E+02 | -4.2E+00 | +5.9E-01 | 2.5E-01 | 4.8E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)     3| +3.02E+02 | -2.5E+02 | +9.1E-01 | 5.0E-01 | 1.0E+03 | 1.3E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    63| +1.48E+02 | -2.5E-04 | +8.9E-01 | 3.9E-03 | 7.8E-01 | 2.8E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    64| +1.72E+02 | +8.7E+02 | -2.7E+01 | 5.0E-01 | 4.9E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)     4| +2.58E+02 | -4.4E+01 | +8.4E-01 | 1.0E+00 | 1.9E+02 | 2.4E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    10| +2.13E+02 | -2.6E-01 | +1.0E-01 | 2.5E-01 | 1.5E+01 | 7.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    30| +1.79E+02 | -9.2E-02 | +8.6E-01 | 7.9E-02 | 1.6E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    68| +1.55E+02 | +9.2E-01 | -1.4E+00 | 2.8E-02 | 3.3E+01 | 7.5E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    59| +1.48E+02 | -1.7E-05 | +1.1E+00 | 2.8E-02 | 4.8E-02 | 6.6E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    64| +1.48E+02 | -2.2E-04 | +8.0E-01 | 7.8E-03 | 2.3E-01 | 4.9E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)     5| +2.58E+02 | +2.7E+03 | -2.1E+02 | 2.0E+00 | 3.1E+01 | 4.1E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)     0| +1.54E+13 |    NaN   |    NaN   | 1.0E+00 | 7.1E+13 |   NaN   | NaN |1
2023-02-17 16:05:12 fides(INFO)    65| +1.69E+02 | -3.0E+00 | +2.5E-01 | 1.2E-01 | 4.9E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    11| +2.12E+02 | -1.3E+00 | +7.0E-01 | 6.2E-02 | 2.4E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    60| +1.48E+02 | -1.7E-05 | +8.7E-01 | 5.7E-02 | 8.5E-02 | 1.3E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)     6| +2.58E+02 | +4.5E+02 | -3.0E+01 | 5.0E-01 | 3.1E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)    65| +1.48E+02 | -2.4E-04 | +9.0E-01 | 1.6E-02 | 3.5E-01 | 7.3E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    31| +1.79E+02 | -1.4E-01 | +7.6E-01 | 1.6E-01 | 1.5E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)     1| +1.08E+07 | -1.5E+13 | +8.4E-02 | 1.0E+00 | 7.1E+13 | 3.1E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    66| +1.60E+02 | -8.8E+00 | +7.2E-01 | 1.2E-01 | 9.3E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    12| +2.12E+02 | -5.9E-01 | +1.0E+00 | 6.2E-02 | 7.5E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)     7| +2.50E+02 | -7.4E+00 | +8.2E-01 | 1.2E-01 | 3.1E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    66| +1.48E+02 | -3.3E-04 | +8.6E-01 | 3.1E-02 | 1.7E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    61| +1.48E+02 | +1.0E-04 | -2.8E+00 | 1.1E-01 | 4.4E-02 | 2.1E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    13| +2.11E+02 | -8.7E-01 | +9.4E-01 | 1.2E-01 | 7.4E+00 | 3.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    32| +1.79E+02 | +2.8E-01 | -1.5E+00 | 3.2E-01 | 1.0E+01 | 5.4E-01 |  2d |0
2023-02-17 16:05:12 fides(INFO)    67| +1.53E+02 | -7.3E+00 | +6.4E-01 | 1.2E-01 | 6.9E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)     8| +2.50E+02 | +4.4E-01 | -5.8E-01 | 2.5E-01 | 1.0E+01 | 6.1E-01 |  2d |0
2023-02-17 16:05:12 fides(INFO)     2| +1.65E+06 | -9.1E+06 | +8.9E-01 | 2.5E-01 | 5.0E+07 | 6.3E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    62| +1.48E+02 | +2.2E-06 | -1.6E-01 | 2.8E-02 | 4.4E-02 | 5.2E-03 |  2d |0
2023-02-17 16:05:12 fides(INFO)    67| +1.48E+02 | +4.0E-04 | -5.8E-01 | 6.2E-02 | 4.1E-01 | 3.0E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)     9| +2.50E+02 | +3.7E-01 | -5.0E-01 | 6.2E-02 | 1.0E+01 | 1.6E-01 |  2d |0
2023-02-17 16:05:12 fides(INFO)    14| +2.09E+02 | -1.7E+00 | +7.7E-01 | 2.5E-01 | 1.0E+01 | 7.0E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    68| +1.51E+02 | -1.7E+00 | +3.2E-01 | 1.2E-01 | 4.7E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:12.603 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1383 and h = 1.69942e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:12.603 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1383: AMICI failed to integrate the forward problem
2023-02-17 16:05:12 fides(INFO)     3| +2.56E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 7.7E+06 | 5.0E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    33| +1.79E+02 | -5.1E-02 | +6.3E-01 | 7.9E-02 | 1.0E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    63| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.1E-03 | 4.4E-02 | 1.3E-03 |  2d |0
2023-02-17 16:05:12.618 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.406 and h = 2.66838e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:12.619 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.406: AMICI failed to integrate the forward problem
2023-02-17 16:05:12 fides(INFO)    68| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 4.1E-01 | 7.5E-03 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    10| +2.50E+02 | -3.0E-01 | +8.5E-01 | 1.6E-02 | 1.0E+01 | 3.9E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    15| +2.04E+02 | -5.2E+00 | +1.0E+00 | 5.0E-01 | 1.8E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)     4| +4.44E+04 | -2.1E+05 | +8.7E-01 | 1.0E+00 | 1.2E+06 | 3.1E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    69| +1.51E+02 | +1.6E+01 | -2.7E+00 | 1.2E-01 | 9.4E+01 | 3.6E-01 |  2d |0
2023-02-17 16:05:12 fides(INFO)    11| +2.50E+02 | +3.0E-02 | -2.0E-01 | 3.1E-02 | 4.8E+00 | 7.8E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    64| +1.48E+02 | +7.2E-07 | -2.8E-01 | 1.8E-03 | 4.4E-02 | 3.4E-04 |  2d |0
2023-02-17 16:05:12 fides(INFO)    69| +1.48E+02 | -6.7E-05 | +9.3E-01 | 3.9E-03 | 4.1E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)     5| +7.00E+03 | -3.7E+04 | +9.0E-01 | 2.0E+00 | 2.0E+05 | 5.6E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    34| +1.79E+02 | -6.4E-02 | +8.2E-01 | 7.9E-02 | 1.1E+01 | 9.4E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    12| +2.50E+02 | -6.6E-02 | +8.1E-01 | 7.8E-03 | 4.8E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    16| +2.04E+02 | +1.6E+02 | -1.8E+01 | 1.0E+00 | 1.5E+01 | 2.6E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    70| +1.48E+02 | -6.2E-05 | +8.7E-01 | 7.8E-03 | 5.2E-02 | 3.2E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    65| +1.48E+02 | +2.0E-06 | -1.0E+00 | 4.4E-04 | 4.4E-02 | 1.2E-04 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    70| +1.51E+02 | +4.9E-01 | -1.4E-01 | 3.1E-02 | 9.4E+01 | 8.4E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)     6| +1.25E+03 | -5.7E+03 | +9.0E-01 | 2.0E+00 | 3.1E+04 | 5.4E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    13| +2.50E+02 | +1.2E-03 | -6.2E-02 | 1.6E-02 | 1.8E+00 | 3.9E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    17| +1.98E+02 | -6.1E+00 | +1.2E+00 | 2.5E-01 | 1.5E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    35| +1.79E+02 | +1.4E-02 | -2.4E-01 | 1.6E-01 | 7.4E+00 | 2.7E-01 |  2d |0
2023-02-17 16:05:12 fides(INFO)    71| +1.50E+02 | -1.3E+00 | +8.2E-01 | 7.8E-03 | 9.4E+01 | 2.0E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    66| +1.48E+02 | +2.5E-07 | -1.3E-01 | 1.1E-04 | 4.4E-02 | 9.0E-05 |  2d |0
2023-02-17 16:05:12 fides(INFO)    71| +1.48E+02 | -1.0E-04 | +9.8E-01 | 1.6E-02 | 6.5E-02 | 5.2E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)     7| +3.67E+02 | -8.8E+02 | +9.0E-01 | 2.0E+00 | 4.9E+03 | 6.3E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    14| +2.50E+02 | -9.9E-03 | +7.1E-01 | 3.9E-03 | 1.8E+00 | 9.8E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    69| +1.55E+02 | +7.1E-02 | -1.6E-01 | 7.0E-03 | 3.3E+01 | 2.0E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    67| +1.48E+02 | +2.2E-06 | -1.4E+00 | 2.8E-05 | 4.4E-02 | 5.5E-05 |  2d |0
2023-02-17 16:05:12 fides(INFO)    18| +1.98E+02 | +2.5E+01 | -2.4E+00 | 5.0E-01 | 3.0E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)    72| +1.48E+02 | -1.5E-04 | +9.8E-01 | 3.1E-02 | 1.3E-01 | 8.8E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    72| +1.49E+02 | -6.0E-01 | +9.0E-01 | 1.6E-02 | 4.2E+01 | 2.6E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    15| +2.50E+02 | -2.1E-05 | +8.1E-02 | 3.9E-03 | 2.0E-01 | 9.7E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)     8| +2.31E+02 | -1.4E+02 | +9.2E-01 | 2.0E+00 | 7.7E+02 | 4.4E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    36| +1.79E+02 | -2.2E-02 | +7.6E-01 | 3.9E-02 | 7.4E+00 | 6.8E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    19| +1.90E+02 | -7.6E+00 | +1.2E+00 | 1.2E-01 | 3.0E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    16| +2.50E+02 | -8.1E-05 | +3.5E-01 | 9.8E-04 | 2.0E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    68| +1.48E+02 | +2.6E-06 | -4.9E+00 | 6.9E-06 | 4.4E-02 | 1.4E-05 |  2d |0
2023-02-17 16:05:12 fides(INFO)    73| +1.49E+02 | -7.1E-01 | +7.0E-01 | 3.1E-02 | 2.8E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    73| +1.48E+02 | -1.1E-04 | +6.6E-01 | 6.2E-02 | 4.3E-02 | 1.8E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)     9| +2.31E+02 | +1.1E+02 | -4.5E+00 | 4.0E+00 | 1.1E+02 | 7.3E+00 | trr |0
2023-02-17 16:05:12 fides(INFO)    17| +2.50E+02 | -6.3E-06 | +7.5E-02 | 9.8E-04 | 1.2E-01 | 2.4E-03 |  2d |1
2023-02-17 16:05:12.833 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 213.323 and h = 2.13543e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:12.833 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 213.323: AMICI failed to integrate the forward problem
2023-02-17 16:05:12 fides(INFO)    37| +1.79E+02 | +0.0E+00 | +0.0E+00 | 7.9E-02 | 7.9E+00 | 3.5E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    20| +1.73E+02 | -1.7E+01 | +1.0E+00 | 2.5E-01 | 3.0E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    18| +2.50E+02 | -3.5E-05 | +7.9E-01 | 2.4E-04 | 1.1E-01 | 4.7E-04 |  2d |1
2023-02-17 16:05:12 fides(INFO)    74| +1.48E+02 | +3.6E-03 | -7.0E+00 | 6.2E-02 | 1.5E-01 | 1.9E-02 |  2d |0
2023-02-17 16:05:12 fides(INFO)    69| +1.48E+02 | +4.9E-06 | -3.5E+01 | 1.7E-06 | 4.4E-02 | 3.5E-06 |  2d |0
2023-02-17 16:05:12 fides(INFO)    74| +1.48E+02 | -2.2E-01 | +3.5E-01 | 3.1E-02 | 3.8E+01 | 3.5E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    10| +2.22E+02 | -9.6E+00 | +2.2E-01 | 6.3E-01 | 1.1E+02 | 1.8E+00 |  2d |1
2023-02-17 16:05:12 fides(INFO)    19| +2.50E+02 | -3.1E-06 | +3.2E-01 | 4.9E-04 | 3.5E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    38| +1.79E+02 | -1.9E-02 | +1.0E+00 | 2.0E-02 | 7.9E+00 | 9.5E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    75| +1.48E+02 | -3.0E-01 | +7.4E-01 | 3.1E-02 | 3.5E+01 | 3.8E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    70| +1.48E+02 | +2.1E-06 | -6.0E+01 | 4.3E-07 | 4.4E-02 | 8.7E-07 |  2d |0
2023-02-17 16:05:12 fides(INFO)    21| +1.73E+02 | +1.7E+01 | -1.4E+00 | 5.0E-01 | 1.0E+02 | 1.0E+00 |  2d |0
2023-02-17 16:05:12 fides(INFO)    75| +1.48E+02 | +9.0E-05 | -4.7E-01 | 1.6E-02 | 1.5E-01 | 4.9E-03 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    20| +2.50E+02 | -2.9E-06 | +3.3E-01 | 4.9E-04 | 3.3E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    11| +2.09E+02 | -1.3E+01 | +1.0E+00 | 1.6E-01 | 6.5E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    76| +1.48E+02 | -7.8E-02 | +3.8E-01 | 3.1E-02 | 1.5E+01 | 4.4E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    76| +1.48E+02 | -3.6E-05 | +6.2E-01 | 3.9E-03 | 1.5E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    71| +1.48E+02 | +3.0E-06 | -3.3E+02 | 1.1E-07 | 4.4E-02 | 2.2E-07 |  2d |0
2023-02-17 16:05:12 fides(INFO)    22| +1.63E+02 | -1.1E+01 | +9.1E-01 | 1.2E-01 | 1.0E+02 | 2.5E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    21| +2.50E+02 | -3.0E-06 | +3.5E-01 | 4.9E-04 | 3.2E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    12| +1.95E+02 | -1.4E+01 | +6.0E-01 | 3.2E-01 | 4.7E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    39| +1.79E+02 | -2.0E-02 | +9.2E-01 | 3.9E-02 | 6.4E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    22| +2.50E+02 | -2.9E-06 | +3.6E-01 | 4.9E-04 | 3.0E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    77| +1.48E+02 | -2.7E-01 | +6.9E-01 | 3.1E-02 | 1.5E+01 | 6.1E-02 |  2d |1
2023-02-17 16:05:12 fides(INFO)    77| +1.48E+02 | -6.3E-06 | +7.1E-01 | 3.9E-03 | 2.1E-01 | 4.2E-04 |  2d |1
2023-02-17 16:05:12 fides(INFO)    23| +1.52E+02 | -1.1E+01 | +8.0E-01 | 2.5E-01 | 5.0E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    72| +1.48E+02 | +6.4E-06 | -2.8E+03 | 2.7E-08 | 4.4E-02 | 5.4E-08 |  2d |0
2023-02-17 16:05:12 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:12 fides(INFO)    70| +1.55E+02 | -1.2E-01 | +7.8E-01 | 1.8E-03 | 3.3E+01 | 5.0E-03 |  2d |1
2023-02-17 16:05:12 fides(INFO)    13| +1.77E+02 | -1.8E+01 | +8.9E-01 | 3.2E-01 | 9.3E+01 | 4.0E-01 |  2d |1
2023-02-17 16:05:12 fides(INFO)    23| +2.50E+02 | -3.0E-06 | +3.9E-01 | 4.9E-04 | 2.9E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    24| +1.52E+02 | +6.1E+00 | -1.7E+00 | 5.0E-01 | 7.6E+01 | 6.8E-01 |  2d |0
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    78| +1.48E+02 | +3.6E+00 | -5.2E+00 | 3.1E-02 | 1.4E+01 | 6.0E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    40| +1.78E+02 | -3.1E-02 | +1.0E+00 | 7.9E-02 | 6.4E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    73| +1.48E+02 | +4.2E-06 | -7.4E+03 | 6.8E-09 | 4.4E-02 | 1.4E-08 |  2d |0
2023-02-17 16:05:13 fides(INFO)    78| +1.48E+02 | +2.4E-06 | -7.3E-01 | 3.9E-03 | 2.8E-02 | 5.0E-04 |  2d |0
2023-02-17 16:05:13 fides(INFO)    24| +2.50E+02 | -2.9E-06 | +4.0E-01 | 4.9E-04 | 2.8E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    14| +1.77E+02 | +5.3E+01 | -3.5E+00 | 6.3E-01 | 1.2E+02 | 1.1E+00 |  2d |0
2023-02-17 16:05:13 fides(INFO)    79| +1.48E+02 | +1.1E-01 | -5.8E-01 | 7.8E-03 | 1.4E+01 | 1.5E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    25| +2.50E+02 | -3.0E-06 | +4.2E-01 | 4.9E-04 | 2.7E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    79| +1.48E+02 | -4.3E-06 | +2.8E+00 | 9.8E-04 | 2.8E-02 | 1.4E-04 |  2d |1
2023-02-17 16:05:13 fides(INFO)    41| +1.78E+02 | +6.6E-03 | -2.4E-01 | 1.6E-01 | 4.1E+00 | 1.8E-01 |  2d |0
2023-02-17 16:05:13 fides(INFO)    25| +1.50E+02 | -1.9E+00 | +7.9E-01 | 1.2E-01 | 7.6E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    26| +2.50E+02 | -2.9E-06 | +4.3E-01 | 4.9E-04 | 2.6E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    15| +1.63E+02 | -1.4E+01 | +1.0E+00 | 1.6E-01 | 1.2E+02 | 2.6E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    74| +1.48E+02 | +1.7E-07 | -1.2E+03 | 1.7E-09 | 4.4E-02 | 3.4E-09 |  2d |0
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    80| +1.48E+02 | -2.9E-02 | +6.0E-01 | 2.0E-03 | 1.4E+01 | 3.7E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    80| +1.48E+02 | -1.0E-06 | +6.1E-01 | 2.0E-03 | 7.0E-02 | 2.9E-04 |  2d |1
2023-02-17 16:05:13 fides(WARNING) Stopping as function difference 1.05E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:13 fides(INFO)    27| +2.50E+02 | -3.0E-06 | +4.5E-01 | 4.9E-04 | 2.6E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    16| +1.53E+02 | -9.5E+00 | +8.3E-01 | 3.2E-01 | 6.9E+01 | 8.2E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    26| +1.49E+02 | -1.3E+00 | +6.4E-01 | 2.4E-01 | 3.7E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    42| +1.78E+02 | -9.1E-03 | +7.5E-01 | 3.9E-02 | 4.1E+00 | 4.4E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    81| +1.48E+02 | -2.3E-02 | +9.7E-01 | 2.0E-03 | 6.0E+00 | 4.7E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    28| +2.50E+02 | -2.9E-06 | +4.6E-01 | 4.9E-04 | 2.5E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    75| +1.48E+02 | +2.5E-06 | -7.2E+04 | 4.2E-10 | 4.4E-02 | 8.5E-10 |  2d |0
2023-02-17 16:05:13 fides(INFO)    27| +1.49E+02 | +1.6E+01 | -5.5E+00 | 2.4E-01 | 2.8E+01 | 4.7E-01 |  2d |0
2023-02-17 16:05:13 fides(INFO)    29| +2.50E+02 | -3.0E-06 | +4.8E-01 | 4.9E-04 | 2.4E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    17| +1.50E+02 | -3.6E+00 | +5.4E-01 | 6.3E-01 | 1.1E+02 | 4.4E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    43| +1.78E+02 | -8.1E-03 | +7.5E-01 | 3.9E-02 | 4.5E+00 | 6.6E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    82| +1.48E+02 | -3.2E-02 | +8.8E-01 | 3.9E-03 | 6.4E+00 | 8.4E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    76| +1.48E+02 | +3.9E-06 | -4.5E+05 | 1.1E-10 | 4.4E-02 | 2.1E-10 |  2d |0
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    30| +2.50E+02 | -2.9E-06 | +4.8E-01 | 4.9E-04 | 2.3E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    28| +1.48E+02 | -3.0E-01 | +3.1E-01 | 5.9E-02 | 2.8E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    18| +1.50E+02 | +3.2E+00 | -1.1E+00 | 6.3E-01 | 1.1E+02 | 6.8E-01 | trr |0
2023-02-17 16:05:13 fides(INFO)    83| +1.48E+02 | -6.3E-03 | +2.3E-01 | 7.8E-03 | 7.4E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    31| +2.50E+02 | -3.0E-06 | +5.0E-01 | 4.9E-04 | 2.3E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    44| +1.78E+02 | +1.6E-03 | -1.3E-01 | 7.9E-02 | 3.3E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:13 fides(INFO)    77| +1.48E+02 | +2.5E-06 | -1.1E+06 | 2.6E-11 | 4.4E-02 | 5.3E-11 |  2d |0
2023-02-17 16:05:13 fides(INFO)    71| +1.55E+02 | -5.4E-02 | +9.5E-01 | 3.5E-03 | 1.5E+01 | 9.6E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    29| +1.48E+02 | -2.9E-01 | +8.0E-01 | 5.9E-02 | 2.2E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    84| +1.48E+02 | -1.7E-02 | +9.2E-01 | 2.0E-03 | 6.3E+00 | 4.0E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    19| +1.48E+02 | -1.3E+00 | +9.3E-01 | 7.1E-02 | 1.1E+02 | 1.9E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    32| +2.50E+02 | -2.9E-06 | +5.0E-01 | 4.9E-04 | 2.3E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)     0| +4.20E+12 |    NaN   |    NaN   | 1.0E+00 | 1.9E+13 |   NaN   | NaN |1
2023-02-17 16:05:13 fides(INFO)    45| +1.78E+02 | -4.2E-03 | +7.6E-01 | 2.0E-02 | 3.3E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    78| +1.48E+02 | +1.2E-06 | -2.1E+06 | 6.6E-12 | 4.4E-02 | 1.3E-11 |  2d |0
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    30| +1.48E+02 | -8.3E-02 | +2.7E-01 | 1.2E-01 | 2.0E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    33| +2.50E+02 | -3.0E-06 | +5.2E-01 | 4.9E-04 | 2.2E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    20| +1.48E+02 | -5.8E-01 | +7.8E-01 | 1.4E-01 | 2.7E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    85| +1.48E+02 | -1.7E-02 | +6.1E-01 | 3.9E-03 | 4.6E+00 | 8.5E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    79| +1.48E+02 | +2.4E-06 | -1.7E+07 | 1.6E-12 | 4.4E-02 | 3.3E-12 |  2d |0
2023-02-17 16:05:13 fides(INFO)     1| +4.24E+06 | -4.2E+12 | +8.7E-02 | 1.0E+00 | 1.9E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    34| +2.50E+02 | -2.9E-06 | +5.2E-01 | 4.9E-04 | 2.2E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    31| +1.48E+02 | +2.7E-01 | -4.4E-01 | 1.2E-01 | 1.4E+01 | 1.3E-01 |  2d |0
2023-02-17 16:05:13 fides(INFO)    46| +1.78E+02 | -7.1E-03 | +9.8E-01 | 3.9E-02 | 3.6E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    80| +1.48E+02 | +3.1E-06 | -8.9E+07 | 4.1E-13 | 4.4E-02 | 8.3E-13 |  2d |0
2023-02-17 16:05:13 fides(INFO)    35| +2.50E+02 | -3.0E-06 | +5.3E-01 | 4.9E-04 | 2.2E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    21| +1.48E+02 | -2.0E-01 | +8.9E-01 | 2.8E-01 | 3.7E+01 | 8.0E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    86| +1.48E+02 | -4.8E-03 | +2.6E-01 | 3.9E-03 | 7.3E+00 | 5.9E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)     2| +6.58E+05 | -3.6E+06 | +9.0E-01 | 2.5E-01 | 2.0E+07 | 6.6E-01 |  2d |1
2023-02-17 16:05:13.358 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 83.5233 and h = 1.6975e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:13.358 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 83.5233: AMICI failed to integrate the forward problem
2023-02-17 16:05:13 fides(INFO)    32| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.0E-02 | 1.4E+01 | 3.4E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    36| +2.50E+02 | -2.9E-06 | +5.3E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    87| +1.48E+02 | -9.4E-03 | +9.6E-01 | 3.9E-03 | 7.9E+00 | 3.9E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    22| +1.48E+02 | +2.8E+00 | -2.5E+01 | 5.7E-01 | 6.0E+00 | 1.7E+00 |  2d |0
2023-02-17 16:05:13 fides(INFO)    47| +1.78E+02 | -8.8E-05 | -1.8E-02 | 7.9E-02 | 2.6E+00 | 9.4E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    81| +1.48E+02 | +2.6E-06 | -3.0E+08 | 1.0E-13 | 4.4E-02 | 2.1E-13 |  2d |0
2023-02-17 16:05:13 fides(INFO)    37| +2.50E+02 | -3.0E-06 | +5.4E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    33| +1.48E+02 | -7.7E-02 | +9.2E-01 | 7.4E-03 | 1.4E+01 | 1.1E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)     3| +1.03E+05 | -5.5E+05 | +9.0E-01 | 5.0E-01 | 3.0E+06 | 1.3E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    38| +2.50E+02 | -2.9E-06 | +5.5E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    82| +1.48E+02 | +3.6E-06 | -1.7E+09 | 2.6E-14 | 4.4E-02 | 5.2E-14 |  2d |0
2023-02-17 16:05:13 fides(INFO)    23| +1.48E+02 | -3.8E-02 | +6.6E-01 | 1.4E-01 | 6.0E+00 | 4.2E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    88| +1.48E+02 | -1.4E-02 | +7.3E-01 | 7.8E-03 | 2.8E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    34| +1.48E+02 | -8.4E-02 | +8.0E-01 | 1.5E-02 | 1.5E+01 | 1.7E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)     4| +1.64E+04 | -8.7E+04 | +9.0E-01 | 1.0E+00 | 4.7E+05 | 1.7E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    48| +1.78E+02 | -2.9E-03 | +7.7E-01 | 2.0E-02 | 2.6E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    39| +2.50E+02 | -3.0E-06 | +5.5E-01 | 4.9E-04 | 2.1E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    24| +1.48E+02 | +9.8E-02 | -1.6E+00 | 1.4E-01 | 6.6E+00 | 9.3E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    83| +1.48E+02 | +3.4E-06 | -6.2E+09 | 6.4E-15 | 4.4E-02 | 1.3E-14 |  2d |0
2023-02-17 16:05:13 fides(INFO)     5| +2.79E+03 | -1.4E+04 | +9.0E-01 | 1.0E+00 | 7.5E+04 | 1.9E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    89| +1.48E+02 | -6.6E-03 | +3.9E-01 | 7.8E-03 | 6.7E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    25| +1.48E+02 | -1.5E-02 | +5.9E-01 | 3.5E-02 | 6.6E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    40| +2.50E+02 | -4.6E-06 | +1.0E+00 | 4.9E-04 | 2.0E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    35| +1.48E+02 | -5.7E-02 | +8.0E-01 | 3.0E-02 | 1.1E+01 | 2.4E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    49| +1.78E+02 | -4.1E-03 | +8.1E-01 | 3.9E-02 | 2.8E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    90| +1.48E+02 | +1.6E-02 | -2.4E+00 | 7.8E-03 | 1.9E+00 | 9.1E-03 |  2d |0
2023-02-17 16:05:13 fides(INFO)    84| +1.48E+02 | -2.4E-07 | +1.8E+09 | 1.6E-15 | 4.4E-02 | 3.2E-15 |  2d |1
2023-02-17 16:05:13 fides(WARNING) Stopping as function difference 2.41E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:13 fides(INFO)    41| +2.50E+02 | -7.0E-06 | +1.0E+00 | 9.8E-04 | 4.2E-03 | 2.4E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)     6| +6.31E+02 | -2.2E+03 | +9.1E-01 | 2.0E+00 | 1.2E+04 | 1.8E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    36| +1.48E+02 | -4.6E-02 | +9.4E-01 | 5.9E-02 | 7.7E+00 | 6.0E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    26| +1.48E+02 | -1.1E-02 | +4.4E-01 | 3.5E-02 | 3.6E+00 | 9.3E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    50| +1.78E+02 | +1.3E-02 | -1.2E+00 | 7.9E-02 | 2.0E+00 | 1.4E-01 |  2d |0
2023-02-17 16:05:13 fides(INFO)    42| +2.50E+02 | -1.4E-05 | +1.0E+00 | 2.0E-03 | 8.9E-03 | 4.7E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    91| +1.48E+02 | +9.8E-03 | -2.5E+00 | 2.0E-03 | 1.9E+00 | 4.1E-03 |  2d |0
2023-02-17 16:05:13 fides(INFO)    72| +1.55E+02 | -7.6E-02 | +8.2E-01 | 7.0E-03 | 7.5E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)     7| +2.91E+02 | -3.4E+02 | +9.1E-01 | 2.0E+00 | 1.9E+03 | 1.1E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    37| +1.48E+02 | -4.3E-02 | +7.8E-01 | 1.2E-01 | 5.8E+00 | 1.0E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    92| +1.48E+02 | -3.6E-04 | +2.2E-01 | 4.9E-04 | 1.9E+00 | 1.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    27| +1.48E+02 | +7.5E-04 | -3.3E-02 | 3.5E-02 | 6.6E+00 | 3.5E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    43| +2.50E+02 | -2.8E-05 | +1.1E+00 | 3.9E-03 | 1.2E-02 | 9.4E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    51| +1.78E+02 | -1.9E-03 | +5.6E-01 | 2.0E-02 | 2.0E+00 | 3.5E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    44| +2.50E+02 | -5.6E-05 | +1.0E+00 | 7.8E-03 | 2.1E-02 | 1.9E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    28| +1.48E+02 | -8.1E-03 | +8.1E-01 | 8.9E-03 | 6.6E+00 | 9.0E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    38| +1.48E+02 | +6.4E-01 | -6.7E+00 | 2.4E-01 | 2.4E+00 | 3.0E-01 |  2d |0
2023-02-17 16:05:13 fides(INFO)    93| +1.48E+02 | -5.6E-04 | +9.9E-01 | 1.2E-04 | 3.3E+00 | 2.2E-04 |  2d |1
2023-02-17 16:05:13 fides(INFO)     8| +2.21E+02 | -7.0E+01 | +1.3E+00 | 2.0E+00 | 2.7E+02 | 1.7E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    45| +2.50E+02 | -1.1E-04 | +1.0E+00 | 1.6E-02 | 3.9E-02 | 3.8E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    39| +1.48E+02 | +1.0E-02 | -3.2E-01 | 5.9E-02 | 2.4E+00 | 7.5E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    29| +1.48E+02 | -3.2E-03 | +9.3E-01 | 1.8E-02 | 1.4E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    52| +1.78E+02 | -1.9E-03 | +7.9E-01 | 2.0E-02 | 2.2E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)     0| +2.98E+09 |    NaN   |    NaN   | 1.0E+00 | 1.4E+10 |   NaN   | NaN |1
2023-02-17 16:05:13 fides(INFO)    46| +2.50E+02 | -2.3E-04 | +1.0E+00 | 3.1E-02 | 7.6E-02 | 7.5E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    94| +1.48E+02 | -6.8E-04 | +1.0E+00 | 2.4E-04 | 2.5E+00 | 4.5E-04 |  2d |1
2023-02-17 16:05:13 fides(INFO)     9| +2.21E+02 | +4.6E+04 | -1.3E+03 | 2.0E+00 | 5.2E+01 | 5.8E+00 |  2d |0
2023-02-17 16:05:13 fides(INFO)    47| +2.50E+02 | -5.0E-04 | +1.1E+00 | 6.2E-02 | 1.5E-01 | 1.5E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    30| +1.48E+02 | -3.8E-03 | +9.6E-01 | 3.5E-02 | 2.2E+00 | 5.5E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    40| +1.48E+02 | -6.9E-03 | +6.8E-01 | 1.5E-02 | 2.4E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    53| +1.78E+02 | -1.1E-03 | +3.1E-01 | 3.9E-02 | 1.8E+00 | 4.4E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    48| +2.50E+02 | -1.4E-03 | +1.3E+00 | 1.2E-01 | 3.0E-01 | 3.0E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    95| +1.48E+02 | -9.9E-04 | +9.4E-01 | 4.9E-04 | 1.4E+00 | 1.0E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)     1| +4.43E+04 | -3.0E+09 | +9.3E-02 | 1.0E+00 | 1.4E+10 | 2.8E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    41| +1.48E+02 | -2.9E-03 | +8.7E-01 | 1.5E-02 | 2.7E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    31| +1.48E+02 | +2.1E-03 | -4.0E-01 | 7.1E-02 | 8.2E-01 | 4.7E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    10| +2.21E+02 | +2.8E+01 | -8.8E-01 | 5.0E-01 | 5.2E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:13 fides(INFO)    49| +2.50E+02 | -6.8E-03 | +1.9E+00 | 2.5E-01 | 5.9E-01 | 5.9E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    42| +1.48E+02 | -4.1E-03 | +9.5E-01 | 3.0E-02 | 1.6E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    54| +1.78E+02 | -1.1E-03 | +1.7E-01 | 3.9E-02 | 1.8E+00 | 8.4E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)     2| +8.94E+03 | -3.5E+04 | +8.9E-01 | 2.5E-01 | 1.8E+05 | 5.9E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)    50| +2.50E+02 | -8.2E-02 | +3.3E+00 | 5.0E-01 | 1.2E+00 | 1.1E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    32| +1.48E+02 | -1.2E-03 | +5.4E-01 | 1.8E-02 | 8.2E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    96| +1.48E+02 | -7.9E-04 | +7.9E-01 | 9.8E-04 | 1.1E+00 | 2.1E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)     3| +1.58E+03 | -7.4E+03 | +9.0E-01 | 5.0E-01 | 3.1E+04 | 1.2E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    11| +2.06E+02 | -1.5E+01 | +9.3E-01 | 1.2E-01 | 5.2E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    51| +2.47E+02 | -2.4E+00 | +4.8E+00 | 1.0E+00 | 2.3E+00 | 2.1E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    43| +1.48E+02 | -3.4E-03 | +6.6E-01 | 5.9E-02 | 1.6E+00 | 5.1E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    73| +1.55E+02 | +3.3E-02 | -5.3E-01 | 1.4E-02 | 7.1E+00 | 3.0E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    55| +1.78E+02 | -1.5E-03 | +7.4E-01 | 9.9E-03 | 1.3E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    33| +1.48E+02 | -1.3E-03 | +4.6E-01 | 1.8E-02 | 2.0E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)     4| +4.27E+02 | -1.2E+03 | +9.0E-01 | 1.0E+00 | 4.9E+03 | 1.2E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    97| +1.48E+02 | -7.3E-04 | +9.8E-01 | 2.0E-03 | 2.3E+00 | 2.7E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    52| +2.31E+02 | -1.6E+01 | +1.8E+00 | 2.0E+00 | 8.6E+00 | 3.7E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    12| +2.01E+02 | -4.9E+00 | +2.2E-01 | 2.5E-01 | 4.3E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)     5| +2.63E+02 | -1.6E+02 | +8.8E-01 | 1.0E+00 | 7.8E+02 | 1.6E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    44| +1.48E+02 | +2.6E-02 | -2.3E+00 | 5.9E-02 | 1.0E+00 | 3.0E-02 |  2d |0
2023-02-17 16:05:13 fides(INFO)    34| +1.48E+02 | -2.1E-04 | +1.2E-01 | 1.8E-02 | 5.5E-01 | 6.0E-03 |  2d |1
2023-02-17 16:05:13.862 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.905 and h = 3.56407e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:13.862 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.905: AMICI failed to integrate the forward problem
2023-02-17 16:05:13 fides(INFO)    98| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 5.3E-01 | 5.2E-03 |  2d |0
2023-02-17 16:05:13 fides(INFO)    56| +1.78E+02 | -8.2E-04 | +8.0E-01 | 9.9E-03 | 1.4E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    53| +2.31E+02 | +7.7E+00 | -1.1E+00 | 4.0E+00 | 4.1E+01 | 1.2E+00 | trr |0
2023-02-17 16:05:13 fides(INFO)    45| +1.48E+02 | -5.8E-04 | +1.4E-01 | 1.5E-02 | 1.0E+00 | 8.4E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    35| +1.48E+02 | -5.4E-04 | +7.7E-01 | 4.4E-03 | 6.2E-01 | 7.9E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    54| +2.30E+02 | -1.7E+00 | +7.7E-01 | 1.4E-01 | 4.1E+01 | 3.5E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    99| +1.48E+02 | -1.6E-04 | +9.8E-01 | 9.8E-04 | 5.3E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)     6| +2.50E+02 | -1.3E+01 | +7.5E-01 | 1.0E+00 | 1.0E+02 | 2.2E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    13| +1.98E+02 | -3.5E+00 | +9.4E-01 | 6.2E-02 | 6.6E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    57| +1.78E+02 | -8.6E-04 | +9.3E-01 | 2.0E-02 | 1.3E+00 | 4.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    46| +1.48E+02 | -1.0E-03 | +8.9E-01 | 3.7E-03 | 2.1E+00 | 4.2E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    36| +1.48E+02 | -3.2E-04 | +6.8E-01 | 8.9E-03 | 4.2E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:13 fides(INFO)    55| +2.23E+02 | -6.5E+00 | +1.2E+00 | 2.8E-01 | 3.8E+01 | 6.7E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:13 fides(INFO)   100| +1.48E+02 | -2.6E-04 | +1.0E+00 | 2.0E-03 | 8.1E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)     7| +2.44E+02 | -5.2E+00 | +6.4E+00 | 1.0E+00 | 5.5E+00 | 2.0E+00 |  2d |1
2023-02-17 16:05:13 fides(INFO)    47| +1.48E+02 | -5.4E-04 | +7.1E-01 | 7.4E-03 | 3.9E-01 | 7.5E-03 |  2d |1
2023-02-17 16:05:13 fides(INFO)    14| +1.94E+02 | -3.5E+00 | +9.2E-01 | 1.2E-01 | 5.1E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:13 fides(INFO)    58| +1.78E+02 | -1.2E-03 | +1.0E+00 | 3.9E-02 | 1.2E+00 | 9.6E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    56| +2.17E+02 | -6.6E+00 | +9.8E-01 | 5.5E-01 | 2.0E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:14 fides(INFO)    37| +1.48E+02 | -1.8E-04 | +9.1E-01 | 8.9E-03 | 2.2E-01 | 5.0E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)   101| +1.48E+02 | -4.1E-04 | +1.0E+00 | 3.9E-03 | 4.2E-01 | 5.6E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)     8| +2.16E+02 | -2.8E+01 | +2.0E+00 | 2.0E+00 | 1.5E+01 | 3.6E+00 |  2d |1
2023-02-17 16:05:14.026 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.61 and h = 3.16878e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:14.027 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.61: AMICI failed to integrate the forward problem
2023-02-17 16:05:14 fides(INFO)    48| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.4E-03 | 4.4E-01 | 5.5E-03 |  2d |0
2023-02-17 16:05:14 fides(INFO)    57| +2.17E+02 | +8.6E+01 | -1.7E+01 | 1.1E+00 | 3.3E+01 | 2.8E+00 |  2d |0
2023-02-17 16:05:14 fides(INFO)    38| +1.48E+02 | -2.4E-04 | +7.6E-01 | 1.8E-02 | 5.1E-01 | 1.4E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)   102| +1.48E+02 | -8.5E-04 | +1.0E+00 | 7.8E-03 | 4.6E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    59| +1.78E+02 | +1.8E-03 | -1.0E+00 | 7.9E-02 | 8.1E-01 | 7.2E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)     9| +2.16E+02 | +8.9E+02 | -4.8E+01 | 4.0E+00 | 2.7E+01 | 1.2E+01 | trr |0
2023-02-17 16:05:14 fides(INFO)    58| +2.15E+02 | -2.0E+00 | +6.1E-01 | 2.5E-01 | 3.3E+01 | 7.0E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    49| +1.48E+02 | -9.2E-05 | +1.0E+00 | 1.9E-03 | 4.4E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    39| +1.48E+02 | +6.3E-04 | -1.1E+00 | 3.5E-02 | 2.0E-01 | 6.4E-03 |  2d |0
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    10| +2.16E+02 | +2.9E+01 | -3.6E+00 | 1.0E+00 | 2.7E+01 | 2.8E+00 |  2d |0
2023-02-17 16:05:14 fides(INFO)   103| +1.48E+02 | -1.4E-03 | +9.5E-01 | 1.6E-02 | 2.9E-01 | 2.2E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    60| +1.78E+02 | -3.3E-04 | +5.7E-01 | 2.0E-02 | 8.1E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    59| +2.12E+02 | -2.4E+00 | +4.6E-01 | 2.5E-01 | 2.7E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    50| +1.48E+02 | -1.5E-04 | +9.8E-01 | 3.7E-03 | 2.6E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    40| +1.48E+02 | -1.0E-04 | +5.6E-01 | 8.9E-03 | 2.0E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    15| +1.93E+02 | -1.1E+00 | +1.0E+00 | 2.5E-01 | 2.3E+01 | 7.3E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    11| +2.16E+02 | +3.8E+00 | -6.2E-01 | 2.5E-01 | 2.7E+01 | 6.3E-01 |  2d |0
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    60| +2.12E+02 | +1.1E-01 | -1.1E-01 | 2.5E-01 | 1.4E+01 | 6.6E-01 |  2d |0
2023-02-17 16:05:14 fides(INFO)   104| +1.48E+02 | -2.0E-03 | +7.5E-01 | 3.1E-02 | 3.1E-01 | 4.5E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    74| +1.55E+02 | -1.7E-02 | +7.7E-01 | 3.5E-03 | 7.1E+00 | 8.1E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    61| +1.78E+02 | +3.3E-05 | -4.2E-02 | 2.0E-02 | 8.6E-01 | 3.1E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)    51| +1.48E+02 | -2.3E-04 | +9.2E-01 | 7.4E-03 | 3.9E-01 | 5.2E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    41| +1.48E+02 | -7.7E-05 | +6.2E-01 | 8.9E-03 | 2.4E-01 | 6.8E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    61| +2.12E+02 | -6.5E-01 | +8.3E-01 | 6.3E-02 | 1.4E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    12| +2.13E+02 | -2.9E+00 | +8.4E-01 | 6.2E-02 | 2.7E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)   105| +1.48E+02 | -2.8E-03 | +5.0E-01 | 6.2E-02 | 1.1E+00 | 9.7E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    52| +1.48E+02 | -3.8E-04 | +9.7E-01 | 1.5E-02 | 2.0E-01 | 8.7E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    62| +2.11E+02 | -8.7E-01 | +6.2E-01 | 1.3E-01 | 1.0E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    13| +2.12E+02 | -7.5E-01 | +3.3E-01 | 1.2E-01 | 1.3E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    42| +1.48E+02 | -6.0E-05 | +7.2E-01 | 8.9E-03 | 1.4E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    62| +1.78E+02 | -2.5E-04 | +8.1E-01 | 4.9E-03 | 8.6E-01 | 7.8E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)   106| +1.48E+02 | +2.0E-03 | -5.2E-01 | 6.2E-02 | 2.4E+00 | 9.6E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)    14| +2.10E+02 | -2.1E+00 | +6.9E-01 | 1.2E-01 | 2.6E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    53| +1.48E+02 | -3.9E-04 | +7.0E-01 | 3.0E-02 | 4.1E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    63| +2.10E+02 | -5.7E-01 | +6.0E-01 | 1.3E-01 | 8.3E+00 | 2.0E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    43| +1.48E+02 | -4.0E-05 | +5.8E-01 | 8.9E-03 | 1.5E-01 | 5.4E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    16| +1.78E+02 | -1.5E+01 | +2.2E+00 | 5.0E-01 | 2.3E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:14 fides(INFO)    15| +2.09E+02 | -1.5E+00 | +5.4E-01 | 1.2E-01 | 1.3E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    63| +1.78E+02 | -1.9E-04 | +8.1E-01 | 9.9E-03 | 6.8E-01 | 5.2E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)   107| +1.48E+02 | -2.9E-04 | +1.3E-01 | 1.6E-02 | 2.4E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    54| +1.48E+02 | +1.5E-03 | -1.5E+00 | 3.0E-02 | 2.5E-01 | 7.4E-03 |  2d |0
2023-02-17 16:05:14 fides(INFO)    64| +2.10E+02 | -2.4E-01 | +1.9E-01 | 1.3E-01 | 1.1E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    44| +1.48E+02 | -3.1E-05 | +5.4E-01 | 8.9E-03 | 1.1E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    16| +2.06E+02 | -2.5E+00 | +6.6E-01 | 1.2E-01 | 2.8E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    64| +1.78E+02 | -2.5E-04 | +6.8E-01 | 2.0E-02 | 7.5E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    65| +2.09E+02 | -5.4E-01 | +8.9E-01 | 3.1E-02 | 1.5E+01 | 6.0E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)   108| +1.48E+02 | -1.0E-03 | +9.3E-01 | 3.9E-03 | 2.9E+00 | 5.1E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    55| +1.48E+02 | -4.0E-05 | +1.0E-01 | 7.4E-03 | 2.5E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    45| +1.48E+02 | -1.9E-05 | +3.1E-01 | 8.9E-03 | 1.3E-01 | 5.3E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    17| +2.04E+02 | -2.1E+00 | +7.1E-01 | 1.2E-01 | 1.8E+01 | 3.4E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    66| +2.09E+02 | -2.2E-01 | +9.8E-01 | 6.3E-02 | 4.9E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)   109| +1.48E+02 | +3.4E-03 | -7.9E+00 | 7.8E-03 | 2.8E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)    46| +1.48E+02 | -8.9E-07 | +1.1E-02 | 8.9E-03 | 1.1E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    65| +1.78E+02 | +2.6E-04 | -3.7E-01 | 2.0E-02 | 5.4E-01 | 3.0E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)    56| +1.48E+02 | -1.5E-04 | +8.9E-01 | 1.9E-03 | 9.1E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    18| +2.02E+02 | -1.9E+00 | +6.4E-01 | 1.2E-01 | 2.4E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    17| +1.78E+02 | +1.7E+01 | -1.2E+00 | 1.0E+00 | 7.0E+01 | 2.9E+00 |  2d |0
2023-02-17 16:05:14 fides(INFO)    67| +2.09E+02 | -1.6E-01 | +9.0E-01 | 1.3E-01 | 2.5E+00 | 2.0E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    47| +1.48E+02 | -3.0E-05 | +7.1E-01 | 2.2E-03 | 1.5E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)   110| +1.48E+02 | +3.3E-05 | -1.2E-01 | 1.8E-03 | 2.8E-01 | 3.1E-03 |  2d |0
2023-02-17 16:05:14 fides(INFO)    57| +1.48E+02 | -6.5E-05 | +8.0E-01 | 3.7E-03 | 1.0E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    19| +2.00E+02 | -2.7E+00 | +9.3E-01 | 1.2E-01 | 1.9E+01 | 3.4E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    75| +1.55E+02 | -2.8E-02 | +9.4E-01 | 7.0E-03 | 4.5E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    68| +2.09E+02 | -5.2E-02 | +8.6E-01 | 2.5E-01 | 2.9E+00 | 2.0E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    66| +1.78E+02 | -1.5E-04 | +6.9E-01 | 4.9E-03 | 5.4E-01 | 7.5E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    20| +1.90E+02 | -1.0E+01 | +1.7E+00 | 2.5E-01 | 2.1E+01 | 6.8E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    48| +1.48E+02 | -7.8E-06 | +9.6E-01 | 2.2E-03 | 8.6E-02 | 9.8E-04 |  2d |1
2023-02-17 16:05:14 fides(INFO)   111| +1.48E+02 | -1.4E-04 | +8.9E-01 | 4.6E-04 | 2.8E-01 | 1.0E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    69| +2.09E+02 | -4.3E-02 | +2.1E+00 | 2.5E-01 | 1.3E+00 | 2.1E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    58| +1.48E+02 | -5.8E-05 | +8.5E-01 | 7.4E-03 | 8.8E-02 | 4.0E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    18| +1.69E+02 | -9.4E+00 | +1.2E+00 | 2.5E-01 | 7.0E+01 | 7.0E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    21| +1.90E+02 | -2.0E+00 | -3.4E-01 | 5.0E-01 | 2.8E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:14 fides(INFO)    49| +1.48E+02 | -5.0E-06 | +6.4E-01 | 4.4E-03 | 4.3E-02 | 1.4E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    67| +1.78E+02 | -1.0E-04 | +1.0E+00 | 4.9E-03 | 6.0E-01 | 9.7E-04 |  2d |1
2023-02-17 16:05:14 fides(INFO)   112| +1.48E+02 | -5.3E-05 | +1.0E+00 | 9.2E-04 | 4.0E-01 | 1.0E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    59| +1.48E+02 | -7.7E-05 | +8.0E-01 | 1.5E-02 | 7.8E-02 | 4.8E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    70| +2.09E+02 | -1.1E-01 | +2.5E+00 | 2.5E-01 | 9.3E-01 | 3.3E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    22| +1.80E+02 | -9.2E+00 | +1.2E+00 | 1.2E-01 | 2.8E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    50| +1.48E+02 | +3.8E-08 | -7.5E-03 | 4.4E-03 | 7.3E-02 | 8.8E-04 |  2d |0
2023-02-17 16:05:14 fides(INFO)   113| +1.48E+02 | -3.5E-05 | +8.3E-01 | 1.8E-03 | 1.4E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    71| +2.08E+02 | -3.1E-01 | +2.3E+00 | 2.5E-01 | 1.8E+00 | 5.8E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    68| +1.78E+02 | -1.2E-04 | +9.3E-01 | 9.9E-03 | 5.1E-01 | 1.5E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    60| +1.48E+02 | +1.9E-04 | -9.5E-01 | 3.0E-02 | 2.2E-01 | 1.6E-02 |  2d |0
2023-02-17 16:05:14.613 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 95.0225 and h = 1.18628e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:14.613 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 95.0225: AMICI failed to integrate the forward problem
2023-02-17 16:05:14 fides(INFO)    23| +1.80E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 4.4E+01 | 6.0E-01 |  2d |0
2023-02-17 16:05:14 fides(INFO)    72| +2.08E+02 | +1.8E+00 | -6.1E+00 | 2.5E-01 | 4.0E+00 | 7.0E-01 |  2d |0
2023-02-17 16:05:14 fides(INFO)   114| +1.48E+02 | +1.2E-04 | -3.3E+00 | 3.7E-03 | 1.3E-01 | 4.6E-03 |  2d |0
2023-02-17 16:05:14 fides(INFO)    51| +1.48E+02 | -3.1E-06 | +1.7E+00 | 1.1E-03 | 7.3E-02 | 2.2E-04 |  2d |1
2023-02-17 16:05:14 fides(INFO)    69| +1.78E+02 | -1.8E-04 | +1.0E+00 | 2.0E-02 | 5.1E-01 | 4.1E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    24| +1.75E+02 | -5.4E+00 | +1.1E+00 | 6.2E-02 | 4.4E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    61| +1.48E+02 | -3.8E-05 | +6.0E-01 | 7.4E-03 | 2.2E-01 | 4.1E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)   115| +1.48E+02 | -1.4E-05 | +8.8E-01 | 9.2E-04 | 1.3E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    73| +2.08E+02 | -1.6E-01 | +1.2E+00 | 6.3E-02 | 4.0E+00 | 1.8E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    52| +1.48E+02 | +6.0E-06 | -1.3E+00 | 2.2E-03 | 2.1E-02 | 6.8E-04 |  2d |0
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    70| +1.78E+02 | +1.2E-05 | -4.9E-02 | 3.9E-02 | 3.7E-01 | 1.5E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)    25| +1.64E+02 | -1.1E+01 | +1.0E+00 | 1.2E-01 | 4.7E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    62| +1.48E+02 | -1.9E-05 | +4.9E-01 | 7.4E-03 | 7.7E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)   116| +1.48E+02 | +1.0E-04 | -4.8E+00 | 1.8E-03 | 1.2E-01 | 1.9E-03 |  2d |0
2023-02-17 16:05:14 fides(INFO)    74| +2.08E+02 | -5.9E-01 | +7.0E-01 | 1.3E-01 | 4.8E+00 | 2.7E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    26| +1.57E+02 | -7.6E+00 | +4.7E-01 | 2.5E-01 | 5.9E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    71| +1.78E+02 | -6.7E-05 | +7.6E-01 | 9.9E-03 | 3.7E-01 | 3.7E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    53| +1.48E+02 | -2.0E-07 | +6.1E-02 | 5.5E-04 | 2.1E-02 | 3.8E-04 |  2d |1
2023-02-17 16:05:14 fides(INFO)    75| +2.06E+02 | -1.4E+00 | +1.5E+00 | 1.3E-01 | 1.0E+01 | 3.4E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    63| +1.48E+02 | -2.3E-05 | +5.6E-01 | 7.4E-03 | 1.8E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)   117| +1.48E+02 | +7.5E-05 | -5.2E+00 | 4.6E-04 | 1.2E-01 | 5.2E-04 |  2d |0
2023-02-17 16:05:14 fides(INFO)    19| +1.66E+02 | -3.0E+00 | +7.7E-01 | 5.0E-01 | 3.8E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    27| +1.50E+02 | -6.6E+00 | +9.6E-01 | 2.5E-01 | 1.7E+02 | 7.0E-01 | trr |1
2023-02-17 16:05:14.763 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.642 and h = 2.79391e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:14.763 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.642: AMICI failed to integrate the forward problem
2023-02-17 16:05:14 fides(INFO)    64| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.4E-03 | 6.7E-02 | 8.8E-04 |  2d |0
2023-02-17 16:05:14 fides(INFO)    76| +2.03E+02 | -3.5E+00 | +1.3E+00 | 2.5E-01 | 5.5E+00 | 6.8E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    54| +1.48E+02 | -1.4E-06 | +7.5E-01 | 1.4E-04 | 1.1E-01 | 6.5E-05 |  2d |1
2023-02-17 16:05:14 fides(WARNING) Stopping as function difference 1.43E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:14 fides(INFO)   118| +1.48E+02 | +6.3E-05 | -5.4E+00 | 1.1E-04 | 1.2E-01 | 1.9E-04 |  2d |0
2023-02-17 16:05:14 fides(INFO)    72| +1.78E+02 | +1.7E-05 | -9.9E-02 | 2.0E-02 | 4.0E-01 | 1.6E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)    28| +1.48E+02 | -1.5E+00 | +6.2E-01 | 2.5E-01 | 5.0E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    77| +2.03E+02 | +1.6E+01 | -1.5E+00 | 5.0E-01 | 2.5E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:14 fides(INFO)    76| +1.55E+02 | +1.6E-01 | -3.1E+00 | 1.4E-02 | 4.2E+00 | 2.8E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)    65| +1.48E+02 | -4.5E-06 | +3.7E-01 | 1.9E-03 | 6.7E-02 | 3.1E-04 |  2d |1
2023-02-17 16:05:14 fides(INFO)   119| +1.48E+02 | -1.9E-06 | +4.0E-01 | 2.9E-05 | 1.2E-01 | 5.0E-05 |  2d |1
2023-02-17 16:05:14 fides(INFO)    29| +1.48E+02 | -5.2E-01 | +9.7E-01 | 2.5E-01 | 4.8E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    78| +1.99E+02 | -3.4E+00 | +6.4E-01 | 1.3E-01 | 2.5E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    73| +1.78E+02 | -5.0E-05 | +7.9E-01 | 4.9E-03 | 4.0E-01 | 4.0E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    66| +1.48E+02 | -1.1E-05 | +1.6E+00 | 1.9E-03 | 1.8E-01 | 4.9E-04 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)   120| +1.48E+02 | -7.8E-07 | +4.1E-01 | 2.9E-05 | 1.2E-01 | 5.0E-05 |  2d |1
2023-02-17 16:05:14 fides(WARNING) Stopping as function difference 7.82E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:14 fides(INFO)    79| +1.97E+02 | -2.9E+00 | +8.4E-01 | 1.3E-01 | 1.5E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    30| +1.48E+02 | -8.9E-02 | +2.0E-01 | 5.0E-01 | 1.9E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    67| +1.48E+02 | -6.2E-06 | +8.9E-01 | 3.7E-03 | 2.7E-02 | 9.0E-04 |  2d |1
2023-02-17 16:05:14 fides(INFO)    74| +1.78E+02 | -5.3E-05 | +8.0E-01 | 9.9E-03 | 3.2E-01 | 2.8E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)     0| +1.31E+11 |    NaN   |    NaN   | 1.0E+00 | 6.0E+11 |   NaN   | NaN |1
2023-02-17 16:05:14 fides(INFO)    68| +1.48E+02 | -1.0E-05 | +8.4E-01 | 7.4E-03 | 8.4E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    31| +1.48E+02 | +8.5E-04 | -1.1E-02 | 1.2E-01 | 1.9E+01 | 1.9E-01 |  2d |0
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    80| +1.97E+02 | +8.7E+00 | -2.4E+00 | 2.5E-01 | 1.3E+01 | 4.3E-01 |  2d |0
2023-02-17 16:05:14 fides(INFO)    75| +1.78E+02 | +2.1E-05 | -1.6E-01 | 2.0E-02 | 3.4E-01 | 1.4E-02 |  2d |0
2023-02-17 16:05:14 fides(INFO)     1| +1.53E+05 | -1.3E+11 | +8.8E-02 | 1.0E+00 | 6.0E+11 | 3.0E+00 |  2d |1
2023-02-17 16:05:14 fides(INFO)    69| +1.48E+02 | -4.2E-06 | +2.3E-01 | 1.5E-02 | 3.2E-02 | 2.0E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    20| +1.60E+02 | -6.0E+00 | +4.7E-01 | 1.0E+00 | 9.6E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:14 fides(INFO)    81| +1.96E+02 | -6.2E-01 | +5.3E-01 | 6.3E-02 | 1.3E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:14 fides(INFO)    32| +1.48E+02 | -1.7E-01 | +7.8E-01 | 3.1E-02 | 1.9E+01 | 4.7E-02 |  2d |1
2023-02-17 16:05:14 fides(INFO)    76| +1.78E+02 | -3.6E-05 | +7.8E-01 | 4.9E-03 | 3.4E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:14 fides(INFO)    70| +1.48E+02 | -1.3E-05 | +5.2E-01 | 3.7E-03 | 9.4E-02 | 2.0E-03 |  2d |1
2023-02-17 16:05:14 fides(INFO)    82| +1.96E+02 | -3.9E-01 | +4.5E-01 | 6.3E-02 | 9.0E+00 | 1.4E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    33| +1.48E+02 | -4.3E-02 | +2.9E-01 | 6.2E-02 | 8.1E+00 | 8.3E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)     2| +2.41E+04 | -1.3E+05 | +9.0E-01 | 2.5E-01 | 7.0E+05 | 6.0E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)     0| +4.56E+02 |    NaN   |    NaN   | 1.0E+00 | 3.3E+02 |   NaN   | NaN |1
2023-02-17 16:05:15 fides(INFO)    83| +1.95E+02 | -3.7E-01 | +6.8E-01 | 6.3E-02 | 1.0E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)     3| +3.93E+03 | -2.0E+04 | +9.0E-01 | 5.0E-01 | 1.1E+05 | 1.2E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    77| +1.78E+02 | -3.7E-05 | +7.0E-01 | 9.9E-03 | 2.7E-01 | 3.2E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    71| +1.48E+02 | -3.5E-08 | +8.7E-03 | 3.7E-03 | 4.8E-02 | 2.3E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    21| +1.56E+02 | -4.0E+00 | +9.7E-01 | 1.0E+00 | 1.2E+02 | 2.2E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    34| +1.48E+02 | -2.6E-02 | +6.1E-01 | 6.2E-02 | 9.4E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)     1| +3.80E+02 | -7.6E+01 | +1.2E-01 | 1.0E+00 | 3.3E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    77| +1.55E+02 | -1.0E-02 | +6.0E-01 | 3.5E-03 | 4.2E+00 | 7.6E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     4| +7.99E+02 | -3.1E+03 | +9.0E-01 | 1.0E+00 | 1.7E+04 | 1.2E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    72| +1.48E+02 | +4.6E-07 | -8.5E-01 | 9.3E-04 | 2.2E-02 | 1.9E-04 |  2d |0
2023-02-17 16:05:15 fides(INFO)    84| +1.95E+02 | -3.1E-01 | +9.2E-01 | 6.3E-02 | 7.2E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)     2| +3.36E+02 | -4.5E+01 | +9.9E-01 | 2.5E-01 | 6.4E+01 | 7.1E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    78| +1.78E+02 | -1.3E-05 | +1.8E-01 | 9.9E-03 | 2.8E-01 | 8.5E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    35| +1.48E+02 | -1.2E-02 | +5.0E-01 | 6.2E-02 | 4.9E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)     5| +3.19E+02 | -4.8E+02 | +9.0E-01 | 1.0E+00 | 2.7E+03 | 1.5E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)     3| +2.66E+02 | -7.0E+01 | +8.4E-01 | 5.0E-01 | 6.2E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    73| +1.48E+02 | +1.7E-07 | -9.3E-01 | 2.3E-04 | 2.2E-02 | 4.8E-05 |  2d |0
2023-02-17 16:05:15 fides(INFO)    22| +1.56E+02 | +6.1E+01 | -2.3E+01 | 2.0E+00 | 4.1E+01 | 4.8E+00 |  2d |0
2023-02-17 16:05:15 fides(INFO)     6| +2.51E+02 | -6.8E+01 | +8.8E-01 | 1.0E+00 | 4.1E+02 | 2.0E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    85| +1.95E+02 | -3.7E-01 | +8.4E-01 | 1.3E-01 | 2.8E+00 | 3.0E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    36| +1.48E+02 | -7.6E-03 | +3.8E-01 | 6.2E-02 | 5.9E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    79| +1.78E+02 | -3.6E-05 | +7.1E-01 | 2.5E-03 | 2.1E-01 | 3.7E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     4| +2.66E+02 | +6.6E+03 | -3.4E+02 | 1.0E+00 | 3.9E+01 | 2.6E+00 |  2d |0
2023-02-17 16:05:15 fides(INFO)    74| +1.48E+02 | -6.6E-08 | +7.5E-01 | 5.8E-05 | 2.2E-02 | 1.3E-05 |  2d |1
2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 6.57E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:15 fides(INFO)     7| +2.22E+02 | -2.9E+01 | +2.1E+00 | 2.0E+00 | 4.3E+01 | 3.6E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    37| +1.48E+02 | +4.8E-03 | -2.8E-01 | 6.2E-02 | 2.0E+00 | 5.5E-02 |  2d |0
2023-02-17 16:05:15 fides(INFO)    86| +1.94E+02 | -7.3E-01 | +1.3E+00 | 2.5E-01 | 5.0E+00 | 5.3E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    23| +1.56E+02 | +4.9E+00 | -7.2E+00 | 5.0E-01 | 4.1E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:15 fides(INFO)     5| +2.50E+02 | -1.6E+01 | +7.2E-01 | 2.5E-01 | 3.9E+01 | 6.6E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    80| +1.78E+02 | -1.6E-05 | +9.2E-01 | 2.5E-03 | 2.3E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    38| +1.48E+02 | -3.9E-03 | +6.1E-01 | 1.6E-02 | 2.0E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)     8| +2.22E+02 | +4.5E+03 | -3.9E+02 | 4.0E+00 | 3.4E+01 | 4.6E+00 | trr |0
2023-02-17 16:05:15 fides(INFO)     6| +2.50E+02 | +5.5E-01 | -4.4E-01 | 2.5E-01 | 1.5E+01 | 6.1E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    87| +1.94E+02 | +9.1E-01 | -1.2E+00 | 5.0E-01 | 4.6E+00 | 1.1E+00 |  2d |0
2023-02-17 16:05:15 fides(INFO)     9| +2.22E+02 | +4.8E+01 | -3.1E+00 | 3.9E-01 | 3.4E+01 | 9.8E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    39| +1.48E+02 | -2.4E-03 | +9.7E-01 | 1.6E-02 | 4.5E+00 | 6.1E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     7| +2.50E+02 | -3.7E-01 | +2.7E-01 | 6.2E-02 | 1.5E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    81| +1.78E+02 | -1.6E-05 | +9.1E-01 | 4.9E-03 | 2.0E-01 | 5.7E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    88| +1.93E+02 | -3.2E-01 | +8.6E-01 | 1.3E-01 | 4.6E+00 | 2.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    24| +1.55E+02 | -5.8E-01 | +1.1E+00 | 1.2E-01 | 4.1E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)     8| +2.50E+02 | -1.7E-01 | +2.8E-01 | 6.2E-02 | 1.1E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    40| +1.48E+02 | -8.2E-04 | +9.4E-01 | 3.1E-02 | 1.2E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    10| +2.15E+02 | -6.9E+00 | +8.9E-01 | 9.8E-02 | 3.4E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    82| +1.78E+02 | -2.3E-05 | +9.9E-01 | 9.9E-03 | 2.0E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     9| +2.50E+02 | +7.5E-02 | -2.7E-01 | 6.2E-02 | 6.6E+00 | 1.5E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)     0| +9.51E+13 |    NaN   |    NaN   | 1.0E+00 | 4.4E+14 |   NaN   | NaN |1
2023-02-17 16:05:15 fides(INFO)    89| +1.93E+02 | -3.5E-01 | +1.9E-01 | 2.5E-01 | 7.6E+00 | 6.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    41| +1.48E+02 | -1.1E-03 | +9.5E-01 | 6.2E-02 | 1.5E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    11| +2.15E+02 | +7.1E+00 | -1.3E+00 | 2.0E-01 | 2.3E+01 | 4.8E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)     1| +9.94E+08 | -9.5E+13 | +8.3E-02 | 1.0E+00 | 4.4E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    78| +1.55E+02 | +3.9E-02 | -1.6E+00 | 3.5E-03 | 4.8E+00 | 9.1E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    10| +2.50E+02 | -1.4E-01 | +7.0E-01 | 1.6E-02 | 6.6E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    90| +1.92E+02 | -8.5E-01 | +1.3E+00 | 6.3E-02 | 1.9E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    25| +1.55E+02 | -3.0E-01 | +4.9E-01 | 2.5E-01 | 2.2E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    12| +2.13E+02 | -2.2E+00 | +8.7E-01 | 4.9E-02 | 2.3E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    42| +1.48E+02 | -2.5E-04 | +1.9E-01 | 1.2E-01 | 8.2E-01 | 4.4E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    83| +1.78E+02 | +6.7E-06 | -1.6E-01 | 2.0E-02 | 1.6E-01 | 6.2E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)    11| +2.50E+02 | -2.0E-04 | +2.5E-02 | 1.6E-02 | 1.2E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)     2| +1.55E+08 | -8.4E+08 | +8.9E-01 | 2.5E-01 | 4.3E+09 | 6.3E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    13| +2.13E+02 | +7.7E-01 | -6.4E-01 | 9.8E-02 | 1.3E+01 | 2.5E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    91| +1.91E+02 | -1.4E+00 | +1.2E+00 | 1.3E-01 | 9.2E+00 | 3.5E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    43| +1.48E+02 | +5.0E-04 | -1.5E-01 | 3.1E-02 | 8.2E-01 | 2.0E-02 |  2d |0
2023-02-17 16:05:15 fides(INFO)    84| +1.78E+02 | -1.0E-05 | +7.3E-01 | 4.9E-03 | 1.6E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     3| +2.36E+07 | -1.3E+08 | +8.9E-01 | 5.0E-01 | 6.6E+08 | 7.0E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    12| +2.50E+02 | -2.7E-03 | +4.2E-01 | 3.9E-03 | 1.1E+00 | 9.4E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    26| +1.54E+02 | -6.9E-01 | +6.5E-01 | 2.5E-01 | 4.8E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    14| +2.13E+02 | -5.2E-01 | +8.2E-01 | 2.4E-02 | 1.3E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)     4| +3.63E+06 | -2.0E+07 | +8.9E-01 | 5.0E-01 | 1.0E+08 | 6.9E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    92| +1.86E+02 | -4.8E+00 | +1.6E+00 | 2.5E-01 | 1.1E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    44| +1.48E+02 | -6.6E-04 | +5.4E-01 | 7.8E-03 | 8.2E-01 | 5.4E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    13| +2.50E+02 | -9.0E-05 | +4.1E-02 | 3.9E-03 | 6.0E-01 | 6.9E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     5| +5.63E+05 | -3.1E+06 | +9.0E-01 | 5.0E-01 | 1.5E+07 | 6.4E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    85| +1.78E+02 | -9.9E-06 | +7.6E-01 | 4.9E-03 | 1.7E-01 | 2.1E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     6| +8.81E+04 | -4.7E+05 | +9.0E-01 | 5.0E-01 | 2.4E+06 | 5.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    45| +1.48E+02 | -3.3E-04 | +9.6E-01 | 7.8E-03 | 1.6E+00 | 1.7E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    15| +2.13E+02 | +1.8E-03 | -2.9E-02 | 4.9E-02 | 6.7E+00 | 1.3E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    14| +2.50E+02 | -9.1E-04 | +7.7E-01 | 9.8E-04 | 5.7E-01 | 2.6E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    86| +1.78E+02 | -3.4E-06 | +1.5E-01 | 9.9E-03 | 1.4E-01 | 3.9E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     7| +1.40E+04 | -7.4E+04 | +9.0E-01 | 5.0E-01 | 3.7E+05 | 5.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    15| +2.50E+02 | -8.7E-07 | +7.3E-03 | 2.0E-03 | 1.4E-01 | 4.9E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    16| +2.13E+02 | -1.0E-01 | +8.0E-01 | 1.2E-02 | 6.7E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    46| +1.48E+02 | -1.5E-04 | +6.8E-01 | 1.6E-02 | 3.0E-01 | 3.7E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    27| +1.54E+02 | -7.9E-02 | +7.8E-01 | 2.5E-01 | 1.3E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)     8| +2.39E+03 | -1.2E+04 | +9.0E-01 | 5.0E-01 | 5.9E+04 | 5.6E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)     9| +5.58E+02 | -1.8E+03 | +9.0E-01 | 5.0E-01 | 9.4E+03 | 5.5E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    93| +1.86E+02 | +1.8E+02 | -2.9E+01 | 5.0E-01 | 5.7E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:15 fides(INFO)    16| +2.50E+02 | -5.7E-05 | +6.4E-01 | 4.9E-04 | 1.4E-01 | 8.6E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    17| +2.12E+02 | -1.4E-01 | +9.7E-01 | 2.4E-02 | 5.6E+00 | 3.2E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    47| +1.48E+02 | -4.1E-05 | +4.3E-01 | 1.6E-02 | 2.4E-01 | 4.6E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    87| +1.78E+02 | -1.5E-05 | +6.0E-01 | 2.5E-03 | 1.4E-01 | 3.2E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    10| +2.88E+02 | -2.7E+02 | +9.0E-01 | 5.0E-01 | 1.5E+03 | 7.1E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    17| +2.50E+02 | -3.3E-07 | +5.3E-01 | 4.9E-04 | 7.1E-03 | 1.2E-03 |  2d |1
2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 3.30E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:15 fides(INFO)    11| +2.50E+02 | -3.8E+01 | +8.3E-01 | 1.0E+00 | 2.3E+02 | 1.1E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    18| +2.12E+02 | -1.4E-01 | +6.8E-01 | 4.9E-02 | 5.5E+00 | 6.9E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    48| +1.48E+02 | -1.5E-05 | +8.3E-01 | 1.6E-02 | 1.2E-01 | 2.9E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    28| +1.54E+02 | -9.8E-03 | +3.6E-01 | 5.0E-01 | 4.1E+00 | 8.0E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    12| +2.50E+02 | -4.6E-01 | +3.9E-01 | 2.0E+00 | 1.7E+01 | 3.8E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    88| +1.78E+02 | -3.8E-06 | +9.1E-01 | 2.5E-03 | 1.1E-01 | 3.0E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    94| +1.86E+02 | +2.7E+00 | -1.2E+00 | 1.3E-01 | 5.7E+01 | 3.4E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    79| +1.55E+02 | -1.3E-03 | +1.4E-01 | 8.8E-04 | 4.8E+00 | 2.4E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    49| +1.48E+02 | -3.8E-06 | +2.6E-01 | 3.1E-02 | 1.1E-01 | 5.9E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    19| +2.12E+02 | +2.0E-02 | -9.4E-02 | 4.9E-02 | 6.4E+00 | 1.3E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    13| +2.50E+02 | +1.4E-01 | -3.5E-01 | 2.0E+00 | 7.7E+00 | 1.1E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    89| +1.78E+02 | -5.9E-06 | +1.0E+00 | 4.9E-03 | 1.1E-01 | 4.1E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    29| +1.54E+02 | +1.0E-02 | -3.5E-01 | 5.0E-01 | 5.2E+00 | 6.8E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    14| +2.50E+02 | -1.6E-01 | +8.5E-01 | 1.1E-02 | 7.7E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    95| +1.84E+02 | -1.7E+00 | +1.5E+00 | 3.1E-02 | 5.7E+01 | 8.1E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    50| +1.48E+02 | +5.1E-07 | -2.8E-02 | 3.1E-02 | 5.9E-02 | 5.0E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    20| +2.12E+02 | -1.1E-01 | +7.9E-01 | 1.2E-02 | 6.4E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    15| +2.50E+02 | +1.1E-02 | -1.4E-01 | 2.1E-02 | 3.7E+00 | 4.7E-02 |  2d |0
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)     0| +1.65E+08 |    NaN   |    NaN   | 1.0E+00 | 7.6E+08 |   NaN   | NaN |1
2023-02-17 16:05:15 fides(INFO)    16| +2.50E+02 | -3.2E-02 | +8.5E-01 | 4.5E-03 | 3.7E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    90| +1.78E+02 | -7.3E-06 | +9.2E-01 | 9.9E-03 | 9.7E-02 | 7.4E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    51| +1.48E+02 | -8.3E-06 | +1.3E+00 | 7.8E-03 | 5.9E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    96| +1.79E+02 | -5.4E+00 | +8.9E-01 | 6.3E-02 | 6.0E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    21| +2.12E+02 | -4.7E-02 | +5.4E-01 | 2.4E-02 | 4.1E+00 | 4.3E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    17| +2.50E+02 | +1.2E-03 | -6.3E-02 | 9.1E-03 | 1.8E+00 | 2.2E-02 |  2d |0
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    30| +1.54E+02 | -1.1E-02 | +7.8E-01 | 1.2E-01 | 5.2E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    52| +1.48E+02 | -3.3E-06 | +9.8E-01 | 1.6E-02 | 9.9E-02 | 2.5E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     1| +1.45E+03 | -1.6E+08 | +1.0E-01 | 1.0E+00 | 7.6E+08 | 2.6E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    18| +2.50E+02 | -7.4E-03 | +8.6E-01 | 2.1E-03 | 1.8E+00 | 5.5E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    22| +2.12E+02 | -4.8E-02 | +3.7E-01 | 2.4E-02 | 5.9E+00 | 4.9E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    97| +1.70E+02 | -9.0E+00 | +9.8E-01 | 1.3E-01 | 3.5E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    91| +1.78E+02 | -3.8E-06 | +3.7E-01 | 2.0E-02 | 9.5E-02 | 3.5E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    19| +2.50E+02 | +1.4E-04 | -3.0E-02 | 4.2E-03 | 8.9E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:15 fides(INFO)     2| +5.27E+02 | -9.2E+02 | +9.2E-01 | 2.5E-01 | 4.8E+03 | 5.0E-01 |  2d |1
2023-02-17 16:05:15.736 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1579 and h = 1.35913e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:15.736 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1579: AMICI failed to integrate the forward problem
2023-02-17 16:05:15 fides(INFO)    53| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-02 | 2.0E-02 | 4.7E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    20| +2.50E+02 | -1.8E-03 | +8.6E-01 | 1.0E-03 | 8.9E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     3| +2.92E+02 | -2.3E+02 | +8.9E-01 | 5.0E-01 | 9.8E+02 | 1.2E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    23| +2.12E+02 | -1.5E-02 | +1.2E-01 | 2.4E-02 | 4.6E+00 | 5.8E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    31| +1.54E+02 | -3.4E-03 | +9.9E-01 | 2.5E-01 | 1.7E+00 | 3.2E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    92| +1.78E+02 | +5.7E-04 | -5.2E+00 | 2.0E-02 | 5.3E-02 | 2.6E-02 |  2d |0
2023-02-17 16:05:15 fides(INFO)     4| +2.59E+02 | -3.3E+01 | +8.3E-01 | 1.0E+00 | 1.4E+02 | 2.4E+00 |  2d |1
2023-02-17 16:05:15 fides(INFO)    21| +2.50E+02 | +1.6E-05 | -1.5E-02 | 2.1E-03 | 4.4E-01 | 5.3E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)    54| +1.48E+02 | -2.6E-06 | +2.0E+00 | 7.8E-03 | 2.0E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    98| +1.70E+02 | +5.5E+00 | -4.3E-01 | 2.5E-01 | 4.4E+01 | 5.9E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    24| +2.12E+02 | -5.1E-02 | +8.9E-01 | 6.1E-03 | 6.2E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    22| +2.50E+02 | -4.4E-04 | +8.6E-01 | 5.1E-04 | 4.4E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     5| +2.59E+02 | +1.3E+03 | -8.4E+01 | 2.0E+00 | 3.4E+01 | 4.2E+00 |  2d |0
2023-02-17 16:05:15 fides(INFO)    32| +1.54E+02 | -3.9E-03 | +1.1E+00 | 5.0E-01 | 1.7E+00 | 5.7E-01 |  2d |1
2023-02-17 16:05:15.818 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 212.759 and h = 2.82009e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:15.818 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 212.759: AMICI failed to integrate the forward problem
2023-02-17 16:05:15 fides(INFO)    55| +1.48E+02 | +1.5E-06 | -8.5E-01 | 1.6E-02 | 4.7E-02 | 2.3E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)    23| +2.50E+02 | +2.0E-06 | -7.3E-03 | 1.0E-03 | 2.2E-01 | 2.6E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)    93| +1.78E+02 | +0.0E+00 | +0.0E+00 | 4.9E-03 | 5.3E-02 | 6.5E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)     6| +2.59E+02 | +2.7E+02 | -1.7E+01 | 5.0E-01 | 3.4E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:15 fides(INFO)    24| +2.50E+02 | -1.1E-04 | +8.6E-01 | 2.5E-04 | 2.2E-01 | 6.5E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    99| +1.66E+02 | -3.9E+00 | +8.5E-01 | 6.3E-02 | 4.4E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    80| +1.55E+02 | -1.4E-03 | +1.0E+00 | 2.2E-04 | 4.5E+00 | 4.0E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    25| +2.12E+02 | -3.8E-02 | +6.7E-01 | 1.2E-02 | 4.4E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    56| +1.48E+02 | +2.2E-06 | -3.4E+00 | 3.9E-03 | 4.7E-02 | 5.8E-04 |  2d |0
2023-02-17 16:05:15 fides(INFO)     7| +2.51E+02 | -8.3E+00 | +8.3E-01 | 1.2E-01 | 3.4E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    33| +1.54E+02 | -1.9E-03 | +6.5E-01 | 1.0E+00 | 4.6E-01 | 6.7E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    25| +2.50E+02 | +2.5E-07 | -3.6E-03 | 5.0E-04 | 1.1E-01 | 1.3E-03 |  2d |0
2023-02-17 16:05:15 fides(INFO)    94| +1.78E+02 | -5.8E-06 | +6.8E-01 | 1.2E-03 | 5.3E-02 | 1.6E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)     8| +2.51E+02 | +4.1E+00 | -1.5E+00 | 2.5E-01 | 1.8E+01 | 5.8E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    26| +2.50E+02 | -2.7E-05 | +8.6E-01 | 1.3E-04 | 1.1E-01 | 3.2E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    26| +2.12E+02 | -2.3E-02 | +6.2E-01 | 1.2E-02 | 3.1E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    57| +1.48E+02 | +2.5E-06 | -7.1E+00 | 9.8E-04 | 4.7E-02 | 1.5E-04 |  2d |0
2023-02-17 16:05:15 fides(INFO)    27| +2.50E+02 | +3.1E-08 | -1.8E-03 | 2.5E-04 | 5.5E-02 | 6.5E-04 |  2d |0
2023-02-17 16:05:15 fides(INFO)    34| +1.54E+02 | +9.7E-02 | -7.4E+00 | 1.0E+00 | 6.1E-01 | 2.0E-01 | trr |0
2023-02-17 16:05:15 fides(INFO)     9| +2.50E+02 | -1.3E+00 | +5.9E-01 | 6.2E-02 | 1.8E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)   100| +1.66E+02 | -9.8E-02 | -4.1E-02 | 1.3E-01 | 2.9E+01 | 3.0E-01 |  2d |0
2023-02-17 16:05:15 fides(INFO)    27| +2.12E+02 | -2.8E-02 | +6.3E-01 | 1.2E-02 | 3.8E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    95| +1.78E+02 | -1.4E-06 | +8.2E-01 | 1.2E-03 | 6.4E-02 | 6.1E-04 |  2d |1
2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 1.45E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    10| +2.50E+02 | -1.3E-02 | +1.4E-01 | 6.2E-02 | 4.1E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:15 fides(INFO)    28| +2.50E+02 | -6.7E-06 | +8.6E-01 | 6.2E-05 | 5.5E-02 | 1.6E-04 |  2d |1
2023-02-17 16:05:15 fides(INFO)    58| +1.48E+02 | +1.1E-06 | -3.8E+00 | 2.4E-04 | 4.7E-02 | 3.8E-05 |  2d |0
2023-02-17 16:05:15 fides(INFO)    29| +2.50E+02 | +3.8E-09 | -9.0E-04 | 1.2E-04 | 2.7E-02 | 3.2E-04 |  2d |0
2023-02-17 16:05:15 fides(INFO)    35| +1.54E+02 | -2.4E-03 | +5.6E-01 | 5.1E-02 | 6.1E-01 | 3.4E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    28| +2.12E+02 | -1.5E-02 | +4.4E-01 | 1.2E-02 | 2.9E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    11| +2.50E+02 | -3.7E-03 | +4.7E-02 | 1.6E-02 | 3.3E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)   101| +1.65E+02 | -1.3E+00 | +7.3E-01 | 3.1E-02 | 2.9E+01 | 7.6E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:15 fides(INFO)    30| +2.50E+02 | -1.7E-06 | +8.6E-01 | 3.1E-05 | 2.7E-02 | 8.1E-05 |  2d |1
2023-02-17 16:05:15 fides(WARNING) Stopping as function difference 1.67E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:15 fides(INFO)    59| +1.48E+02 | +4.8E-06 | -1.8E+01 | 6.1E-05 | 4.7E-02 | 1.4E-05 |  2d |0
2023-02-17 16:05:15 fides(INFO)    12| +2.50E+02 | -2.0E-02 | +8.9E-01 | 3.9E-03 | 3.3E+00 | 7.5E-03 |  2d |1
2023-02-17 16:05:15 fides(INFO)    29| +2.12E+02 | -2.6E-02 | +5.8E-01 | 1.2E-02 | 3.7E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    36| +1.54E+02 | -4.8E-04 | +1.0E+00 | 5.1E-02 | 2.1E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:15 fides(INFO)    13| +2.50E+02 | -9.9E-03 | +5.1E-01 | 7.8E-03 | 2.0E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)   102| +1.63E+02 | -1.7E+00 | +9.7E-01 | 3.1E-02 | 4.7E+01 | 6.4E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    60| +1.48E+02 | +3.8E-06 | -1.5E+01 | 1.5E-05 | 4.7E-02 | 1.1E-05 |  2d |0
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    30| +2.12E+02 | -1.1E-02 | +3.6E-01 | 1.2E-02 | 2.7E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    14| +2.50E+02 | -1.2E-05 | +3.7E-03 | 7.8E-03 | 6.2E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    61| +1.48E+02 | +3.9E-06 | -1.5E+01 | 3.8E-06 | 4.7E-02 | 1.0E-05 |  2d |0
2023-02-17 16:05:16 fides(INFO)    37| +1.54E+02 | -7.3E-04 | +1.2E+00 | 1.0E-01 | 2.7E-01 | 2.0E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    15| +2.50E+02 | -1.2E-03 | +6.7E-01 | 2.0E-03 | 6.4E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    31| +2.12E+02 | -2.3E-02 | +5.4E-01 | 1.2E-02 | 3.5E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)     0| +1.33E+09 |    NaN   |    NaN   | 1.0E+00 | 6.1E+09 |   NaN   | NaN |1
2023-02-17 16:05:16 fides(INFO)    62| +1.48E+02 | +5.4E-06 | -5.3E+01 | 9.5E-07 | 4.7E-02 | 2.5E-06 |  2d |0
2023-02-17 16:05:16 fides(INFO)    16| +2.50E+02 | -1.4E-05 | +9.4E-01 | 2.0E-03 | 1.1E-02 | 4.7E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    38| +1.54E+02 | -6.6E-05 | +8.6E-02 | 2.0E-01 | 1.3E-01 | 2.8E-02 | trr |1
2023-02-17 16:05:16 fides(INFO)   103| +1.61E+02 | -2.2E+00 | +8.5E-01 | 6.3E-02 | 2.6E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    81| +1.55E+02 | -1.9E-03 | +1.0E+00 | 4.4E-04 | 3.4E+00 | 8.2E-04 |  2d |1
2023-02-17 16:05:16 fides(INFO)     1| +1.40E+06 | -1.3E+09 | +9.5E-02 | 1.0E+00 | 6.1E+09 | 2.8E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)     0| +1.62E+11 |    NaN   |    NaN   | 1.0E+00 | 7.4E+11 |   NaN   | NaN |1
2023-02-17 16:05:16 fides(INFO)    32| +2.12E+02 | -9.2E-03 | +3.1E-01 | 1.2E-02 | 2.6E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    17| +2.50E+02 | -2.8E-05 | +9.4E-01 | 3.9E-03 | 1.7E-02 | 9.3E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    63| +1.48E+02 | +3.6E-06 | -1.3E+02 | 2.4E-07 | 4.7E-02 | 6.2E-07 |  2d |0
2023-02-17 16:05:16 fides(INFO)    18| +2.50E+02 | -5.7E-05 | +9.7E-01 | 7.8E-03 | 2.0E-02 | 1.9E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    39| +1.54E+02 | +4.5E-03 | -1.1E+00 | 3.1E-02 | 2.8E-01 | 6.3E-02 |  2d |0
2023-02-17 16:05:16 fides(INFO)   104| +1.58E+02 | -2.9E+00 | +6.1E-01 | 1.3E-01 | 4.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)     2| +2.19E+05 | -1.2E+06 | +9.0E-01 | 2.5E-01 | 6.4E+06 | 5.9E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    64| +1.48E+02 | +4.2E-06 | -5.8E+02 | 6.0E-08 | 4.7E-02 | 1.6E-07 |  2d |0
2023-02-17 16:05:16 fides(INFO)     1| +1.28E+06 | -1.6E+11 | +9.1E-02 | 1.0E+00 | 7.4E+11 | 2.9E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    33| +2.12E+02 | -2.0E-02 | +5.0E-01 | 1.2E-02 | 3.3E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    19| +2.50E+02 | -1.2E-04 | +1.0E+00 | 1.6E-02 | 2.3E-02 | 3.7E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)     3| +3.43E+04 | -1.8E+05 | +9.0E-01 | 5.0E-01 | 1.0E+06 | 9.3E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)     2| +2.77E+05 | -1.0E+06 | +8.9E-01 | 2.5E-01 | 4.6E+06 | 6.2E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    40| +1.54E+02 | -8.6E-04 | +6.4E-01 | 7.8E-03 | 2.8E-01 | 1.6E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    20| +2.50E+02 | -2.6E-04 | +1.0E+00 | 3.1E-02 | 2.5E-02 | 7.5E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    65| +1.48E+02 | +8.8E-07 | -4.9E+02 | 1.5E-08 | 4.7E-02 | 3.9E-08 |  2d |0
2023-02-17 16:05:16 fides(INFO)    34| +2.12E+02 | -8.1E-03 | +2.9E-01 | 1.2E-02 | 2.4E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)   105| +1.54E+02 | -4.0E+00 | +6.8E-01 | 1.3E-01 | 3.6E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)     4| +5.57E+03 | -2.9E+04 | +9.0E-01 | 5.0E-01 | 1.6E+05 | 8.9E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    21| +2.50E+02 | -6.0E-04 | +1.1E+00 | 6.2E-02 | 2.9E-02 | 1.5E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)     3| +4.42E+04 | -2.3E+05 | +9.0E-01 | 5.0E-01 | 8.5E+05 | 1.2E+00 |  2d |1
2023-02-17 16:05:16.222 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0112 and h = 1.07533e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:16.223 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0112: AMICI failed to integrate the forward problem
2023-02-17 16:05:16 fides(INFO)    66| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.7E-09 | 4.7E-02 | 9.7E-09 |  2d |0
2023-02-17 16:05:16 fides(INFO)    22| +2.50E+02 | -1.6E-03 | +1.2E+00 | 1.2E-01 | 3.1E-02 | 3.0E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    41| +1.54E+02 | -1.2E-04 | +6.7E-01 | 7.8E-03 | 8.3E-02 | 6.4E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    35| +2.12E+02 | -1.7E-02 | +4.6E-01 | 1.2E-02 | 3.1E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)     5| +1.06E+03 | -4.5E+03 | +9.0E-01 | 5.0E-01 | 2.5E+04 | 8.7E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)     4| +7.14E+03 | -3.7E+04 | +9.0E-01 | 1.0E+00 | 1.3E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    67| +1.48E+02 | +3.4E-06 | -3.0E+04 | 9.3E-10 | 4.7E-02 | 2.4E-09 |  2d |0
2023-02-17 16:05:16 fides(INFO)    23| +2.50E+02 | -5.9E-03 | +1.5E+00 | 2.5E-01 | 3.8E-02 | 5.8E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)     5| +1.28E+03 | -5.9E+03 | +9.0E-01 | 1.0E+00 | 2.1E+04 | 1.4E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)     6| +3.55E+02 | -7.0E+02 | +9.0E-01 | 5.0E-01 | 3.9E+03 | 1.1E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    36| +2.12E+02 | -7.5E-03 | +2.8E-01 | 1.2E-02 | 2.3E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)   106| +1.54E+02 | +5.3E+00 | -1.0E+00 | 1.3E-01 | 5.8E+01 | 2.9E-01 |  2d |0
2023-02-17 16:05:16 fides(INFO)    42| +1.54E+02 | -4.8E-05 | +2.0E-01 | 7.8E-03 | 1.1E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    24| +2.50E+02 | -3.9E-02 | +2.2E+00 | 5.0E-01 | 4.4E-02 | 1.1E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)     6| +3.74E+02 | -9.1E+02 | +9.0E-01 | 1.0E+00 | 3.4E+03 | 1.7E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    68| +1.48E+02 | +3.9E-06 | -1.4E+05 | 2.3E-10 | 4.7E-02 | 6.1E-10 |  2d |0
2023-02-17 16:05:16 fides(INFO)     7| +2.50E+02 | -1.1E+02 | +9.0E-01 | 1.0E+00 | 6.1E+02 | 1.8E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    37| +2.12E+02 | -1.5E-02 | +4.4E-01 | 1.2E-02 | 2.9E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)     7| +2.55E+02 | -1.2E+02 | +8.7E-01 | 1.0E+00 | 5.3E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    43| +1.54E+02 | -1.0E-04 | +7.9E-01 | 1.9E-03 | 7.6E-02 | 3.7E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    69| +1.48E+02 | +3.7E-07 | -5.2E+04 | 5.8E-11 | 4.7E-02 | 1.5E-10 |  2d |0
2023-02-17 16:05:16 fides(INFO)    25| +2.49E+02 | -8.1E-01 | +4.2E+00 | 1.0E+00 | 1.7E-01 | 2.1E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    38| +2.12E+02 | -7.2E-03 | +2.8E-01 | 1.2E-02 | 2.2E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)     8| +2.41E+02 | -8.4E+00 | +7.4E-01 | 2.0E+00 | 7.8E+01 | 5.9E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)   107| +1.54E+02 | +1.2E+00 | -4.8E-01 | 3.1E-02 | 5.8E+01 | 7.7E-02 |  2d |0
2023-02-17 16:05:16 fides(INFO)     8| +2.39E+02 | -1.5E+01 | +1.2E+00 | 2.0E+00 | 5.9E+01 | 3.9E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    26| +2.32E+02 | -1.7E+01 | +5.1E+00 | 2.0E+00 | 2.5E+00 | 3.9E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    82| +1.55E+02 | -2.1E-03 | +9.8E-01 | 8.8E-04 | 1.7E+00 | 1.7E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    44| +1.54E+02 | -5.7E-05 | +5.3E-01 | 3.9E-03 | 1.0E-01 | 5.3E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    70| +1.48E+02 | +4.8E-06 | -2.7E+06 | 1.5E-11 | 4.7E-02 | 3.8E-11 |  2d |0
2023-02-17 16:05:16 fides(INFO)     9| +2.33E+02 | -8.3E+00 | +6.4E-01 | 2.0E+00 | 1.4E+01 | 2.9E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    39| +2.12E+02 | -1.3E-02 | +4.2E-01 | 1.2E-02 | 2.7E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)     9| +2.39E+02 | +6.9E+01 | -1.4E+01 | 4.0E+00 | 3.0E+01 | 6.6E+00 |  2d |0
2023-02-17 16:05:16 fides(INFO)   108| +1.54E+02 | -5.2E-01 | +5.3E-01 | 7.9E-03 | 5.8E+01 | 2.0E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    45| +1.54E+02 | -4.4E-05 | +4.6E-01 | 3.9E-03 | 5.3E-02 | 5.4E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    71| +1.48E+02 | +4.2E-06 | -9.5E+06 | 3.6E-12 | 4.7E-02 | 9.5E-12 |  2d |0
2023-02-17 16:05:16 fides(INFO)    27| +2.32E+02 | +2.5E+02 | -1.5E+01 | 4.0E+00 | 3.4E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    40| +2.12E+02 | -7.0E-03 | +2.8E-01 | 1.2E-02 | 2.1E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    10| +2.39E+02 | +1.5E+01 | -1.6E+00 | 1.0E+00 | 3.0E+01 | 1.7E+00 |  2d |0
2023-02-17 16:05:16 fides(INFO)    28| +2.32E+02 | +1.9E+01 | -1.8E+00 | 1.0E+00 | 3.4E+01 | 3.0E+00 |  2d |0
2023-02-17 16:05:16 fides(INFO)    72| +1.48E+02 | +2.0E-06 | -1.8E+07 | 9.1E-13 | 4.7E-02 | 2.4E-12 |  2d |0
2023-02-17 16:05:16 fides(INFO)    11| +2.39E+02 | +1.2E+01 | -1.4E+00 | 2.5E-01 | 3.0E+01 | 6.3E-01 |  2d |0
2023-02-17 16:05:16 fides(INFO)    46| +1.54E+02 | -2.3E-05 | +2.1E-01 | 3.9E-03 | 7.2E-02 | 6.6E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)   109| +1.53E+02 | -2.4E-01 | +9.9E-01 | 7.9E-03 | 2.4E+01 | 1.6E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    41| +2.12E+02 | -1.2E-02 | +4.1E-01 | 1.2E-02 | 2.5E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    29| +2.32E+02 | +8.3E+00 | -8.0E-01 | 2.5E-01 | 3.4E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:16 fides(INFO)    12| +2.36E+02 | -3.5E+00 | +8.4E-01 | 6.2E-02 | 3.0E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    73| +1.48E+02 | -2.3E-06 | +8.4E+07 | 2.3E-13 | 4.7E-02 | 5.9E-13 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    30| +2.28E+02 | -4.1E+00 | +8.7E-01 | 6.2E-02 | 3.4E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    42| +2.12E+02 | -6.9E-03 | +3.0E-01 | 1.2E-02 | 2.0E+00 | 3.2E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    13| +2.35E+02 | -1.2E+00 | +3.5E-01 | 1.2E-01 | 1.8E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    47| +1.54E+02 | -3.3E-05 | +8.3E-01 | 9.7E-04 | 4.4E-02 | 1.8E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    31| +2.28E+02 | -3.7E-01 | +6.1E-02 | 1.2E-01 | 2.1E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    74| +1.48E+02 | +1.5E-07 | -2.7E+06 | 4.5E-13 | 4.7E-02 | 1.2E-12 |  2d |0
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)   110| +1.53E+02 | -3.9E-01 | +9.0E-01 | 1.6E-02 | 1.9E+01 | 3.5E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    14| +2.31E+02 | -3.8E+00 | +7.4E-01 | 1.2E-01 | 3.9E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    43| +2.12E+02 | -1.1E-02 | +4.2E-01 | 1.2E-02 | 2.4E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    32| +2.26E+02 | -1.8E+00 | +9.2E-01 | 3.1E-02 | 4.1E+01 | 5.6E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    48| +1.54E+02 | -2.4E-05 | +5.7E-01 | 1.9E-03 | 6.1E-02 | 3.1E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    75| +1.48E+02 | +6.5E-06 | -4.7E+08 | 1.1E-13 | 4.7E-02 | 3.0E-13 |  2d |0
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    10| +2.13E+02 | -1.9E+01 | +7.5E-01 | 2.0E+00 | 3.3E+01 | 4.2E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    15| +2.29E+02 | -1.6E+00 | +4.5E-01 | 1.2E-01 | 2.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    33| +2.24E+02 | -1.9E+00 | +8.4E-01 | 6.2E-02 | 2.9E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    44| +2.12E+02 | -7.0E-03 | +3.2E-01 | 1.2E-02 | 1.9E+00 | 3.2E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    16| +2.26E+02 | -3.5E+00 | +7.4E-01 | 1.2E-01 | 3.7E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    76| +1.48E+02 | +8.7E-06 | -2.5E+09 | 2.8E-14 | 4.7E-02 | 7.4E-14 |  2d |0
2023-02-17 16:05:16 fides(INFO)   111| +1.52E+02 | -5.8E-01 | +9.4E-01 | 3.1E-02 | 2.7E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    49| +1.54E+02 | -1.9E-05 | +6.5E-01 | 1.9E-03 | 4.1E-02 | 2.5E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    34| +2.21E+02 | -3.0E+00 | +1.1E+00 | 1.2E-01 | 1.7E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    17| +2.24E+02 | -1.4E+00 | +4.0E-01 | 1.2E-01 | 2.0E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    45| +2.12E+02 | -1.0E-02 | +4.3E-01 | 1.2E-02 | 2.2E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    83| +1.55E+02 | -1.3E-03 | +9.9E-01 | 1.8E-03 | 1.6E+00 | 3.3E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    11| +2.13E+02 | +2.1E+02 | -1.6E+01 | 2.0E+00 | 4.2E+01 | 4.5E+00 |  2d |0
2023-02-17 16:05:16 fides(INFO)    77| +1.48E+02 | +5.7E-06 | -6.6E+09 | 7.1E-15 | 4.7E-02 | 1.9E-14 |  2d |0
2023-02-17 16:05:16 fides(INFO)    35| +2.19E+02 | -2.2E+00 | +8.5E-01 | 2.5E-01 | 1.8E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    18| +2.21E+02 | -3.2E+00 | +7.2E-01 | 1.2E-01 | 3.6E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    50| +1.54E+02 | -1.3E-05 | +4.5E-01 | 1.9E-03 | 3.6E-02 | 3.0E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    46| +2.12E+02 | -1.9E-02 | +9.6E-01 | 1.2E-02 | 1.8E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    36| +2.18E+02 | -8.3E-01 | +7.5E-02 | 5.0E-01 | 2.4E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    78| +1.48E+02 | +5.4E-06 | -2.5E+10 | 1.8E-15 | 4.7E-02 | 4.6E-15 |  2d |0
2023-02-17 16:05:16 fides(INFO)   112| +1.52E+02 | -7.8E-01 | +9.4E-01 | 6.3E-02 | 1.6E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    19| +2.20E+02 | -8.3E-01 | +2.6E-01 | 1.2E-01 | 1.9E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    37| +2.14E+02 | -3.7E+00 | +6.3E-01 | 1.2E-01 | 4.5E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    51| +1.54E+02 | -9.0E-06 | +2.6E-01 | 1.9E-03 | 3.7E-02 | 3.6E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    47| +2.12E+02 | +3.2E-02 | -8.1E-01 | 2.4E-02 | 1.2E+00 | 5.0E-02 |  2d |0
2023-02-17 16:05:16 fides(INFO)    79| +1.48E+02 | +4.8E-06 | -8.8E+10 | 4.4E-16 | 4.7E-02 | 1.2E-15 |  2d |0
2023-02-17 16:05:16 fides(WARNING) Stopping as trust region radius 1.11E-16 is smaller than machine precision.
2023-02-17 16:05:16 fides(INFO)    38| +2.13E+02 | -1.1E+00 | +5.1E-01 | 1.2E-01 | 1.4E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    20| +2.18E+02 | -2.7E+00 | +6.5E-01 | 1.2E-01 | 3.5E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    48| +2.12E+02 | -5.5E-03 | +5.2E-01 | 6.1E-03 | 1.2E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    52| +1.54E+02 | -7.7E-06 | +2.0E-01 | 1.9E-03 | 2.8E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    39| +2.11E+02 | -2.1E+00 | +7.8E-01 | 1.2E-01 | 2.4E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)   113| +1.51E+02 | -4.7E-01 | +5.7E-01 | 1.3E-01 | 1.7E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    21| +2.16E+02 | -1.1E+00 | +4.0E-01 | 1.2E-01 | 1.7E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    49| +2.12E+02 | -7.4E-03 | +9.4E-01 | 6.1E-03 | 1.3E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)    53| +1.54E+02 | -9.0E-06 | +8.1E-01 | 4.9E-04 | 3.4E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    40| +2.07E+02 | -3.4E+00 | +8.4E-01 | 2.5E-01 | 1.2E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    22| +2.13E+02 | -3.0E+00 | +7.8E-01 | 1.2E-01 | 2.8E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:16.826 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 106.88 and h = 5.48355e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:16.826 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 106.88: AMICI failed to integrate the forward problem
2023-02-17 16:05:16 fides(INFO)    12| +2.13E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 4.2E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:16 fides(INFO)    41| +1.94E+02 | -1.4E+01 | +1.5E+00 | 5.0E-01 | 2.6E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)    50| +2.12E+02 | +1.7E-03 | -1.1E-01 | 1.2E-02 | 1.1E+00 | 2.3E-02 |  2d |0
2023-02-17 16:05:16 fides(INFO)    54| +1.54E+02 | -6.0E-06 | +5.0E-01 | 9.7E-04 | 2.3E-02 | 1.8E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    23| +2.06E+02 | -7.7E+00 | +1.2E+00 | 2.5E-01 | 1.6E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    84| +1.55E+02 | -2.7E-03 | +1.0E+00 | 3.5E-03 | 1.4E+00 | 6.4E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:16 fides(INFO)     0| +1.85E+12 |    NaN   |    NaN   | 1.0E+00 | 8.5E+12 |   NaN   | NaN |1
2023-02-17 16:05:16 fides(INFO)    51| +2.12E+02 | -3.0E-03 | +6.5E-01 | 3.1E-03 | 1.1E+00 | 6.3E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    42| +1.94E+02 | +5.1E+03 | -1.7E+02 | 1.0E+00 | 2.9E+01 | 2.2E+00 | trr |0
2023-02-17 16:05:16 fides(INFO)     1| +2.10E+09 | -1.8E+12 | +8.5E-02 | 1.0E+00 | 8.5E+12 | 3.1E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    24| +1.95E+02 | -1.0E+01 | +5.5E-01 | 5.0E-01 | 3.5E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    55| +1.54E+02 | -4.6E-06 | +4.7E-01 | 9.7E-04 | 1.7E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)   114| +1.51E+02 | -1.6E-01 | +3.1E-01 | 1.3E-01 | 2.1E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    52| +2.12E+02 | -3.7E-03 | +1.0E+00 | 3.1E-03 | 1.0E+00 | 6.3E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    43| +1.77E+02 | -1.7E+01 | +1.0E+00 | 2.5E-01 | 2.9E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)     2| +3.18E+08 | -1.8E+09 | +8.9E-01 | 2.5E-01 | 9.7E+09 | 7.1E-01 |  2d |1
2023-02-17 16:05:16 fides(INFO)    25| +1.75E+02 | -2.1E+01 | +8.6E-01 | 5.0E-01 | 6.0E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    56| +1.54E+02 | -2.9E-06 | +2.9E-01 | 9.7E-04 | 2.0E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:16 fides(INFO)    44| +1.77E+02 | -1.2E+01 | -2.0E-01 | 5.0E-01 | 9.9E+01 | 9.3E-01 |  2d |0
2023-02-17 16:05:16 fides(INFO)    53| +2.12E+02 | -7.0E-03 | +1.0E+00 | 6.1E-03 | 9.4E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:16 fides(INFO)     3| +4.90E+07 | -2.7E+08 | +8.9E-01 | 5.0E-01 | 1.5E+09 | 1.4E+00 |  2d |1
2023-02-17 16:05:16 fides(INFO)    26| +1.75E+02 | +6.0E+04 | -1.8E+03 | 1.0E+00 | 1.0E+02 | 2.2E+00 |  2d |0
2023-02-17 16:05:16 fides(INFO)     4| +7.48E+06 | -4.2E+07 | +8.9E-01 | 1.0E+00 | 2.2E+08 | 1.0E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    57| +1.54E+02 | -3.3E-06 | +3.1E-01 | 9.7E-04 | 1.4E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    45| +1.66E+02 | -1.1E+01 | +9.8E-01 | 1.2E-01 | 9.9E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    54| +2.12E+02 | -1.2E-02 | +9.9E-01 | 1.2E-02 | 8.8E-01 | 2.9E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    27| +1.63E+02 | -1.2E+01 | +3.7E-01 | 2.5E-01 | 1.0E+02 | 5.4E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)     5| +1.15E+06 | -6.3E+06 | +9.0E-01 | 1.0E+00 | 3.4E+07 | 1.1E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    13| +2.06E+02 | -7.3E+00 | +8.5E-01 | 1.2E-01 | 4.2E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    58| +1.54E+02 | -6.0E-07 | +6.4E-02 | 9.7E-04 | 1.5E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)     6| +1.78E+05 | -9.7E+05 | +9.0E-01 | 1.0E+00 | 5.2E+06 | 1.3E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    46| +1.52E+02 | -1.4E+01 | +7.9E-01 | 2.5E-01 | 5.9E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)   115| +1.51E+02 | -5.6E-03 | +1.3E-02 | 1.3E-01 | 1.6E+01 | 7.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    55| +2.12E+02 | -2.5E-02 | +1.0E+00 | 2.4E-02 | 8.6E-01 | 6.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    28| +1.51E+02 | -1.2E+01 | +9.6E-01 | 2.5E-01 | 2.5E+02 | 3.5E-01 | trr |1
2023-02-17 16:05:17 fides(INFO)     7| +2.79E+04 | -1.5E+05 | +9.0E-01 | 1.0E+00 | 8.1E+05 | 8.1E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)     8| +4.54E+03 | -2.3E+04 | +9.0E-01 | 1.0E+00 | 1.3E+05 | 7.8E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    85| +1.55E+02 | -3.3E-03 | +1.0E+00 | 7.0E-03 | 1.9E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    47| +1.51E+02 | -1.3E+00 | +2.1E-01 | 5.0E-01 | 1.1E+02 | 5.1E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    59| +1.54E+02 | -3.0E-06 | +8.6E-01 | 2.4E-04 | 1.1E-02 | 5.2E-04 |  2d |1
2023-02-17 16:05:17 fides(INFO)    56| +2.12E+02 | -5.2E-02 | +1.1E+00 | 4.9E-02 | 8.0E-01 | 1.3E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    29| +1.51E+02 | +5.9E-01 | -2.9E-01 | 2.5E-01 | 5.0E+01 | 3.4E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)     9| +8.89E+02 | -3.7E+03 | +9.0E-01 | 1.0E+00 | 2.0E+04 | 8.8E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    57| +2.11E+02 | -1.3E-01 | +1.2E+00 | 9.8E-02 | 1.0E+00 | 2.6E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    48| +1.48E+02 | -2.4E+00 | +8.2E-01 | 1.0E-01 | 6.8E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    10| +3.24E+02 | -5.7E+02 | +9.1E-01 | 1.0E+00 | 3.1E+03 | 1.6E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    30| +1.50E+02 | -1.3E+00 | +8.1E-01 | 6.2E-02 | 5.0E+01 | 9.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    60| +1.54E+02 | -2.0E-06 | +5.0E-01 | 4.9E-04 | 2.5E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    11| +2.37E+02 | -8.7E+01 | +9.3E-01 | 1.0E+00 | 4.7E+02 | 1.8E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    58| +2.11E+02 | -5.4E-01 | +1.7E+00 | 2.0E-01 | 2.1E+00 | 5.4E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)   116| +1.51E+02 | -1.1E-01 | +9.8E-01 | 1.1E-02 | 7.6E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    49| +1.48E+02 | +1.3E+00 | -1.0E+00 | 2.1E-01 | 2.4E+01 | 2.4E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)    31| +1.49E+02 | -7.1E-01 | +6.6E-01 | 1.2E-01 | 4.5E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    61| +1.54E+02 | -9.9E-07 | +4.4E-01 | 4.9E-04 | 9.8E-03 | 8.5E-04 |  2d |1
2023-02-17 16:05:17 fides(WARNING) Stopping as function difference 9.90E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:17.202 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 148.098 and h = 1.74276e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:17.202 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 148.098: AMICI failed to integrate the forward problem
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    59| +2.07E+02 | -3.4E+00 | +2.0E+00 | 3.9E-01 | 5.3E+00 | 1.0E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    50| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.1E-02 | 2.4E+01 | 7.1E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    12| +2.37E+02 | -3.1E+01 | -7.3E-01 | 2.0E+00 | 5.8E+01 | 2.8E+00 |  2d |0
2023-02-17 16:05:17 fides(INFO)    32| +1.49E+02 | +9.6E-02 | -1.4E-01 | 1.2E-01 | 3.0E+01 | 1.9E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    60| +2.07E+02 | +9.3E+01 | -1.7E+01 | 7.8E-01 | 1.9E+01 | 2.0E+00 |  2d |0
2023-02-17 16:05:17 fides(INFO)    13| +2.24E+02 | -1.2E+01 | +9.6E-01 | 5.0E-01 | 5.8E+01 | 7.2E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    61| +2.05E+02 | -2.5E+00 | +9.4E-01 | 2.0E-01 | 1.9E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    33| +1.48E+02 | -7.1E-01 | +8.5E-01 | 3.1E-02 | 3.0E+01 | 5.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    51| +1.48E+02 | -3.1E-01 | +8.5E-01 | 1.3E-02 | 2.4E+01 | 2.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    14| +1.90E+02 | -1.6E+01 | +1.2E+00 | 2.5E-01 | 3.8E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    62| +1.99E+02 | -5.8E+00 | +3.0E-01 | 3.9E-01 | 3.2E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:17.296 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.7814 and h = 9.97554e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:17.296 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.7814: AMICI failed to integrate the forward problem
2023-02-17 16:05:17 fides(INFO)    52| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.6E-02 | 2.4E+01 | 2.3E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)   117| +1.51E+02 | -4.8E-02 | +9.2E-01 | 2.3E-02 | 5.6E+00 | 3.5E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    34| +1.48E+02 | -2.2E-01 | +9.6E-01 | 6.2E-02 | 2.2E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    14| +2.24E+02 | -3.2E+00 | -2.8E+00 | 1.0E+00 | 3.1E+01 | 1.6E+00 |  2d |0
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)     0| +8.25E+04 |    NaN   |    NaN   | 1.0E+00 | 3.8E+05 |   NaN   | NaN |1
2023-02-17 16:05:17 fides(INFO)    53| +1.48E+02 | -1.0E-01 | +9.5E-01 | 6.4E-03 | 2.4E+01 | 8.8E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    63| +1.93E+02 | -6.6E+00 | +1.4E-01 | 3.9E-01 | 8.1E+01 | 8.7E-01 |  2d |1
2023-02-17 16:05:17.330 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.4894 and h = 1.16646e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:17.330 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.4894: AMICI failed to integrate the forward problem
2023-02-17 16:05:17 fides(INFO)    35| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 1.2E+01 | 1.2E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)     1| +3.63E+02 | -8.2E+04 | +1.1E-01 | 1.0E+00 | 3.8E+05 | 2.4E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    15| +2.20E+02 | -4.9E+00 | +3.7E-01 | 2.5E-01 | 3.1E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    36| +1.48E+02 | -1.2E-01 | +9.0E-01 | 3.1E-02 | 1.2E+01 | 3.5E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    64| +1.81E+02 | -1.2E+01 | +7.5E-01 | 9.8E-02 | 9.0E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)     2| +3.32E+02 | -3.2E+01 | +9.2E-01 | 2.5E-01 | 5.0E+01 | 7.4E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    54| +1.48E+02 | -1.2E-01 | +7.6E-01 | 1.3E-02 | 1.3E+01 | 2.3E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)   118| +1.51E+02 | -6.4E-03 | +1.5E+00 | 2.3E-02 | 1.2E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    16| +2.06E+02 | -1.3E+01 | +8.9E-01 | 2.5E-01 | 7.9E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    86| +1.55E+02 | -4.1E-03 | +3.6E-01 | 1.4E-02 | 1.0E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    65| +1.81E+02 | +1.6E+00 | -1.2E-01 | 2.0E-01 | 4.8E+01 | 5.1E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)     3| +2.77E+02 | -5.5E+01 | +9.8E-01 | 5.0E-01 | 3.7E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    37| +1.48E+02 | -1.1E-01 | +9.5E-01 | 6.2E-02 | 2.1E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)     4| +2.77E+02 | +6.4E+03 | -2.6E+02 | 1.0E+00 | 4.2E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:17 fides(INFO)    55| +1.48E+02 | -6.5E-02 | +9.1E-01 | 2.6E-02 | 1.9E+01 | 1.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    66| +1.75E+02 | -5.4E+00 | +9.3E-01 | 4.9E-02 | 4.8E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    17| +1.79E+02 | -2.8E+01 | +1.1E+00 | 5.0E-01 | 3.2E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:17 fides(INFO)    38| +1.48E+02 | -9.0E-02 | +8.3E-01 | 1.2E-01 | 6.6E+00 | 8.6E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)     5| +2.54E+02 | -2.2E+01 | +9.0E-01 | 2.5E-01 | 4.2E+01 | 6.8E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    56| +1.48E+02 | -2.7E-02 | +5.2E-01 | 5.1E-02 | 4.7E+00 | 3.5E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    67| +1.67E+02 | -8.4E+00 | +1.0E+00 | 9.8E-02 | 4.1E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    18| +1.79E+02 | +1.8E+03 | -8.2E+01 | 1.0E+00 | 1.2E+02 | 1.8E+00 |  2d |0
2023-02-17 16:05:17 fides(INFO)     6| +2.54E+02 | +7.1E+01 | -7.5E+00 | 5.0E-01 | 2.8E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:17.483 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 125.418 and h = 8.51644e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:17.484 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 125.418: AMICI failed to integrate the forward problem
2023-02-17 16:05:17 fides(INFO)   119| +1.51E+02 | +0.0E+00 | +0.0E+00 | 2.3E-02 | 1.5E+00 | 4.8E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    39| +1.48E+02 | +1.2E+00 | -5.1E+00 | 2.5E-01 | 7.7E+00 | 3.1E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)     7| +2.50E+02 | -4.2E+00 | +5.5E-01 | 1.2E-01 | 2.8E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    57| +1.48E+02 | -1.1E-02 | +2.6E-01 | 5.1E-02 | 9.1E+00 | 5.9E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    68| +1.62E+02 | -4.6E+00 | +4.8E-01 | 2.0E-01 | 4.1E+01 | 3.5E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    40| +1.48E+02 | +1.3E-03 | -2.5E-02 | 6.2E-02 | 7.7E+00 | 7.9E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    15| +1.90E+02 | +4.9E+01 | -2.8E+00 | 5.0E-01 | 4.8E+01 | 1.0E+00 |  2d |0
2023-02-17 16:05:17 fides(INFO)    19| +1.60E+02 | -1.8E+01 | +8.4E-01 | 2.5E-01 | 1.2E+02 | 4.3E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)     8| +2.50E+02 | -1.6E-01 | +2.4E-01 | 1.2E-01 | 1.2E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    58| +1.48E+02 | +8.0E-02 | -1.2E+00 | 5.1E-02 | 2.2E+00 | 5.7E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    69| +1.51E+02 | -1.2E+01 | +7.2E-01 | 2.0E-01 | 6.9E+01 | 4.9E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    20| +1.51E+02 | -9.0E+00 | +8.8E-01 | 5.0E-01 | 1.2E+02 | 6.7E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)     9| +2.50E+02 | -9.9E-02 | +2.6E-01 | 3.1E-02 | 7.6E+00 | 8.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    41| +1.48E+02 | -2.0E-02 | +7.7E-01 | 1.6E-02 | 7.7E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    10| +2.50E+02 | -3.4E-02 | +1.9E-01 | 3.1E-02 | 5.7E+00 | 5.8E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    59| +1.48E+02 | -5.2E-04 | +4.9E-03 | 1.3E-02 | 2.2E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    70| +1.51E+02 | +2.7E+02 | -7.7E+00 | 2.0E-01 | 8.4E+01 | 5.1E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)   120| +1.51E+02 | -5.6E-03 | +1.1E+00 | 5.7E-03 | 1.5E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    21| +1.50E+02 | -1.9E+00 | +3.7E-01 | 1.0E+00 | 9.2E+01 | 5.6E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    42| +1.48E+02 | -1.3E-02 | +7.5E-01 | 3.1E-02 | 3.5E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    11| +2.50E+02 | -5.3E-02 | +7.6E-01 | 7.8E-03 | 4.2E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    71| +1.51E+02 | +1.2E+01 | -1.2E+00 | 4.9E-02 | 8.4E+01 | 1.3E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    60| +1.48E+02 | -8.1E-03 | +9.6E-01 | 3.2E-03 | 6.6E+00 | 4.2E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    12| +2.50E+02 | +1.6E-04 | -2.7E-02 | 1.6E-02 | 1.0E+00 | 3.9E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    22| +1.50E+02 | +9.7E+01 | -1.7E+01 | 1.0E+00 | 7.2E+01 | 1.9E+00 | trr |0
2023-02-17 16:05:17 fides(INFO)    43| +1.48E+02 | -1.5E-02 | +8.0E-01 | 6.2E-02 | 4.6E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    87| +1.55E+02 | -1.2E-02 | +1.1E+00 | 1.4E-02 | 6.1E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    13| +2.50E+02 | -1.8E-03 | +3.1E-01 | 3.9E-03 | 1.0E+00 | 9.9E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    72| +1.49E+02 | -1.3E+00 | +4.8E-01 | 1.2E-02 | 8.4E+01 | 3.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    61| +1.48E+02 | -5.4E-03 | +8.5E-01 | 6.4E-03 | 2.1E+00 | 8.1E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    44| +1.48E+02 | +4.5E-02 | -1.5E+00 | 1.2E-01 | 1.9E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)    23| +1.50E+02 | +2.6E+00 | -9.5E-01 | 2.2E-01 | 7.2E+01 | 4.7E-01 |  2d |0
2023-02-17 16:05:17.680 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 148.597 and h = 1.48907e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:17.680 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 148.597: AMICI failed to integrate the forward problem
2023-02-17 16:05:17 fides(INFO)   121| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.1E-02 | 6.2E-01 | 2.4E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    14| +2.50E+02 | -2.2E-04 | +8.8E-02 | 3.9E-03 | 6.6E-01 | 7.3E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    73| +1.49E+02 | -5.1E-01 | +9.6E-01 | 1.2E-02 | 2.2E+01 | 2.8E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    62| +1.48E+02 | -5.5E-03 | +7.8E-01 | 1.3E-02 | 2.6E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    45| +1.48E+02 | -6.4E-03 | +5.3E-01 | 3.1E-02 | 1.9E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    15| +2.50E+02 | -9.5E-04 | +7.9E-01 | 9.8E-04 | 5.9E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    24| +1.49E+02 | -8.5E-01 | +7.4E-01 | 5.6E-02 | 7.2E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    74| +1.48E+02 | -3.2E-01 | +5.1E-01 | 2.4E-02 | 1.9E+01 | 6.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    16| +1.80E+02 | -9.8E+00 | +1.0E+00 | 1.2E-01 | 4.8E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    16| +2.50E+02 | +8.8E-07 | -5.1E-03 | 2.0E-03 | 1.8E-01 | 4.9E-03 |  2d |0
2023-02-17 16:05:17 fides(INFO)    63| +1.48E+02 | -2.1E-03 | +5.0E-01 | 2.6E-02 | 8.1E-01 | 2.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    46| +1.48E+02 | -5.4E-03 | +6.0E-01 | 3.1E-02 | 3.7E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    25| +1.48E+02 | -8.8E-01 | +6.9E-01 | 5.6E-02 | 2.2E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    17| +2.50E+02 | -8.9E-05 | +5.8E-01 | 4.9E-04 | 1.8E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    75| +1.48E+02 | -3.1E-01 | +5.0E-01 | 2.4E-02 | 4.2E+01 | 4.6E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    18| +2.50E+02 | -7.5E-09 | +1.1E-03 | 4.9E-04 | 3.3E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    64| +1.48E+02 | -1.5E-03 | +7.8E-01 | 2.6E-02 | 9.6E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    47| +1.48E+02 | -2.6E-03 | +4.2E-01 | 3.1E-02 | 9.2E-01 | 2.9E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    26| +1.48E+02 | -9.9E-02 | +9.3E-01 | 5.6E-02 | 2.5E+01 | 3.9E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    76| +1.48E+02 | -1.6E-01 | +2.8E-01 | 2.4E-02 | 3.0E+01 | 6.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)   122| +1.51E+02 | -3.0E-03 | +1.0E+00 | 2.8E-03 | 6.2E-01 | 6.0E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    19| +2.50E+02 | -2.1E-06 | +3.4E-01 | 1.2E-04 | 3.3E-02 | 3.1E-04 |  2d |1
2023-02-17 16:05:17 fides(WARNING) Stopping as function difference 2.08E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:17 fides(INFO)    65| +1.48E+02 | -1.5E-03 | +6.6E-01 | 5.1E-02 | 5.0E-01 | 3.1E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    77| +1.48E+02 | +1.9E-01 | -3.5E-01 | 2.4E-02 | 1.5E+01 | 5.6E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    48| +1.48E+02 | -1.7E-03 | +2.6E-01 | 3.1E-02 | 1.8E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    27| +1.48E+02 | -6.9E-02 | +8.6E-01 | 1.1E-01 | 1.3E+01 | 7.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    49| +1.48E+02 | -3.8E-04 | +5.7E-02 | 3.1E-02 | 4.7E-01 | 3.3E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    66| +1.48E+02 | +1.0E-03 | -2.9E-01 | 5.1E-02 | 6.0E-01 | 1.4E-02 |  2d |0
2023-02-17 16:05:17 fides(INFO)    28| +1.48E+02 | +5.3E-02 | -7.0E-01 | 2.2E-01 | 1.2E+01 | 1.7E-01 |  2d |0
2023-02-17 16:05:17 fides(INFO)    78| +1.48E+02 | -1.1E-01 | +7.5E-01 | 6.1E-03 | 1.5E+01 | 1.4E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    88| +1.55E+02 | -1.1E-02 | +8.7E-01 | 2.8E-02 | 1.3E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    50| +1.48E+02 | -1.8E-03 | +7.2E-01 | 7.8E-03 | 1.6E+00 | 4.8E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    67| +1.48E+02 | -7.1E-04 | +6.3E-01 | 1.3E-02 | 6.0E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    79| +1.48E+02 | -8.6E-02 | +7.4E-01 | 6.1E-03 | 1.9E+01 | 1.0E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)   123| +1.51E+02 | -5.0E-03 | +1.0E+00 | 5.7E-03 | 7.4E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    17| +1.67E+02 | -1.3E+01 | +1.1E+00 | 2.5E-01 | 7.2E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:17 fides(INFO)    29| +1.48E+02 | -2.5E-02 | +7.2E-01 | 5.6E-02 | 1.2E+01 | 4.2E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)     0| +3.21E+02 |    NaN   |    NaN   | 1.0E+00 | 6.2E+01 |   NaN   | NaN |1
2023-02-17 16:05:17 fides(INFO)    51| +1.48E+02 | -5.0E-04 | +8.4E-01 | 7.8E-03 | 8.3E-01 | 2.3E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    80| +1.48E+02 | -6.5E-02 | +7.7E-01 | 6.1E-03 | 1.1E+01 | 1.3E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:17 fides(INFO)    30| +1.48E+02 | -1.4E-02 | +7.1E-01 | 5.6E-02 | 6.4E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:17 fides(INFO)    68| +1.48E+02 | -4.2E-04 | +9.6E-01 | 1.3E-02 | 9.6E-01 | 6.4E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)     1| +3.21E+02 | +4.3E+02 | -5.6E+00 | 1.0E+00 | 6.2E+01 | 2.8E+00 |  2d |0
2023-02-17 16:05:17 fides(INFO)    52| +1.48E+02 | -4.8E-04 | +9.1E-01 | 1.6E-02 | 3.7E-01 | 6.7E-03 |  2d |1
2023-02-17 16:05:17 fides(INFO)    81| +1.48E+02 | -5.7E-02 | +7.3E-01 | 1.2E-02 | 1.1E+01 | 2.3E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    69| +1.48E+02 | -5.7E-04 | +9.7E-01 | 2.6E-02 | 2.2E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    31| +1.48E+02 | -9.6E-03 | +6.6E-01 | 5.6E-02 | 7.1E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    82| +1.48E+02 | -5.1E-02 | +9.4E-01 | 1.2E-02 | 8.9E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    53| +1.48E+02 | -6.3E-04 | +8.3E-01 | 3.1E-02 | 4.0E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)     2| +2.80E+02 | -4.0E+01 | +9.6E-01 | 2.5E-01 | 6.2E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    70| +1.48E+02 | -6.9E-04 | +8.2E-01 | 5.1E-02 | 4.2E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    32| +1.48E+02 | -5.2E-03 | +5.1E-01 | 5.6E-02 | 3.7E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    83| +1.48E+02 | +2.1E-03 | -4.7E-02 | 2.4E-02 | 5.7E+00 | 4.9E-02 |  2d |0
2023-02-17 16:05:18 fides(INFO)   124| +1.51E+02 | -9.3E-03 | +1.0E+00 | 1.1E-02 | 6.5E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    71| +1.48E+02 | +4.6E-03 | -3.1E+00 | 1.0E-01 | 2.6E-01 | 2.0E-02 |  2d |0
2023-02-17 16:05:18 fides(INFO)     3| +2.54E+02 | -2.6E+01 | +2.9E-01 | 5.0E-01 | 5.4E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)    54| +1.48E+02 | +8.5E-04 | -6.5E-01 | 6.2E-02 | 2.8E-01 | 1.6E-02 |  2d |0
2023-02-17 16:05:18 fides(INFO)    33| +1.48E+02 | -3.3E-03 | +3.4E-01 | 5.6E-02 | 4.6E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    84| +1.48E+02 | -1.1E-02 | +4.4E-01 | 6.1E-03 | 5.7E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    72| +1.48E+02 | -6.8E-05 | +1.2E-01 | 2.6E-02 | 2.6E-01 | 5.1E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    55| +1.48E+02 | -2.2E-04 | +4.7E-01 | 1.6E-02 | 2.8E-01 | 4.3E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    34| +1.48E+02 | -8.4E-04 | +8.3E-02 | 5.6E-02 | 2.3E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)     4| +2.28E+02 | -2.7E+01 | +3.4E-01 | 5.0E-01 | 1.6E+02 | 1.3E+00 | trr |1
2023-02-17 16:05:18 fides(INFO)    85| +1.48E+02 | -1.9E-02 | +7.3E-01 | 6.1E-03 | 1.0E+01 | 1.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    73| +1.48E+02 | -2.6E-04 | +7.4E-01 | 6.4E-03 | 6.1E-01 | 4.8E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    89| +1.55E+02 | -3.5E-03 | +3.7E-01 | 5.6E-02 | 1.2E+00 | 8.0E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    35| +1.48E+02 | -3.9E-03 | +7.8E-01 | 1.4E-02 | 3.9E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    56| +1.48E+02 | -2.6E-04 | +5.1E-01 | 1.6E-02 | 7.1E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)     5| +2.10E+02 | -1.8E+01 | +8.4E-01 | 5.0E-01 | 1.2E+02 | 9.0E-01 | trr |1
2023-02-17 16:05:18 fides(INFO)   125| +1.51E+02 | -1.5E-02 | +9.6E-01 | 2.3E-02 | 5.4E-01 | 4.7E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    36| +1.48E+02 | -8.9E-04 | +5.7E-01 | 2.8E-02 | 1.3E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    86| +1.48E+02 | -6.1E-03 | +8.1E-01 | 6.1E-03 | 3.6E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    74| +1.48E+02 | -6.5E-05 | +8.5E-01 | 6.4E-03 | 1.4E-01 | 3.0E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    18| +1.59E+02 | -7.6E+00 | +9.5E-01 | 5.0E-01 | 6.4E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)    57| +1.48E+02 | -9.3E-05 | +2.6E-01 | 1.6E-02 | 2.3E-01 | 3.3E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)     6| +2.10E+02 | +3.0E+00 | -1.1E+00 | 1.0E+00 | 1.7E+01 | 2.6E+00 | trr |0
2023-02-17 16:05:18 fides(INFO)    87| +1.48E+02 | -6.2E-03 | +9.5E-01 | 1.2E-02 | 2.9E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    75| +1.48E+02 | -7.0E-05 | +8.8E-01 | 1.3E-02 | 5.9E-02 | 4.5E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    37| +1.48E+02 | -4.7E-04 | +8.7E-01 | 2.8E-02 | 1.2E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    58| +1.48E+02 | -1.4E-04 | +2.8E-01 | 1.6E-02 | 6.3E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    88| +1.48E+02 | -5.2E-03 | +6.7E-01 | 2.4E-02 | 1.8E+00 | 5.6E-02 |  2d |1
2023-02-17 16:05:18.263 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.9411 and h = 2.74506e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:18.263 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.9411: AMICI failed to integrate the forward problem
2023-02-17 16:05:18 fides(INFO)    76| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.6E-02 | 1.4E-01 | 6.6E-03 |  2d |0
2023-02-17 16:05:18 fides(INFO)     7| +2.10E+02 | +3.5E+00 | -8.7E-01 | 2.5E-01 | 1.7E+01 | 6.7E-01 | trr |0
2023-02-17 16:05:18 fides(INFO)    38| +1.48E+02 | -5.7E-04 | +9.4E-01 | 5.6E-02 | 8.1E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    59| +1.48E+02 | +4.7E-05 | -1.0E-01 | 1.6E-02 | 2.5E-01 | 4.0E-03 |  2d |0
2023-02-17 16:05:18 fides(INFO)     8| +2.07E+02 | -2.5E+00 | +1.0E+00 | 6.2E-02 | 1.7E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    89| +1.48E+02 | -5.3E-03 | +9.7E-01 | 2.4E-02 | 1.4E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)   126| +1.51E+02 | -8.3E-03 | +6.3E-01 | 4.5E-02 | 4.6E-01 | 9.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    77| +1.48E+02 | -3.5E-05 | +1.1E+00 | 6.4E-03 | 1.4E-01 | 1.7E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    39| +1.48E+02 | -2.7E-04 | +5.7E-01 | 1.1E-01 | 1.1E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)     9| +2.06E+02 | -1.6E+00 | +9.2E-01 | 1.2E-01 | 1.2E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    60| +1.48E+02 | -9.4E-05 | +5.6E-01 | 3.9E-03 | 2.5E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    78| +1.48E+02 | -5.3E-05 | +9.6E-01 | 1.3E-02 | 7.7E-02 | 3.5E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    90| +1.48E+02 | -7.1E-03 | +1.0E+00 | 4.9E-02 | 5.7E-01 | 1.2E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    40| +1.48E+02 | +7.1E-03 | -3.8E+00 | 1.1E-01 | 3.3E-01 | 4.1E-02 |  2d |0
2023-02-17 16:05:18 fides(INFO)    61| +1.48E+02 | -6.1E-05 | +9.4E-01 | 3.9E-03 | 6.2E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    10| +2.00E+02 | -5.3E+00 | +1.7E+00 | 2.5E-01 | 1.4E+01 | 6.7E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    91| +1.48E+02 | -1.3E-02 | +1.1E+00 | 9.8E-02 | 9.1E-01 | 2.3E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    79| +1.48E+02 | -8.0E-05 | +9.8E-01 | 2.6E-02 | 8.9E-02 | 6.5E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    41| +1.48E+02 | +4.1E-05 | -6.7E-02 | 2.8E-02 | 3.3E-01 | 1.0E-02 |  2d |0
2023-02-17 16:05:18 fides(INFO)    62| +1.48E+02 | -4.5E-05 | +1.0E+00 | 7.8E-03 | 7.3E-02 | 2.2E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    11| +2.00E+02 | +1.7E+01 | -1.7E+00 | 5.0E-01 | 2.0E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    80| +1.48E+02 | -8.7E-05 | +1.0E+00 | 5.1E-02 | 4.7E-02 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    19| +1.58E+02 | -1.4E+00 | +1.0E+00 | 1.0E+00 | 7.7E+01 | 2.6E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)    92| +1.48E+02 | -9.6E-03 | +3.9E-01 | 2.0E-01 | 2.3E+00 | 4.7E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    42| +1.48E+02 | -1.2E-04 | +6.2E-01 | 7.0E-03 | 3.3E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    90| +1.55E+02 | +1.5E-03 | -2.4E-01 | 5.6E-02 | 2.7E+00 | 2.9E-02 |  2d |0
2023-02-17 16:05:18 fides(INFO)   127| +1.51E+02 | -3.0E-03 | +9.3E-01 | 4.5E-02 | 4.5E-01 | 3.3E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    12| +1.93E+02 | -6.9E+00 | +1.3E+00 | 1.2E-01 | 2.0E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    63| +1.48E+02 | -5.4E-05 | +7.4E-01 | 1.6E-02 | 2.2E-01 | 5.5E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    81| +1.48E+02 | +2.1E-05 | -8.9E-01 | 1.0E-01 | 6.7E-02 | 7.8E-03 | trr |0
2023-02-17 16:05:18 fides(INFO)    43| +1.48E+02 | -7.2E-05 | +9.8E-01 | 7.0E-03 | 7.4E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    93| +1.48E+02 | -9.5E-03 | +7.6E-01 | 2.0E-01 | 5.4E+00 | 1.4E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    64| +1.48E+02 | -1.5E-05 | +2.0E-01 | 1.6E-02 | 8.4E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    13| +1.73E+02 | -2.0E+01 | +1.1E+00 | 2.5E-01 | 3.5E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    82| +1.48E+02 | -4.9E-06 | +4.6E-01 | 1.8E-02 | 6.7E-02 | 2.0E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    65| +1.48E+02 | -4.3E-05 | +6.9E-01 | 3.9E-03 | 2.9E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    94| +1.48E+02 | -5.2E-03 | +1.5E+00 | 2.0E-01 | 1.6E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    44| +1.48E+02 | -2.0E-05 | +8.0E-01 | 1.4E-02 | 2.1E-01 | 3.0E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    14| +1.68E+02 | -5.9E+00 | +3.9E-01 | 5.0E-01 | 7.4E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)    83| +1.48E+02 | +1.2E-05 | -7.1E-01 | 1.8E-02 | 2.7E-02 | 3.9E-03 |  2d |0
2023-02-17 16:05:18 fides(INFO)    95| +1.48E+02 | -1.4E-03 | +5.1E-01 | 2.0E-01 | 7.2E-01 | 1.6E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    45| +1.48E+02 | -2.4E-05 | +9.3E-01 | 2.8E-02 | 2.8E-01 | 5.8E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    66| +1.48E+02 | -4.5E-06 | +4.3E-01 | 3.9E-03 | 5.4E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)   128| +1.51E+02 | -3.9E-04 | +1.4E+00 | 4.5E-02 | 4.1E-01 | 7.7E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    84| +1.48E+02 | -3.8E-06 | +7.6E-01 | 4.5E-03 | 2.7E-02 | 9.9E-04 |  2d |1
2023-02-17 16:05:18 fides(INFO)    15| +1.60E+02 | -7.7E+00 | +8.1E-01 | 5.0E-01 | 1.3E+02 | 9.3E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    67| +1.48E+02 | -1.0E-05 | +1.6E+00 | 3.9E-03 | 2.2E-02 | 9.0E-04 |  2d |1
2023-02-17 16:05:18 fides(INFO)    46| +1.48E+02 | -2.3E-05 | +7.7E-01 | 5.6E-02 | 1.6E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    96| +1.48E+02 | -8.4E-04 | +9.8E-01 | 2.0E-01 | 4.1E-01 | 4.6E-02 |  2d |1
2023-02-17 16:05:18.650 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 183.579 and h = 4.55724e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:18.650 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 183.579: AMICI failed to integrate the forward problem
2023-02-17 16:05:18 fides(INFO)    16| +1.60E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 5.0E+01 | 1.8E+00 |  2d |0
2023-02-17 16:05:18 fides(INFO)    85| +1.48E+02 | -6.5E-07 | +2.4E-01 | 9.0E-03 | 3.3E-02 | 8.6E-04 |  2d |1
2023-02-17 16:05:18 fides(INFO)    47| +1.48E+02 | +3.8E-04 | -4.8E+00 | 1.1E-01 | 1.4E-01 | 2.1E-02 |  2d |0
2023-02-17 16:05:18 fides(INFO)    97| +1.48E+02 | -2.0E-04 | +1.7E+00 | 2.0E-01 | 2.4E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    68| +1.48E+02 | -1.4E-05 | +1.3E+00 | 7.8E-03 | 6.2E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    86| +1.48E+02 | -1.4E-06 | +2.3E+00 | 2.2E-03 | 1.7E-02 | 2.8E-04 |  2d |1
2023-02-17 16:05:18 fides(WARNING) Stopping as function difference 1.44E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:18 fides(INFO)    17| +1.56E+02 | -3.5E+00 | +9.4E-01 | 2.3E-01 | 5.0E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    20| +1.58E+02 | +1.5E+00 | -8.6E+00 | 2.0E+00 | 4.7E+01 | 6.1E+00 | trr |0
2023-02-17 16:05:18 fides(INFO)    69| +1.48E+02 | -9.0E-06 | +5.7E-01 | 1.6E-02 | 2.4E-02 | 2.7E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    48| +1.48E+02 | -8.7E-07 | +2.8E-02 | 2.8E-02 | 1.4E-01 | 5.3E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    98| +1.48E+02 | -9.9E-04 | +1.5E+00 | 2.0E-01 | 1.8E-01 | 1.4E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)   129| +1.51E+02 | -1.2E-04 | +9.9E-01 | 4.5E-02 | 9.1E-02 | 9.4E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    18| +1.49E+02 | -6.9E+00 | +1.3E+00 | 4.6E-01 | 5.0E+01 | 8.3E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    70| +1.48E+02 | -1.0E-05 | +9.8E-01 | 1.6E-02 | 4.7E-02 | 2.8E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    49| +1.48E+02 | -1.5E-05 | +5.9E-01 | 7.0E-03 | 1.5E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    99| +1.48E+02 | -1.2E-03 | +1.4E+00 | 2.0E-01 | 2.6E-01 | 2.5E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    19| +1.49E+02 | +2.1E+01 | -9.6E+00 | 9.2E-01 | 5.3E+01 | 8.2E-01 | trr |0
2023-02-17 16:05:18 fides(INFO)    71| +1.48E+02 | +7.4E-05 | -3.6E+00 | 3.1E-02 | 2.6E-02 | 2.3E-03 |  2d |0
2023-02-17 16:05:18 fides(INFO)    91| +1.55E+02 | -2.5E-03 | +6.8E-01 | 2.8E-03 | 2.7E+00 | 7.4E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    50| +1.48E+02 | -4.1E-06 | +1.4E+00 | 7.0E-03 | 1.1E-01 | 9.8E-04 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)   100| +1.48E+02 | -7.8E-04 | +1.4E+00 | 2.0E-01 | 3.0E-01 | 2.8E-01 |  2d |1
2023-02-17 16:05:18.802 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 68.1343 and h = 1.67073e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:18.803 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 68.1343: AMICI failed to integrate the forward problem
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)    20| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 5.3E+01 | 2.0E-01 |  2d |0
2023-02-17 16:05:18 fides(INFO)    51| +1.48E+02 | -5.2E-07 | +2.2E-01 | 1.4E-02 | 7.3E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:18 fides(INFO)    72| +1.48E+02 | +2.5E-05 | -2.1E+00 | 7.8E-03 | 2.6E-02 | 9.4E-04 |  2d |0
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)     0| +3.01E+13 |    NaN   |    NaN   | 1.0E+00 | 1.4E+14 |   NaN   | NaN |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)   130| +1.51E+02 | -4.7E-06 | +1.1E+00 | 4.5E-02 | 9.5E-02 | 3.3E-04 |  2d |1
2023-02-17 16:05:18 fides(INFO)    21| +1.49E+02 | -5.5E-01 | +9.1E-01 | 2.9E-02 | 5.3E+01 | 5.2E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)   101| +1.48E+02 | -3.8E-04 | +1.4E+00 | 2.0E-01 | 1.5E-01 | 2.7E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    52| +1.48E+02 | -1.1E-06 | +9.4E-01 | 3.5E-03 | 7.1E-02 | 4.6E-04 |  2d |1
2023-02-17 16:05:18 fides(WARNING) Stopping as function difference 1.13E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:18 fides(INFO)    73| +1.48E+02 | +1.7E-05 | -1.9E+00 | 2.0E-03 | 2.6E-02 | 7.1E-04 |  2d |0
2023-02-17 16:05:18 fides(INFO)     1| +1.44E+07 | -3.0E+13 | +8.2E-02 | 1.0E+00 | 1.4E+14 | 3.2E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)     2| +2.20E+06 | -1.2E+07 | +8.9E-01 | 2.5E-01 | 6.6E+07 | 7.2E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)    22| +1.48E+02 | -5.6E-01 | +9.4E-01 | 5.8E-02 | 1.4E+01 | 9.7E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    74| +1.48E+02 | +1.6E-05 | -2.0E+00 | 4.9E-04 | 2.6E-02 | 6.6E-04 |  2d |0
2023-02-17 16:05:18 fides(INFO)     3| +3.38E+05 | -1.9E+06 | +8.9E-01 | 5.0E-01 | 1.0E+07 | 1.4E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)   102| +1.48E+02 | -1.8E-04 | +1.4E+00 | 2.0E-01 | 2.6E-02 | 2.6E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)     4| +5.60E+04 | -2.8E+05 | +8.7E-01 | 1.0E+00 | 1.6E+06 | 2.0E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)    21| +1.56E+02 | -1.6E+00 | +9.1E-01 | 5.0E-01 | 4.7E+01 | 1.3E+00 | trr |1
2023-02-17 16:05:18 fides(INFO)    23| +1.48E+02 | +4.3E-01 | -9.2E-01 | 1.2E-01 | 7.4E+00 | 1.9E-01 |  2d |0
2023-02-17 16:05:18 fides(INFO)     5| +8.88E+03 | -4.7E+04 | +9.0E-01 | 1.0E+00 | 2.4E+05 | 1.0E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)    75| +1.48E+02 | -2.6E-06 | +4.8E-01 | 1.2E-04 | 2.6E-02 | 2.8E-04 |  2d |1
2023-02-17 16:05:18 fides(INFO)   103| +1.48E+02 | -1.1E-04 | +1.4E+00 | 2.0E-01 | 3.4E-02 | 2.7E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)     6| +1.56E+03 | -7.3E+03 | +9.0E-01 | 1.0E+00 | 3.8E+04 | 1.0E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)     7| +4.27E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 5.9E+03 | 1.0E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)    24| +1.48E+02 | -9.2E-02 | +6.4E-01 | 2.9E-02 | 7.4E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:18 fides(INFO)    76| +1.48E+02 | -2.1E-07 | +2.3E-01 | 1.2E-04 | 8.4E-02 | 3.4E-05 |  2d |1
2023-02-17 16:05:18 fides(INFO)   131| +1.51E+02 | -6.9E-07 | +1.3E+00 | 4.5E-02 | 2.8E-02 | 1.9E-04 |  2d |1
2023-02-17 16:05:18 fides(WARNING) Stopping as function difference 6.90E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:18 fides(INFO)   104| +1.48E+02 | -5.9E-05 | +1.5E+00 | 3.9E-01 | 4.0E-02 | 2.7E-01 |  2d |1
2023-02-17 16:05:18 fides(INFO)     8| +2.64E+02 | -1.6E+02 | +8.9E-01 | 1.0E+00 | 9.2E+02 | 1.4E+00 |  2d |1
2023-02-17 16:05:18 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:18 fides(INFO)     0| +1.63E+13 |    NaN   |    NaN   | 1.0E+00 | 7.5E+13 |   NaN   | NaN |1
2023-02-17 16:05:19 fides(INFO)    77| +1.48E+02 | -2.0E-06 | +2.0E+01 | 3.1E-05 | 1.5E-02 | 1.3E-05 |  2d |1
2023-02-17 16:05:19 fides(INFO)     9| +2.33E+02 | -3.1E+01 | +1.2E+00 | 1.0E+00 | 1.2E+02 | 1.8E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    25| +1.48E+02 | -1.3E-01 | +9.4E-01 | 2.9E-02 | 4.3E+00 | 4.4E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)     1| +1.16E+07 | -1.6E+13 | +8.4E-02 | 1.0E+00 | 7.5E+13 | 3.1E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)   105| +1.48E+02 | -2.8E-05 | +1.3E+00 | 3.9E-01 | 1.3E-02 | 2.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    92| +1.55E+02 | -8.4E-04 | +9.3E-01 | 2.8E-03 | 1.3E+00 | 5.2E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    26| +1.48E+02 | -1.5E-01 | +8.7E-01 | 5.8E-02 | 5.6E+00 | 8.7E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    10| +2.33E+02 | +6.2E+01 | -1.3E+01 | 2.0E+00 | 2.2E+01 | 6.0E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)    78| +1.48E+02 | +3.4E-07 | -2.4E+00 | 6.1E-05 | 2.4E-02 | 1.6E-05 |  2d |0
2023-02-17 16:05:19 fides(INFO)     2| +1.77E+06 | -9.8E+06 | +8.9E-01 | 2.5E-01 | 5.3E+07 | 5.8E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   106| +1.48E+02 | -1.5E-05 | +1.3E+00 | 3.9E-01 | 8.3E-03 | 2.5E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    11| +2.33E+02 | +2.3E+00 | -6.2E-01 | 5.0E-01 | 2.2E+01 | 1.5E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)     3| +2.75E+05 | -1.5E+06 | +9.0E-01 | 5.0E-01 | 8.2E+06 | 9.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    27| +1.48E+02 | -7.8E-02 | +2.0E-01 | 1.2E-01 | 3.8E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   107| +1.48E+02 | -1.3E-05 | +2.0E+00 | 3.9E-01 | 1.5E-02 | 2.4E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    79| +1.48E+02 | +2.0E-06 | -2.1E+01 | 1.5E-05 | 2.4E-02 | 8.3E-06 |  2d |0
2023-02-17 16:05:19 fides(INFO)    12| +2.32E+02 | -8.6E-01 | +1.8E-01 | 1.2E-01 | 2.2E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)     4| +4.30E+04 | -2.3E+05 | +9.0E-01 | 1.0E+00 | 1.3E+06 | 8.8E-01 |  2d |1
2023-02-17 16:05:19.102 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 82.3892 and h = 4.26295e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:19.102 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 82.3892: AMICI failed to integrate the forward problem
2023-02-17 16:05:19 fides(INFO)    28| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.9E-02 | 1.3E+01 | 5.4E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)    13| +2.30E+02 | -1.8E+00 | +9.1E-01 | 3.1E-02 | 3.9E+01 | 5.7E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)     0| +6.04E+09 |    NaN   |    NaN   | 1.0E+00 | 2.2E+10 |   NaN   | NaN |1
2023-02-17 16:05:19 fides(INFO)   108| +1.48E+02 | +1.4E-06 | -6.3E-01 | 3.9E-01 | 5.6E-03 | 2.3E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)    22| +1.54E+02 | -2.6E+00 | +1.0E+00 | 5.0E-01 | 8.5E+01 | 6.8E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    14| +2.28E+02 | -1.9E+00 | +8.6E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)     5| +6.90E+03 | -3.6E+04 | +9.0E-01 | 1.0E+00 | 2.0E+05 | 8.5E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)     1| +2.23E+07 | -6.0E+09 | +1.2E-01 | 1.0E+00 | 2.2E+10 | 2.7E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    80| +1.48E+02 | +1.0E-06 | -1.2E+01 | 3.8E-06 | 2.4E-02 | 6.6E-06 |  2d |0
2023-02-17 16:05:19 fides(INFO)    29| +1.48E+02 | -7.8E-02 | +9.0E-01 | 7.2E-03 | 1.3E+01 | 1.4E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)   109| +1.48E+02 | +2.0E-06 | -1.5E+00 | 6.6E-02 | 5.6E-03 | 5.7E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)    15| +2.25E+02 | -3.3E+00 | +1.1E+00 | 1.2E-01 | 1.8E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)     2| +3.45E+06 | -1.9E+07 | +8.9E-01 | 2.5E-01 | 1.0E+08 | 7.3E-01 |  2d |1
2023-02-17 16:05:19.180 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 82.9518 and h = 2.54562e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:19 fides(INFO)    81| +1.48E+02 | -1.2E-07 | +3.7E+00 | 9.5E-07 | 2.4E-02 | 1.7E-06 |  2d |1
2023-02-17 16:05:19.180 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 82.9518: AMICI failed to integrate the forward problem
2023-02-17 16:05:19 fides(WARNING) Stopping as function difference 1.25E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    30| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.4E-02 | 5.8E+00 | 2.6E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)    16| +2.22E+02 | -3.0E+00 | +1.0E+00 | 2.5E-01 | 2.0E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)   110| +1.48E+02 | +3.0E-06 | -7.9E+00 | 1.7E-02 | 5.6E-03 | 1.4E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)     3| +5.50E+05 | -2.9E+06 | +9.0E-01 | 5.0E-01 | 1.6E+07 | 1.5E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    31| +1.48E+02 | -3.2E-02 | +9.3E-01 | 3.6E-03 | 5.8E+00 | 6.8E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    17| +2.22E+02 | +4.3E+00 | -1.1E+00 | 5.0E-01 | 2.1E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)     6| +1.26E+03 | -5.6E+03 | +9.0E-01 | 1.0E+00 | 3.1E+04 | 9.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    93| +1.55E+02 | -9.2E-04 | +7.3E-01 | 5.6E-03 | 3.2E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)     4| +9.46E+04 | -4.6E+05 | +8.9E-01 | 1.0E+00 | 2.4E+06 | 2.8E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)   111| +1.48E+02 | +2.3E-06 | -2.3E+01 | 4.1E-03 | 5.6E-03 | 3.5E-03 |  2d |0
2023-02-17 16:05:19 fides(INFO)    32| +1.48E+02 | -3.9E-02 | +8.8E-01 | 7.2E-03 | 4.9E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    18| +2.21E+02 | -5.4E-01 | +8.7E-02 | 1.2E-01 | 2.1E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)     5| +1.50E+04 | -8.0E+04 | +9.0E-01 | 2.0E+00 | 3.8E+05 | 1.4E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)   112| +1.48E+02 | +4.4E-06 | -1.5E+02 | 1.0E-03 | 5.6E-03 | 8.8E-04 |  2d |0
2023-02-17 16:05:19 fides(INFO)    19| +2.20E+02 | -1.7E+00 | +8.8E-01 | 3.1E-02 | 3.9E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)     6| +2.54E+03 | -1.3E+04 | +9.0E-01 | 2.0E+00 | 6.0E+04 | 1.6E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)     7| +3.71E+02 | -8.8E+02 | +9.0E-01 | 1.0E+00 | 4.9E+03 | 1.2E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    33| +1.48E+02 | -4.7E-02 | +7.9E-01 | 1.4E-02 | 5.2E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    20| +2.18E+02 | -1.3E+00 | +7.5E-01 | 6.2E-02 | 2.5E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   113| +1.48E+02 | +1.9E-06 | -1.8E+02 | 2.6E-04 | 5.6E-03 | 2.2E-04 |  2d |0
2023-02-17 16:05:19 fides(INFO)     7| +5.75E+02 | -2.0E+03 | +9.0E-01 | 2.0E+00 | 9.6E+03 | 2.5E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)     0| +2.54E+08 |    NaN   |    NaN   | 1.0E+00 | 1.2E+09 |   NaN   | NaN |1
2023-02-17 16:05:19 fides(INFO)    23| +1.53E+02 | -4.4E-01 | +1.0E+00 | 1.0E+00 | 3.4E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:19.338 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.009 and h = 2.78692e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:19 fides(INFO)     8| +2.31E+02 | -1.4E+02 | +9.2E-01 | 1.0E+00 | 7.8E+02 | 2.2E+00 |  2d |1
2023-02-17 16:05:19.339 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.009: AMICI failed to integrate the forward problem
2023-02-17 16:05:19 fides(INFO)    34| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.9E-02 | 2.5E+00 | 4.4E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)    21| +2.17E+02 | -1.0E+00 | +4.8E-01 | 1.2E-01 | 1.5E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   114| +1.48E+02 | +2.9E-06 | -4.5E+02 | 6.5E-05 | 5.6E-03 | 5.5E-05 |  2d |0
2023-02-17 16:05:19 fides(INFO)     1| +4.19E+03 | -2.5E+08 | +1.0E-01 | 1.0E+00 | 1.2E+09 | 2.6E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)     8| +2.83E+02 | -2.9E+02 | +8.9E-01 | 2.0E+00 | 1.5E+03 | 4.2E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    22| +2.16E+02 | -1.5E+00 | +5.7E-01 | 1.2E-01 | 3.0E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)     9| +2.31E+02 | -7.6E+00 | -1.7E-01 | 2.0E+00 | 1.1E+02 | 4.0E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)    35| +1.48E+02 | -1.3E-02 | +8.5E-01 | 7.2E-03 | 2.5E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)   115| +1.48E+02 | +3.9E-06 | -7.4E+02 | 1.6E-05 | 5.6E-03 | 1.4E-05 |  2d |0
2023-02-17 16:05:19 fides(INFO)     9| +2.34E+02 | -5.0E+01 | +1.1E+00 | 4.0E+00 | 2.2E+02 | 3.3E+00 | trr |1
2023-02-17 16:05:19 fides(INFO)    23| +2.16E+02 | +4.5E-01 | -3.4E-01 | 1.2E-01 | 1.5E+01 | 3.1E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)     2| +1.07E+03 | -3.1E+03 | +9.1E-01 | 2.5E-01 | 1.3E+04 | 5.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    36| +1.48E+02 | -1.6E-02 | +8.0E-01 | 1.4E-02 | 2.6E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)   116| +1.48E+02 | +4.0E-06 | -7.9E+02 | 4.0E-06 | 5.6E-03 | 3.9E-06 |  2d |0
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    10| +2.34E+02 | +9.9E+02 | -4.3E+01 | 4.0E+00 | 3.4E+01 | 1.2E+01 | trr |0
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    10| +2.08E+02 | -2.3E+01 | +9.7E-01 | 5.0E-01 | 1.1E+02 | 9.7E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    24| +2.15E+02 | -6.5E-01 | +8.1E-01 | 3.1E-02 | 1.5E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)     3| +4.00E+02 | -6.7E+02 | +9.1E-01 | 5.0E-01 | 2.7E+03 | 1.2E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    37| +1.48E+02 | -2.3E-02 | +8.8E-01 | 2.9E-02 | 1.8E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    25| +2.14E+02 | -8.9E-01 | +9.9E-01 | 6.2E-02 | 1.2E+01 | 9.4E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)   117| +1.48E+02 | +4.0E-06 | -8.0E+02 | 1.0E-06 | 5.6E-03 | 1.9E-06 |  2d |0
2023-02-17 16:05:19 fides(INFO)    11| +1.66E+02 | -4.2E+01 | +9.2E-01 | 9.9E-01 | 4.1E+01 | 1.8E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    11| +2.34E+02 | +6.6E+01 | -5.4E+00 | 1.0E+00 | 3.4E+01 | 2.9E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)     4| +2.93E+02 | -1.1E+02 | +8.8E-01 | 1.0E+00 | 4.5E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    12| +2.34E+02 | +2.7E+00 | -3.2E-01 | 2.5E-01 | 3.4E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)    26| +2.14E+02 | -7.9E-01 | +7.4E-01 | 1.2E-01 | 1.2E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    38| +1.48E+02 | -4.1E-02 | +7.8E-01 | 5.8E-02 | 2.5E+00 | 8.0E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)   118| +1.48E+02 | +1.7E-07 | -6.1E+01 | 2.5E-07 | 5.6E-03 | 6.3E-07 |  2d |0
2023-02-17 16:05:19 fides(INFO)    94| +1.55E+02 | -5.9E-04 | +9.5E-01 | 5.6E-03 | 9.6E-01 | 1.4E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)     5| +2.57E+02 | -3.6E+01 | +8.3E-01 | 2.0E+00 | 6.1E+01 | 3.7E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    12| +1.66E+02 | +4.4E+01 | -2.9E+00 | 2.0E+00 | 1.7E+02 | 1.3E+00 | trr |0
2023-02-17 16:05:19 fides(INFO)    27| +2.14E+02 | +4.2E-01 | -3.2E-01 | 1.2E-01 | 1.4E+01 | 3.1E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)    13| +2.29E+02 | -4.4E+00 | +9.0E-01 | 6.2E-02 | 3.4E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    24| +1.53E+02 | -8.0E-01 | +5.0E-01 | 2.0E+00 | 3.9E+01 | 8.7E-01 | trr |1
2023-02-17 16:05:19 fides(INFO)     6| +2.57E+02 | +4.7E+01 | -1.1E+01 | 4.0E+00 | 3.5E+01 | 1.1E+01 | trr |0
2023-02-17 16:05:19 fides(INFO)    39| +1.48E+02 | +1.5E-01 | -1.8E+00 | 1.2E-01 | 1.7E+00 | 1.7E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)    14| +2.26E+02 | -3.0E+00 | +5.2E-01 | 1.2E-01 | 2.6E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    28| +2.13E+02 | -6.3E-01 | +7.9E-01 | 3.1E-02 | 1.4E+01 | 7.3E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)   119| +1.48E+02 | +6.6E-07 | -8.0E+02 | 6.3E-08 | 5.6E-03 | 1.6E-07 |  2d |0
2023-02-17 16:05:19 fides(INFO)     7| +2.57E+02 | +1.8E+02 | -1.1E+01 | 9.4E-01 | 3.5E+01 | 2.6E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)    13| +1.56E+02 | -1.1E+01 | +9.8E-01 | 1.2E-01 | 1.7E+02 | 3.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    25| +1.53E+02 | +7.1E+01 | -7.4E+01 | 2.0E+00 | 1.6E+01 | 5.5E+00 | trr |0
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    40| +1.48E+02 | -9.7E-03 | +3.9E-01 | 2.9E-02 | 1.7E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    15| +2.22E+02 | -4.1E+00 | +8.2E-01 | 1.2E-01 | 3.8E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    29| +2.12E+02 | -4.7E-01 | +7.7E-01 | 6.2E-02 | 8.9E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)     8| +2.57E+02 | +8.1E-01 | -1.4E-01 | 2.3E-01 | 3.5E+01 | 6.2E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)   120| +1.48E+02 | +4.5E-06 | -2.1E+04 | 1.6E-08 | 5.6E-03 | 3.9E-08 |  2d |0
2023-02-17 16:05:19 fides(INFO)    14| +1.52E+02 | -3.8E+00 | +3.0E-01 | 2.4E-01 | 6.1E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    16| +2.19E+02 | -3.8E+00 | +4.6E-01 | 2.5E-01 | 2.4E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    41| +1.48E+02 | +7.5E-03 | -2.4E-01 | 2.9E-02 | 1.5E+00 | 4.2E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)     9| +2.53E+02 | -4.7E+00 | +9.2E-01 | 5.9E-02 | 3.5E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   121| +1.48E+02 | +4.3E-06 | -7.9E+04 | 4.0E-09 | 5.6E-03 | 9.9E-09 |  2d |0
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    30| +2.12E+02 | -4.6E-01 | +5.7E-01 | 1.2E-01 | 1.2E+01 | 3.4E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    10| +2.51E+02 | -1.7E+00 | +2.9E-01 | 1.2E-01 | 2.5E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    17| +2.12E+02 | -7.1E+00 | +7.3E-01 | 2.5E-01 | 5.7E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    26| +1.52E+02 | -5.0E-01 | +8.9E-01 | 5.0E-01 | 1.6E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    42| +1.48E+02 | -5.7E-03 | +4.9E-01 | 7.2E-03 | 1.5E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    31| +2.12E+02 | -2.4E-01 | +2.0E-01 | 1.2E-01 | 1.1E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   122| +1.48E+02 | +1.7E-08 | -1.3E+03 | 9.9E-10 | 5.6E-03 | 2.5E-09 |  2d |0
2023-02-17 16:05:19 fides(INFO)    15| +1.49E+02 | -3.3E+00 | +9.6E-01 | 2.4E-01 | 1.8E+02 | 3.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    18| +2.10E+02 | -1.2E+00 | +6.9E-02 | 2.5E-01 | 2.5E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    11| +2.50E+02 | -7.6E-01 | +3.8E-01 | 1.2E-01 | 2.2E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    27| +1.52E+02 | +4.7E+01 | -1.8E+02 | 1.0E+00 | 2.4E+01 | 2.5E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)    32| +2.11E+02 | -6.6E-01 | +7.8E-01 | 3.1E-02 | 1.8E+01 | 6.6E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    12| +2.50E+02 | +2.4E-01 | -3.5E-01 | 1.2E-01 | 1.0E+01 | 3.1E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)   123| +1.48E+02 | +5.2E-07 | -1.6E+05 | 2.5E-10 | 5.6E-03 | 6.2E-10 |  2d |0
2023-02-17 16:05:19 fides(INFO)    16| +1.49E+02 | +8.2E+00 | -5.7E+00 | 4.8E-01 | 3.0E+01 | 6.5E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)    43| +1.48E+02 | -4.2E-03 | +8.9E-01 | 7.2E-03 | 4.1E+00 | 1.0E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    19| +2.05E+02 | -5.1E+00 | +8.5E-01 | 6.2E-02 | 6.3E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    13| +2.50E+02 | -3.4E-01 | +5.9E-01 | 2.9E-02 | 1.0E+01 | 7.7E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    33| +2.11E+02 | -4.2E-01 | +8.2E-01 | 6.2E-02 | 7.7E+00 | 1.4E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   124| +1.48E+02 | +4.5E-07 | -5.3E+05 | 6.2E-11 | 5.6E-03 | 1.5E-10 |  2d |0
2023-02-17 16:05:19 fides(INFO)    17| +1.48E+02 | -5.2E-01 | +5.3E-01 | 1.2E-01 | 3.0E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    28| +1.52E+02 | -1.9E-01 | +1.0E+00 | 2.5E-01 | 2.4E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    20| +2.02E+02 | -3.3E+00 | +7.9E-01 | 1.2E-01 | 3.1E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    44| +1.48E+02 | -3.9E-03 | +9.1E-01 | 1.4E-02 | 4.6E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    14| +2.50E+02 | -9.7E-04 | +4.9E-02 | 2.9E-02 | 1.8E+00 | 7.5E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    34| +2.10E+02 | -3.5E-01 | +4.0E-01 | 1.2E-01 | 7.9E+00 | 3.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   125| +1.48E+02 | +4.6E-06 | -2.2E+07 | 1.5E-11 | 5.6E-03 | 3.9E-11 |  2d |0
2023-02-17 16:05:19 fides(INFO)    15| +2.50E+02 | -9.4E-04 | +5.5E-02 | 7.3E-03 | 1.7E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    18| +1.48E+02 | -2.8E-01 | +8.6E-01 | 1.2E-01 | 2.8E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    45| +1.48E+02 | -7.6E-03 | +9.4E-01 | 2.9E-02 | 5.2E-01 | 3.8E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    21| +1.94E+02 | -8.3E+00 | +1.3E+00 | 2.5E-01 | 1.8E+01 | 6.6E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    29| +1.52E+02 | +1.9E+00 | -5.6E+00 | 5.0E-01 | 1.5E+01 | 1.0E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)    35| +2.09E+02 | -9.0E-01 | +6.7E-01 | 1.2E-01 | 1.5E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    95| +1.55E+02 | -6.7E-04 | +1.3E+00 | 1.1E-02 | 1.6E-01 | 3.0E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    16| +2.50E+02 | -4.3E-03 | +9.0E-01 | 1.8E-03 | 1.6E+00 | 3.3E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)   126| +1.48E+02 | +5.1E-06 | -9.7E+07 | 3.9E-12 | 5.6E-03 | 9.6E-12 |  2d |0
2023-02-17 16:05:19 fides(INFO)    46| +1.48E+02 | -5.5E-03 | +6.3E-01 | 5.8E-02 | 8.4E-01 | 7.6E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    19| +1.48E+02 | +1.9E-01 | -6.3E-01 | 2.4E-01 | 8.0E+00 | 2.7E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)    17| +2.50E+02 | -3.0E-03 | +6.2E-01 | 3.7E-03 | 1.0E+00 | 6.5E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    22| +1.94E+02 | +3.1E+01 | -2.3E+00 | 5.0E-01 | 3.7E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:19 fides(INFO)    36| +2.09E+02 | -3.3E-01 | +3.2E-01 | 1.2E-01 | 8.2E+00 | 3.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    30| +1.52E+02 | -3.1E-01 | +9.7E-01 | 1.2E-01 | 1.5E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)   127| +1.48E+02 | -1.7E-08 | +1.3E+06 | 9.7E-13 | 5.6E-03 | 2.4E-12 |  2d |1
2023-02-17 16:05:19 fides(WARNING) Stopping as function difference 1.67E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:19 fides(INFO)    47| +1.48E+02 | +2.1E-01 | -7.9E+00 | 5.8E-02 | 9.7E-01 | 8.8E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    20| +1.48E+02 | -2.8E-02 | +9.8E-02 | 6.0E-02 | 8.0E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    18| +2.50E+02 | -2.0E-06 | +3.5E-02 | 3.7E-03 | 9.8E-02 | 9.7E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    23| +1.84E+02 | -9.8E+00 | +1.2E+00 | 1.2E-01 | 3.7E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    37| +2.08E+02 | -9.1E-01 | +6.3E-01 | 1.2E-01 | 1.6E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    48| +1.48E+02 | +1.0E-02 | -8.1E-01 | 1.4E-02 | 9.7E-01 | 2.4E-02 |  2d |0
2023-02-17 16:05:19 fides(INFO)    19| +2.50E+02 | -9.4E-07 | +1.6E-02 | 9.2E-04 | 9.8E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    24| +1.67E+02 | -1.7E+01 | +8.6E-01 | 2.5E-01 | 4.5E+01 | 5.5E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    38| +2.08E+02 | -5.2E-01 | +4.6E-01 | 1.2E-01 | 8.6E+00 | 3.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    21| +1.48E+02 | -8.0E-02 | +8.6E-01 | 1.5E-02 | 1.4E+01 | 2.2E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    31| +1.52E+02 | -6.6E-02 | +1.2E-01 | 2.5E-01 | 6.1E+00 | 5.4E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    20| +2.50E+02 | -2.8E-05 | +6.5E-01 | 2.3E-04 | 9.7E-02 | 6.0E-04 |  2d |1
2023-02-17 16:05:19 fides(INFO)    49| +1.48E+02 | -1.7E-03 | +3.6E-01 | 3.6E-03 | 9.7E-01 | 7.1E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    25| +1.67E+02 | +7.7E+01 | -4.4E+00 | 5.0E-01 | 1.3E+02 | 9.0E-01 |  2d |0
2023-02-17 16:05:19 fides(INFO)    39| +2.06E+02 | -1.4E+00 | +7.7E-01 | 1.2E-01 | 1.6E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    22| +1.48E+02 | -5.0E-02 | +7.1E-01 | 3.0E-02 | 5.9E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    21| +2.50E+02 | -1.4E-07 | +5.9E-01 | 2.3E-04 | 4.1E-03 | 6.1E-04 |  2d |1
2023-02-17 16:05:19 fides(WARNING) Stopping as function difference 1.37E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:19 fides(INFO)    32| +1.51E+02 | -1.0E-01 | +9.6E-01 | 6.2E-02 | 2.0E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    50| +1.48E+02 | -1.3E-03 | +9.2E-01 | 3.6E-03 | 3.0E+00 | 4.7E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    26| +1.55E+02 | -1.1E+01 | +9.2E-01 | 1.2E-01 | 1.3E+02 | 2.2E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)    40| +2.03E+02 | -3.1E+00 | +1.2E+00 | 2.5E-01 | 1.0E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    23| +1.48E+02 | -1.2E-02 | +8.1E-01 | 3.0E-02 | 6.3E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    51| +1.48E+02 | -4.9E-04 | +9.2E-01 | 7.2E-03 | 2.8E-01 | 9.2E-03 |  2d |1
2023-02-17 16:05:19 fides(INFO)    41| +1.81E+02 | -2.3E+01 | +1.5E+00 | 5.0E-01 | 2.1E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    24| +1.48E+02 | -7.0E-03 | +7.9E-01 | 6.0E-02 | 1.6E+00 | 6.3E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    33| +1.51E+02 | -9.7E-02 | +1.0E+00 | 1.2E-01 | 1.1E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    96| +1.55E+02 | -1.3E-03 | +1.1E+00 | 2.2E-02 | 3.0E-01 | 5.9E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)    27| +1.52E+02 | -3.2E+00 | +4.0E-01 | 2.5E-01 | 6.4E+01 | 5.8E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:19 fides(INFO)     0| +3.19E+13 |    NaN   |    NaN   | 1.0E+00 | 1.1E+14 |   NaN   | NaN |1
2023-02-17 16:05:19 fides(INFO)    52| +1.48E+02 | -9.3E-04 | +9.5E-01 | 1.4E-02 | 2.6E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:19 fides(INFO)     1| +3.54E+10 | -3.2E+13 | +1.1E-01 | 1.0E+00 | 1.1E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:19 fides(INFO)    25| +1.48E+02 | -7.8E-03 | +9.6E-01 | 1.2E-01 | 2.7E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:19 fides(INFO)    28| +1.48E+02 | -4.0E+00 | +7.6E-01 | 2.5E-01 | 7.2E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    42| +1.81E+02 | +8.1E+03 | -2.3E+02 | 1.0E+00 | 8.1E+01 | 2.2E+00 |  2d |0
2023-02-17 16:05:20 fides(INFO)     2| +5.33E+09 | -3.0E+10 | +8.9E-01 | 2.5E-01 | 1.6E+11 | 6.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)     0| +4.83E+06 |    NaN   |    NaN   | 1.0E+00 | 1.7E+07 |   NaN   | NaN |1
2023-02-17 16:05:20 fides(INFO)    53| +1.48E+02 | -4.7E-04 | +4.8E-01 | 2.9E-02 | 2.0E-01 | 3.6E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    34| +1.51E+02 | -1.9E-01 | +1.1E+00 | 2.5E-01 | 1.1E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    26| +1.48E+02 | -1.0E-02 | +9.4E-01 | 2.4E-01 | 9.7E-01 | 2.3E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)     3| +8.04E+08 | -4.5E+09 | +8.9E-01 | 5.0E-01 | 2.4E+10 | 1.0E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    29| +1.48E+02 | +1.0E+01 | -8.3E+00 | 5.0E-01 | 4.5E+01 | 6.2E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    43| +1.67E+02 | -1.4E+01 | +5.2E-01 | 2.5E-01 | 8.1E+01 | 5.4E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)     4| +1.22E+08 | -6.8E+08 | +8.9E-01 | 5.0E-01 | 3.7E+09 | 9.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    54| +1.48E+02 | +1.7E-02 | -4.2E+00 | 2.9E-02 | 3.8E-01 | 3.9E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    27| +1.48E+02 | -5.8E-03 | +5.0E-01 | 4.8E-01 | 1.2E+00 | 4.0E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)     1| +1.28E+04 | -4.8E+06 | +1.4E-01 | 1.0E+00 | 1.7E+07 | 2.5E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)     5| +1.86E+07 | -1.0E+08 | +8.9E-01 | 5.0E-01 | 5.6E+08 | 9.9E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    30| +1.48E+02 | -1.8E-01 | +2.6E-01 | 1.2E-01 | 4.5E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)     6| +2.87E+06 | -1.6E+07 | +8.9E-01 | 5.0E-01 | 8.6E+07 | 1.3E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    55| +1.48E+02 | +1.3E-03 | -7.8E-01 | 7.2E-03 | 3.8E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    28| +1.48E+02 | +4.0E-01 | -9.0E+00 | 4.8E-01 | 1.4E+00 | 2.9E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    44| +1.57E+02 | -9.8E+00 | +9.7E-01 | 2.5E-01 | 1.6E+02 | 4.4E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)     2| +2.26E+03 | -1.1E+04 | +9.0E-01 | 2.5E-01 | 5.8E+04 | 6.5E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    31| +1.48E+02 | -2.7E-01 | +4.4E-01 | 1.2E-01 | 2.3E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    35| +1.51E+02 | -3.5E-01 | +1.4E+00 | 5.0E-01 | 1.1E+01 | 8.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)     7| +4.44E+05 | -2.4E+06 | +9.0E-01 | 1.0E+00 | 1.3E+07 | 8.8E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    56| +1.48E+02 | -9.3E-05 | +1.2E-01 | 1.8E-03 | 3.8E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    29| +1.48E+02 | +1.1E-02 | -5.7E-01 | 1.2E-01 | 1.4E+00 | 7.4E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    45| +1.57E+02 | +2.2E+01 | -2.4E+00 | 5.0E-01 | 4.8E+01 | 9.0E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)     3| +6.12E+02 | -1.6E+03 | +8.5E-01 | 5.0E-01 | 9.1E+03 | 1.3E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)     8| +6.95E+04 | -3.7E+05 | +9.0E-01 | 1.0E+00 | 2.0E+06 | 8.4E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    32| +1.48E+02 | +2.6E-01 | -6.8E-01 | 1.2E-01 | 1.5E+01 | 1.8E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    36| +1.51E+02 | +2.5E+00 | -4.0E+00 | 1.0E+00 | 1.0E+01 | 1.4E+00 | trr |0
2023-02-17 16:05:20 fides(INFO)     4| +2.63E+02 | -3.5E+02 | +9.2E-01 | 1.0E+00 | 1.5E+03 | 1.5E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    57| +1.48E+02 | -3.2E-04 | +9.4E-01 | 4.5E-04 | 1.7E+00 | 6.7E-04 |  2d |1
2023-02-17 16:05:20 fides(INFO)     9| +1.11E+04 | -5.8E+04 | +9.0E-01 | 1.0E+00 | 3.2E+05 | 8.1E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    30| +1.48E+02 | -3.2E-03 | +5.3E-01 | 3.0E-02 | 1.4E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    46| +1.53E+02 | -3.8E+00 | +7.6E-01 | 1.2E-01 | 4.8E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)     5| +2.12E+02 | -5.1E+01 | +8.7E-01 | 1.0E+00 | 1.8E+02 | 2.0E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    33| +1.48E+02 | -8.0E-02 | +6.2E-01 | 3.1E-02 | 1.5E+01 | 4.6E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    97| +1.55E+02 | -2.7E-03 | +1.0E+00 | 4.5E-02 | 3.4E-01 | 1.2E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    10| +1.93E+03 | -9.2E+03 | +9.0E-01 | 1.0E+00 | 5.0E+04 | 7.9E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    58| +1.48E+02 | -3.7E-05 | +8.7E-01 | 9.0E-04 | 1.5E-01 | 1.1E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    31| +1.48E+02 | -9.8E-04 | +9.6E-01 | 3.0E-02 | 2.6E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    34| +1.48E+02 | -5.9E-02 | +9.7E-01 | 3.1E-02 | 2.0E+01 | 2.3E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    37| +1.50E+02 | -4.3E-01 | +1.1E+00 | 2.4E-01 | 1.0E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    11| +4.92E+02 | -1.4E+03 | +9.1E-01 | 1.0E+00 | 7.9E+03 | 1.0E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    47| +1.51E+02 | -2.3E+00 | +6.2E-01 | 2.5E-01 | 6.9E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    32| +1.48E+02 | -4.7E-04 | +9.4E-01 | 6.0E-02 | 3.0E-01 | 3.0E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)     6| +2.12E+02 | +2.6E+02 | -1.2E+01 | 2.0E+00 | 6.4E+01 | 5.9E+00 |  2d |0
2023-02-17 16:05:20 fides(INFO)    59| +1.48E+02 | -3.2E-05 | +7.2E-01 | 1.8E-03 | 2.2E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:20.266 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0723 and h = 2.40154e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:20.267 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0723: AMICI failed to integrate the forward problem
2023-02-17 16:05:20 fides(INFO)    35| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 1.1E+01 | 4.3E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    12| +2.72E+02 | -2.2E+02 | +9.0E-01 | 1.0E+00 | 1.3E+03 | 1.7E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)     7| +1.99E+02 | -1.3E+01 | +6.2E-01 | 5.0E-01 | 6.4E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    60| +1.48E+02 | -2.0E-05 | +9.7E-01 | 1.8E-03 | 7.1E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    48| +1.49E+02 | -1.6E+00 | +8.2E-01 | 2.5E-01 | 3.4E+01 | 3.8E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    38| +1.50E+02 | -5.7E-01 | +8.6E-01 | 4.7E-01 | 1.0E+01 | 6.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    33| +1.48E+02 | -4.8E-04 | +6.8E-01 | 1.2E-01 | 6.7E-01 | 5.8E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)     8| +1.74E+02 | -2.6E+01 | +1.1E+00 | 5.0E-01 | 6.9E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    13| +2.42E+02 | -3.0E+01 | +9.2E-01 | 2.0E+00 | 1.8E+02 | 1.7E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    36| +1.48E+02 | -1.9E-02 | +9.6E-01 | 1.6E-02 | 1.1E+01 | 1.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    61| +1.48E+02 | -3.3E-05 | +9.9E-01 | 3.6E-03 | 8.7E-02 | 3.4E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)     9| +1.74E+02 | +1.6E+03 | -7.8E+01 | 1.0E+00 | 5.5E+01 | 1.9E+00 |  2d |0
2023-02-17 16:05:20 fides(INFO)    39| +1.50E+02 | -1.8E-01 | +6.6E-01 | 9.5E-01 | 1.6E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    49| +1.49E+02 | +2.9E+00 | -2.1E+00 | 5.0E-01 | 2.9E+01 | 7.0E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    14| +2.31E+02 | -1.2E+01 | +1.7E+00 | 2.0E+00 | 1.5E+01 | 1.6E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    34| +1.48E+02 | +1.2E-03 | -1.0E+00 | 1.2E-01 | 3.1E-01 | 4.8E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    37| +1.48E+02 | -3.0E-02 | +9.8E-01 | 3.1E-02 | 1.2E+01 | 2.0E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    10| +1.64E+02 | -9.2E+00 | +4.7E-01 | 2.5E-01 | 5.5E+01 | 5.4E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    62| +1.48E+02 | -3.8E-05 | +1.0E+00 | 7.2E-03 | 4.1E-02 | 6.5E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    35| +1.48E+02 | -1.4E-04 | +3.2E-01 | 3.0E-02 | 3.1E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    50| +1.49E+02 | -3.2E-01 | +5.7E-01 | 1.2E-01 | 2.9E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    15| +2.31E+02 | +7.6E+01 | -9.5E+00 | 4.0E+00 | 1.8E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:20.371 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 169.86 and h = 3.38851e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:20.371 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 169.86: AMICI failed to integrate the forward problem
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    40| +1.50E+02 | +0.0E+00 | +0.0E+00 | 9.5E-01 | 4.9E+00 | 1.2E-01 | trr |0
2023-02-17 16:05:20 fides(INFO)    11| +1.53E+02 | -1.1E+01 | +8.7E-01 | 2.5E-01 | 1.4E+02 | 5.7E-01 | trr |1
2023-02-17 16:05:20 fides(INFO)    38| +1.48E+02 | -2.8E-02 | +9.4E-01 | 6.2E-02 | 8.8E+00 | 4.0E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    12| +1.53E+02 | +1.6E+01 | -2.6E+00 | 2.5E-01 | 1.0E+02 | 4.8E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    63| +1.48E+02 | +8.3E-05 | -4.8E+00 | 1.4E-02 | 2.5E-02 | 2.6E-03 | trr |0
2023-02-17 16:05:20 fides(INFO)    16| +2.23E+02 | -7.1E+00 | +1.5E+00 | 1.0E+00 | 1.8E+01 | 3.0E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    36| +1.48E+02 | -2.0E-04 | +7.1E-01 | 3.0E-02 | 9.1E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    39| +1.48E+02 | -2.8E-02 | +7.5E-01 | 1.2E-01 | 7.4E+00 | 5.4E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    51| +1.48E+02 | -4.1E-01 | +8.9E-01 | 1.2E-01 | 2.5E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    41| +1.50E+02 | -1.4E-02 | +8.3E-01 | 5.6E-02 | 4.9E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    98| +1.55E+02 | -6.4E-03 | +1.1E+00 | 8.9E-02 | 3.8E-01 | 2.3E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    13| +1.49E+02 | -4.1E+00 | +8.9E-01 | 6.2E-02 | 1.0E+02 | 1.2E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    64| +1.48E+02 | +3.4E-06 | -4.5E-01 | 2.1E-03 | 2.5E-02 | 6.6E-04 |  2d |0
2023-02-17 16:05:20 fides(INFO)    37| +1.48E+02 | -7.0E-05 | +8.9E-01 | 3.0E-02 | 1.5E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    42| +1.50E+02 | -4.2E-03 | +8.2E-01 | 1.1E-01 | 2.0E+00 | 4.5E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    40| +1.48E+02 | +5.1E-01 | -5.3E+00 | 2.5E-01 | 4.6E+00 | 2.8E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    17| +2.23E+02 | +7.1E+02 | -4.1E+01 | 2.0E+00 | 4.3E+01 | 4.5E+00 | trr |0
2023-02-17 16:05:20 fides(INFO)    14| +1.48E+02 | -1.4E+00 | +4.5E-01 | 1.2E-01 | 3.6E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    52| +1.48E+02 | -4.3E-01 | +9.3E-01 | 2.5E-01 | 2.0E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    65| +1.48E+02 | +2.7E-06 | -1.2E+00 | 5.2E-04 | 2.5E-02 | 1.7E-04 |  2d |0
2023-02-17 16:05:20 fides(INFO)    15| +1.47E+02 | -7.8E-01 | +9.0E-01 | 1.2E-01 | 6.5E+01 | 8.9E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    38| +1.48E+02 | -1.0E-04 | +8.9E-01 | 6.0E-02 | 2.1E-01 | 2.2E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    41| +1.48E+02 | +3.7E-03 | -1.2E-01 | 6.2E-02 | 4.6E+00 | 6.9E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    18| +2.04E+02 | -2.0E+01 | +9.7E-01 | 5.0E-01 | 4.3E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    53| +1.48E+02 | +3.2E-01 | -6.9E-01 | 5.0E-01 | 1.5E+01 | 5.8E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    43| +1.50E+02 | -1.3E-03 | +9.6E-01 | 2.3E-01 | 9.1E-01 | 7.4E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    16| +1.46E+02 | -4.7E-01 | +7.8E-01 | 2.5E-01 | 1.7E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    66| +1.48E+02 | +2.9E-06 | -3.5E+00 | 1.3E-04 | 2.5E-02 | 5.5E-05 |  2d |0
2023-02-17 16:05:20 fides(INFO)    54| +1.48E+02 | -1.1E-01 | +6.7E-01 | 1.2E-01 | 1.5E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    42| +1.48E+02 | -7.8E-03 | +7.4E-01 | 1.6E-02 | 4.6E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    19| +2.04E+02 | -9.9E+00 | -1.7E+00 | 1.0E+00 | 6.2E+01 | 1.7E+00 |  2d |0
2023-02-17 16:05:20 fides(INFO)    39| +1.48E+02 | -2.5E-05 | +1.5E-01 | 1.2E-01 | 1.1E-01 | 3.9E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    44| +1.50E+02 | -1.2E-04 | +6.0E-01 | 4.5E-01 | 6.7E-01 | 3.3E-02 | trr |1
2023-02-17 16:05:20 fides(INFO)    17| +1.46E+02 | +7.2E+00 | -7.9E+00 | 5.0E-01 | 4.2E+01 | 4.1E-01 | trr |0
2023-02-17 16:05:20 fides(INFO)    67| +1.48E+02 | +1.3E-06 | -3.1E+00 | 3.2E-05 | 2.5E-02 | 3.0E-05 |  2d |0
2023-02-17 16:05:20 fides(INFO)    43| +1.48E+02 | -3.4E-03 | +8.9E-01 | 1.6E-02 | 3.5E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    40| +1.48E+02 | -4.7E-05 | +1.3E-01 | 3.0E-02 | 2.5E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    55| +1.48E+02 | -1.0E-01 | +4.5E-01 | 1.2E-01 | 1.1E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    20| +1.85E+02 | -1.8E+01 | +9.9E-01 | 2.5E-01 | 6.2E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    18| +1.46E+02 | -3.0E-01 | +5.9E-01 | 5.2E-02 | 4.2E+01 | 8.5E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    99| +1.55E+02 | -1.5E-02 | +1.1E+00 | 1.8E-01 | 1.2E+00 | 4.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    45| +1.50E+02 | +7.4E-05 | -4.2E-01 | 4.5E-01 | 1.1E-01 | 9.1E-03 | trr |0
2023-02-17 16:05:20 fides(INFO)    19| +1.46E+02 | +3.2E-01 | -1.4E+00 | 5.2E-02 | 1.0E+01 | 9.8E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    68| +1.48E+02 | +4.7E-06 | -1.6E+01 | 8.1E-06 | 2.5E-02 | 2.1E-05 |  2d |0
2023-02-17 16:05:20 fides(INFO)    44| +1.48E+02 | -3.0E-03 | +9.2E-01 | 3.1E-02 | 3.2E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    56| +1.48E+02 | +1.0E-03 | -1.4E-02 | 1.2E-01 | 2.1E+01 | 1.5E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    41| +1.48E+02 | -5.8E-05 | +7.2E-01 | 7.5E-03 | 2.3E-01 | 2.1E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    21| +1.74E+02 | -1.2E+01 | +1.5E-01 | 5.0E-01 | 5.0E+01 | 8.8E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    20| +1.46E+02 | -4.0E-02 | +5.6E-01 | 1.3E-02 | 1.0E+01 | 2.5E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    69| +1.48E+02 | +5.0E-06 | -4.4E+01 | 2.0E-06 | 2.5E-02 | 5.4E-06 |  2d |0
2023-02-17 16:05:20 fides(INFO)    46| +1.50E+02 | -5.6E-05 | +7.1E-01 | 1.1E-02 | 1.1E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    42| +1.48E+02 | -1.7E-05 | +7.9E-01 | 7.5E-03 | 2.3E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    57| +1.48E+02 | -9.3E-02 | +8.0E-01 | 3.1E-02 | 2.1E+01 | 3.8E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    45| +1.48E+02 | -3.3E-03 | +8.3E-01 | 6.2E-02 | 2.5E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    22| +1.51E+02 | -2.2E+01 | +9.1E-01 | 1.2E-01 | 2.9E+02 | 2.1E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    21| +1.46E+02 | -5.9E-02 | +9.1E-01 | 1.3E-02 | 7.7E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    43| +1.48E+02 | -6.8E-06 | +3.7E-01 | 1.5E-02 | 6.3E-02 | 3.5E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    47| +1.50E+02 | -1.7E-05 | +1.1E+00 | 1.1E-02 | 2.5E-01 | 9.0E-04 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    70| +1.48E+02 | +5.2E-06 | -1.7E+02 | 5.1E-07 | 2.5E-02 | 1.3E-06 |  2d |0
2023-02-17 16:05:20 fides(INFO)    46| +1.48E+02 | +1.7E-02 | -2.3E+00 | 1.2E-01 | 2.0E+00 | 8.2E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    23| +1.49E+02 | -2.8E+00 | +8.9E-01 | 2.5E-01 | 7.8E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    58| +1.48E+02 | -4.0E-02 | +7.7E-01 | 6.2E-02 | 3.8E+00 | 6.6E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)   100| +1.55E+02 | +9.5E-01 | -3.5E+01 | 3.6E-01 | 7.2E+00 | 9.0E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    22| +1.46E+02 | -7.1E-02 | +9.0E-01 | 2.6E-02 | 1.3E+01 | 2.5E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    23| +1.46E+02 | +4.0E-02 | -3.5E-01 | 5.2E-02 | 4.5E+00 | 8.6E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    71| +1.48E+02 | +6.4E-06 | -8.1E+02 | 1.3E-07 | 2.5E-02 | 3.4E-07 |  2d |0
2023-02-17 16:05:20.687 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 144.786 and h = 1.83601e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:20.687 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 144.786: AMICI failed to integrate the forward problem
2023-02-17 16:05:20 fides(INFO)    44| +1.48E+02 | -9.4E-06 | +5.6E-01 | 1.5E-02 | 2.3E-01 | 3.6E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    24| +1.49E+02 | +2.3E+00 | -1.8E+00 | 5.0E-01 | 4.3E+01 | 6.0E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    48| +1.50E+02 | -7.6E-06 | +8.9E-01 | 2.2E-02 | 7.1E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    59| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 7.8E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    47| +1.48E+02 | -1.0E-03 | +3.8E-01 | 3.1E-02 | 2.0E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    24| +1.46E+02 | -3.0E-02 | +7.4E-01 | 1.3E-02 | 4.5E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    45| +1.48E+02 | -5.4E-06 | +1.5E+00 | 1.5E-02 | 3.2E-02 | 3.3E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    25| +1.48E+02 | -5.5E-01 | +7.1E-01 | 1.2E-01 | 4.3E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    49| +1.50E+02 | -1.4E-06 | +5.6E-01 | 4.3E-02 | 7.3E-02 | 6.6E-04 | trr |1
2023-02-17 16:05:20 fides(WARNING) Stopping as function difference 1.40E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    60| +1.48E+02 | -1.9E-02 | +9.7E-01 | 3.1E-02 | 7.8E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    25| +1.46E+02 | -3.0E-02 | +8.3E-01 | 1.3E-02 | 8.2E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    48| +1.48E+02 | -2.4E-04 | +8.1E-02 | 3.1E-02 | 1.5E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    72| +1.48E+02 | +5.9E-06 | -3.0E+03 | 3.2E-08 | 2.5E-02 | 8.4E-08 |  2d |0
2023-02-17 16:05:20 fides(INFO)    26| +1.46E+02 | -2.7E-02 | +5.9E-01 | 2.6E-02 | 3.9E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    46| +1.48E+02 | -4.8E-06 | +8.4E-01 | 3.0E-02 | 3.2E-02 | 6.4E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    61| +1.48E+02 | -2.6E-02 | +7.4E-01 | 6.2E-02 | 2.8E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    26| +1.48E+02 | -1.0E-01 | +3.2E-01 | 1.2E-01 | 2.6E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    49| +1.48E+02 | -1.2E-03 | +7.9E-01 | 7.8E-03 | 1.9E+00 | 6.9E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    27| +1.46E+02 | -6.5E-03 | +5.1E-02 | 2.6E-02 | 3.4E+00 | 5.2E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    47| +1.48E+02 | -1.0E-05 | +1.3E+00 | 6.0E-02 | 2.2E-02 | 1.2E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    27| +1.48E+02 | -2.0E-01 | +3.4E-01 | 1.2E-01 | 2.1E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)   101| +1.55E+02 | -1.2E-02 | +8.2E-01 | 8.9E-02 | 7.2E+00 | 2.2E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    50| +1.48E+02 | -4.1E-04 | +6.0E-01 | 1.6E-02 | 8.3E-01 | 8.6E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    73| +1.48E+02 | +2.7E-06 | -5.5E+03 | 7.9E-09 | 2.5E-02 | 2.1E-08 |  2d |0
2023-02-17 16:05:20 fides(INFO)    62| +1.48E+02 | -2.6E-02 | +7.2E-01 | 6.2E-02 | 8.3E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    28| +1.46E+02 | -3.5E-02 | +8.3E-01 | 6.5E-03 | 9.0E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:20.822 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.271 and h = 1.32109e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:20.822 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.271: AMICI failed to integrate the forward problem
2023-02-17 16:05:20 fides(INFO)    28| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 2.6E+01 | 3.4E-01 |  2d |0
2023-02-17 16:05:20.824 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0627 and h = 1.71793e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:20.824 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0627: AMICI failed to integrate the forward problem
2023-02-17 16:05:20 fides(INFO)    48| +1.48E+02 | +2.9E-05 | -2.9E+00 | 1.2E-01 | 2.1E-02 | 2.0E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    74| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.0E-09 | 2.5E-02 | 5.2E-09 |  2d |0
2023-02-17 16:05:20 fides(INFO)    29| +1.46E+02 | -1.6E-02 | +4.7E-01 | 1.3E-02 | 2.2E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    51| +1.48E+02 | -1.9E-04 | +9.1E-01 | 1.6E-02 | 7.3E-01 | 3.0E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    63| +1.48E+02 | -1.5E-02 | +6.0E-01 | 6.2E-02 | 1.7E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    30| +1.46E+02 | -8.6E-03 | +6.4E-01 | 1.3E-02 | 2.5E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)     0| +1.14E+14 |    NaN   |    NaN   | 1.0E+00 | 5.2E+14 |   NaN   | NaN |1
2023-02-17 16:05:20 fides(INFO)    49| +1.48E+02 | +1.5E-06 | -4.3E-01 | 3.0E-02 | 2.1E-02 | 5.0E-03 |  2d |0
2023-02-17 16:05:20 fides(INFO)    29| +1.48E+02 | -1.8E-01 | +7.1E-01 | 3.1E-02 | 2.6E+01 | 8.5E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    52| +1.48E+02 | -2.4E-04 | +9.8E-01 | 3.1E-02 | 5.8E-01 | 7.6E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    75| +1.48E+02 | +6.1E-06 | -2.0E+05 | 5.0E-10 | 2.5E-02 | 1.3E-09 |  2d |0
2023-02-17 16:05:20 fides(INFO)    31| +1.46E+02 | -2.3E-03 | +1.4E-01 | 1.3E-02 | 2.2E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    64| +1.48E+02 | -2.0E-02 | +6.5E-01 | 6.2E-02 | 7.4E+00 | 5.9E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    30| +1.48E+02 | -1.1E-02 | +2.7E-01 | 3.1E-02 | 3.2E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:20 fides(INFO)    50| +1.48E+02 | +6.8E-07 | -6.8E-01 | 7.5E-03 | 2.1E-02 | 1.3E-03 |  2d |0
2023-02-17 16:05:20 fides(INFO)    76| +1.48E+02 | +3.5E-06 | -4.5E+05 | 1.2E-10 | 2.5E-02 | 3.3E-10 |  2d |0
2023-02-17 16:05:20 fides(INFO)     1| +6.16E+07 | -1.1E+14 | +8.2E-02 | 1.0E+00 | 5.2E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:20 fides(INFO)    53| +1.48E+02 | -2.0E-04 | +8.3E-01 | 6.2E-02 | 5.2E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    32| +1.46E+02 | -4.8E-03 | +7.4E-01 | 3.2E-03 | 1.8E+00 | 6.6E-03 |  2d |1
2023-02-17 16:05:20.925 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 86.193 and h = 1.72762e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:20.925 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 86.193: AMICI failed to integrate the forward problem
2023-02-17 16:05:20 fides(INFO)    65| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 1.4E+00 | 5.2E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    51| +1.48E+02 | +2.2E-06 | -7.3E+00 | 1.9E-03 | 2.1E-02 | 3.2E-04 |  2d |0
2023-02-17 16:05:20 fides(INFO)    31| +1.48E+02 | -1.7E-02 | +7.5E-01 | 3.1E-02 | 9.8E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    77| +1.48E+02 | +2.6E-06 | -1.3E+06 | 3.1E-11 | 2.5E-02 | 8.2E-11 |  2d |0
2023-02-17 16:05:20 fides(INFO)    33| +1.46E+02 | -3.1E-03 | +8.2E-01 | 3.2E-03 | 2.9E+00 | 4.2E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    54| +1.48E+02 | +4.9E-03 | -1.1E+01 | 1.2E-01 | 2.3E-01 | 4.1E-02 | trr |0
2023-02-17 16:05:20 fides(INFO)     2| +9.41E+06 | -5.2E+07 | +8.9E-01 | 2.5E-01 | 2.8E+08 | 7.1E-01 |  2d |1
2023-02-17 16:05:20 fides(INFO)    66| +1.48E+02 | -4.0E-03 | +6.3E-01 | 1.6E-02 | 1.4E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    32| +1.48E+02 | -4.0E-03 | +6.8E-01 | 3.1E-02 | 1.9E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    34| +1.46E+02 | -4.0E-03 | +9.9E-01 | 6.5E-03 | 1.5E+00 | 4.6E-03 |  2d |1
2023-02-17 16:05:20 fides(INFO)    52| +1.48E+02 | +4.0E-06 | -3.4E+01 | 4.7E-04 | 2.1E-02 | 7.9E-05 |  2d |0
2023-02-17 16:05:20 fides(INFO)    78| +1.48E+02 | +4.4E-08 | -9.1E+04 | 7.7E-12 | 2.5E-02 | 2.0E-11 |  2d |0
2023-02-17 16:05:20 fides(INFO)   102| +1.55E+02 | +3.2E-01 | -5.2E+00 | 1.8E-01 | 5.9E+00 | 3.7E-01 |  2d |0
2023-02-17 16:05:20 fides(INFO)    67| +1.48E+02 | -5.2E-03 | +9.5E-01 | 1.6E-02 | 4.9E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)    55| +1.48E+02 | +1.4E-04 | -6.3E-01 | 3.0E-02 | 2.3E-01 | 1.0E-02 |  2d |0
2023-02-17 16:05:20 fides(INFO)    35| +1.46E+02 | -5.8E-03 | +8.9E-01 | 1.3E-02 | 1.6E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:20 fides(INFO)     3| +1.45E+06 | -8.0E+06 | +8.9E-01 | 5.0E-01 | 4.3E+07 | 1.4E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    53| +1.48E+02 | +4.1E-07 | -5.7E+00 | 1.2E-04 | 2.1E-02 | 2.1E-05 |  2d |0
2023-02-17 16:05:21 fides(INFO)    33| +1.48E+02 | -1.0E-03 | +6.5E-01 | 3.1E-02 | 2.0E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    36| +1.46E+02 | +4.0E-02 | -2.7E+00 | 2.6E-02 | 1.8E+00 | 3.7E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    56| +1.48E+02 | -4.8E-05 | +5.9E-01 | 7.6E-03 | 2.3E-01 | 2.6E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    68| +1.48E+02 | -5.3E-03 | +9.9E-01 | 3.1E-02 | 7.2E-01 | 2.6E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    79| +1.48E+02 | +5.2E-06 | -4.3E+07 | 1.9E-12 | 2.5E-02 | 5.1E-12 |  2d |0
2023-02-17 16:05:21 fides(INFO)    54| +1.48E+02 | +1.5E-06 | -2.5E+01 | 2.9E-05 | 2.1E-02 | 7.5E-06 |  2d |0
2023-02-17 16:05:21 fides(INFO)    57| +1.48E+02 | -2.3E-05 | +9.9E-01 | 7.6E-03 | 3.4E-01 | 9.9E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    37| +1.46E+02 | -1.2E-03 | +2.5E-01 | 6.5E-03 | 1.8E+00 | 9.2E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    34| +1.48E+02 | -9.9E-06 | +6.5E-03 | 3.1E-02 | 4.8E-01 | 8.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     4| +2.35E+05 | -1.2E+06 | +8.8E-01 | 1.0E+00 | 6.7E+06 | 2.6E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    69| +1.48E+02 | -8.6E-03 | +9.2E-01 | 6.2E-02 | 1.8E+00 | 5.1E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    80| +1.48E+02 | +8.5E-07 | -2.8E+07 | 4.8E-13 | 2.5E-02 | 1.3E-12 |  2d |0
2023-02-17 16:05:21 fides(INFO)    38| +1.46E+02 | -3.3E-03 | +4.5E-01 | 6.5E-03 | 1.1E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    55| +1.48E+02 | +1.8E-06 | -3.0E+01 | 7.3E-06 | 2.1E-02 | 5.7E-06 |  2d |0
2023-02-17 16:05:21 fides(INFO)    35| +1.48E+02 | -6.9E-04 | +7.4E-01 | 7.8E-03 | 1.4E+00 | 7.9E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    58| +1.48E+02 | -1.9E-05 | +1.1E+00 | 1.5E-02 | 1.3E-01 | 2.0E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    39| +1.46E+02 | -3.8E-04 | +7.1E-02 | 6.5E-03 | 2.5E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    70| +1.48E+02 | -1.3E-02 | +8.6E-01 | 1.2E-01 | 8.4E-01 | 9.7E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    81| +1.48E+02 | +7.9E-07 | -1.1E+08 | 1.2E-13 | 2.5E-02 | 3.2E-13 |  2d |0
2023-02-17 16:05:21 fides(INFO)   103| +1.55E+02 | +3.8E-02 | -1.3E+00 | 4.5E-02 | 5.9E+00 | 9.2E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    56| +1.48E+02 | -5.9E-07 | +1.0E+01 | 1.8E-06 | 2.1E-02 | 4.8E-06 |  2d |1
2023-02-17 16:05:21 fides(WARNING) Stopping as function difference 5.86E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    40| +1.46E+02 | -1.7E-03 | +8.7E-01 | 1.6E-03 | 8.0E-01 | 3.2E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    36| +1.48E+02 | -1.1E-04 | +7.6E-01 | 7.8E-03 | 3.1E-01 | 4.2E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    59| +1.48E+02 | -1.1E-05 | +5.4E-01 | 3.0E-02 | 1.8E-01 | 4.4E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     5| +2.86E+04 | -2.1E+05 | +8.8E-01 | 2.0E+00 | 1.0E+06 | 3.7E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    71| +1.48E+02 | +1.8E-02 | -5.8E-01 | 2.5E-01 | 3.0E+00 | 2.0E-01 |  2d |0
2023-02-17 16:05:21 fides(INFO)    82| +1.48E+02 | +3.6E-06 | -1.9E+09 | 3.0E-14 | 2.5E-02 | 8.0E-14 |  2d |0
2023-02-17 16:05:21 fides(INFO)    41| +1.46E+02 | -1.3E-03 | +6.2E-01 | 3.2E-03 | 7.2E-01 | 5.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    37| +1.48E+02 | -8.5E-05 | +8.3E-01 | 1.6E-02 | 2.0E-01 | 5.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    60| +1.48E+02 | +1.0E-04 | -1.9E+00 | 3.0E-02 | 8.2E-02 | 4.3E-03 |  2d |0
2023-02-17 16:05:21 fides(INFO)    72| +1.48E+02 | -6.5E-03 | +6.5E-01 | 6.2E-02 | 3.0E+00 | 4.9E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    42| +1.46E+02 | -7.8E-04 | +9.8E-01 | 3.2E-03 | 9.5E-01 | 2.1E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    83| +1.48E+02 | +4.0E-06 | -8.4E+09 | 7.6E-15 | 2.5E-02 | 2.0E-14 |  2d |0
2023-02-17 16:05:21 fides(INFO)    38| +1.48E+02 | -9.7E-05 | +8.8E-01 | 3.1E-02 | 3.3E-01 | 6.6E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    61| +1.48E+02 | +4.5E-07 | -2.4E-02 | 7.6E-03 | 8.2E-02 | 1.1E-03 |  2d |0
2023-02-17 16:05:21 fides(INFO)    43| +1.46E+02 | -1.2E-03 | +1.0E+00 | 6.5E-03 | 6.6E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    73| +1.48E+02 | -4.4E-03 | +6.8E-01 | 6.2E-02 | 8.8E-01 | 4.2E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    84| +1.48E+02 | +4.2E-06 | -3.6E+10 | 1.9E-15 | 2.5E-02 | 5.0E-15 |  2d |0
2023-02-17 16:05:21 fides(INFO)    39| +1.48E+02 | +1.3E-04 | -6.9E-01 | 6.2E-02 | 1.3E-01 | 1.9E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    62| +1.48E+02 | -5.9E-06 | +6.7E-01 | 1.9E-03 | 8.2E-02 | 3.4E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    44| +1.46E+02 | -1.6E-03 | +8.3E-01 | 1.3E-02 | 5.3E-01 | 8.7E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    74| +1.48E+02 | -4.4E-03 | +6.7E-01 | 6.2E-02 | 2.7E+00 | 4.5E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)     6| +4.64E+03 | -2.4E+04 | +9.0E-01 | 2.0E+00 | 1.3E+05 | 3.3E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)     0| +2.13E+14 |    NaN   |    NaN   | 1.0E+00 | 9.8E+14 |   NaN   | NaN |1
2023-02-17 16:05:21 fides(INFO)    85| +1.48E+02 | +4.1E-06 | -1.4E+11 | 4.7E-16 | 2.5E-02 | 1.3E-15 |  2d |0
2023-02-17 16:05:21 fides(WARNING) Stopping as trust region radius 1.18E-16 is smaller than machine precision.
2023-02-17 16:05:21 fides(INFO)    45| +1.46E+02 | +6.0E-02 | -8.1E+00 | 2.6E-02 | 8.6E-01 | 4.3E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    40| +1.48E+02 | -3.5E-05 | +6.0E-01 | 1.6E-02 | 1.3E-01 | 4.9E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    63| +1.48E+02 | -7.1E-06 | +1.8E+00 | 1.9E-03 | 1.7E-01 | 1.7E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    75| +1.48E+02 | -2.8E-03 | +6.2E-01 | 6.2E-02 | 7.4E-01 | 3.8E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)   104| +1.55E+02 | +2.6E-03 | -1.4E-01 | 1.1E-02 | 5.9E+00 | 2.2E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    46| +1.46E+02 | +1.8E-03 | -7.5E-01 | 6.5E-03 | 8.6E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)     7| +9.19E+02 | -3.7E+03 | +8.9E-01 | 2.0E+00 | 2.0E+04 | 2.2E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    64| +1.48E+02 | +1.4E-06 | -3.1E-01 | 3.8E-03 | 3.7E-02 | 4.5E-04 |  2d |0
2023-02-17 16:05:21 fides(INFO)    41| +1.48E+02 | -3.0E-05 | +7.2E-01 | 1.6E-02 | 2.0E-01 | 2.4E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    47| +1.46E+02 | -4.0E-04 | +6.0E-01 | 1.6E-03 | 8.6E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     1| +1.48E+11 | -2.1E+14 | +8.2E-02 | 1.0E+00 | 9.8E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    76| +1.48E+02 | -2.8E-03 | +5.6E-01 | 6.2E-02 | 2.2E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)     8| +9.19E+02 | -1.4E+02 | -2.0E-01 | 2.0E+00 | 3.3E+03 | 2.2E+00 |  2d |0
2023-02-17 16:05:21 fides(INFO)    65| +1.48E+02 | +2.1E-06 | -5.0E-01 | 9.5E-04 | 3.7E-02 | 3.1E-04 |  2d |0
2023-02-17 16:05:21 fides(INFO)    42| +1.48E+02 | -2.1E-05 | +6.9E-01 | 1.6E-02 | 9.4E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    48| +1.46E+02 | -1.9E-04 | +9.8E-01 | 1.6E-03 | 3.7E-01 | 1.0E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     2| +2.20E+10 | -1.3E+11 | +8.9E-01 | 2.5E-01 | 6.8E+11 | 6.4E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    77| +1.48E+02 | -1.4E-03 | +3.5E-01 | 6.2E-02 | 6.9E-01 | 3.3E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    49| +1.46E+02 | -3.0E-04 | +1.0E+00 | 3.2E-03 | 6.2E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     9| +3.33E+02 | -5.9E+02 | +9.0E-01 | 2.1E-01 | 3.3E+03 | 4.7E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    43| +1.48E+02 | -1.2E-05 | +5.2E-01 | 1.6E-02 | 9.8E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    66| +1.48E+02 | -1.4E-07 | +3.5E-02 | 2.4E-04 | 3.7E-02 | 2.9E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)     0| +1.86E+09 |    NaN   |    NaN   | 1.0E+00 | 8.6E+09 |   NaN   | NaN |1
2023-02-17 16:05:21 fides(INFO)    50| +1.46E+02 | -5.1E-04 | +9.6E-01 | 6.5E-03 | 2.8E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    78| +1.48E+02 | -1.7E-03 | +3.0E-01 | 6.2E-02 | 2.3E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)     3| +3.28E+09 | -1.9E+10 | +8.9E-01 | 5.0E-01 | 1.0E+11 | 8.7E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    10| +2.28E+02 | -1.0E+02 | +8.6E-01 | 4.3E-01 | 5.4E+02 | 9.9E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)     1| +2.20E+06 | -1.9E+09 | +9.9E-02 | 1.0E+00 | 8.6E+09 | 2.7E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    44| +1.48E+02 | -1.5E-05 | +6.7E-01 | 1.6E-02 | 7.9E-02 | 3.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    51| +1.46E+02 | +7.0E-04 | -9.2E-01 | 1.3E-02 | 8.4E-01 | 6.3E-03 |  2d |0
2023-02-17 16:05:21 fides(INFO)    67| +1.48E+02 | -8.6E-07 | +5.3E+00 | 5.9E-05 | 3.3E-02 | 1.2E-05 |  2d |1
2023-02-17 16:05:21 fides(WARNING) Stopping as function difference 8.62E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:21 fides(INFO)   105| +1.55E+02 | -8.5E-03 | +6.0E-01 | 2.8E-03 | 5.9E+00 | 4.9E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    79| +1.48E+02 | +1.1E-03 | -2.0E-01 | 6.2E-02 | 8.1E-01 | 3.0E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    11| +1.88E+02 | -4.1E+01 | +1.6E+00 | 8.5E-01 | 1.3E+02 | 1.2E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)     4| +4.92E+08 | -2.8E+09 | +8.9E-01 | 5.0E-01 | 1.5E+10 | 8.7E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    52| +1.46E+02 | -1.7E-04 | +6.4E-01 | 3.2E-03 | 8.4E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    45| +1.48E+02 | -1.1E-06 | +4.7E-02 | 1.6E-02 | 7.5E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     2| +3.47E+05 | -1.9E+06 | +9.0E-01 | 2.5E-01 | 1.0E+07 | 7.1E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    80| +1.48E+02 | -7.4E-04 | +2.9E-01 | 1.6E-02 | 8.1E-01 | 8.7E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    12| +1.88E+02 | +1.8E+02 | -1.0E+01 | 8.5E-01 | 4.7E+01 | 1.7E+00 |  2d |0
2023-02-17 16:05:21 fides(INFO)    53| +1.46E+02 | -1.7E-05 | +4.3E-02 | 3.2E-03 | 1.7E-01 | 4.1E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     5| +7.40E+07 | -4.2E+08 | +8.9E-01 | 5.0E-01 | 2.3E+09 | 8.6E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    46| +1.48E+02 | -1.1E-05 | +1.1E+00 | 3.9E-03 | 8.3E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    81| +1.48E+02 | -1.4E-03 | +9.3E-01 | 1.6E-02 | 3.1E+00 | 8.4E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     3| +5.82E+04 | -2.9E+05 | +9.0E-01 | 5.0E-01 | 1.6E+06 | 1.5E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    54| +1.46E+02 | -1.8E-04 | +7.2E-01 | 8.1E-04 | 6.2E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    13| +1.72E+02 | -1.6E+01 | +8.2E-01 | 2.1E-01 | 4.7E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)     4| +1.27E+04 | -4.5E+04 | +7.8E-01 | 1.0E+00 | 2.5E+05 | 2.8E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)     6| +1.12E+07 | -6.3E+07 | +8.9E-01 | 5.0E-01 | 3.4E+08 | 8.6E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    55| +1.46E+02 | -4.9E-05 | +7.7E-01 | 8.1E-04 | 1.8E-01 | 6.1E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    47| +1.48E+02 | +1.1E-06 | -2.4E-01 | 7.8E-03 | 5.0E-02 | 1.3E-03 |  2d |0
2023-02-17 16:05:21 fides(INFO)    14| +1.61E+02 | -1.0E+01 | +5.5E-01 | 4.3E-01 | 5.5E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    82| +1.48E+02 | -4.8E-04 | +9.7E-01 | 3.1E-02 | 2.5E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)     5| +2.16E+03 | -1.1E+04 | +9.0E-01 | 2.0E+00 | 4.1E+04 | 1.6E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    56| +1.46E+02 | -5.8E-05 | +1.0E+00 | 1.6E-03 | 2.9E-01 | 5.0E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    48| +1.48E+02 | +4.3E-07 | -2.9E-01 | 2.0E-03 | 5.0E-02 | 3.3E-04 |  2d |0
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)     0| +9.42E+04 |    NaN   |    NaN   | 1.0E+00 | 4.3E+05 |   NaN   | NaN |1
2023-02-17 16:05:21 fides(INFO)     6| +5.05E+02 | -1.7E+03 | +9.0E-01 | 2.0E+00 | 6.5E+03 | 1.7E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)     7| +1.68E+06 | -9.5E+06 | +8.9E-01 | 5.0E-01 | 5.1E+07 | 8.4E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    83| +1.48E+02 | -7.6E-04 | +9.7E-01 | 6.2E-02 | 2.2E-01 | 2.9E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    15| +1.52E+02 | -9.5E+00 | +8.4E-01 | 4.3E-01 | 8.5E+01 | 8.2E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    57| +1.46E+02 | -1.3E-04 | +9.6E-01 | 3.2E-03 | 1.2E-01 | 1.7E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     7| +2.69E+02 | -2.4E+02 | +8.8E-01 | 2.0E+00 | 1.0E+03 | 2.6E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    49| +1.48E+02 | +2.5E-06 | -4.3E+00 | 4.9E-04 | 5.0E-02 | 8.3E-05 |  2d |0
2023-02-17 16:05:21 fides(INFO)     1| +4.02E+02 | -9.4E+04 | +1.2E-01 | 1.0E+00 | 4.3E+05 | 2.3E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)     8| +2.44E+02 | -2.5E+01 | +9.0E-01 | 2.0E+00 | 1.4E+02 | 4.3E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)   106| +1.55E+02 | -1.7E-03 | +4.9E-01 | 2.8E-03 | 3.7E+00 | 6.9E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    58| +1.46E+02 | -2.9E-05 | +1.6E-01 | 6.5E-03 | 6.3E-01 | 3.4E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    16| +1.52E+02 | +2.5E+00 | -4.9E-01 | 8.5E-01 | 5.2E+01 | 1.7E+00 |  2d |0
2023-02-17 16:05:21 fides(INFO)     8| +2.49E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 7.7E+06 | 8.0E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    84| +1.48E+02 | -1.0E-03 | +9.5E-01 | 1.2E-01 | 2.7E-01 | 5.3E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)     2| +3.63E+02 | -3.9E+01 | +9.5E-01 | 2.5E-01 | 5.8E+01 | 7.3E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    50| +1.48E+02 | +1.3E-06 | -3.5E+00 | 1.2E-04 | 5.0E-02 | 2.5E-05 |  2d |0
2023-02-17 16:05:21 fides(INFO)    59| +1.46E+02 | -9.3E-05 | +2.7E-01 | 1.6E-03 | 1.9E-01 | 2.8E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     3| +2.89E+02 | -7.4E+01 | +9.9E-01 | 5.0E-01 | 5.2E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    17| +1.46E+02 | -6.0E+00 | +9.8E-01 | 2.1E-01 | 5.2E+01 | 4.3E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)     9| +3.71E+04 | -2.1E+05 | +9.0E-01 | 5.0E-01 | 1.1E+06 | 6.7E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    60| +1.46E+02 | -3.1E-05 | +2.5E-01 | 1.6E-03 | 2.7E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    85| +1.48E+02 | -6.7E-04 | +8.8E-01 | 2.5E-01 | 1.1E-01 | 8.8E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    51| +1.48E+02 | +2.4E-06 | -7.9E+00 | 3.1E-05 | 5.0E-02 | 1.4E-05 |  2d |0
2023-02-17 16:05:21 fides(INFO)     4| +2.89E+02 | +3.2E+03 | -6.9E+01 | 1.0E+00 | 4.9E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:21 fides(INFO)    18| +1.42E+02 | -4.2E+00 | +5.2E-01 | 4.3E-01 | 5.2E+01 | 8.8E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    61| +1.46E+02 | -5.1E-06 | +5.1E-02 | 1.6E-03 | 1.2E-01 | 1.6E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    86| +1.48E+02 | +7.0E-04 | -8.6E+00 | 5.0E-01 | 2.1E-01 | 2.3E-02 | trr |0
2023-02-17 16:05:21 fides(INFO)     5| +2.60E+02 | -2.9E+01 | +9.1E-01 | 2.5E-01 | 4.9E+01 | 6.8E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    10| +5.74E+03 | -3.1E+04 | +9.0E-01 | 5.0E-01 | 1.7E+05 | 5.8E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    52| +1.48E+02 | -2.4E-06 | +8.4E+00 | 7.6E-06 | 5.0E-02 | 1.3E-05 |  2d |1
2023-02-17 16:05:21 fides(INFO)    62| +1.46E+02 | -2.6E-05 | +8.0E-01 | 4.0E-04 | 1.6E-01 | 5.0E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    87| +1.48E+02 | +1.8E-05 | -4.6E-01 | 3.8E-02 | 2.1E-01 | 5.9E-03 |  2d |0
2023-02-17 16:05:21 fides(INFO)     6| +2.60E+02 | +3.1E+02 | -1.7E+01 | 5.0E-01 | 3.4E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:21 fides(INFO)    11| +1.04E+03 | -4.7E+03 | +9.0E-01 | 5.0E-01 | 2.6E+04 | 4.6E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    19| +1.40E+02 | -1.5E+00 | +5.0E-01 | 4.3E-01 | 2.9E+01 | 8.6E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)     9| +2.44E+02 | -6.9E+00 | -1.6E+00 | 4.0E+00 | 1.8E+01 | 5.3E+00 |  2d |0
2023-02-17 16:05:21 fides(INFO)    63| +1.46E+02 | -1.6E-05 | +5.8E-01 | 8.1E-04 | 7.3E-02 | 7.1E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    53| +1.48E+02 | +8.9E-07 | -2.2E+00 | 1.5E-05 | 4.0E-02 | 2.2E-05 |  2d |0
2023-02-17 16:05:21 fides(INFO)     7| +2.51E+02 | -9.0E+00 | +8.5E-01 | 1.2E-01 | 3.4E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    88| +1.48E+02 | -8.8E-06 | +5.9E-01 | 9.4E-03 | 2.1E-01 | 1.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    12| +3.35E+02 | -7.1E+02 | +9.0E-01 | 5.0E-01 | 4.1E+03 | 4.6E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    10| +2.43E+02 | -1.2E+00 | +3.1E-02 | 1.0E+00 | 1.8E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    64| +1.46E+02 | -1.0E-05 | +9.0E-01 | 8.1E-04 | 7.2E-02 | 2.3E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)   107| +1.55E+02 | -1.4E-03 | +1.0E+00 | 2.8E-03 | 2.7E+00 | 6.8E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     8| +2.51E+02 | +5.4E+00 | -1.8E+00 | 2.5E-01 | 1.8E+01 | 6.5E-01 |  2d |0
2023-02-17 16:05:21 fides(INFO)    54| +1.48E+02 | +3.1E-06 | -2.0E+01 | 3.8E-06 | 4.0E-02 | 5.6E-06 |  2d |0
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    20| +1.40E+02 | +3.8E-01 | -3.1E-01 | 4.3E-01 | 1.7E+01 | 7.8E-01 |  2d |0
2023-02-17 16:05:21 fides(INFO)    11| +2.36E+02 | -6.8E+00 | +7.5E-01 | 2.5E-01 | 5.1E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    65| +1.46E+02 | -1.5E-05 | +9.4E-01 | 1.6E-03 | 1.6E-01 | 4.5E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    89| +1.48E+02 | -4.1E-06 | +1.2E+00 | 9.4E-03 | 6.7E-02 | 1.4E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)     9| +2.50E+02 | -1.3E+00 | +5.9E-01 | 6.2E-02 | 1.8E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    55| +1.48E+02 | +7.0E-06 | -1.6E+02 | 9.5E-07 | 4.0E-02 | 1.4E-06 |  2d |0
2023-02-17 16:05:21 fides(INFO)    13| +2.29E+02 | -1.1E+02 | +9.1E-01 | 5.0E-01 | 6.3E+02 | 4.6E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    66| +1.46E+02 | -1.3E-05 | +4.4E-01 | 3.2E-03 | 6.0E-02 | 7.6E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    12| +2.30E+02 | -6.2E+00 | +5.1E-01 | 5.0E-01 | 2.2E+01 | 8.4E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    21| +1.40E+02 | -3.0E-01 | +6.9E-01 | 1.1E-01 | 1.7E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    10| +2.50E+02 | -1.2E-02 | +1.3E-01 | 6.2E-02 | 4.0E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    90| +1.48E+02 | -4.1E-06 | +8.8E-01 | 1.9E-02 | 6.2E-02 | 2.8E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    56| +1.48E+02 | +3.7E-06 | -3.4E+02 | 2.4E-07 | 4.0E-02 | 3.5E-07 |  2d |0
2023-02-17 16:05:21 fides(INFO)    67| +1.46E+02 | +1.6E-04 | -1.2E+00 | 3.2E-03 | 2.0E-01 | 3.4E-03 |  2d |0
2023-02-17 16:05:21 fides(INFO)    13| +2.16E+02 | -1.4E+01 | +8.9E-01 | 5.0E-01 | 6.9E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    11| +2.50E+02 | +6.8E-03 | -1.1E-01 | 1.6E-02 | 3.2E+00 | 4.1E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    91| +1.48E+02 | -3.6E-06 | +6.4E-01 | 3.8E-02 | 4.7E-02 | 5.2E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    14| +1.99E+02 | -3.0E+01 | +1.2E+00 | 5.0E-01 | 9.7E+01 | 7.7E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    68| +1.46E+02 | -1.8E-05 | +4.8E-01 | 8.1E-04 | 2.0E-01 | 8.5E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    57| +1.48E+02 | +2.6E-06 | -9.5E+02 | 6.0E-08 | 4.0E-02 | 8.7E-08 |  2d |0
2023-02-17 16:05:21 fides(INFO)    12| +2.50E+02 | -2.4E-02 | +8.5E-01 | 3.9E-03 | 3.2E+00 | 1.0E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    22| +1.40E+02 | -2.6E-01 | +9.3E-01 | 1.1E-01 | 2.2E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    69| +1.46E+02 | -4.8E-06 | +7.2E-01 | 8.1E-04 | 5.7E-02 | 2.1E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    92| +1.48E+02 | -3.3E-06 | +8.1E-01 | 3.8E-02 | 3.1E-02 | 4.2E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    14| +1.56E+02 | -6.0E+01 | +1.6E+00 | 1.0E+00 | 3.9E+01 | 1.7E+00 |  2d |1
2023-02-17 16:05:21 fides(INFO)    58| +1.48E+02 | +2.7E-06 | -4.0E+03 | 1.5E-08 | 4.0E-02 | 2.2E-08 |  2d |0
2023-02-17 16:05:21 fides(INFO)    13| +2.50E+02 | +8.1E-04 | -5.6E-02 | 7.8E-03 | 1.6E+00 | 2.0E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    15| +1.99E+02 | +3.0E+01 | -3.5E+00 | 1.0E+00 | 5.7E+01 | 1.7E+00 |  2d |0
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    70| +1.46E+02 | -4.4E-06 | +8.6E-01 | 8.1E-04 | 6.3E-02 | 2.4E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)   108| +1.55E+02 | -1.2E-03 | +9.4E-01 | 5.6E-03 | 1.1E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:21 fides(INFO)    93| +1.48E+02 | +3.3E-04 | -8.6E+00 | 7.5E-02 | 3.7E-02 | 1.2E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    15| +1.56E+02 | +1.1E+02 | -8.8E+00 | 2.0E+00 | 1.0E+02 | 9.6E-01 | trr |0
2023-02-17 16:05:21 fides(INFO)    14| +2.50E+02 | -5.9E-03 | +8.5E-01 | 2.0E-03 | 1.6E+00 | 5.1E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    23| +1.39E+02 | -3.7E-01 | +9.2E-01 | 2.1E-01 | 1.3E+01 | 3.5E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    59| +1.48E+02 | +2.1E-06 | -1.2E+04 | 3.7E-09 | 4.0E-02 | 5.4E-09 |  2d |0
2023-02-17 16:05:21 fides(INFO)    71| +1.46E+02 | -5.9E-06 | +7.5E-01 | 1.6E-03 | 5.1E-02 | 2.2E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    15| +2.50E+02 | +7.7E-05 | -2.5E-02 | 3.9E-03 | 7.4E-01 | 1.0E-02 |  2d |0
2023-02-17 16:05:21 fides(INFO)    16| +1.52E+02 | -4.2E+00 | +9.5E-01 | 1.2E-01 | 1.0E+02 | 1.5E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    16| +1.81E+02 | -1.8E+01 | +1.1E+00 | 2.5E-01 | 5.7E+01 | 4.3E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    72| +1.46E+02 | -5.3E-06 | +5.5E-01 | 1.6E-03 | 5.0E-02 | 5.7E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    94| +1.48E+02 | +1.0E-05 | -6.8E-01 | 1.9E-02 | 3.7E-02 | 2.9E-03 |  2d |0
2023-02-17 16:05:21 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:21 fides(INFO)    60| +1.48E+02 | +4.7E-06 | -1.1E+05 | 9.3E-10 | 4.0E-02 | 1.4E-09 |  2d |0
2023-02-17 16:05:21 fides(INFO)    16| +2.50E+02 | -1.3E-03 | +8.3E-01 | 9.8E-04 | 7.4E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:21 fides(INFO)    17| +1.50E+02 | -2.0E+00 | +3.0E-01 | 2.3E-01 | 4.8E+01 | 3.4E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    73| +1.46E+02 | +9.2E-06 | -4.0E-01 | 1.6E-03 | 5.9E-02 | 9.5E-04 |  2d |0
2023-02-17 16:05:21 fides(INFO)    24| +1.39E+02 | -4.8E-01 | +8.3E-01 | 4.3E-01 | 1.1E+01 | 6.7E-01 |  2d |1
2023-02-17 16:05:21 fides(INFO)    95| +1.48E+02 | -5.7E-06 | +1.4E+00 | 4.7E-03 | 3.7E-02 | 7.4E-04 |  2d |1
2023-02-17 16:05:21 fides(INFO)    61| +1.48E+02 | +1.6E-06 | -1.5E+05 | 2.3E-10 | 4.0E-02 | 3.4E-10 |  2d |0
2023-02-17 16:05:21 fides(INFO)    17| +2.50E+02 | +4.9E-06 | -8.7E-03 | 2.0E-03 | 3.2E-01 | 5.0E-03 |  2d |0
2023-02-17 16:05:22 fides(INFO)    74| +1.46E+02 | -4.1E-06 | +6.5E-01 | 4.0E-04 | 5.9E-02 | 2.5E-04 |  2d |1
2023-02-17 16:05:22 fides(INFO)    17| +1.67E+02 | -1.4E+01 | +8.9E-01 | 5.0E-01 | 5.8E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    18| +2.50E+02 | -2.7E-04 | +8.0E-01 | 4.9E-04 | 3.2E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    18| +1.48E+02 | -1.6E+00 | +6.1E-01 | 2.3E-01 | 1.2E+02 | 2.6E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    96| +1.48E+02 | +3.9E-06 | -6.2E+00 | 9.4E-03 | 2.9E-02 | 9.1E-04 |  2d |0
2023-02-17 16:05:22 fides(INFO)    75| +1.46E+02 | -3.8E-07 | +2.3E-01 | 4.0E-04 | 6.0E-02 | 5.3E-05 |  2d |1
2023-02-17 16:05:22 fides(INFO)    62| +1.48E+02 | +3.3E-06 | -1.2E+06 | 5.8E-11 | 4.0E-02 | 8.5E-11 |  2d |0
2023-02-17 16:05:22 fides(INFO)    25| +1.39E+02 | +4.3E+00 | -5.8E+00 | 8.5E-01 | 1.2E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:22.041 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.735 and h = 9.95199e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:22.041 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.735: AMICI failed to integrate the forward problem
2023-02-17 16:05:22 fides(INFO)    19| +2.50E+02 | -2.6E-07 | +4.0E-03 | 9.8E-04 | 1.0E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    19| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.3E-01 | 2.6E+01 | 2.0E-01 |  2d |0
2023-02-17 16:05:22.048 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.486 and h = 4.04049e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:22.048 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.486: AMICI failed to integrate the forward problem
2023-02-17 16:05:22 fides(INFO)    97| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.4E-03 | 2.9E-02 | 2.3E-04 |  2d |0
2023-02-17 16:05:22 fides(INFO)    76| +1.46E+02 | -1.5E-06 | +3.3E+00 | 1.0E-04 | 4.1E-02 | 1.9E-05 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    63| +1.48E+02 | +3.0E-06 | -4.5E+06 | 1.5E-11 | 4.0E-02 | 2.1E-11 |  2d |0
2023-02-17 16:05:22 fides(INFO)    20| +2.50E+02 | -2.9E-05 | +7.8E-01 | 2.4E-04 | 1.0E-01 | 4.4E-04 |  2d |1
2023-02-17 16:05:22 fides(INFO)    18| +1.59E+02 | -7.7E+00 | +1.0E+00 | 1.0E+00 | 1.1E+02 | 2.3E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)   109| +1.55E+02 | -2.1E-03 | +9.3E-01 | 1.1E-02 | 1.7E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    77| +1.46E+02 | -8.5E-07 | +1.0E+00 | 2.0E-04 | 4.6E-02 | 3.6E-05 |  2d |1
2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 8.51E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    20| +1.48E+02 | -2.1E-01 | +8.8E-01 | 5.8E-02 | 2.6E+01 | 5.1E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    21| +2.50E+02 | -2.3E-07 | +4.5E-02 | 4.9E-04 | 2.9E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    64| +1.48E+02 | +6.6E-06 | -3.9E+07 | 3.6E-12 | 4.0E-02 | 5.3E-12 |  2d |0
2023-02-17 16:05:22 fides(INFO)    98| +1.48E+02 | +5.9E-06 | -3.8E+01 | 5.9E-04 | 2.9E-02 | 5.7E-05 |  2d |0
2023-02-17 16:05:22 fides(INFO)    26| +1.39E+02 | -1.5E-02 | +3.4E-02 | 2.1E-01 | 1.2E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    21| +1.48E+02 | -1.6E-01 | +7.1E-01 | 1.2E-01 | 2.0E+01 | 9.4E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    99| +1.48E+02 | +3.9E-06 | -3.0E+01 | 1.5E-04 | 2.9E-02 | 1.7E-05 |  2d |0
2023-02-17 16:05:22.130 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0572 and h = 1.54133e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:22.131 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0572: AMICI failed to integrate the forward problem
2023-02-17 16:05:22 fides(INFO)    22| +2.50E+02 | -4.9E-07 | +1.0E-01 | 1.2E-04 | 2.8E-02 | 3.2E-04 |  2d |1
2023-02-17 16:05:22 fides(INFO)    65| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.1E-13 | 4.0E-02 | 1.3E-12 |  2d |0
2023-02-17 16:05:22 fides(INFO)    23| +2.50E+02 | -1.1E-06 | +9.0E-01 | 3.1E-05 | 2.5E-02 | 5.5E-05 |  2d |1
2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 1.13E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:22 fides(INFO)    22| +1.48E+02 | -3.6E-02 | +2.4E-01 | 1.2E-01 | 1.7E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    19| +1.59E+02 | +1.8E+02 | -1.6E+02 | 2.0E+00 | 5.3E+01 | 5.5E+00 | trr |0
2023-02-17 16:05:22 fides(INFO)    66| +1.48E+02 | +3.3E-06 | -3.1E+08 | 2.3E-13 | 4.0E-02 | 3.3E-13 |  2d |0
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)   100| +1.48E+02 | +5.2E-06 | -4.3E+01 | 3.7E-05 | 2.9E-02 | 9.3E-06 |  2d |0
2023-02-17 16:05:22 fides(INFO)    27| +1.39E+02 | -1.3E-01 | +6.0E-01 | 5.3E-02 | 8.7E+00 | 7.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)   110| +1.55E+02 | -5.9E-03 | +1.0E+00 | 2.2E-02 | 1.2E+00 | 5.5E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    23| +1.48E+02 | -9.7E-02 | +4.3E-01 | 2.9E-02 | 1.1E+01 | 5.1E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    67| +1.48E+02 | +3.5E-06 | -1.3E+09 | 5.7E-14 | 4.0E-02 | 8.3E-14 |  2d |0
2023-02-17 16:05:22 fides(INFO)   101| +1.48E+02 | -7.2E-07 | +6.0E+00 | 9.2E-06 | 2.9E-02 | 8.6E-06 |  2d |1
2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 7.25E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)     0| +1.05E+12 |    NaN   |    NaN   | 1.0E+00 | 4.6E+12 |   NaN   | NaN |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    20| +1.58E+02 | -1.4E+00 | +1.0E+00 | 5.0E-01 | 5.3E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    68| +1.48E+02 | +4.8E-07 | -7.4E+08 | 1.4E-14 | 4.0E-02 | 2.1E-14 |  2d |0
2023-02-17 16:05:22 fides(INFO)    24| +1.48E+02 | -3.9E-02 | +6.7E-01 | 2.9E-02 | 5.8E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     1| +2.02E+10 | -1.0E+12 | +9.0E-02 | 1.0E+00 | 4.6E+12 | 3.0E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    28| +1.39E+02 | -9.6E-02 | +9.6E-01 | 5.3E-02 | 2.9E+01 | 6.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)     0| +8.11E+12 |    NaN   |    NaN   | 1.0E+00 | 2.8E+13 |   NaN   | NaN |1
2023-02-17 16:05:22 fides(INFO)    69| +1.48E+02 | +4.7E-06 | -2.9E+10 | 3.6E-15 | 4.0E-02 | 5.2E-15 |  2d |0
2023-02-17 16:05:22 fides(INFO)     2| +3.02E+09 | -1.7E+10 | +8.9E-01 | 2.5E-01 | 9.3E+10 | 6.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    25| +1.48E+02 | -9.3E-03 | +8.9E-01 | 2.9E-02 | 7.5E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     1| +3.54E+10 | -8.1E+12 | +1.1E-01 | 1.0E+00 | 2.8E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)     3| +4.53E+08 | -2.6E+09 | +8.9E-01 | 5.0E-01 | 1.4E+10 | 6.3E-01 |  2d |1
2023-02-17 16:05:22.287 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.9304 and h = 2.14384e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:22.287 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.9304: AMICI failed to integrate the forward problem
2023-02-17 16:05:22 fides(INFO)    26| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.8E-02 | 2.0E+00 | 4.0E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    70| +1.48E+02 | +3.6E-06 | -8.7E+10 | 8.9E-16 | 4.0E-02 | 1.3E-15 |  2d |0
2023-02-17 16:05:22 fides(WARNING) Stopping as trust region radius 2.22E-16 is smaller than machine precision.
2023-02-17 16:05:22 fides(INFO)     2| +5.99E+09 | -2.9E+10 | +8.8E-01 | 2.5E-01 | 1.4E+11 | 6.6E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    29| +1.39E+02 | -4.5E-02 | +7.2E-01 | 1.1E-01 | 3.4E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)   111| +1.55E+02 | -3.6E-03 | +2.9E-01 | 4.5E-02 | 1.0E+00 | 8.3E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    21| +1.54E+02 | -3.7E+00 | +1.0E+00 | 1.0E+00 | 6.3E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)     0| +3.21E+07 |    NaN   |    NaN   | 1.0E+00 | 1.5E+08 |   NaN   | NaN |1
2023-02-17 16:05:22 fides(INFO)     4| +6.84E+07 | -3.8E+08 | +8.9E-01 | 5.0E-01 | 2.1E+09 | 5.8E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    27| +1.48E+02 | -6.2E-03 | +7.5E-01 | 1.5E-02 | 2.0E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     3| +8.99E+08 | -5.1E+09 | +8.9E-01 | 5.0E-01 | 2.1E+10 | 8.5E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     5| +1.04E+07 | -5.8E+07 | +8.9E-01 | 5.0E-01 | 3.1E+08 | 5.8E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     4| +1.36E+08 | -7.6E+08 | +8.9E-01 | 5.0E-01 | 3.2E+09 | 8.5E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    30| +1.39E+02 | +1.1E-02 | -1.3E-01 | 1.1E-01 | 4.2E+00 | 1.3E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)    28| +1.48E+02 | -4.2E-03 | +9.5E-01 | 2.9E-02 | 5.4E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     1| +1.89E+03 | -3.2E+07 | +1.1E-01 | 1.0E+00 | 1.5E+08 | 2.5E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)     6| +1.58E+06 | -8.8E+06 | +8.9E-01 | 5.0E-01 | 4.8E+07 | 5.7E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     5| +2.07E+07 | -1.2E+08 | +8.9E-01 | 5.0E-01 | 4.8E+08 | 8.5E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     2| +6.31E+02 | -1.3E+03 | +9.1E-01 | 2.5E-01 | 6.5E+03 | 6.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    29| +1.48E+02 | -2.8E-03 | +8.5E-01 | 5.8E-02 | 1.3E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     3| +3.08E+02 | -3.2E+02 | +9.0E-01 | 5.0E-01 | 1.3E+03 | 1.2E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)     6| +3.16E+06 | -1.7E+07 | +8.9E-01 | 5.0E-01 | 7.3E+07 | 8.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    22| +1.54E+02 | +2.2E+00 | -3.0E+01 | 2.0E+00 | 5.7E+01 | 6.3E+00 | trr |0
2023-02-17 16:05:22 fides(INFO)     7| +2.44E+05 | -1.3E+06 | +8.9E-01 | 5.0E-01 | 7.3E+06 | 5.6E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    31| +1.39E+02 | -1.9E-02 | +7.2E-01 | 2.7E-02 | 4.2E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     4| +2.56E+02 | -5.2E+01 | +8.6E-01 | 1.0E+00 | 2.0E+02 | 1.9E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)     0| +3.56E+11 |    NaN   |    NaN   | 1.0E+00 | 1.6E+12 |   NaN   | NaN |1
2023-02-17 16:05:22 fides(INFO)     7| +4.86E+05 | -2.7E+06 | +8.9E-01 | 5.0E-01 | 1.1E+07 | 8.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    30| +1.48E+02 | -1.3E-03 | +3.4E-01 | 1.2E-01 | 2.6E+00 | 7.4E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     8| +3.80E+04 | -2.1E+05 | +9.0E-01 | 5.0E-01 | 1.1E+06 | 5.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)   112| +1.55E+02 | -2.6E-03 | +2.1E-01 | 4.5E-02 | 2.8E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     5| +2.56E+02 | +6.0E+02 | -5.2E+01 | 2.0E+00 | 3.0E+01 | 2.5E+00 | trr |0
2023-02-17 16:05:22 fides(INFO)     8| +7.55E+04 | -4.1E+05 | +9.0E-01 | 5.0E-01 | 1.7E+06 | 8.2E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     1| +3.50E+05 | -3.6E+11 | +8.7E-02 | 1.0E+00 | 1.6E+12 | 3.0E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)     9| +6.10E+03 | -3.2E+04 | +9.0E-01 | 5.0E-01 | 1.7E+05 | 4.1E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     9| +1.19E+04 | -6.4E+04 | +9.0E-01 | 5.0E-01 | 2.7E+05 | 7.8E-01 |  2d |1
2023-02-17 16:05:22.461 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2575 and h = 1.54213e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:22.461 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2575: AMICI failed to integrate the forward problem
2023-02-17 16:05:22 fides(INFO)     6| +2.56E+02 | +9.4E+01 | -7.3E+00 | 3.7E-01 | 3.0E+01 | 9.5E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)    31| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 8.9E-01 | 6.5E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)    32| +1.39E+02 | -1.3E-02 | +9.9E-01 | 2.7E-02 | 4.0E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     2| +5.43E+04 | -3.0E+05 | +9.0E-01 | 2.5E-01 | 1.6E+06 | 6.6E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)     7| +2.50E+02 | -5.5E+00 | +8.5E-01 | 9.3E-02 | 3.0E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    10| +2.01E+03 | -9.9E+03 | +9.0E-01 | 5.0E-01 | 4.1E+04 | 6.9E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    10| +1.14E+03 | -5.0E+03 | +9.0E-01 | 5.0E-01 | 2.7E+04 | 4.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     8| +2.50E+02 | +1.6E+00 | -9.5E-01 | 1.9E-01 | 1.4E+01 | 3.7E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)    32| +1.48E+02 | +2.9E-03 | -5.7E-01 | 2.9E-02 | 8.9E-01 | 1.9E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)    11| +4.82E+02 | -1.5E+03 | +9.0E-01 | 5.0E-01 | 6.4E+03 | 6.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    23| +1.53E+02 | -7.1E-01 | +1.0E+00 | 5.0E-01 | 5.7E+01 | 1.6E+00 | trr |1
2023-02-17 16:05:22 fides(INFO)     3| +8.67E+03 | -4.6E+04 | +9.0E-01 | 5.0E-01 | 2.5E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    33| +1.38E+02 | -2.4E-02 | +9.7E-01 | 5.3E-02 | 3.0E+00 | 6.2E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     9| +2.50E+02 | -8.0E-01 | +6.2E-01 | 4.6E-02 | 1.4E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    11| +3.71E+02 | -7.7E+02 | +9.0E-01 | 5.0E-01 | 4.3E+03 | 4.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    12| +2.60E+02 | -2.2E+02 | +8.9E-01 | 5.0E-01 | 9.9E+02 | 6.6E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     4| +1.54E+03 | -7.1E+03 | +9.0E-01 | 1.0E+00 | 3.9E+04 | 1.1E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    10| +2.50E+02 | -3.1E-02 | +6.2E-01 | 4.6E-02 | 2.1E+00 | 8.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    11| +2.50E+02 | -3.3E-02 | +6.6E-01 | 4.6E-02 | 1.8E+00 | 8.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    33| +1.48E+02 | +1.3E-03 | -3.4E-01 | 7.3E-03 | 8.9E-01 | 9.9E-03 |  2d |0
2023-02-17 16:05:22 fides(INFO)    12| +2.59E+02 | -1.1E+02 | +8.8E-01 | 5.0E-01 | 6.6E+02 | 3.8E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    13| +2.37E+02 | -2.4E+01 | +8.6E-01 | 5.0E-01 | 1.3E+02 | 8.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    12| +2.50E+02 | -4.3E-02 | +7.5E-01 | 4.6E-02 | 2.0E+00 | 8.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)     5| +4.32E+02 | -1.1E+03 | +9.0E-01 | 1.0E+00 | 6.1E+03 | 1.1E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)   113| +1.55E+02 | -6.3E-03 | +1.0E+00 | 1.1E-02 | 5.7E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    34| +1.48E+02 | -1.5E-03 | +6.4E-01 | 1.8E-03 | 8.9E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    13| +2.50E+02 | -9.2E+00 | +7.3E-01 | 5.0E-01 | 8.8E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    34| +1.38E+02 | -4.0E-02 | +9.5E-01 | 1.1E-01 | 4.8E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    13| +2.49E+02 | -4.7E-02 | +7.7E-01 | 4.6E-02 | 1.7E+00 | 8.6E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    14| +2.14E+02 | -2.2E+01 | +1.2E+00 | 1.0E+00 | 2.0E+01 | 1.6E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)     6| +2.67E+02 | -1.6E+02 | +8.8E-01 | 1.0E+00 | 9.6E+02 | 1.7E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    14| +2.49E+02 | -1.3E-01 | +1.0E+00 | 9.3E-02 | 1.9E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     7| +2.50E+02 | -1.7E+01 | +7.9E-01 | 1.0E+00 | 1.3E+02 | 2.6E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    35| +1.48E+02 | -3.8E-04 | +9.6E-01 | 1.8E-03 | 1.8E+00 | 1.1E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    15| +2.49E+02 | -4.1E-01 | +1.3E+00 | 1.9E-01 | 2.0E+00 | 3.3E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    14| +2.50E+02 | +2.3E-02 | -1.5E-01 | 5.0E-01 | 5.1E+00 | 6.6E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)    15| +2.14E+02 | +3.3E+02 | -3.4E+01 | 2.0E+00 | 3.7E+01 | 6.2E+00 |  2d |0
2023-02-17 16:05:22 fides(INFO)     8| +2.50E+02 | -1.4E-01 | -1.0E+00 | 2.0E+00 | 3.8E+00 | 4.9E+00 |  2d |0
2023-02-17 16:05:22 fides(INFO)    35| +1.38E+02 | -6.2E-02 | +8.9E-01 | 2.1E-01 | 2.3E+00 | 2.3E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    16| +2.47E+02 | -2.3E+00 | +1.9E+00 | 3.7E-01 | 2.8E+00 | 6.8E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    15| +2.50E+02 | -6.3E-02 | +8.5E-01 | 6.4E-03 | 5.1E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    36| +1.48E+02 | -2.0E-04 | +5.0E-01 | 3.6E-03 | 3.0E-01 | 3.3E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    16| +2.14E+02 | +2.2E+00 | -3.4E-01 | 5.0E-01 | 3.7E+01 | 1.4E+00 |  2d |0
2023-02-17 16:05:22 fides(INFO)    17| +2.40E+02 | -6.7E+00 | +1.8E+00 | 7.4E-01 | 7.3E+00 | 8.6E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)     9| +2.50E+02 | -8.6E-03 | +1.0E-01 | 5.0E-01 | 3.8E+00 | 1.2E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    24| +1.52E+02 | -1.9E+00 | +9.2E-01 | 1.0E+00 | 4.7E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    16| +2.50E+02 | +2.3E-03 | -6.4E-02 | 1.3E-02 | 2.5E+00 | 3.1E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)    17| +2.09E+02 | -5.2E+00 | +6.9E-01 | 1.2E-01 | 3.7E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    18| +2.36E+02 | -4.1E+00 | +1.3E+00 | 1.5E+00 | 1.4E+01 | 4.4E+00 |  2d |1
2023-02-17 16:05:22 fides(INFO)    36| +1.38E+02 | +5.4E-02 | -6.1E-01 | 4.3E-01 | 4.7E+00 | 4.4E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    10| +2.50E+02 | +5.7E-03 | -9.2E-02 | 1.2E-01 | 3.3E+00 | 3.0E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)    37| +1.48E+02 | -1.8E-04 | +9.6E-01 | 3.6E-03 | 1.1E+00 | 2.0E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    25| +1.52E+02 | +5.7E+01 | -6.0E+02 | 2.0E+00 | 3.9E+01 | 5.8E+00 |  2d |0
2023-02-17 16:05:22 fides(INFO)    17| +2.50E+02 | -1.4E-02 | +8.5E-01 | 3.0E-03 | 2.5E+00 | 7.7E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    18| +2.06E+02 | -2.6E+00 | +5.9E-01 | 1.2E-01 | 3.1E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    11| +2.50E+02 | +5.8E-03 | -9.2E-02 | 3.1E-02 | 3.3E+00 | 7.5E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)   114| +1.55E+02 | -1.9E-03 | +1.2E+00 | 2.2E-02 | 1.1E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    19| +2.36E+02 | +9.5E+01 | -9.3E+00 | 3.0E+00 | 2.4E+01 | 8.5E+00 |  2d |0
2023-02-17 16:05:22 fides(INFO)    12| +2.50E+02 | -3.3E-02 | +6.7E-01 | 7.8E-03 | 3.3E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    38| +1.48E+02 | -7.9E-05 | +9.6E-01 | 7.3E-03 | 1.5E-01 | 4.0E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    18| +2.50E+02 | +2.5E-04 | -2.9E-02 | 6.0E-03 | 1.2E+00 | 1.5E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)    37| +1.38E+02 | -2.0E-02 | +6.4E-01 | 1.1E-01 | 4.7E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    19| +2.06E+02 | -8.1E-01 | +2.2E-01 | 1.2E-01 | 2.8E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    13| +2.50E+02 | -2.2E-06 | +1.8E-02 | 7.8E-03 | 1.5E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    20| +2.36E+02 | +9.2E+00 | -1.7E+00 | 7.4E-01 | 2.4E+01 | 2.1E+00 |  2d |0
2023-02-17 16:05:22 fides(INFO)    19| +2.50E+02 | -3.4E-03 | +8.5E-01 | 1.5E-03 | 1.2E+00 | 3.8E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    39| +1.48E+02 | -1.2E-04 | +9.2E-01 | 1.5E-02 | 2.8E-01 | 7.9E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    14| +2.50E+02 | -9.8E-07 | +7.6E-03 | 2.0E-03 | 1.5E-01 | 4.5E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    20| +2.04E+02 | -1.3E+00 | +8.4E-01 | 3.1E-02 | 2.9E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    21| +2.36E+02 | +3.0E+00 | -6.5E-01 | 1.9E-01 | 2.4E+01 | 4.5E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    20| +2.50E+02 | +2.5E-05 | -1.2E-02 | 2.9E-03 | 6.1E-01 | 7.3E-03 |  2d |0
2023-02-17 16:05:22 fides(INFO)    38| +1.38E+02 | +9.9E-02 | -1.4E+00 | 1.1E-01 | 1.7E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)    15| +2.50E+02 | -5.2E-05 | +5.1E-01 | 4.9E-04 | 1.5E-01 | 1.1E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    40| +1.48E+02 | -2.0E-04 | +9.7E-01 | 2.9E-02 | 1.2E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    22| +2.34E+02 | -2.0E+00 | +8.8E-01 | 4.6E-02 | 2.4E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    21| +2.04E+02 | -9.6E-02 | +1.7E-01 | 6.2E-02 | 1.4E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    21| +2.50E+02 | -8.4E-04 | +8.5E-01 | 7.4E-04 | 6.1E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    16| +2.50E+02 | -3.3E-07 | +1.2E-02 | 4.9E-04 | 6.6E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)   115| +1.55E+02 | -6.8E-04 | +2.8E-01 | 2.2E-02 | 1.1E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    23| +2.32E+02 | -1.8E+00 | +7.1E-01 | 9.3E-02 | 1.8E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    41| +1.48E+02 | -2.8E-04 | +8.2E-01 | 5.8E-02 | 3.4E-01 | 3.0E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    22| +2.50E+02 | -1.8E-05 | +3.2E-02 | 1.5E-03 | 3.0E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    22| +2.04E+02 | -2.9E-01 | +8.3E-01 | 1.6E-02 | 1.4E+01 | 3.2E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    39| +1.38E+02 | -7.3E-03 | +3.5E-01 | 2.7E-02 | 1.7E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    17| +2.50E+02 | -1.2E-05 | +7.5E-01 | 1.2E-04 | 6.6E-02 | 3.1E-04 |  2d |1
2023-02-17 16:05:22 fides(INFO)    24| +2.30E+02 | -2.1E+00 | +7.9E-01 | 9.3E-02 | 2.5E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    42| +1.48E+02 | -2.1E-04 | +4.1E-01 | 1.2E-01 | 1.7E-01 | 5.5E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    23| +2.50E+02 | -1.7E-04 | +8.8E-01 | 3.7E-04 | 2.9E-01 | 7.5E-04 |  2d |1
2023-02-17 16:05:22 fides(INFO)    18| +2.50E+02 | -7.4E-08 | +6.3E-02 | 2.4E-04 | 1.4E-02 | 5.8E-04 |  2d |1
2023-02-17 16:05:22 fides(INFO)    23| +2.04E+02 | -7.7E-02 | +6.5E-01 | 3.1E-02 | 6.0E+00 | 8.6E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    25| +2.30E+02 | -2.2E-01 | -7.7E-02 | 1.9E-01 | 1.9E+01 | 4.3E-01 |  2d |0
2023-02-17 16:05:22 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:22 fides(INFO)    40| +1.38E+02 | -8.6E-03 | +8.7E-01 | 2.7E-02 | 5.2E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    19| +2.50E+02 | -4.4E-07 | +4.3E-01 | 6.1E-05 | 1.4E-02 | 1.2E-04 |  2d |1
2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 4.40E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:22 fides(INFO)    24| +2.50E+02 | -7.4E-05 | +4.8E-01 | 7.4E-04 | 1.7E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:22 fides(INFO)    43| +1.48E+02 | +2.0E-03 | -1.1E+00 | 1.2E-01 | 5.7E-01 | 5.6E-02 |  2d |0
2023-02-17 16:05:22 fides(INFO)    24| +2.04E+02 | -3.4E-02 | +4.1E-01 | 3.1E-02 | 4.5E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    26| +2.29E+02 | -1.3E+00 | +8.9E-01 | 4.6E-02 | 1.9E+01 | 9.9E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    25| +2.50E+02 | +2.5E-08 | -1.1E-03 | 7.4E-04 | 6.5E-02 | 7.7E-04 |  2d |0
2023-02-17 16:05:22 fides(INFO)    41| +1.38E+02 | -9.0E-03 | +8.7E-01 | 5.3E-02 | 1.2E+00 | 5.1E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    25| +2.04E+02 | -5.4E-02 | +6.3E-01 | 3.1E-02 | 4.4E+00 | 9.1E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    27| +2.26E+02 | -2.5E+00 | +1.1E+00 | 9.3E-02 | 1.8E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)   116| +1.55E+02 | -3.1E-03 | +1.5E+00 | 2.2E-02 | 2.6E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    44| +1.48E+02 | -2.7E-04 | +5.1E-01 | 2.9E-02 | 5.7E-01 | 1.4E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    26| +2.50E+02 | -9.4E-06 | +8.5E-01 | 8.1E-05 | 6.5E-02 | 2.0E-04 |  2d |1
2023-02-17 16:05:22.937 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 176.485 and h = 1.21791e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:22.937 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 176.485: AMICI failed to integrate the forward problem
2023-02-17 16:05:22 fides(INFO)    26| +2.04E+02 | -4.1E-02 | +6.5E-01 | 3.1E-02 | 3.2E+00 | 9.4E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    26| +1.52E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 3.9E+01 | 1.4E+00 |  2d |0
2023-02-17 16:05:22 fides(INFO)    28| +2.24E+02 | -2.5E+00 | +6.5E-01 | 1.9E-01 | 1.8E+01 | 3.7E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    42| +1.38E+02 | -1.0E-02 | +4.5E-01 | 1.1E-01 | 1.6E+00 | 1.0E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    27| +2.50E+02 | -4.3E-07 | +7.1E-02 | 1.6E-04 | 3.2E-02 | 3.6E-04 |  2d |1
2023-02-17 16:05:22 fides(INFO)    45| +1.48E+02 | -6.2E-05 | +9.4E-01 | 2.9E-02 | 1.8E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    29| +2.20E+02 | -3.2E+00 | +6.5E-01 | 1.9E-01 | 3.8E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:22 fides(INFO)    27| +2.04E+02 | -5.0E-02 | +7.9E-01 | 3.1E-02 | 2.9E+00 | 9.3E-02 |  2d |1
2023-02-17 16:05:22 fides(INFO)    28| +2.50E+02 | -1.9E-06 | +8.5E-01 | 4.0E-05 | 3.0E-02 | 8.7E-05 |  2d |1
2023-02-17 16:05:22 fides(WARNING) Stopping as function difference 1.85E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:22 fides(INFO)    46| +1.48E+02 | -8.3E-05 | +9.3E-01 | 5.8E-02 | 8.7E-02 | 2.2E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    43| +1.38E+02 | +2.4E-02 | -4.4E-01 | 1.1E-01 | 1.9E+00 | 1.0E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    28| +2.03E+02 | -1.0E-01 | +1.0E+00 | 6.2E-02 | 2.3E+00 | 1.9E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    30| +2.20E+02 | -1.4E-01 | -3.0E-02 | 1.9E-01 | 1.9E+01 | 4.7E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)     0| +2.00E+11 |    NaN   |    NaN   | 1.0E+00 | 1.1E+12 |   NaN   | NaN |1
2023-02-17 16:05:23 fides(INFO)    47| +1.48E+02 | -9.9E-05 | +8.3E-01 | 1.2E-01 | 7.9E-02 | 4.0E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    29| +2.03E+02 | -2.9E-01 | +1.2E+00 | 1.2E-01 | 2.1E+00 | 3.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    31| +2.19E+02 | -1.3E+00 | +8.0E-01 | 4.6E-02 | 1.9E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    44| +1.38E+02 | -9.8E-03 | +6.3E-01 | 2.7E-02 | 1.9E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    48| +1.48E+02 | +1.9E-03 | -6.7E+00 | 2.3E-01 | 7.6E-02 | 7.1E-02 |  2d |0
2023-02-17 16:05:23 fides(INFO)   117| +1.55E+02 | -2.6E-03 | +1.3E+00 | 2.2E-02 | 1.2E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    30| +2.02E+02 | -1.2E+00 | +1.6E+00 | 2.5E-01 | 2.8E+00 | 7.5E-01 |  2d |1
2023-02-17 16:05:23.071 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 104.324 and h = 1.41477e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:23.071 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 104.324: AMICI failed to integrate the forward problem
2023-02-17 16:05:23 fides(INFO)    27| +1.52E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 3.9E+01 | 3.6E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)     1| +1.25E+05 | -2.0E+11 | +8.0E-02 | 1.0E+00 | 1.1E+12 | 2.8E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    32| +2.17E+02 | -2.0E+00 | +1.1E+00 | 9.3E-02 | 1.7E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)     0| +1.23E+09 |    NaN   |    NaN   | 1.0E+00 | 6.1E+09 |   NaN   | NaN |1
2023-02-17 16:05:23 fides(INFO)    45| +1.38E+02 | -4.0E-03 | +9.7E-01 | 2.7E-02 | 2.4E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    49| +1.48E+02 | +3.2E-05 | -3.0E-01 | 5.8E-02 | 7.6E-02 | 1.8E-02 |  2d |0
2023-02-17 16:05:23 fides(INFO)    31| +1.94E+02 | -7.9E+00 | +2.2E+00 | 5.0E-01 | 3.7E+00 | 1.5E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    33| +2.15E+02 | -2.1E+00 | +8.2E-01 | 1.9E-01 | 1.6E+01 | 4.0E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    50| +1.48E+02 | -1.7E-05 | +5.5E-01 | 1.5E-02 | 7.6E-02 | 4.5E-03 |  2d |1
2023-02-17 16:05:23 fides(INFO)    34| +2.11E+02 | -3.7E+00 | +8.1E-01 | 3.7E-01 | 2.3E+01 | 9.5E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    32| +1.94E+02 | +4.8E+02 | -2.6E+01 | 1.0E+00 | 2.5E+01 | 2.5E+00 |  2d |0
2023-02-17 16:05:23 fides(INFO)     2| +5.32E+04 | -7.2E+04 | +9.6E-01 | 2.5E-01 | 5.9E+05 | 6.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)     1| +5.39E+04 | -1.2E+09 | +8.5E-02 | 1.0E+00 | 6.1E+09 | 2.8E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    46| +1.38E+02 | -6.8E-03 | +9.8E-01 | 5.3E-02 | 1.0E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    51| +1.48E+02 | -6.5E-06 | +8.5E-01 | 1.5E-02 | 5.4E-02 | 4.0E-03 |  2d |1
2023-02-17 16:05:23 fides(INFO)    35| +1.95E+02 | -1.7E+01 | +6.7E-01 | 7.4E-01 | 2.2E+01 | 1.9E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    33| +1.79E+02 | -1.5E+01 | +1.5E+00 | 2.5E-01 | 2.5E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    28| +1.51E+02 | -2.0E-01 | +1.0E+00 | 3.1E-02 | 3.9E+01 | 9.0E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)   118| +1.55E+02 | -1.6E-03 | +1.3E+00 | 4.5E-02 | 4.2E-01 | 9.0E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)     2| +8.35E+03 | -4.6E+04 | +9.0E-01 | 2.5E-01 | 2.7E+05 | 6.4E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    52| +1.48E+02 | -9.5E-06 | +7.9E-01 | 2.9E-02 | 2.8E-02 | 7.8E-03 |  2d |1
2023-02-17 16:05:23 fides(INFO)    47| +1.38E+02 | -1.2E-02 | +9.5E-01 | 1.1E-01 | 1.2E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    36| +1.95E+02 | +7.6E+01 | -2.6E+00 | 7.4E-01 | 1.1E+02 | 1.5E+00 |  2d |0
2023-02-17 16:05:23 fides(INFO)    34| +1.79E+02 | +3.4E+01 | -2.2E+00 | 5.0E-01 | 4.6E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:23 fides(INFO)    37| +1.78E+02 | -1.7E+01 | +8.4E-01 | 1.9E-01 | 1.1E+02 | 3.6E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    53| +1.48E+02 | -1.7E-05 | +9.4E-01 | 5.8E-02 | 4.8E-02 | 1.5E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)     3| +1.39E+03 | -7.0E+03 | +9.1E-01 | 5.0E-01 | 4.2E+04 | 1.3E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)     3| +1.25E+04 | -4.1E+04 | +9.4E-01 | 5.0E-01 | 1.9E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    35| +1.69E+02 | -1.1E+01 | +1.1E+00 | 1.2E-01 | 4.6E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    48| +1.38E+02 | -1.3E-02 | +5.7E-01 | 2.1E-01 | 1.2E+00 | 1.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    38| +1.66E+02 | -1.2E+01 | +5.0E-01 | 3.7E-01 | 4.7E+01 | 8.2E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    54| +1.48E+02 | -1.7E-05 | +9.6E-01 | 1.2E-01 | 1.8E-02 | 2.6E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)   119| +1.55E+02 | -1.1E-03 | +1.6E+00 | 4.5E-02 | 4.4E-01 | 8.6E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    36| +1.55E+02 | -1.4E+01 | +8.2E-01 | 2.5E-01 | 6.2E+01 | 4.9E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)     4| +3.46E+02 | -1.0E+03 | +9.1E-01 | 1.0E+00 | 6.8E+03 | 5.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    39| +1.59E+02 | -6.7E+00 | +3.1E-01 | 3.7E-01 | 1.2E+02 | 7.0E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    55| +1.48E+02 | +5.0E-04 | -1.2E+01 | 2.3E-01 | 4.5E-02 | 2.3E-02 | trr |0
2023-02-17 16:05:23 fides(INFO)    49| +1.38E+02 | +3.6E-01 | -3.5E+00 | 2.1E-01 | 1.4E+00 | 1.8E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    37| +1.49E+02 | -5.6E+00 | +7.6E-01 | 5.0E-01 | 1.1E+02 | 7.2E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    40| +1.51E+02 | -8.9E+00 | +9.5E-01 | 3.7E-01 | 2.3E+02 | 3.2E-01 | trr |1
2023-02-17 16:05:23 fides(INFO)    56| +1.48E+02 | +1.9E-05 | -1.0E+00 | 3.7E-02 | 4.5E-02 | 5.8E-03 |  2d |0
2023-02-17 16:05:23 fides(INFO)     5| +1.68E+02 | -1.8E+02 | +1.0E+00 | 1.0E+00 | 1.2E+03 | 6.2E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    29| +1.51E+02 | -3.0E-01 | +1.0E+00 | 6.2E-02 | 2.3E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    50| +1.38E+02 | +5.8E-03 | -2.0E-01 | 5.3E-02 | 1.4E+00 | 4.8E-02 |  2d |0
2023-02-17 16:05:23 fides(INFO)    41| +1.51E+02 | +2.8E+00 | -1.1E+00 | 3.7E-01 | 4.8E+01 | 5.7E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    38| +1.49E+02 | +3.5E+00 | -1.7E+00 | 1.0E+00 | 5.2E+01 | 7.7E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    57| +1.48E+02 | -1.9E-06 | +3.4E-01 | 9.3E-03 | 4.5E-02 | 1.4E-03 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)   120| +1.55E+02 | -1.7E-03 | +1.3E+00 | 4.5E-02 | 6.1E-01 | 1.2E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)     6| +1.68E+02 | -3.3E+00 | -2.8E-02 | 1.0E+00 | 2.0E+02 | 1.2E+00 |  2d |0
2023-02-17 16:05:23.374 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 77.935 and h = 1.24774e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:23.374 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 77.935: AMICI failed to integrate the forward problem
2023-02-17 16:05:23 fides(INFO)    39| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.7E-01 | 5.2E+01 | 1.9E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    42| +1.49E+02 | -1.3E+00 | +7.7E-01 | 8.8E-02 | 4.8E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    51| +1.38E+02 | -5.3E-03 | +5.0E-01 | 1.3E-02 | 1.4E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    58| +1.48E+02 | +4.1E-07 | -6.7E-01 | 9.3E-03 | 4.6E-02 | 1.4E-03 |  2d |0
2023-02-17 16:05:23 fides(INFO)     4| +2.02E+03 | -1.0E+04 | +9.0E-01 | 1.0E+00 | 4.4E+04 | 8.0E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    43| +1.49E+02 | +8.8E-01 | -6.9E-01 | 1.8E-01 | 3.0E+01 | 2.9E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    40| +1.49E+02 | -5.5E-01 | +8.8E-01 | 4.2E-02 | 5.2E+01 | 5.0E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)     7| +1.58E+02 | -1.1E+01 | +8.9E-01 | 2.1E-01 | 2.0E+02 | 3.0E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    59| +1.48E+02 | +3.4E-07 | -9.7E-01 | 2.3E-03 | 4.6E-02 | 3.4E-04 |  2d |0
2023-02-17 16:05:23 fides(INFO)    52| +1.38E+02 | -4.2E-03 | +9.7E-01 | 1.3E-02 | 6.4E+00 | 9.9E-03 |  2d |1
2023-02-17 16:05:23 fides(INFO)    44| +1.49E+02 | -3.3E-01 | +7.0E-01 | 4.4E-02 | 3.0E+01 | 7.4E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    41| +1.48E+02 | -4.1E-01 | +9.6E-01 | 8.3E-02 | 4.1E+01 | 9.4E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)     8| +1.52E+02 | -5.7E+00 | +8.5E-01 | 4.3E-01 | 6.1E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)   121| +1.55E+02 | -4.6E-03 | +1.2E+00 | 8.9E-02 | 7.5E-01 | 2.4E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    60| +1.48E+02 | +8.9E-07 | -3.2E+00 | 5.8E-04 | 4.6E-02 | 8.6E-05 |  2d |0
2023-02-17 16:05:23 fides(INFO)    42| +1.48E+02 | -4.1E-01 | +8.1E-01 | 1.7E-01 | 3.2E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    45| +1.48E+02 | -4.8E-01 | +7.5E-01 | 4.4E-02 | 2.3E+01 | 7.1E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    53| +1.38E+02 | -1.8E-03 | +9.8E-01 | 2.7E-02 | 6.1E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    61| +1.48E+02 | +3.9E-07 | -1.5E+00 | 1.5E-04 | 4.6E-02 | 2.4E-05 |  2d |0
2023-02-17 16:05:23.546 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 133.055 and h = 1.26071e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:23.546 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 133.055: AMICI failed to integrate the forward problem
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    30| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 9.4E+00 | 3.6E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    46| +1.48E+02 | +4.8E-02 | -1.0E-01 | 8.8E-02 | 2.6E+01 | 1.5E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    43| +1.48E+02 | +9.7E-02 | -2.0E-01 | 3.3E-01 | 2.9E+01 | 3.7E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)     9| +1.50E+02 | -2.2E+00 | +1.0E+00 | 8.5E-01 | 3.9E+01 | 8.0E-01 | trr |1
2023-02-17 16:05:23 fides(INFO)    54| +1.38E+02 | -3.5E-03 | +9.7E-01 | 5.3E-02 | 8.2E-01 | 3.8E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    47| +1.48E+02 | -1.7E-01 | +8.0E-01 | 2.2E-02 | 2.6E+01 | 3.8E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    62| +1.48E+02 | -1.0E-06 | +4.0E+00 | 3.6E-05 | 4.6E-02 | 1.2E-05 |  2d |1
2023-02-17 16:05:23 fides(WARNING) Stopping as function difference 1.03E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:23 fides(INFO)     5| +4.14E+02 | -1.6E+03 | +9.0E-01 | 1.0E+00 | 6.8E+03 | 8.2E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)   122| +1.55E+02 | -1.0E-02 | +1.1E+00 | 1.8E-01 | 1.4E+00 | 4.7E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    44| +1.48E+02 | -1.8E-01 | +8.0E-01 | 8.3E-02 | 2.9E+01 | 9.2E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    10| +1.50E+02 | -4.8E-02 | +2.5E-01 | 8.5E-01 | 8.1E+00 | 1.0E+00 | trr |1
2023-02-17 16:05:23 fides(INFO)    55| +1.38E+02 | -5.4E-03 | +8.0E-01 | 1.1E-01 | 7.0E-01 | 7.5E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    48| +1.48E+02 | -2.3E-01 | +9.6E-01 | 4.4E-02 | 9.2E+00 | 6.3E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    45| +1.48E+02 | -1.7E-01 | +8.5E-01 | 1.7E-01 | 1.7E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)   123| +1.55E+02 | +6.4E-01 | -5.7E+01 | 3.6E-01 | 6.7E+00 | 9.0E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    49| +1.48E+02 | -1.6E-01 | +5.9E-01 | 8.8E-02 | 1.4E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    56| +1.38E+02 | +2.1E-01 | -6.3E+00 | 2.1E-01 | 6.0E-01 | 1.6E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    11| +1.50E+02 | -3.8E-02 | +9.0E-01 | 1.7E-01 | 1.3E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    46| +1.48E+02 | +1.0E-01 | -4.8E-01 | 3.3E-01 | 1.8E+01 | 3.3E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    50| +1.48E+02 | +2.8E-01 | -5.9E-01 | 8.8E-02 | 6.2E+00 | 1.4E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    31| +1.51E+02 | -1.4E-02 | +1.0E+00 | 3.1E-02 | 9.4E+00 | 8.9E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    47| +1.48E+02 | -7.1E-02 | +7.5E-01 | 8.3E-02 | 1.8E+01 | 8.2E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    57| +1.38E+02 | +6.1E-03 | -6.6E-01 | 5.3E-02 | 6.0E-01 | 4.0E-02 |  2d |0
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)     0| +3.10E+09 |    NaN   |    NaN   | 1.0E+00 | 1.4E+10 |   NaN   | NaN |1
2023-02-17 16:05:23 fides(INFO)    12| +1.50E+02 | -1.9E-02 | +8.5E-01 | 3.4E-01 | 2.0E+00 | 4.1E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)   124| +1.55E+02 | -6.6E-03 | +9.7E-01 | 8.9E-02 | 6.7E+00 | 2.3E-01 |  2d |1
2023-02-17 16:05:23.765 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.64 and h = 4.19393e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:23.765 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.64: AMICI failed to integrate the forward problem
2023-02-17 16:05:23 fides(INFO)    48| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.3E-02 | 8.8E+00 | 6.9E-02 |  2d |0
2023-02-17 16:05:23 fides(INFO)    51| +1.48E+02 | -1.1E-01 | +6.1E-01 | 2.2E-02 | 6.2E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    13| +1.50E+02 | -5.3E-03 | +3.6E-01 | 6.8E-01 | 1.7E+00 | 6.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    58| +1.38E+02 | -1.4E-03 | +5.2E-01 | 1.3E-02 | 6.0E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    52| +1.48E+02 | -4.2E-02 | +8.8E-01 | 2.2E-02 | 9.9E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)     1| +1.92E+04 | -3.1E+09 | +9.3E-02 | 1.0E+00 | 1.4E+10 | 2.8E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    49| +1.48E+02 | -2.9E-02 | +8.6E-01 | 2.1E-02 | 8.8E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)   125| +1.55E+02 | -2.5E-02 | +3.9E-01 | 1.8E-01 | 1.0E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    14| +1.50E+02 | +2.2E-03 | -2.6E-01 | 6.8E-01 | 3.5E+00 | 2.8E-01 | trr |0
2023-02-17 16:05:23 fides(INFO)    53| +1.48E+02 | -6.1E-02 | +9.5E-01 | 4.4E-02 | 2.4E+00 | 5.8E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    50| +1.48E+02 | -2.5E-02 | +9.6E-01 | 4.2E-02 | 1.2E+01 | 3.5E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)     2| +3.81E+03 | -1.5E+04 | +9.1E-01 | 2.5E-01 | 6.4E+04 | 5.8E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    59| +1.38E+02 | -1.1E-03 | +9.5E-01 | 1.3E-02 | 2.1E+00 | 8.8E-03 |  2d |1
2023-02-17 16:05:23 fides(INFO)     6| +1.81E+02 | -2.3E+02 | +8.9E-01 | 1.0E+00 | 1.0E+03 | 1.2E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    54| +1.48E+02 | -7.4E-02 | +9.0E-01 | 8.8E-02 | 4.8E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)     3| +8.29E+02 | -3.0E+03 | +9.1E-01 | 5.0E-01 | 1.2E+04 | 1.4E+00 |  2d |1
2023-02-17 16:05:23 fides(INFO)    15| +1.50E+02 | -3.8E-03 | +8.1E-01 | 1.2E-01 | 3.5E+00 | 7.0E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    51| +1.48E+02 | -1.9E-02 | +9.5E-01 | 8.3E-02 | 5.1E+00 | 6.7E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:23 fides(INFO)    60| +1.38E+02 | -1.6E-03 | +9.7E-01 | 2.7E-02 | 4.5E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)   126| +1.55E+02 | +3.1E-01 | -3.2E+00 | 1.8E-01 | 1.2E+01 | 3.4E-01 |  2d |0
2023-02-17 16:05:23.931 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.6304 and h = 1.05166e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:23.932 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.6304: AMICI failed to integrate the forward problem
2023-02-17 16:05:23 fides(INFO)    32| +1.51E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 4.6E+00 | 1.8E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)     4| +8.29E+02 | +5.6E+03 | -3.0E+01 | 1.0E+00 | 2.0E+03 | 2.8E+00 |  2d |0
2023-02-17 16:05:23 fides(INFO)    16| +1.50E+02 | -7.9E-04 | +7.6E-01 | 2.4E-01 | 9.1E-01 | 1.3E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)    55| +1.48E+02 | +3.2E-02 | -5.2E-01 | 1.8E-01 | 1.5E+00 | 1.9E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    52| +1.48E+02 | -1.9E-02 | +8.1E-01 | 1.7E-01 | 5.9E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:23 fides(INFO)     5| +3.55E+02 | -4.7E+02 | +8.8E-01 | 2.5E-01 | 2.0E+03 | 5.3E-01 |  2d |1
2023-02-17 16:05:23.973 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 146.739 and h = 3.74372e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:23.973 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 146.739: AMICI failed to integrate the forward problem
2023-02-17 16:05:23 fides(INFO)    56| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.8E-02 | 1.5E+00 | 5.0E-02 |  2d |0
2023-02-17 16:05:23 fides(INFO)    61| +1.38E+02 | -2.6E-03 | +9.1E-01 | 5.3E-02 | 1.8E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:23 fides(INFO)    53| +1.48E+02 | +4.3E-02 | -1.3E+00 | 3.3E-01 | 2.9E+00 | 2.2E-01 |  2d |0
2023-02-17 16:05:23 fides(INFO)    17| +1.50E+02 | -1.6E-04 | +8.4E-01 | 4.7E-01 | 5.0E-01 | 1.7E-01 | trr |1
2023-02-17 16:05:24 fides(INFO)   127| +1.55E+02 | -3.7E-02 | +7.2E-01 | 4.2E-02 | 1.2E+01 | 8.6E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)     6| +2.54E+02 | -1.0E+02 | +8.0E-01 | 5.0E-01 | 3.6E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    57| +1.48E+02 | -1.1E-02 | +6.4E-01 | 9.6E-03 | 1.5E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    54| +1.48E+02 | -5.9E-03 | +4.5E-01 | 8.3E-02 | 2.9E+00 | 5.4E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    62| +1.38E+02 | +1.8E-03 | -3.4E-01 | 1.1E-01 | 4.0E-01 | 6.8E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)     7| +1.53E+02 | -2.7E+01 | +8.6E-01 | 1.0E+00 | 1.5E+02 | 2.0E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    18| +1.50E+02 | +5.0E-05 | -4.1E-01 | 4.7E-01 | 3.0E-01 | 7.7E-03 | trr |0
2023-02-17 16:05:24 fides(INFO)     7| +2.49E+02 | -4.7E+00 | +6.1E-01 | 1.0E+00 | 4.7E+01 | 2.6E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    55| +1.48E+02 | -3.9E-03 | +2.8E-01 | 8.3E-02 | 3.9E+00 | 6.4E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    58| +1.48E+02 | -7.2E-03 | +8.7E-01 | 9.6E-03 | 3.6E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:24.073 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 91.1719 and h = 1.21884e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.073 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 91.1719: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    33| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 4.6E+00 | 3.8E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)   128| +1.55E+02 | -2.4E-02 | +1.9E-01 | 4.2E-02 | 1.1E+01 | 9.2E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    19| +1.50E+02 | -4.8E-05 | +8.1E-01 | 1.4E-02 | 3.0E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)     8| +2.43E+02 | -5.9E+00 | +1.1E+00 | 1.0E+00 | 1.6E+01 | 2.5E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    63| +1.38E+02 | -1.0E-03 | +5.1E-01 | 2.7E-02 | 4.0E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    56| +1.48E+02 | +6.8E-03 | -4.1E-01 | 8.3E-02 | 1.9E+00 | 5.1E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)    59| +1.48E+02 | -6.9E-03 | +7.8E-01 | 1.9E-02 | 5.3E-01 | 2.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)     9| +2.27E+02 | -1.6E+01 | +1.6E+00 | 2.0E+00 | 2.4E+01 | 4.5E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    20| +1.50E+02 | -1.1E-05 | +5.6E-01 | 2.9E-02 | 7.4E-02 | 1.8E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)     8| +1.52E+02 | -7.5E-01 | +9.6E-01 | 1.0E+00 | 4.2E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    64| +1.38E+02 | -1.5E-03 | +4.7E-01 | 2.7E-02 | 1.9E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    60| +1.48E+02 | -1.4E-02 | +8.8E-01 | 3.8E-02 | 1.2E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    57| +1.48E+02 | -1.5E-03 | +1.6E-01 | 2.1E-02 | 1.9E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)   129| +1.54E+02 | -7.7E-02 | +1.1E+00 | 1.0E-02 | 2.3E+01 | 2.1E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    10| +2.27E+02 | +4.8E+03 | -1.3E+02 | 4.0E+00 | 3.3E+01 | 7.2E+00 | trr |0
2023-02-17 16:05:24 fides(INFO)    21| +1.50E+02 | -5.6E-07 | +7.6E-02 | 2.9E-02 | 7.5E-02 | 1.6E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)     9| +1.52E+02 | +8.3E+01 | -9.5E+01 | 2.0E+00 | 1.9E+01 | 4.7E+00 |  2d |0
2023-02-17 16:05:24 fides(INFO)    58| +1.48E+02 | -4.3E-03 | +9.4E-01 | 5.2E-03 | 5.9E+00 | 3.9E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    61| +1.48E+02 | +6.8E-03 | -3.8E-01 | 7.7E-02 | 6.1E-01 | 1.0E-01 |  2d |0
2023-02-17 16:05:24 fides(INFO)    65| +1.38E+02 | -1.0E-03 | +4.3E-01 | 2.7E-02 | 4.5E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    22| +1.50E+02 | -2.7E-06 | +4.9E-01 | 7.1E-03 | 1.9E-02 | 8.7E-04 |  2d |1
2023-02-17 16:05:24 fides(INFO)    11| +2.27E+02 | +4.6E+01 | -4.0E+00 | 7.1E-01 | 3.3E+01 | 1.8E+00 |  2d |0
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)   130| +1.54E+02 | -3.0E-02 | +1.1E+00 | 2.1E-02 | 3.5E+00 | 4.8E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    62| +1.48E+02 | -3.8E-03 | +6.9E-01 | 1.9E-02 | 6.1E-01 | 2.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    59| +1.48E+02 | -6.3E-04 | +8.8E-01 | 1.0E-02 | 5.0E-01 | 6.9E-03 |  2d |1
2023-02-17 16:05:24.245 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 78.9074 and h = 1.0834e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.246 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 78.9074: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    34| +1.51E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 4.6E+00 | 8.9E-03 |  2d |0
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    10| +1.52E+02 | +2.3E+00 | -1.1E+01 | 5.0E-01 | 1.9E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:24 fides(INFO)    66| +1.38E+02 | -8.5E-04 | +3.4E-01 | 2.7E-02 | 6.9E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    12| +2.22E+02 | -5.2E+00 | +4.5E-01 | 1.8E-01 | 3.3E+01 | 4.4E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    23| +1.50E+02 | -2.8E-08 | +4.4E-02 | 7.1E-03 | 2.2E-02 | 4.1E-04 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    60| +1.48E+02 | -6.7E-04 | +8.4E-01 | 2.1E-02 | 6.4E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    63| +1.48E+02 | -2.7E-03 | +3.8E-01 | 1.9E-02 | 6.8E-01 | 2.3E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    13| +2.14E+02 | -7.9E+00 | +9.1E-01 | 1.8E-01 | 4.9E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)   131| +1.54E+02 | -4.3E-02 | +1.0E+00 | 4.2E-02 | 3.0E+00 | 9.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    61| +1.48E+02 | -7.4E-04 | +9.1E-01 | 4.2E-02 | 2.8E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    64| +1.48E+02 | -4.7E-03 | +5.2E-01 | 1.9E-02 | 3.0E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    24| +1.50E+02 | -1.5E-07 | +6.6E-01 | 1.8E-03 | 1.2E-02 | 1.4E-04 |  2d |1
2023-02-17 16:05:24 fides(WARNING) Stopping as function difference 1.50E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:24 fides(INFO)    67| +1.38E+02 | -9.3E-04 | +3.2E-01 | 2.7E-02 | 5.1E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    14| +1.95E+02 | -1.9E+01 | +1.3E+00 | 3.5E-01 | 2.8E+01 | 7.9E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    11| +1.52E+02 | -1.4E-01 | +9.4E-01 | 1.2E-01 | 1.9E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    65| +1.48E+02 | -2.7E-03 | +6.2E-01 | 1.9E-02 | 6.9E-01 | 2.0E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    62| +1.48E+02 | -1.1E-03 | +9.6E-01 | 8.3E-02 | 3.9E-01 | 4.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)   132| +1.54E+02 | -7.1E-02 | +8.4E-01 | 8.3E-02 | 5.1E+00 | 1.9E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    15| +1.95E+02 | -8.5E+00 | -3.6E-01 | 7.1E-01 | 5.5E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:24 fides(INFO)    68| +1.38E+02 | -5.6E-04 | +1.7E-01 | 2.7E-02 | 7.0E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    63| +1.48E+02 | -1.3E-03 | +9.2E-01 | 1.7E-01 | 2.4E-01 | 8.2E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    66| +1.48E+02 | -1.3E-03 | +3.5E-01 | 1.9E-02 | 6.8E-01 | 2.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    16| +1.83E+02 | -1.2E+01 | +1.0E+00 | 1.8E-01 | 5.5E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    12| +1.52E+02 | -2.0E-01 | +7.0E-01 | 2.5E-01 | 2.1E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    67| +1.48E+02 | +5.7E-03 | -9.3E-01 | 1.9E-02 | 6.4E-01 | 1.5E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)    69| +1.38E+02 | -8.7E-04 | +7.9E-01 | 6.7E-03 | 6.0E-01 | 4.4E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)     0| +1.22E+14 |    NaN   |    NaN   | 1.0E+00 | 5.6E+14 |   NaN   | NaN |1
2023-02-17 16:05:24 fides(INFO)    64| +1.48E+02 | +1.8E-03 | -1.7E+00 | 3.3E-01 | 1.5E-01 | 1.3E-01 |  2d |0
2023-02-17 16:05:24.455 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 111.961 and h = 1.39991e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.456 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 111.961: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)   133| +1.54E+02 | -5.6E-02 | +8.6E-01 | 1.7E-01 | 1.0E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    35| +1.51E+02 | +0.0E+00 | +0.0E+00 | 9.8E-04 | 4.6E+00 | 2.2E-03 |  2d |0
2023-02-17 16:05:24 fides(INFO)    65| +1.48E+02 | -1.2E-04 | +2.7E-01 | 8.3E-02 | 1.5E-01 | 3.2E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    68| +1.48E+02 | -9.4E-04 | +4.7E-01 | 4.8E-03 | 6.4E-01 | 4.4E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    17| +1.67E+02 | -1.6E+01 | +6.3E-01 | 3.5E-01 | 5.7E+01 | 6.6E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    70| +1.38E+02 | -6.7E-04 | +7.7E-01 | 1.3E-02 | 8.1E-01 | 7.8E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    13| +1.52E+02 | -1.9E-01 | +8.0E-01 | 2.5E-01 | 1.9E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)     1| +7.10E+07 | -1.2E+14 | +8.3E-02 | 1.0E+00 | 5.6E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    18| +1.54E+02 | -1.3E+01 | +9.7E-01 | 3.5E-01 | 2.2E+02 | 9.7E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    69| +1.48E+02 | -5.4E-04 | +8.7E-01 | 4.8E-03 | 1.3E+00 | 5.9E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    66| +1.48E+02 | +1.3E-03 | -7.9E-01 | 8.3E-02 | 5.7E-01 | 3.9E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)   134| +1.54E+02 | -1.9E-02 | +6.2E-01 | 1.7E-01 | 2.8E+00 | 1.9E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)     2| +1.09E+07 | -6.0E+07 | +8.9E-01 | 2.5E-01 | 3.3E+08 | 6.6E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    71| +1.38E+02 | -8.8E-04 | +9.9E-01 | 2.7E-02 | 3.1E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    19| +1.54E+02 | +6.4E+00 | -9.7E-01 | 7.1E-01 | 7.2E+01 | 9.7E-01 |  2d |0
2023-02-17 16:05:24 fides(INFO)    67| +1.48E+02 | -3.0E-04 | +6.2E-01 | 2.1E-02 | 5.7E-01 | 9.7E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    70| +1.48E+02 | -5.7E-04 | +9.2E-01 | 9.6E-03 | 1.8E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)     3| +1.68E+06 | -9.2E+06 | +8.9E-01 | 5.0E-01 | 5.0E+07 | 1.1E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    14| +1.52E+02 | -2.2E-01 | +6.7E-01 | 5.0E-01 | 2.5E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:24.587 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 88.6128 and h = 1.23616e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.587 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 88.6128: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    36| +1.51E+02 | +0.0E+00 | +0.0E+00 | 2.4E-04 | 4.6E+00 | 5.6E-04 |  2d |0
2023-02-17 16:05:24 fides(INFO)    72| +1.38E+02 | -1.7E-03 | +9.8E-01 | 5.3E-02 | 3.0E-01 | 2.9E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    71| +1.48E+02 | -1.0E-03 | +8.9E-01 | 1.9E-02 | 2.1E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:24.596 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.536 and h = 2.82335e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.596 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.536: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    68| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.1E-02 | 5.3E-02 | 7.1E-03 |  2d |0
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    20| +1.51E+02 | -3.6E+00 | +8.2E-01 | 1.8E-01 | 7.2E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)   135| +1.54E+02 | -2.3E-02 | +1.0E+00 | 1.7E-01 | 1.2E+01 | 5.4E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)     4| +2.61E+05 | -1.4E+06 | +9.0E-01 | 5.0E-01 | 7.7E+06 | 5.7E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    69| +1.48E+02 | -1.4E-05 | +1.1E+00 | 5.2E-03 | 5.3E-02 | 1.8E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)     5| +4.12E+04 | -2.2E+05 | +9.0E-01 | 5.0E-01 | 1.2E+06 | 5.2E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    72| +1.48E+02 | +1.4E-03 | -1.1E+00 | 3.8E-02 | 2.3E-01 | 4.4E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)    21| +1.50E+02 | -1.2E+00 | +4.4E-01 | 3.5E-01 | 7.7E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    73| +1.38E+02 | -2.9E-03 | +9.1E-01 | 1.1E-01 | 4.1E-01 | 5.7E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)     6| +6.71E+03 | -3.4E+04 | +9.0E-01 | 5.0E-01 | 1.9E+05 | 4.1E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    70| +1.48E+02 | -2.2E-05 | +9.2E-01 | 1.0E-02 | 1.0E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:24.659 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.443 and h = 3.24687e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.659 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.443: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    73| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.6E-03 | 2.3E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)   136| +1.54E+02 | -1.3E-02 | +1.6E+00 | 1.7E-01 | 4.5E+00 | 8.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    22| +1.49E+02 | -3.9E-01 | +7.7E-02 | 3.5E-01 | 4.4E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    15| +1.51E+02 | -2.6E-01 | +1.2E+00 | 5.0E-01 | 1.4E+01 | 6.9E-01 | trr |1
2023-02-17 16:05:24 fides(INFO)     7| +1.25E+03 | -5.5E+03 | +9.0E-01 | 5.0E-01 | 3.0E+04 | 4.1E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    74| +1.38E+02 | +4.9E-02 | -5.3E+00 | 2.1E-01 | 2.9E-01 | 1.1E-01 |  2d |0
2023-02-17 16:05:24 fides(INFO)    71| +1.48E+02 | -3.9E-05 | +9.4E-01 | 2.1E-02 | 5.5E-02 | 6.9E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    74| +1.48E+02 | -9.3E-05 | +8.1E-01 | 2.4E-03 | 2.3E-01 | 2.8E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)     8| +3.91E+02 | -8.6E+02 | +9.0E-01 | 5.0E-01 | 4.8E+03 | 4.0E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    23| +1.48E+02 | -9.5E-01 | +5.1E-01 | 8.9E-02 | 5.4E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    16| +1.51E+02 | -1.2E-01 | +8.4E-01 | 1.0E+00 | 7.2E+00 | 1.6E+00 |  2d |1
2023-02-17 16:05:24.718 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 94.2389 and h = 1.24166e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.718 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 94.2389: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    37| +1.51E+02 | +0.0E+00 | +0.0E+00 | 6.1E-05 | 4.6E+00 | 1.4E-04 |  2d |0
2023-02-17 16:05:24.727 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.508 and h = 2.16248e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.728 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.508: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    72| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.2E-02 | 8.9E-02 | 1.3E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)    75| +1.38E+02 | +1.4E-03 | -5.2E-01 | 5.3E-02 | 2.9E-01 | 2.8E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)    75| +1.48E+02 | -1.6E-04 | +9.4E-01 | 4.8E-03 | 8.1E-02 | 5.3E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)     9| +2.62E+02 | -1.3E+02 | +8.9E-01 | 5.0E-01 | 7.6E+02 | 3.8E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    24| +1.48E+02 | -2.6E-01 | +9.1E-01 | 8.9E-02 | 2.8E+01 | 8.1E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)   137| +1.54E+02 | -1.6E-02 | +1.2E+00 | 1.7E-01 | 1.7E+00 | 2.4E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    76| +1.48E+02 | -2.8E-04 | +9.8E-01 | 9.6E-03 | 1.8E-01 | 9.1E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    17| +1.51E+02 | -3.1E-01 | +1.5E+00 | 2.0E+00 | 7.5E+00 | 3.3E-01 | trr |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    10| +2.50E+02 | -1.2E+01 | +7.8E-01 | 5.0E-01 | 1.1E+02 | 1.5E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    73| +1.48E+02 | -2.4E-05 | +1.2E+00 | 1.0E-02 | 8.9E-02 | 3.3E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    76| +1.38E+02 | -3.9E-04 | +4.8E-01 | 1.3E-02 | 2.9E-01 | 7.2E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    25| +1.48E+02 | -3.1E-01 | +8.7E-01 | 1.8E-01 | 2.9E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    77| +1.48E+02 | -2.8E-04 | +8.3E-01 | 1.9E-02 | 8.6E-02 | 1.8E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    11| +2.50E+02 | -2.3E-04 | +3.8E-02 | 1.0E+00 | 9.9E-01 | 2.7E+00 |  2d |1
2023-02-17 16:05:24 fides(INFO)    74| +1.48E+02 | -3.3E-05 | +9.7E-01 | 2.1E-02 | 5.8E-02 | 6.5E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)   138| +1.54E+02 | -5.5E-03 | +1.5E+00 | 1.7E-01 | 1.5E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    18| +1.51E+02 | -4.8E-01 | +9.4E-01 | 2.0E+00 | 9.3E+00 | 4.2E-01 | trr |1
2023-02-17 16:05:24 fides(INFO)    26| +1.48E+02 | +3.8E-01 | -1.6E+00 | 3.5E-01 | 1.4E+01 | 3.3E-01 |  2d |0
2023-02-17 16:05:24 fides(INFO)    12| +2.50E+02 | +1.4E-04 | -2.8E-02 | 2.5E-01 | 9.4E-01 | 6.0E-01 |  2d |0
2023-02-17 16:05:24.822 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2018 and h = 1.60887e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.822 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2018: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    78| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.8E-02 | 1.8E-01 | 1.2E-02 | trr |0
2023-02-17 16:05:24 fides(INFO)    77| +1.38E+02 | -5.1E-04 | +8.1E-01 | 1.3E-02 | 1.2E+00 | 6.7E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    75| +1.48E+02 | -5.3E-05 | +9.5E-01 | 4.2E-02 | 7.3E-02 | 1.2E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    19| +1.51E+02 | +1.9E+00 | -1.3E+00 | 2.0E+00 | 4.8E+01 | 5.6E-01 | trr |0
2023-02-17 16:05:24 fides(INFO)    27| +1.48E+02 | -4.3E-02 | +5.1E-01 | 8.9E-02 | 1.4E+01 | 8.3E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    13| +2.50E+02 | +1.5E-04 | -3.1E-02 | 6.2E-02 | 9.4E-01 | 1.5E-01 |  2d |0
2023-02-17 16:05:24 fides(INFO)    78| +1.38E+02 | -6.3E-04 | +9.5E-01 | 2.7E-02 | 1.9E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    79| +1.48E+02 | +1.3E-04 | -5.2E-01 | 6.2E-03 | 1.8E-01 | 3.0E-03 |  2d |0
2023-02-17 16:05:24 fides(INFO)    38| +1.51E+02 | -1.5E-04 | +1.0E+00 | 1.5E-05 | 4.6E+00 | 3.5E-05 |  2d |1
2023-02-17 16:05:24.882 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.542 and h = 2.33234e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.882 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.542: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    76| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.3E-02 | 4.4E-02 | 2.3E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)   139| +1.54E+02 | -5.3E-03 | +1.4E+00 | 1.7E-01 | 1.0E+00 | 2.2E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    28| +1.48E+02 | -4.4E-02 | +4.8E-01 | 8.9E-02 | 1.2E+01 | 6.3E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    20| +1.50E+02 | -7.5E-01 | +8.6E-01 | 8.9E-02 | 4.8E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    14| +2.50E+02 | +1.5E-04 | -3.1E-02 | 1.6E-02 | 9.4E-01 | 3.8E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    80| +1.48E+02 | -4.6E-05 | +6.3E-01 | 1.5E-03 | 1.8E-01 | 7.9E-04 |  2d |1
2023-02-17 16:05:24 fides(INFO)    77| +1.48E+02 | -2.1E-05 | +9.8E-01 | 2.1E-02 | 4.4E-02 | 5.7E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    79| +1.38E+02 | -9.6E-04 | +6.9E-01 | 5.3E-02 | 2.3E-01 | 2.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    29| +1.48E+02 | -2.1E-02 | +2.8E-01 | 8.9E-02 | 1.3E+01 | 8.5E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    15| +2.50E+02 | -1.1E-03 | +2.1E-01 | 3.9E-03 | 9.4E-01 | 9.7E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    81| +1.48E+02 | -1.7E-05 | +1.0E+00 | 1.5E-03 | 1.6E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    21| +1.50E+02 | -2.0E-01 | +6.3E-01 | 1.8E-01 | 1.2E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)    78| +1.48E+02 | -3.4E-05 | +9.7E-01 | 4.2E-02 | 6.2E-02 | 1.1E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)   140| +1.54E+02 | -3.3E-03 | +1.4E+00 | 1.7E-01 | 7.0E-01 | 2.4E-01 |  2d |1
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    80| +1.38E+02 | +3.6E-03 | -9.5E-01 | 5.3E-02 | 3.3E-01 | 2.7E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:24 fides(INFO)    16| +2.50E+02 | -1.1E-03 | +8.7E-01 | 9.8E-04 | 7.3E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    30| +1.48E+02 | +3.0E-02 | -3.0E-01 | 8.9E-02 | 6.8E+00 | 7.7E-02 |  2d |0
2023-02-17 16:05:24 fides(INFO)    82| +1.48E+02 | -2.5E-05 | +9.9E-01 | 3.1E-03 | 5.1E-02 | 2.2E-03 |  2d |1
2023-02-17 16:05:24 fides(INFO)    79| +1.48E+02 | -4.2E-05 | +9.6E-01 | 8.3E-02 | 3.2E-02 | 2.0E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    22| +1.50E+02 | -1.2E-02 | +9.6E-01 | 1.8E-01 | 3.8E+00 | 7.2E-02 |  2d |1
2023-02-17 16:05:24.994 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 94.9704 and h = 1.35144e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:24.994 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 94.9704: AMICI failed to integrate the forward problem
2023-02-17 16:05:24 fides(INFO)    39| +1.51E+02 | +0.0E+00 | +0.0E+00 | 3.1E-05 | 4.5E+00 | 7.0E-05 |  2d |0
2023-02-17 16:05:24 fides(INFO)    31| +1.48E+02 | -2.3E-02 | +2.8E-01 | 2.2E-02 | 6.8E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:24 fides(INFO)    17| +2.50E+02 | -3.1E-04 | +3.4E-01 | 2.0E-03 | 4.0E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    81| +1.38E+02 | -5.1E-04 | +5.1E-01 | 1.3E-02 | 3.3E-01 | 6.8E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    83| +1.48E+02 | -3.0E-05 | +8.6E-01 | 6.2E-03 | 1.1E-01 | 4.6E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    80| +1.48E+02 | -1.2E-05 | +4.7E-01 | 1.7E-01 | 4.8E-02 | 3.2E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    23| +1.50E+02 | +3.0E-02 | -8.8E-01 | 3.6E-01 | 1.2E+00 | 1.4E-01 | trr |0
2023-02-17 16:05:25 fides(INFO)    32| +1.48E+02 | -2.0E-02 | +8.0E-01 | 2.2E-02 | 8.7E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)   141| +1.54E+02 | -1.8E-03 | +1.4E+00 | 1.7E-01 | 7.8E-01 | 2.4E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    18| +2.50E+02 | +2.5E-06 | -8.0E-03 | 2.0E-03 | 2.4E-01 | 4.8E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)    84| +1.48E+02 | +1.5E-04 | -2.3E+00 | 1.2E-02 | 5.4E-02 | 3.0E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)    81| +1.48E+02 | +2.1E-03 | -1.3E+01 | 1.7E-01 | 6.4E-02 | 2.1E-02 | trr |0
2023-02-17 16:05:25 fides(INFO)    82| +1.38E+02 | -3.2E-04 | +8.1E-01 | 1.3E-02 | 4.4E-01 | 6.1E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    33| +1.48E+02 | -5.4E-03 | +5.8E-01 | 4.4E-02 | 2.6E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    24| +1.50E+02 | -3.2E-03 | +8.6E-01 | 1.7E-02 | 1.2E+00 | 7.4E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    19| +2.50E+02 | -1.6E-04 | +7.2E-01 | 4.9E-04 | 2.4E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    85| +1.48E+02 | -2.4E-06 | +1.0E-01 | 3.1E-03 | 5.4E-02 | 8.1E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)    82| +1.48E+02 | +8.3E-05 | -1.2E+00 | 1.5E-02 | 6.4E-02 | 5.2E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)    34| +1.48E+02 | -1.9E-03 | +8.6E-01 | 4.4E-02 | 3.0E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    20| +2.50E+02 | +2.0E-09 | -4.6E-04 | 4.9E-04 | 2.9E-02 | 1.2E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)    83| +1.38E+02 | -5.3E-04 | +8.8E-01 | 2.7E-02 | 1.8E-01 | 1.2E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    25| +1.50E+02 | -4.6E-03 | +9.1E-01 | 3.3E-02 | 1.4E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)   142| +1.54E+02 | -1.0E-03 | +1.4E+00 | 1.7E-01 | 2.3E-01 | 2.6E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    86| +1.48E+02 | -9.0E-06 | +8.1E-01 | 7.7E-04 | 1.3E-01 | 7.8E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)    35| +1.48E+02 | -1.3E-03 | +5.8E-01 | 8.9E-02 | 7.3E-01 | 4.4E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    83| +1.48E+02 | -7.3E-06 | +3.4E-01 | 3.7E-03 | 6.4E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:25.130 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 137.357 and h = 1.59524e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:25.130 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 137.357: AMICI failed to integrate the forward problem
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    40| +1.51E+02 | +0.0E+00 | +0.0E+00 | 7.6E-06 | 4.5E+00 | 1.7E-05 |  2d |0
2023-02-17 16:05:25 fides(INFO)    21| +2.50E+02 | -8.2E-07 | +1.7E-01 | 1.2E-04 | 2.9E-02 | 3.1E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)    84| +1.38E+02 | -3.0E-04 | +1.8E-01 | 5.3E-02 | 2.2E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    87| +1.48E+02 | -6.9E-06 | +8.7E-01 | 1.5E-03 | 2.7E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    26| +1.50E+02 | -5.2E-03 | +8.9E-01 | 6.6E-02 | 1.7E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    36| +1.48E+02 | -6.0E-04 | +6.7E-01 | 8.9E-02 | 1.6E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    84| +1.48E+02 | -1.8E-06 | +7.3E-01 | 3.7E-03 | 1.3E-01 | 2.7E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)    22| +2.50E+02 | -1.1E-06 | +8.8E-01 | 3.1E-05 | 2.3E-02 | 5.9E-05 |  2d |1
2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 1.08E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:25 fides(INFO)    88| +1.48E+02 | -6.1E-06 | +9.5E-01 | 3.1E-03 | 2.1E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    37| +1.48E+02 | +3.6E-04 | -4.3E-01 | 8.9E-02 | 3.6E-01 | 3.9E-02 |  2d |0
2023-02-17 16:05:25 fides(INFO)    85| +1.48E+02 | -2.1E-06 | +3.2E+01 | 3.7E-03 | 1.1E-02 | 2.2E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)    27| +1.50E+02 | -2.7E-03 | +6.6E-01 | 1.3E-01 | 9.8E-01 | 3.9E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)   143| +1.54E+02 | -6.4E-04 | +1.3E+00 | 3.3E-01 | 5.7E-01 | 2.7E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    85| +1.38E+02 | -8.7E-04 | +3.8E-01 | 1.3E-02 | 4.6E-01 | 7.8E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    89| +1.48E+02 | -4.8E-06 | +5.7E-01 | 6.2E-03 | 3.0E-02 | 3.3E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    86| +1.48E+02 | +2.4E-06 | -4.6E+01 | 7.5E-03 | 7.2E-03 | 4.1E-04 |  2d |0
2023-02-17 16:05:25 fides(INFO)    28| +1.50E+02 | -2.5E-04 | +1.6E-01 | 1.3E-01 | 1.1E+00 | 2.6E-02 | trr |1
2023-02-17 16:05:25 fides(INFO)    38| +1.48E+02 | -1.9E-04 | +7.0E-01 | 2.2E-02 | 3.6E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    86| +1.38E+02 | -3.5E-04 | +5.9E-01 | 1.3E-02 | 7.5E-01 | 5.9E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    90| +1.48E+02 | +2.6E-04 | -6.1E+00 | 6.2E-03 | 3.6E-02 | 3.9E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)   144| +1.54E+02 | -3.3E-04 | +1.3E+00 | 3.3E-01 | 1.9E-01 | 2.9E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    87| +1.48E+02 | -2.2E-06 | +1.0E+02 | 1.9E-03 | 7.2E-03 | 1.0E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)    29| +1.50E+02 | -8.3E-04 | +5.2E-01 | 3.0E-02 | 1.8E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    41| +1.51E+02 | -1.8E-05 | +9.7E-01 | 1.9E-06 | 4.5E+00 | 4.3E-06 |  2d |1
2023-02-17 16:05:25 fides(INFO)    39| +1.48E+02 | -6.3E-05 | +9.4E-01 | 2.2E-02 | 5.1E-01 | 8.6E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)     0| +1.23E+14 |    NaN   |    NaN   | 1.0E+00 | 5.6E+14 |   NaN   | NaN |1
2023-02-17 16:05:25 fides(INFO)    87| +1.38E+02 | -2.5E-04 | +7.5E-01 | 1.3E-02 | 1.9E-01 | 5.5E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    91| +1.48E+02 | +9.5E-05 | -3.5E+00 | 1.5E-03 | 3.6E-02 | 1.6E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)    88| +1.48E+02 | -2.4E-07 | +7.6E+00 | 3.7E-03 | 5.7E-03 | 2.0E-04 |  2d |1
2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 2.41E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    30| +1.50E+02 | -7.7E-05 | +5.7E-01 | 3.0E-02 | 7.1E-01 | 3.9E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    40| +1.48E+02 | -5.6E-05 | +8.4E-01 | 4.4E-02 | 2.2E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)     1| +9.94E+11 | -1.2E+14 | +8.2E-02 | 1.0E+00 | 5.6E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    92| +1.48E+02 | +2.8E-05 | -1.5E+00 | 3.9E-04 | 3.6E-02 | 8.5E-04 |  2d |0
2023-02-17 16:05:25 fides(INFO)   145| +1.54E+02 | -1.5E-04 | +1.4E+00 | 3.3E-01 | 1.8E-01 | 2.4E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    88| +1.38E+02 | -4.1E-04 | +7.3E-01 | 2.7E-02 | 2.6E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    41| +1.48E+02 | -6.0E-05 | +7.6E-01 | 8.9E-02 | 2.7E-01 | 3.1E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    31| +1.50E+02 | +3.6E-05 | -4.1E-01 | 3.0E-02 | 6.1E-02 | 6.7E-03 | trr |0
2023-02-17 16:05:25 fides(INFO)     2| +1.47E+11 | -8.5E+11 | +8.9E-01 | 2.5E-01 | 4.6E+12 | 6.6E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    93| +1.48E+02 | -1.7E-06 | +2.5E-01 | 9.6E-05 | 3.6E-02 | 2.1E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)     3| +2.19E+10 | -1.3E+11 | +8.9E-01 | 5.0E-01 | 6.8E+11 | 8.1E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)   146| +1.54E+02 | -9.2E-05 | +1.4E+00 | 3.3E-01 | 9.7E-02 | 2.6E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    42| +1.48E+02 | +6.0E-04 | -3.3E+00 | 1.8E-01 | 1.3E-01 | 5.3E-02 |  2d |0
2023-02-17 16:05:25 fides(INFO)    32| +1.50E+02 | -2.9E-05 | +7.7E-01 | 6.3E-03 | 6.1E-02 | 1.6E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    89| +1.38E+02 | -1.5E-04 | +1.6E-01 | 2.7E-02 | 2.0E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)     4| +3.26E+09 | -1.9E+10 | +8.9E-01 | 5.0E-01 | 1.0E+11 | 8.1E-01 |  2d |1
2023-02-17 16:05:25.403 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 85.3984 and h = 1.13613e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:25.403 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 85.3984: AMICI failed to integrate the forward problem
2023-02-17 16:05:25 fides(INFO)    42| +1.51E+02 | +0.0E+00 | +0.0E+00 | 3.8E-06 | 4.5E+00 | 8.7E-06 |  2d |0
2023-02-17 16:05:25 fides(INFO)     5| +4.90E+08 | -2.8E+09 | +8.9E-01 | 5.0E-01 | 1.5E+10 | 8.3E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    94| +1.48E+02 | -3.3E-06 | +1.2E+01 | 2.4E-05 | 4.5E-02 | 1.3E-05 |  2d |1
2023-02-17 16:05:25 fides(INFO)    43| +1.48E+02 | -5.1E-06 | +7.7E-02 | 4.4E-02 | 1.3E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)     6| +7.38E+07 | -4.2E+08 | +8.9E-01 | 5.0E-01 | 2.3E+09 | 7.9E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)     0| +2.27E+09 |    NaN   |    NaN   | 1.0E+00 | 1.0E+10 |   NaN   | NaN |1
2023-02-17 16:05:25 fides(INFO)   147| +1.54E+02 | -4.9E-05 | +1.4E+00 | 3.3E-01 | 2.1E-02 | 2.5E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    33| +1.50E+02 | -1.1E-05 | +8.4E-01 | 1.3E-02 | 1.4E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    90| +1.38E+02 | -4.6E-04 | +6.0E-01 | 6.7E-03 | 3.9E-01 | 3.6E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    95| +1.48E+02 | +4.0E-06 | -2.2E+01 | 4.8E-05 | 1.4E-02 | 2.8E-05 |  2d |0
2023-02-17 16:05:25 fides(INFO)     7| +1.12E+07 | -6.3E+07 | +8.9E-01 | 5.0E-01 | 3.4E+08 | 8.4E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    44| +1.48E+02 | -3.1E-05 | +7.5E-01 | 1.1E-02 | 2.4E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)     8| +1.70E+06 | -9.5E+06 | +8.9E-01 | 5.0E-01 | 5.1E+07 | 8.3E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    34| +1.50E+02 | -2.3E-06 | +5.8E-01 | 2.5E-02 | 7.8E-02 | 7.5E-04 | trr |1
2023-02-17 16:05:25 fides(INFO)    96| +1.48E+02 | +2.7E-06 | -1.6E+01 | 1.2E-05 | 1.4E-02 | 2.5E-05 |  2d |0
2023-02-17 16:05:25 fides(INFO)   148| +1.54E+02 | -2.6E-05 | +1.4E+00 | 3.3E-01 | 9.4E-03 | 2.4E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)     1| +1.35E+06 | -2.3E+09 | +9.7E-02 | 1.0E+00 | 1.0E+10 | 2.7E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    45| +1.48E+02 | -9.5E-06 | +7.1E-01 | 2.2E-02 | 6.8E-02 | 6.2E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)     9| +2.61E+05 | -1.4E+06 | +8.9E-01 | 5.0E-01 | 7.8E+06 | 8.0E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    97| +1.48E+02 | +3.7E-06 | -4.7E+01 | 3.0E-06 | 1.4E-02 | 7.1E-06 |  2d |0
2023-02-17 16:05:25 fides(INFO)    91| +1.38E+02 | -1.1E-04 | +9.8E-01 | 6.7E-03 | 3.1E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)     2| +2.13E+05 | -1.1E+06 | +9.0E-01 | 2.5E-01 | 6.4E+06 | 6.5E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    35| +1.50E+02 | +2.5E-06 | -5.7E-01 | 2.5E-02 | 2.0E-02 | 1.5E-03 | trr |0
2023-02-17 16:05:25 fides(INFO)   149| +1.54E+02 | -1.4E-05 | +1.4E+00 | 3.3E-01 | 9.2E-03 | 2.3E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    10| +4.03E+04 | -2.2E+05 | +9.0E-01 | 5.0E-01 | 1.2E+06 | 7.4E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    46| +1.48E+02 | -6.7E-06 | +1.2E+00 | 2.2E-02 | 5.2E-02 | 5.8E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)     3| +3.59E+04 | -1.8E+05 | +9.0E-01 | 5.0E-01 | 9.9E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    98| +1.48E+02 | +2.4E-06 | -1.1E+02 | 7.5E-07 | 1.4E-02 | 1.8E-06 |  2d |0
2023-02-17 16:05:25 fides(INFO)    92| +1.38E+02 | -2.4E-04 | +1.0E+00 | 1.3E-02 | 1.3E-01 | 5.0E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    36| +1.50E+02 | -1.6E-06 | +8.4E-01 | 4.0E-04 | 2.0E-02 | 3.8E-04 |  2d |1
2023-02-17 16:05:25 fides(INFO)    47| +1.48E+02 | -5.3E-06 | +6.6E-01 | 4.4E-02 | 5.8E-02 | 1.1E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)     4| +5.68E+03 | -3.0E+04 | +9.0E-01 | 1.0E+00 | 1.6E+05 | 1.0E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    11| +6.40E+03 | -3.4E+04 | +9.0E-01 | 5.0E-01 | 1.8E+05 | 6.0E-01 |  2d |1
2023-02-17 16:05:25.573 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 114.461 and h = 1.42314e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:25.573 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 114.461: AMICI failed to integrate the forward problem
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)   150| +1.54E+02 | -7.9E-06 | +1.4E+00 | 3.3E-01 | 5.7E-03 | 2.1E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    43| +1.51E+02 | +0.0E+00 | +0.0E+00 | 9.5E-07 | 4.5E+00 | 2.2E-06 |  2d |0
2023-02-17 16:05:25 fides(INFO)    99| +1.48E+02 | +3.0E-06 | -5.4E+02 | 1.9E-07 | 1.4E-02 | 4.4E-07 |  2d |0
2023-02-17 16:05:25 fides(INFO)     5| +1.04E+03 | -4.6E+03 | +9.0E-01 | 1.0E+00 | 2.4E+04 | 8.1E-01 |  2d |1
2023-02-17 16:05:25.590 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 168.763 and h = 2.32709e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:25.590 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 168.763: AMICI failed to integrate the forward problem
2023-02-17 16:05:25 fides(INFO)    93| +1.38E+02 | -4.2E-04 | +9.8E-01 | 2.7E-02 | 4.6E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    37| +1.50E+02 | +0.0E+00 | +0.0E+00 | 7.9E-04 | 1.1E-02 | 3.5E-04 |  2d |0
2023-02-17 16:05:25 fides(INFO)    48| +1.48E+02 | -7.0E-06 | +1.2E+00 | 4.4E-02 | 3.3E-02 | 1.0E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    12| +1.18E+03 | -5.2E+03 | +9.0E-01 | 5.0E-01 | 2.9E+04 | 4.5E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)     6| +3.31E+02 | -7.1E+02 | +9.0E-01 | 1.0E+00 | 3.9E+03 | 7.6E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)   151| +1.54E+02 | -4.2E-06 | +1.3E+00 | 3.3E-01 | 3.9E-03 | 1.7E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)   100| +1.48E+02 | -5.3E-08 | +3.8E+01 | 4.7E-08 | 1.4E-02 | 1.1E-07 |  2d |1
2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 5.31E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:25 fides(INFO)    13| +3.70E+02 | -8.1E+02 | +9.0E-01 | 5.0E-01 | 4.5E+03 | 1.0E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    38| +1.50E+02 | -1.7E-07 | +8.8E-01 | 2.0E-04 | 1.1E-02 | 8.9E-05 |  2d |1
2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 1.74E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:25 fides(INFO)    94| +1.38E+02 | -6.3E-04 | +7.2E-01 | 5.3E-02 | 1.1E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:25 fides(INFO)    49| +1.48E+02 | +4.9E-06 | -5.2E-01 | 8.9E-02 | 3.7E-02 | 1.8E-02 |  2d |0
2023-02-17 16:05:25 fides(INFO)     7| +2.31E+02 | -1.0E+02 | +8.7E-01 | 1.0E+00 | 6.2E+02 | 1.4E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    14| +2.52E+02 | -1.2E+02 | +8.8E-01 | 5.0E-01 | 6.9E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)   152| +1.54E+02 | -2.1E-06 | +1.3E+00 | 3.3E-01 | 2.0E-03 | 1.2E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    50| +1.48E+02 | +7.5E-07 | -2.5E-01 | 2.2E-02 | 3.7E-02 | 4.6E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)    95| +1.38E+02 | +9.1E-03 | -2.5E+00 | 5.3E-02 | 2.5E-01 | 2.5E-02 |  2d |0
2023-02-17 16:05:25 fides(INFO)    15| +2.40E+02 | -1.2E+01 | +7.3E-01 | 1.0E+00 | 9.1E+01 | 2.7E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)     8| +2.04E+02 | -2.7E+01 | +1.1E+00 | 2.0E+00 | 1.1E+02 | 3.7E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)   153| +1.54E+02 | -6.1E-07 | +8.8E-01 | 3.3E-01 | 1.2E-03 | 4.8E-02 |  2d |1
2023-02-17 16:05:25 fides(WARNING) Stopping as function difference 6.15E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:25 fides(INFO)    51| +1.48E+02 | +2.3E-07 | -2.4E-01 | 5.5E-03 | 3.7E-02 | 1.1E-03 |  2d |0
2023-02-17 16:05:25 fides(INFO)    16| +2.32E+02 | -8.6E+00 | +1.1E+00 | 1.0E+00 | 1.7E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    96| +1.38E+02 | -1.4E-04 | +1.4E-01 | 1.3E-02 | 2.5E-01 | 6.3E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)     9| +2.04E+02 | +1.3E+03 | -5.7E+01 | 4.0E+00 | 4.6E+01 | 4.4E+00 | trr |0
2023-02-17 16:05:25.751 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 95.8575 and h = 1.32106e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:25.752 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 95.8575: AMICI failed to integrate the forward problem
2023-02-17 16:05:25 fides(INFO)    44| +1.51E+02 | +0.0E+00 | +0.0E+00 | 2.4E-07 | 4.5E+00 | 5.4E-07 |  2d |0
2023-02-17 16:05:25 fides(INFO)    17| +2.22E+02 | -9.5E+00 | +2.3E-01 | 2.0E+00 | 4.5E+01 | 4.4E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    52| +1.48E+02 | +3.1E-06 | -8.0E+00 | 1.4E-03 | 3.7E-02 | 2.8E-04 |  2d |0
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)     0| +7.56E+07 |    NaN   |    NaN   | 1.0E+00 | 3.5E+08 |   NaN   | NaN |1
2023-02-17 16:05:25 fides(INFO)    18| +2.05E+02 | -1.7E+01 | +9.8E-01 | 5.0E-01 | 5.7E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    53| +1.48E+02 | +9.8E-07 | -4.0E+00 | 3.5E-04 | 3.7E-02 | 7.2E-05 |  2d |0
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    10| +2.04E+02 | +2.9E+01 | -1.7E+00 | 6.1E-01 | 4.6E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:25 fides(INFO)    97| +1.38E+02 | -2.1E-04 | +8.1E-01 | 3.3E-03 | 4.0E-01 | 1.5E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)     0| +2.91E+12 |    NaN   |    NaN   | 1.0E+00 | 1.3E+13 |   NaN   | NaN |1
2023-02-17 16:05:25 fides(INFO)    54| +1.48E+02 | +3.3E-06 | -1.6E+01 | 8.7E-05 | 3.7E-02 | 2.1E-05 |  2d |0
2023-02-17 16:05:25 fides(INFO)     1| +1.15E+03 | -7.6E+07 | +1.0E-01 | 1.0E+00 | 3.5E+08 | 2.6E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    19| +2.05E+02 | +3.0E+02 | -1.6E+01 | 1.0E+00 | 3.0E+01 | 2.3E+00 |  2d |0
2023-02-17 16:05:25 fides(INFO)    11| +1.95E+02 | -9.4E+00 | +9.2E-01 | 1.5E-01 | 4.6E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    98| +1.38E+02 | -1.5E-04 | +7.3E-01 | 6.7E-03 | 1.9E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    55| +1.48E+02 | +1.8E-06 | -9.2E+00 | 2.2E-05 | 3.7E-02 | 1.3E-05 |  2d |0
2023-02-17 16:05:25 fides(INFO)     2| +4.22E+02 | -7.3E+02 | +8.9E-01 | 2.5E-01 | 3.0E+03 | 5.3E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)    20| +1.93E+02 | -1.3E+01 | +1.1E+00 | 2.5E-01 | 3.0E+01 | 5.7E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)     0| +2.93E+04 |    NaN   |    NaN   | 1.0E+00 | 1.3E+05 |   NaN   | NaN |1
2023-02-17 16:05:25 fides(INFO)     1| +1.31E+08 | -2.9E+12 | +8.7E-02 | 1.0E+00 | 1.3E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    12| +1.84E+02 | -1.1E+01 | +7.4E-01 | 3.0E-01 | 5.2E+01 | 5.6E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)     3| +2.61E+02 | -1.6E+02 | +8.8E-01 | 5.0E-01 | 5.4E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    99| +1.38E+02 | -8.6E-05 | +9.8E-01 | 6.7E-03 | 1.3E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)    56| +1.48E+02 | +1.6E-06 | -8.3E+00 | 5.4E-06 | 3.7E-02 | 9.9E-06 |  2d |0
2023-02-17 16:05:25.897 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 100 and h = 1.26382e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:25.897 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 100: AMICI failed to integrate the forward problem
2023-02-17 16:05:25 fides(INFO)    45| +1.51E+02 | +0.0E+00 | +0.0E+00 | 6.0E-08 | 4.5E+00 | 1.4E-07 |  2d |0
2023-02-17 16:05:25 fides(INFO)    21| +1.93E+02 | -1.0E+01 | -3.3E-02 | 5.0E-01 | 4.8E+01 | 1.0E+00 |  2d |0
2023-02-17 16:05:25 fides(INFO)     1| +4.30E+02 | -2.9E+04 | +1.2E-01 | 1.0E+00 | 1.3E+05 | 2.3E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)     4| +2.55E+02 | -6.8E+00 | +2.9E-01 | 1.0E+00 | 7.7E+01 | 2.3E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    57| +1.48E+02 | +3.5E-07 | -4.8E+00 | 1.4E-06 | 3.7E-02 | 2.5E-06 |  2d |0
2023-02-17 16:05:25 fides(INFO)    13| +1.77E+02 | -7.0E+00 | +4.1E-01 | 3.0E-01 | 8.9E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)    22| +1.84E+02 | -8.9E+00 | +1.1E+00 | 1.2E-01 | 4.8E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)     5| +2.42E+02 | -1.3E+01 | +1.2E+00 | 1.0E+00 | 5.6E+01 | 2.2E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)     2| +2.22E+07 | -1.1E+08 | +8.9E-01 | 2.5E-01 | 5.9E+08 | 7.1E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:25 fides(INFO)   100| +1.38E+02 | -1.7E-04 | +9.9E-01 | 1.3E-02 | 7.1E-02 | 4.4E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)     2| +3.86E+02 | -4.4E+01 | +9.8E-01 | 2.5E-01 | 6.2E+01 | 7.4E-01 |  2d |1
2023-02-17 16:05:25.952 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1525 and h = 2.26931e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:25.952 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1525: AMICI failed to integrate the forward problem
2023-02-17 16:05:25 fides(INFO)    58| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.4E-07 | 3.7E-02 | 6.2E-07 |  2d |0
2023-02-17 16:05:25 fides(INFO)    14| +1.69E+02 | -8.1E+00 | +8.9E-01 | 3.0E-01 | 1.1E+02 | 8.4E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)     6| +2.42E+02 | +3.1E+02 | -1.0E+01 | 2.0E+00 | 2.7E+01 | 3.9E+00 |  2d |0
2023-02-17 16:05:25 fides(INFO)    23| +1.68E+02 | -1.5E+01 | +9.7E-01 | 2.5E-01 | 5.6E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:25 fides(INFO)     3| +3.17E+02 | -6.8E+01 | +8.3E-01 | 5.0E-01 | 5.8E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:25 fides(INFO)    59| +1.48E+02 | +2.8E-08 | -5.6E+00 | 8.5E-08 | 3.7E-02 | 1.5E-07 |  2d |0
2023-02-17 16:05:25 fides(INFO)   101| +1.38E+02 | -3.3E-04 | +9.9E-01 | 2.7E-02 | 1.3E-01 | 8.7E-03 |  2d |1
2023-02-17 16:05:25 fides(INFO)     7| +2.13E+02 | -2.9E+01 | +1.5E+00 | 5.0E-01 | 2.7E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    15| +1.63E+02 | -5.7E+00 | +4.1E-01 | 6.1E-01 | 5.5E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)     3| +4.98E+06 | -1.7E+07 | +9.0E-01 | 5.0E-01 | 9.1E+07 | 1.1E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    24| +1.55E+02 | -1.3E+01 | +6.9E-01 | 5.0E-01 | 7.3E+01 | 9.4E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)     4| +2.26E+02 | -9.2E+01 | +8.5E-01 | 1.0E+00 | 8.9E+01 | 2.8E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    60| +1.48E+02 | +3.1E-06 | -2.4E+03 | 2.1E-08 | 3.7E-02 | 3.9E-08 |  2d |0
2023-02-17 16:05:26 fides(INFO)    16| +1.58E+02 | -5.4E+00 | +9.5E-01 | 6.1E-01 | 1.7E+02 | 6.5E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)     8| +1.99E+02 | -1.5E+01 | +1.2E+00 | 1.0E+00 | 5.0E+01 | 2.8E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)   102| +1.38E+02 | -6.2E-04 | +9.6E-01 | 5.3E-02 | 7.0E-02 | 1.7E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    25| +1.53E+02 | -2.5E+00 | +2.0E-01 | 5.0E-01 | 5.7E+01 | 8.0E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    61| +1.48E+02 | +1.3E-06 | -4.1E+03 | 5.3E-09 | 3.7E-02 | 9.7E-09 |  2d |0
2023-02-17 16:05:26 fides(INFO)     4| +8.59E+05 | -4.1E+06 | +9.0E-01 | 1.0E+00 | 1.6E+07 | 1.8E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    17| +1.58E+02 | +1.8E+01 | -3.5E+00 | 1.2E+00 | 3.4E+01 | 1.4E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)     5| +2.26E+02 | +5.5E+02 | -2.1E+01 | 2.0E+00 | 2.7E+01 | 5.1E+00 | trr |0
2023-02-17 16:05:26 fides(INFO)   103| +1.38E+02 | +2.9E-03 | -2.1E+00 | 1.1E-01 | 8.4E-02 | 3.3E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)    26| +1.48E+02 | -4.2E+00 | +6.1E-01 | 1.1E-01 | 6.8E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    46| +1.51E+02 | -1.3E-07 | +8.7E-01 | 1.5E-08 | 4.5E+00 | 3.4E-08 |  2d |1
2023-02-17 16:05:26 fides(WARNING) Stopping as function difference 1.29E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:26 fides(INFO)    18| +1.55E+02 | -3.1E+00 | +8.8E-01 | 2.1E-01 | 3.4E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)     9| +1.99E+02 | +5.3E+04 | -1.3E+03 | 2.0E+00 | 5.0E+01 | 4.7E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)    62| +1.48E+02 | +5.8E-07 | -7.3E+03 | 1.3E-09 | 3.7E-02 | 2.4E-09 |  2d |0
2023-02-17 16:05:26.114 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 201.089 and h = 7.23664e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:26.115 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 201.089: AMICI failed to integrate the forward problem
2023-02-17 16:05:26 fides(INFO)    27| +1.48E+02 | +1.3E+00 | -9.5E-01 | 1.1E-01 | 3.1E+01 | 2.7E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)     6| +2.26E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 2.7E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)     5| +1.43E+05 | -7.2E+05 | +9.0E-01 | 2.0E+00 | 2.8E+06 | 2.3E+00 | trr |1
2023-02-17 16:05:26 fides(INFO)    63| +1.48E+02 | +2.9E-06 | -1.5E+05 | 3.3E-10 | 3.7E-02 | 6.0E-10 |  2d |0
2023-02-17 16:05:26 fides(INFO)   104| +1.38E+02 | -1.3E-04 | +3.0E-01 | 2.7E-02 | 8.4E-02 | 8.3E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    19| +1.50E+02 | -4.7E+00 | +1.1E+00 | 4.3E-01 | 6.0E+01 | 5.4E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    10| +1.61E+02 | -3.7E+01 | +1.1E+00 | 5.0E-01 | 5.0E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)     7| +2.21E+02 | -4.9E+00 | +8.1E-01 | 1.2E-01 | 2.7E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    28| +1.48E+02 | -4.9E-01 | +6.8E-01 | 2.8E-02 | 3.1E+01 | 6.5E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    64| +1.48E+02 | +2.7E-06 | -5.3E+05 | 8.3E-11 | 3.7E-02 | 1.5E-10 |  2d |0
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    20| +1.50E+02 | +4.7E-01 | -2.8E-01 | 8.5E-01 | 1.5E+01 | 6.8E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)     8| +2.08E+02 | -1.2E+01 | +1.4E+00 | 2.5E-01 | 2.0E+01 | 6.2E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)   105| +1.38E+02 | +4.1E-03 | -2.1E+00 | 2.7E-02 | 2.1E-01 | 1.4E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)    11| +1.56E+02 | -4.6E+00 | +9.5E-01 | 1.0E+00 | 9.1E+01 | 1.6E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    29| +1.48E+02 | -2.1E-01 | +9.2E-01 | 2.8E-02 | 2.5E+01 | 7.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     6| +2.37E+04 | -1.2E+05 | +9.0E-01 | 2.0E+00 | 4.7E+05 | 3.6E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    65| +1.48E+02 | +2.7E-06 | -2.2E+06 | 2.1E-11 | 3.7E-02 | 3.8E-11 |  2d |0
2023-02-17 16:05:26 fides(INFO)    21| +1.49E+02 | -1.1E+00 | +8.3E-01 | 1.3E-01 | 1.5E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)     9| +2.08E+02 | -1.5E+00 | -1.2E-01 | 5.0E-01 | 3.3E+01 | 8.1E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)     0| +1.12E+14 |    NaN   |    NaN   | 1.0E+00 | 5.2E+14 |   NaN   | NaN |1
2023-02-17 16:05:26 fides(INFO)    12| +1.56E+02 | +7.5E+01 | -7.0E+00 | 2.0E+00 | 8.2E+01 | 1.0E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)   106| +1.38E+02 | +6.0E-04 | -7.9E-01 | 6.7E-03 | 2.1E-01 | 5.7E-03 |  2d |0
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    30| +1.48E+02 | -8.9E-02 | +8.5E-01 | 5.7E-02 | 1.0E+01 | 7.7E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    66| +1.48E+02 | +2.9E-06 | -9.2E+06 | 5.2E-12 | 3.7E-02 | 9.4E-12 |  2d |0
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    10| +2.02E+02 | -6.1E+00 | +9.3E-01 | 1.2E-01 | 3.3E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)     1| +8.83E+08 | -1.1E+14 | +8.3E-02 | 1.0E+00 | 5.2E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    22| +1.49E+02 | +2.3E+01 | -9.5E+00 | 2.6E-01 | 1.0E+01 | 4.8E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)    13| +1.51E+02 | -5.3E+00 | +7.2E-01 | 1.9E-01 | 8.2E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    31| +1.48E+02 | +4.5E-01 | -5.9E+00 | 1.1E-01 | 6.9E+00 | 3.2E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)   107| +1.38E+02 | +6.3E-05 | -1.6E-01 | 1.7E-03 | 2.1E-01 | 3.1E-03 |  2d |0
2023-02-17 16:05:26 fides(INFO)    67| +1.48E+02 | +2.1E-06 | -2.7E+07 | 1.3E-12 | 3.7E-02 | 2.4E-12 |  2d |0
2023-02-17 16:05:26 fides(INFO)    11| +1.93E+02 | -9.1E+00 | +9.1E-01 | 2.5E-01 | 4.4E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:26.296 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 93.9924 and h = 1.89086e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:26.296 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 93.9924: AMICI failed to integrate the forward problem
2023-02-17 16:05:26 fides(INFO)    23| +1.49E+02 | +1.5E-02 | -4.4E-02 | 6.5E-02 | 1.0E+01 | 1.2E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)    14| +1.51E+02 | +0.0E+00 | +0.0E+00 | 1.9E-01 | 9.0E+01 | 2.2E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)    32| +1.48E+02 | +4.8E-04 | -1.8E-02 | 2.8E-02 | 6.9E+00 | 7.9E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)   108| +1.38E+02 | -1.1E-04 | +7.5E-01 | 4.2E-04 | 2.1E-01 | 8.8E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)    68| +1.48E+02 | +2.5E-06 | -1.3E+08 | 3.2E-13 | 3.7E-02 | 5.9E-13 |  2d |0
2023-02-17 16:05:26.333 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 149.627 and h = 2.79486e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:26.333 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 149.627: AMICI failed to integrate the forward problem
2023-02-17 16:05:26 fides(INFO)    24| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 1.0E+01 | 3.1E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)    15| +1.50E+02 | -1.4E+00 | +9.4E-01 | 4.7E-02 | 9.0E+01 | 6.0E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    12| +1.81E+02 | -1.2E+01 | +8.2E-01 | 5.0E-01 | 5.6E+01 | 7.3E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)     2| +1.73E+08 | -7.1E+08 | +8.9E-01 | 2.5E-01 | 3.8E+09 | 7.1E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)     7| +3.98E+03 | -2.0E+04 | +9.1E-01 | 4.0E+00 | 7.7E+04 | 1.9E+00 | trr |1
2023-02-17 16:05:26 fides(INFO)    33| +1.48E+02 | -1.0E-02 | +8.0E-01 | 7.1E-03 | 6.9E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    69| +1.48E+02 | +2.7E-06 | -5.5E+08 | 8.1E-14 | 3.7E-02 | 1.5E-13 |  2d |0
2023-02-17 16:05:26 fides(INFO)    25| +1.49E+02 | -5.8E-02 | +9.4E-01 | 4.1E-03 | 1.0E+01 | 8.1E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)   109| +1.38E+02 | -2.5E-05 | +9.9E-01 | 4.2E-04 | 4.1E-01 | 1.6E-04 |  2d |1
2023-02-17 16:05:26.373 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 110.183 and h = 2.72528e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:26 fides(INFO)    16| +1.49E+02 | -7.5E-01 | +6.9E-01 | 9.4E-02 | 4.8E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:26.374 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 110.183: AMICI failed to integrate the forward problem
2023-02-17 16:05:26 fides(INFO)    13| +1.81E+02 | +0.0E+00 | +0.0E+00 | 1.0E+00 | 7.6E+01 | 1.8E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)    34| +1.48E+02 | -6.1E-03 | +9.6E-01 | 1.4E-02 | 3.4E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     3| +3.61E+07 | -1.4E+08 | +9.1E-01 | 5.0E-01 | 6.1E+08 | 1.3E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    70| +1.48E+02 | +2.6E-06 | -2.2E+09 | 2.0E-14 | 3.7E-02 | 3.7E-14 |  2d |0
2023-02-17 16:05:26 fides(INFO)    26| +1.49E+02 | -9.6E-02 | +9.2E-01 | 8.1E-03 | 9.2E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)   110| +1.38E+02 | +1.9E-05 | -1.5E-01 | 8.3E-04 | 1.2E-01 | 1.8E-03 |  2d |0
2023-02-17 16:05:26 fides(INFO)     8| +3.98E+03 | +2.9E+07 | -4.3E+04 | 4.0E+00 | 1.2E+04 | 4.0E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)    17| +1.48E+02 | -6.0E-01 | +9.6E-01 | 9.4E-02 | 5.3E+01 | 8.7E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    14| +1.76E+02 | -5.2E+00 | +7.9E-01 | 2.5E-01 | 7.6E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    35| +1.48E+02 | -9.4E-03 | +8.1E-01 | 2.8E-02 | 3.3E+00 | 6.7E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    71| +1.48E+02 | +1.6E-06 | -5.3E+09 | 5.0E-15 | 3.7E-02 | 9.2E-15 |  2d |0
2023-02-17 16:05:26 fides(INFO)     4| +5.59E+06 | -3.1E+07 | +8.9E-01 | 1.0E+00 | 1.2E+08 | 2.7E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    27| +1.49E+02 | -1.1E-01 | +6.8E-01 | 1.6E-02 | 9.8E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    18| +1.48E+02 | -4.1E-01 | +6.9E-01 | 1.9E-01 | 3.0E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    15| +1.73E+02 | -2.9E+00 | +8.6E-01 | 5.0E-01 | 5.1E+01 | 8.3E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)   111| +1.38E+02 | -3.0E-05 | +7.7E-01 | 2.1E-04 | 1.2E-01 | 4.6E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)    36| +1.48E+02 | +2.9E-02 | -4.5E+00 | 5.7E-02 | 5.5E-01 | 7.5E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)    72| +1.48E+02 | +8.8E-07 | -1.2E+10 | 1.3E-15 | 3.7E-02 | 2.3E-15 |  2d |0
2023-02-17 16:05:26 fides(INFO)    28| +1.49E+02 | -9.7E-02 | +9.9E-01 | 1.6E-02 | 6.3E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     5| +8.13E+05 | -4.8E+06 | +9.0E-01 | 2.0E+00 | 1.8E+07 | 7.7E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    19| +1.48E+02 | +2.1E-01 | -3.7E-01 | 1.9E-01 | 3.0E+01 | 2.4E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)    37| +1.48E+02 | +2.2E-04 | -1.1E-01 | 1.4E-02 | 5.5E-01 | 1.9E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)    73| +1.48E+02 | +2.8E-06 | -1.4E+11 | 3.2E-16 | 3.7E-02 | 5.8E-16 |  2d |0
2023-02-17 16:05:26 fides(WARNING) Stopping as trust region radius 7.88E-17 is smaller than machine precision.
2023-02-17 16:05:26 fides(INFO)    16| +1.72E+02 | -9.8E-01 | +8.3E-01 | 1.0E+00 | 2.6E+01 | 1.8E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)   112| +1.38E+02 | -9.3E-06 | +1.0E+00 | 4.2E-04 | 1.9E-01 | 1.3E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    20| +1.48E+02 | -1.8E-01 | +7.7E-01 | 4.7E-02 | 3.0E+01 | 6.0E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    29| +1.48E+02 | -1.4E-01 | +9.6E-01 | 3.2E-02 | 1.2E+01 | 3.6E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    38| +1.48E+02 | -4.4E-04 | +7.1E-01 | 3.5E-03 | 5.5E-01 | 4.7E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)     6| +1.19E+05 | -6.9E+05 | +9.0E-01 | 2.0E+00 | 2.8E+06 | 7.1E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)   113| +1.38E+02 | -1.2E-05 | +9.3E-01 | 8.3E-04 | 7.9E-02 | 2.6E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    30| +1.48E+02 | -2.6E-01 | +9.8E-01 | 6.5E-02 | 5.8E+00 | 7.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    21| +1.48E+02 | -1.0E-01 | +8.8E-01 | 9.4E-02 | 1.6E+01 | 7.9E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    17| +1.71E+02 | -6.7E-01 | +7.0E-01 | 2.0E+00 | 1.5E+01 | 1.0E+00 | trr |1
2023-02-17 16:05:26 fides(INFO)    39| +1.48E+02 | +7.8E-05 | -1.8E-01 | 3.5E-03 | 5.8E-01 | 9.0E-03 |  2d |0
2023-02-17 16:05:26 fides(INFO)     9| +8.88E+02 | -3.1E+03 | +8.6E-01 | 7.6E-01 | 1.2E+04 | 1.1E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)     7| +1.79E+04 | -1.0E+05 | +9.0E-01 | 2.0E+00 | 4.3E+05 | 6.7E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    22| +1.48E+02 | -7.5E-02 | +7.7E-01 | 1.9E-01 | 1.6E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    31| +1.48E+02 | -2.5E-01 | +7.2E-01 | 1.3E-01 | 1.2E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)   114| +1.38E+02 | -2.0E-05 | +9.2E-01 | 1.7E-03 | 1.1E-01 | 4.9E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    40| +1.48E+02 | -1.1E-04 | +7.4E-01 | 8.8E-04 | 5.8E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    18| +1.71E+02 | -8.7E-02 | +4.2E-01 | 2.0E+00 | 2.1E+01 | 2.5E-01 | trr |1
2023-02-17 16:05:26 fides(INFO)    23| +1.48E+02 | +1.0E+00 | -5.4E+00 | 3.8E-01 | 7.1E+00 | 3.7E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)     8| +2.80E+03 | -1.5E+04 | +9.0E-01 | 2.0E+00 | 6.7E+04 | 6.3E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    32| +1.48E+02 | +5.2E-01 | -1.0E+00 | 1.3E-01 | 5.8E+00 | 1.7E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)     0| +7.69E+12 |    NaN   |    NaN   | 1.0E+00 | 3.5E+13 |   NaN   | NaN |1
2023-02-17 16:05:26 fides(INFO)   115| +1.38E+02 | -3.9E-05 | +1.0E+00 | 3.3E-03 | 7.0E-02 | 9.6E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)    41| +1.48E+02 | -2.5E-05 | +7.3E-01 | 8.8E-04 | 2.7E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    24| +1.48E+02 | -9.4E-03 | +8.2E-02 | 9.4E-02 | 7.1E+00 | 9.4E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    19| +1.71E+02 | -2.1E-03 | +1.3E-02 | 2.0E+00 | 6.5E+00 | 4.3E-01 | trr |1
2023-02-17 16:05:26 fides(INFO)    33| +1.48E+02 | -9.3E-02 | +3.4E-01 | 3.2E-02 | 5.8E+00 | 6.9E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     9| +5.59E+02 | -2.2E+03 | +9.1E-01 | 2.0E+00 | 1.1E+04 | 7.0E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    42| +1.48E+02 | -1.5E-05 | +1.1E+00 | 8.8E-04 | 2.2E-01 | 3.7E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)   116| +1.38E+02 | -7.0E-05 | +9.8E-01 | 6.7E-03 | 7.5E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    25| +1.48E+02 | -3.0E-02 | +8.9E-01 | 2.4E-02 | 8.6E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    34| +1.48E+02 | -9.3E-02 | +5.2E-01 | 3.2E-02 | 6.4E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     1| +8.84E+10 | -7.6E+12 | +8.6E-02 | 1.0E+00 | 3.5E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    10| +2.39E+02 | -3.2E+02 | +9.2E-01 | 2.0E+00 | 1.7E+03 | 5.7E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    20| +1.71E+02 | -5.0E-02 | +6.7E-01 | 1.5E-01 | 7.6E+00 | 7.0E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    43| +1.48E+02 | -1.3E-05 | +8.4E-01 | 1.8E-03 | 1.8E-01 | 2.2E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)    26| +1.48E+02 | -1.0E-02 | +2.2E-01 | 4.7E-02 | 3.3E+00 | 4.4E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    35| +1.48E+02 | -4.0E-02 | +9.7E-01 | 3.2E-02 | 5.5E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)   117| +1.38E+02 | -1.4E-04 | +9.9E-01 | 1.3E-02 | 6.5E-02 | 3.8E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    44| +1.48E+02 | -8.8E-06 | +6.8E-01 | 3.5E-03 | 1.4E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    21| +1.71E+02 | -5.9E-03 | +8.5E-01 | 1.5E-01 | 4.6E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    11| +2.39E+02 | +7.4E+01 | -1.7E+00 | 4.0E+00 | 2.7E+02 | 8.5E+00 | trr |0
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    10| +2.85E+02 | -6.0E+02 | +9.2E-01 | 1.5E+00 | 2.6E+03 | 1.3E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    36| +1.48E+02 | -6.2E-02 | +9.5E-01 | 6.5E-02 | 2.1E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     2| +1.32E+10 | -7.5E+10 | +8.9E-01 | 2.5E-01 | 4.1E+11 | 6.5E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    27| +1.48E+02 | -1.3E-02 | +9.3E-01 | 1.2E-02 | 1.0E+01 | 8.6E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)   118| +1.38E+02 | -2.7E-04 | +1.0E+00 | 2.7E-02 | 6.5E-02 | 7.4E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    45| +1.48E+02 | +2.4E-04 | -4.5E+00 | 3.5E-03 | 5.8E-02 | 6.0E-03 |  2d |0
2023-02-17 16:05:26 fides(INFO)    22| +1.71E+02 | -3.4E-05 | +7.4E-02 | 2.9E-01 | 3.5E-01 | 1.5E-02 | trr |1
2023-02-17 16:05:26 fides(INFO)    12| +1.96E+02 | -4.3E+01 | +9.1E-01 | 7.1E-01 | 2.7E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:26.755 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.898 and h = 2.79382e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:26 fides(INFO)    37| +1.48E+02 | -6.4E-02 | +7.6E-01 | 1.3E-01 | 3.7E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:26.755 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.898: AMICI failed to integrate the forward problem
2023-02-17 16:05:26 fides(INFO)    28| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.4E-02 | 9.6E-01 | 1.4E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)     3| +1.99E+09 | -1.1E+10 | +8.9E-01 | 5.0E-01 | 6.1E+10 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    46| +1.48E+02 | +2.3E-05 | -9.3E-01 | 8.8E-04 | 5.8E-02 | 1.5E-03 |  2d |0
2023-02-17 16:05:26 fides(INFO)    13| +1.96E+02 | +2.8E+01 | -2.9E+00 | 1.4E+00 | 6.6E+01 | 2.4E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)   119| +1.38E+02 | -4.7E-04 | +9.0E-01 | 5.3E-02 | 6.5E-02 | 1.4E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     4| +3.02E+08 | -1.7E+09 | +8.9E-01 | 5.0E-01 | 9.2E+09 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    29| +1.48E+02 | -6.8E-04 | +8.6E-01 | 5.9E-03 | 9.6E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    38| +1.48E+02 | +7.6E-01 | -5.7E+00 | 2.6E-01 | 2.5E+00 | 1.5E-01 |  2d |0
2023-02-17 16:05:26 fides(INFO)    23| +1.71E+02 | -3.2E-06 | +7.1E-03 | 2.9E-02 | 4.0E-01 | 3.5E-03 | trr |1
2023-02-17 16:05:26 fides(INFO)    47| +1.48E+02 | -3.7E-06 | +2.9E-01 | 2.2E-04 | 5.8E-02 | 4.0E-04 |  2d |1
2023-02-17 16:05:26 fides(INFO)     5| +4.59E+07 | -2.6E+08 | +8.9E-01 | 5.0E-01 | 1.4E+09 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    14| +1.84E+02 | -1.2E+01 | +1.0E+00 | 3.5E-01 | 6.6E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    30| +1.48E+02 | -5.9E-04 | +8.9E-01 | 1.2E-02 | 1.6E+00 | 6.7E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)   120| +1.38E+02 | +1.4E-02 | -6.7E+00 | 1.1E-01 | 1.0E-01 | 3.3E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)    11| +2.85E+02 | +3.6E+02 | -7.6E+00 | 1.5E+00 | 3.1E+02 | 2.2E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)    39| +1.48E+02 | +4.4E-03 | -7.9E-02 | 5.5E-02 | 2.5E+00 | 4.2E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)    24| +1.71E+02 | +1.4E-06 | -3.8E-03 | 2.8E-03 | 3.8E-01 | 3.8E-03 | trr |0
2023-02-17 16:05:26 fides(INFO)    48| +1.48E+02 | +2.7E-07 | -1.8E-01 | 2.2E-04 | 8.8E-02 | 1.5E-04 |  2d |0
2023-02-17 16:05:26 fides(INFO)    15| +1.83E+02 | -1.2E+00 | +1.6E-01 | 7.1E-01 | 1.9E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)     6| +7.05E+06 | -3.9E+07 | +8.9E-01 | 5.0E-01 | 2.1E+08 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    31| +1.48E+02 | -4.6E-04 | +8.6E-01 | 2.4E-02 | 6.7E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    40| +1.48E+02 | -1.3E-02 | +5.9E-01 | 1.4E-02 | 2.5E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)   121| +1.38E+02 | +4.9E-04 | -8.2E-01 | 2.7E-02 | 1.0E-01 | 8.3E-03 |  2d |0
2023-02-17 16:05:26 fides(INFO)    49| +1.48E+02 | -5.0E-06 | +4.4E+00 | 5.5E-05 | 8.8E-02 | 4.3E-05 |  2d |1
2023-02-17 16:05:26 fides(INFO)    16| +1.79E+02 | -3.4E+00 | +8.2E-01 | 1.8E-01 | 5.0E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    25| +1.71E+02 | -1.7E-04 | +7.8E-01 | 4.6E-04 | 3.8E-01 | 1.0E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)     7| +1.09E+06 | -6.0E+06 | +9.0E-01 | 1.0E+00 | 3.2E+07 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    32| +1.48E+02 | -3.8E-04 | +9.3E-01 | 4.7E-02 | 1.1E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    41| +1.48E+02 | -8.9E-03 | +9.5E-01 | 1.4E-02 | 6.2E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    50| +1.48E+02 | +5.8E-06 | -1.8E+01 | 1.1E-04 | 2.2E-02 | 6.4E-05 |  2d |0
2023-02-17 16:05:26 fides(INFO)    17| +1.71E+02 | -8.0E+00 | +1.6E+00 | 3.5E-01 | 1.5E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    33| +1.48E+02 | -4.0E-04 | +8.7E-01 | 9.4E-02 | 4.7E-01 | 4.4E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)     8| +1.70E+05 | -9.2E+05 | +9.0E-01 | 1.0E+00 | 5.0E+06 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    26| +1.71E+02 | -3.4E-05 | +4.9E-01 | 9.3E-04 | 2.3E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)   122| +1.38E+02 | -7.0E-05 | +4.2E-01 | 6.7E-03 | 1.0E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    42| +1.48E+02 | -9.9E-03 | +9.7E-01 | 2.7E-02 | 9.7E-01 | 2.5E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    51| +1.48E+02 | +2.8E-06 | -1.4E+01 | 2.8E-05 | 2.2E-02 | 2.2E-05 |  2d |0
2023-02-17 16:05:26 fides(INFO)    18| +1.71E+02 | +3.0E+02 | -2.0E+01 | 7.1E-01 | 2.1E+01 | 1.6E+00 |  2d |0
2023-02-17 16:05:26 fides(INFO)    34| +1.48E+02 | +7.5E-04 | -1.0E+00 | 1.9E-01 | 6.7E-01 | 8.2E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)     9| +2.68E+04 | -1.4E+05 | +9.0E-01 | 1.0E+00 | 7.8E+05 | 1.0E+00 |  2d |1
2023-02-17 16:05:26 fides(INFO)    43| +1.48E+02 | -1.2E-02 | +7.9E-01 | 5.5E-02 | 2.6E+00 | 5.2E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    52| +1.48E+02 | +3.9E-06 | -2.4E+01 | 6.9E-06 | 2.2E-02 | 1.5E-05 |  2d |0
2023-02-17 16:05:26 fides(INFO)    19| +1.62E+02 | -9.5E+00 | +1.2E+00 | 1.8E-01 | 2.1E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)   123| +1.38E+02 | -8.0E-05 | +7.7E-01 | 6.7E-03 | 3.9E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:26 fides(INFO)    12| +2.47E+02 | -3.8E+01 | +7.3E-01 | 2.0E-01 | 3.1E+02 | 5.2E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    27| +1.71E+02 | -7.2E-07 | +3.4E-02 | 9.3E-04 | 7.9E-02 | 7.6E-04 | trr |1
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    10| +4.40E+03 | -2.2E+04 | +9.0E-01 | 1.0E+00 | 1.2E+05 | 9.9E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    35| +1.48E+02 | -1.6E-04 | +6.1E-01 | 4.7E-02 | 6.7E-01 | 2.0E-02 |  2d |1
2023-02-17 16:05:26 fides(INFO)    44| +1.48E+02 | +3.3E-02 | -1.1E+00 | 1.1E-01 | 1.1E+00 | 6.7E-02 |  2d |0
2023-02-17 16:05:26 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:26 fides(INFO)    20| +1.53E+02 | -8.3E+00 | +5.2E-01 | 3.5E-01 | 3.1E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:26 fides(INFO)    53| +1.48E+02 | +1.4E-06 | -1.6E+01 | 1.7E-06 | 2.2E-02 | 4.9E-06 |  2d |0
2023-02-17 16:05:27 fides(INFO)   124| +1.38E+02 | -1.1E-04 | +9.2E-01 | 1.3E-02 | 6.8E-02 | 3.3E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    11| +8.75E+02 | -3.5E+03 | +9.1E-01 | 1.0E+00 | 1.9E+04 | 1.2E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    28| +1.71E+02 | -9.9E-06 | +6.4E-01 | 1.4E-04 | 7.1E-02 | 3.4E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    36| +1.48E+02 | -8.3E-05 | +4.2E-01 | 4.7E-02 | 2.9E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    45| +1.48E+02 | -3.6E-03 | +3.1E-01 | 2.7E-02 | 1.1E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    12| +3.28E+02 | -5.5E+02 | +9.1E-01 | 1.0E+00 | 3.0E+03 | 1.3E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    54| +1.48E+02 | +4.5E-06 | -1.7E+02 | 4.3E-07 | 2.2E-02 | 1.2E-06 |  2d |0
2023-02-17 16:05:27 fides(INFO)    21| +1.51E+02 | -2.4E+00 | +9.6E-01 | 3.5E-01 | 1.2E+02 | 3.2E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)   125| +1.38E+02 | -1.1E-04 | +3.9E-01 | 2.7E-02 | 7.3E-02 | 6.6E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    37| +1.48E+02 | -7.3E-05 | +3.1E-01 | 4.7E-02 | 5.2E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    13| +2.49E+02 | -7.9E+01 | +9.0E-01 | 2.0E+00 | 4.7E+02 | 1.3E+00 | trr |1
2023-02-17 16:05:27 fides(INFO)    29| +1.71E+02 | -8.2E-07 | +8.0E+00 | 1.4E-04 | 2.1E-02 | 2.3E-05 | trr |1
2023-02-17 16:05:27 fides(WARNING) Stopping as function difference 8.24E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:27 fides(INFO)    46| +1.48E+02 | -6.3E-03 | +4.6E-01 | 2.7E-02 | 3.9E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    55| +1.48E+02 | +7.1E-07 | -1.1E+02 | 1.1E-07 | 2.2E-02 | 3.1E-07 |  2d |0
2023-02-17 16:05:27 fides(INFO)    22| +1.51E+02 | +4.0E-01 | -2.8E-01 | 7.1E-01 | 6.6E+01 | 8.1E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)    38| +1.48E+02 | +4.8E-05 | -1.8E-01 | 4.7E-02 | 2.2E-01 | 1.6E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)   126| +1.38E+02 | +1.9E-03 | -1.4E+00 | 2.7E-02 | 2.1E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)    14| +2.29E+02 | -1.9E+01 | +1.5E+00 | 2.0E+00 | 5.4E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    47| +1.48E+02 | -2.5E-03 | +3.4E-01 | 2.7E-02 | 9.6E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    56| +1.48E+02 | +3.7E-06 | -2.2E+03 | 2.7E-08 | 2.2E-02 | 7.7E-08 |  2d |0
2023-02-17 16:05:27 fides(INFO)    23| +1.49E+02 | -1.6E+00 | +7.3E-01 | 1.8E-01 | 6.6E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    39| +1.48E+02 | -5.2E-05 | +4.6E-01 | 1.2E-02 | 2.2E-01 | 4.1E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    15| +2.29E+02 | +6.1E+02 | -3.0E+01 | 2.0E+00 | 3.3E+01 | 3.5E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)    13| +2.19E+02 | -2.8E+01 | +8.4E-01 | 2.0E-01 | 3.5E+02 | 3.7E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)   127| +1.38E+02 | -1.5E-04 | +4.1E-01 | 6.7E-03 | 2.1E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    24| +1.48E+02 | -9.6E-01 | +9.8E-01 | 1.8E-01 | 6.9E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    48| +1.48E+02 | -3.0E-03 | +3.5E-01 | 2.7E-02 | 2.3E+00 | 3.2E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    16| +2.08E+02 | -2.2E+01 | +7.3E-01 | 5.0E-01 | 3.3E+01 | 9.8E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    40| +1.48E+02 | -4.7E-05 | +8.9E-01 | 1.2E-02 | 6.1E-01 | 4.0E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    57| +1.48E+02 | +4.0E-06 | -9.6E+03 | 6.7E-09 | 2.2E-02 | 1.9E-08 |  2d |0
2023-02-17 16:05:27 fides(INFO)    49| +1.48E+02 | +1.4E-03 | -1.9E-01 | 2.7E-02 | 8.8E-01 | 1.3E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)    25| +1.48E+02 | -6.1E-01 | +8.2E-01 | 3.5E-01 | 2.9E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)     0| +2.51E+02 |    NaN   |    NaN   | 1.0E+00 | 2.5E+01 |   NaN   | NaN |1
2023-02-17 16:05:27 fides(INFO)   128| +1.38E+02 | -6.6E-05 | +6.4E-01 | 6.7E-03 | 1.8E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:27.170 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0041 and h = 1.08836e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:27 fides(INFO)    17| +1.74E+02 | -3.4E+01 | +1.1E+00 | 5.0E-01 | 9.3E+01 | 8.2E-01 |  2d |1
2023-02-17 16:05:27.171 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0041: AMICI failed to integrate the forward problem
2023-02-17 16:05:27 fides(INFO)    41| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.4E-02 | 8.5E-02 | 7.8E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)    58| +1.48E+02 | +3.8E-06 | -3.6E+04 | 1.7E-09 | 2.2E-02 | 4.8E-09 |  2d |0
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    50| +1.48E+02 | -1.3E-03 | +4.4E-01 | 6.8E-03 | 8.8E-01 | 5.1E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    26| +1.48E+02 | +4.7E+01 | -3.5E+01 | 7.1E-01 | 2.0E+01 | 1.7E+00 | trr |0
2023-02-17 16:05:27 fides(INFO)    42| +1.48E+02 | -1.7E-05 | +1.0E+00 | 5.9E-03 | 8.5E-02 | 2.0E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     1| +2.51E+02 | +2.0E+04 | -8.4E+02 | 1.0E+00 | 2.5E+01 | 2.4E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)   129| +1.38E+02 | -5.4E-05 | +8.4E-01 | 6.7E-03 | 7.3E-02 | 1.6E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    59| +1.48E+02 | +5.9E-06 | -2.3E+05 | 4.2E-10 | 2.2E-02 | 1.2E-09 |  2d |0
2023-02-17 16:05:27 fides(INFO)    18| +1.74E+02 | +6.4E+03 | -2.0E+02 | 1.0E+00 | 6.8E+01 | 2.0E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)    51| +1.48E+02 | -1.3E-03 | +9.3E-01 | 6.8E-03 | 2.7E+00 | 6.0E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    27| +1.48E+02 | +1.3E+00 | -2.3E+00 | 1.8E-01 | 2.0E+01 | 4.2E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)    43| +1.48E+02 | -1.3E-05 | +9.4E-01 | 1.2E-02 | 2.3E-01 | 3.9E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     2| +2.51E+02 | +2.4E+01 | -1.9E+00 | 2.5E-01 | 2.5E+01 | 6.1E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)    19| +1.56E+02 | -1.7E+01 | +8.1E-01 | 2.5E-01 | 6.8E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)   130| +1.38E+02 | -1.0E-04 | +9.2E-01 | 1.3E-02 | 7.2E-02 | 3.0E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    28| +1.48E+02 | -9.1E-02 | +4.6E-01 | 4.4E-02 | 2.0E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    52| +1.48E+02 | -8.8E-04 | +9.8E-01 | 1.4E-02 | 2.9E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    14| +2.17E+02 | -2.3E+00 | +5.5E-01 | 4.1E-01 | 1.8E+02 | 8.8E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    60| +1.48E+02 | +2.3E-06 | -3.4E+05 | 1.1E-10 | 2.2E-02 | 3.0E-10 |  2d |0
2023-02-17 16:05:27 fides(INFO)    44| +1.48E+02 | -1.3E-05 | +8.1E-01 | 2.4E-02 | 4.7E-02 | 7.5E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)   131| +1.38E+02 | -8.7E-05 | +3.3E-01 | 2.7E-02 | 6.9E-02 | 6.1E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    20| +1.53E+02 | -3.2E+00 | +9.5E-01 | 5.0E-01 | 1.1E+02 | 1.6E+00 | trr |1
2023-02-17 16:05:27 fides(INFO)    53| +1.48E+02 | -1.4E-03 | +9.6E-01 | 2.7E-02 | 4.2E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    29| +1.48E+02 | -4.4E-02 | +4.4E-01 | 4.4E-02 | 8.9E+00 | 4.9E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)     3| +2.49E+02 | -2.2E+00 | +6.1E-01 | 6.2E-02 | 2.5E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    61| +1.48E+02 | +3.9E-06 | -2.4E+06 | 2.6E-11 | 2.2E-02 | 7.5E-11 |  2d |0
2023-02-17 16:05:27 fides(INFO)    45| +1.48E+02 | -1.6E-05 | +5.7E-01 | 4.7E-02 | 1.4E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    54| +1.48E+02 | -1.7E-03 | +9.2E-01 | 5.5E-02 | 2.8E-01 | 3.4E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    21| +1.53E+02 | +7.2E-01 | -2.2E-01 | 1.0E+00 | 5.8E+01 | 7.4E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    30| +1.48E+02 | -2.2E-02 | +5.1E-01 | 4.4E-02 | 5.5E+00 | 5.4E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)   132| +1.38E+02 | +1.2E-02 | -5.8E+00 | 2.7E-02 | 1.7E-01 | 1.8E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)     4| +2.49E+02 | -1.8E-01 | +6.1E-01 | 6.2E-02 | 5.3E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    62| +1.48E+02 | +4.5E-06 | -1.1E+07 | 6.6E-12 | 2.2E-02 | 1.9E-11 |  2d |0
2023-02-17 16:05:27 fides(INFO)    46| +1.48E+02 | +1.8E-05 | -4.3E-01 | 4.7E-02 | 6.3E-02 | 1.3E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)    15| +2.16E+02 | -6.6E-01 | +7.3E-01 | 4.1E-01 | 1.6E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    22| +1.50E+02 | -2.6E+00 | +7.4E-01 | 2.5E-01 | 5.8E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    55| +1.48E+02 | +6.0E-03 | -4.5E+00 | 1.1E-01 | 1.3E-01 | 8.0E-02 | trr |0
2023-02-17 16:05:27 fides(INFO)    31| +1.48E+02 | -4.7E-03 | +7.7E-01 | 4.4E-02 | 2.8E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    63| +1.48E+02 | +4.3E-06 | -4.2E+07 | 1.6E-12 | 2.2E-02 | 4.7E-12 |  2d |0
2023-02-17 16:05:27 fides(INFO)   133| +1.38E+02 | +3.1E-03 | -3.3E+00 | 6.7E-03 | 1.7E-01 | 9.3E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)    47| +1.48E+02 | -4.0E-06 | +2.3E-01 | 1.2E-02 | 6.3E-02 | 3.3E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     5| +2.49E+02 | -2.8E-01 | +7.8E-01 | 6.2E-02 | 5.7E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    56| +1.48E+02 | -1.2E-04 | +2.0E-01 | 2.7E-02 | 1.3E-01 | 2.0E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    23| +1.49E+02 | -1.4E+00 | +9.5E-01 | 2.5E-01 | 8.6E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    64| +1.48E+02 | +4.0E-06 | -1.6E+08 | 4.1E-13 | 2.2E-02 | 1.2E-12 |  2d |0
2023-02-17 16:05:27 fides(INFO)    32| +1.48E+02 | -2.6E-03 | +4.8E-01 | 8.9E-02 | 2.2E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)   134| +1.38E+02 | +1.1E-04 | -2.6E-01 | 1.7E-03 | 1.7E-01 | 3.3E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)    48| +1.48E+02 | -6.0E-06 | +7.3E-01 | 2.9E-03 | 2.5E-01 | 8.3E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    24| +1.48E+02 | -6.4E-01 | +9.9E-01 | 5.0E-01 | 3.4E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    65| +1.48E+02 | +4.5E-06 | -6.9E+08 | 1.0E-13 | 2.2E-02 | 2.9E-13 |  2d |0
2023-02-17 16:05:27 fides(INFO)    16| +2.16E+02 | -5.6E-02 | -4.4E-01 | 4.1E-01 | 6.3E+01 | 6.8E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)    57| +1.48E+02 | -2.0E-04 | +2.5E-01 | 6.8E-03 | 3.9E-01 | 4.7E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     6| +2.48E+02 | -6.8E-01 | +1.1E+00 | 1.2E-01 | 5.1E+00 | 2.6E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    33| +1.48E+02 | +1.3E-02 | -1.0E+00 | 8.9E-02 | 1.0E+00 | 9.4E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)    49| +1.48E+02 | -3.0E-06 | +3.2E+00 | 2.9E-03 | 1.8E-02 | 8.2E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    58| +1.48E+02 | -1.6E-04 | +8.9E-01 | 1.7E-03 | 1.1E+00 | 1.4E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    25| +1.48E+02 | -4.2E-01 | +6.1E-01 | 1.0E+00 | 3.0E+01 | 9.1E-01 | trr |1
2023-02-17 16:05:27 fides(INFO)   135| +1.38E+02 | -8.8E-05 | +7.3E-01 | 4.2E-04 | 1.7E-01 | 8.4E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    66| +1.48E+02 | +4.6E-06 | -2.9E+09 | 2.6E-14 | 2.2E-02 | 7.3E-14 |  2d |0
2023-02-17 16:05:27 fides(INFO)    34| +1.48E+02 | -2.0E-03 | +4.5E-01 | 2.2E-02 | 1.0E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)     7| +2.45E+02 | -3.4E+00 | +1.6E+00 | 2.5E-01 | 8.1E+00 | 5.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    50| +1.48E+02 | +2.1E-07 | -1.4E-01 | 5.9E-03 | 1.7E-02 | 1.6E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)    59| +1.48E+02 | -5.6E-05 | +8.7E-01 | 3.4E-03 | 1.0E-01 | 2.4E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    26| +1.48E+02 | +1.1E+01 | -1.8E+01 | 1.0E+00 | 1.1E+01 | 1.5E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)    17| +2.16E+02 | -3.1E-01 | +1.0E+00 | 9.4E-02 | 6.3E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    67| +1.48E+02 | +4.1E-06 | -1.0E+10 | 6.4E-15 | 2.2E-02 | 1.8E-14 |  2d |0
2023-02-17 16:05:27 fides(INFO)   136| +1.38E+02 | -1.0E-05 | +9.1E-01 | 4.2E-04 | 1.9E-01 | 1.3E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    35| +1.48E+02 | -9.6E-04 | +8.6E-01 | 2.2E-02 | 2.5E+00 | 6.4E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    51| +1.48E+02 | +5.1E-07 | -1.2E+00 | 1.5E-03 | 1.7E-02 | 4.0E-04 |  2d |0
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    60| +1.48E+02 | -5.0E-05 | +8.3E-01 | 6.8E-03 | 1.2E-01 | 3.6E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    27| +1.48E+02 | -9.3E-02 | +2.3E-01 | 1.5E-01 | 1.1E+01 | 3.8E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    68| +1.48E+02 | +4.0E-06 | -4.0E+10 | 1.6E-15 | 2.2E-02 | 4.6E-15 |  2d |0
2023-02-17 16:05:27 fides(INFO)    36| +1.48E+02 | -6.1E-04 | +8.1E-01 | 4.4E-02 | 4.8E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)     8| +2.19E+02 | -2.6E+01 | +2.2E+00 | 5.0E-01 | 1.7E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)   137| +1.38E+02 | -1.5E-05 | +8.9E-01 | 8.3E-04 | 9.0E-02 | 2.8E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    52| +1.48E+02 | -2.6E-07 | +1.9E+00 | 3.7E-04 | 1.7E-02 | 1.0E-04 |  2d |1
2023-02-17 16:05:27 fides(WARNING) Stopping as function difference 2.58E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:27 fides(INFO)    61| +1.48E+02 | -7.9E-05 | +9.1E-01 | 1.4E-02 | 8.3E-02 | 4.6E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    28| +1.48E+02 | -7.1E-02 | +6.8E-01 | 3.7E-02 | 1.9E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:27.544 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2248 and h = 8.49905e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:27.544 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2248: AMICI failed to integrate the forward problem
2023-02-17 16:05:27 fides(INFO)    37| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.9E-02 | 1.2E+00 | 2.2E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)    69| +1.48E+02 | +3.9E-06 | -1.5E+11 | 4.0E-16 | 2.2E-02 | 1.1E-15 |  2d |0
2023-02-17 16:05:27 fides(WARNING) Stopping as trust region radius 1.00E-16 is smaller than machine precision.
2023-02-17 16:05:27 fides(INFO)    18| +2.16E+02 | -4.3E-02 | -8.6E-02 | 1.9E-01 | 3.2E+00 | 4.7E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)   138| +1.38E+02 | -2.0E-05 | +9.4E-01 | 1.7E-03 | 1.7E-01 | 3.9E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    38| +1.48E+02 | -2.5E-04 | +8.3E-01 | 2.2E-02 | 1.2E+00 | 5.5E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    62| +1.48E+02 | +3.9E-05 | -2.8E-01 | 2.7E-02 | 1.8E-01 | 1.4E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)    29| +1.48E+02 | -1.9E-02 | +7.6E-01 | 3.7E-02 | 3.9E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)   139| +1.38E+02 | -2.5E-05 | +8.7E-01 | 3.3E-03 | 6.6E-02 | 7.2E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    63| +1.48E+02 | -3.2E-05 | +7.2E-01 | 6.8E-03 | 1.8E-01 | 3.4E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    39| +1.48E+02 | -1.2E-04 | +6.4E-01 | 4.4E-02 | 2.7E-01 | 1.4E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    30| +1.48E+02 | -9.9E-03 | +9.2E-01 | 7.3E-02 | 7.7E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)     9| +2.19E+02 | +2.1E+02 | -9.7E+00 | 1.0E+00 | 5.0E+01 | 2.8E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)    19| +2.16E+02 | -3.8E-02 | +1.1E+00 | 4.7E-02 | 3.2E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)   140| +1.38E+02 | -4.7E-05 | +1.0E+00 | 6.7E-03 | 8.1E-02 | 1.4E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    64| +1.48E+02 | -2.2E-05 | +6.9E-01 | 6.8E-03 | 6.6E-02 | 1.5E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    40| +1.48E+02 | +3.4E-05 | -1.3E-01 | 4.4E-02 | 3.9E-01 | 9.7E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)    31| +1.48E+02 | +2.0E-03 | -4.7E-01 | 1.5E-01 | 1.1E+00 | 6.4E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)     0| +1.95E+08 |    NaN   |    NaN   | 1.0E+00 | 9.0E+08 |   NaN   | NaN |1
2023-02-17 16:05:27 fides(INFO)    65| +1.48E+02 | -2.0E-05 | +5.7E-01 | 6.8E-03 | 1.9E-01 | 3.2E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    41| +1.48E+02 | -6.6E-05 | +7.8E-01 | 1.1E-02 | 3.9E-01 | 2.4E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    32| +1.48E+02 | -1.7E-03 | +7.5E-01 | 3.7E-02 | 1.1E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)     0| +2.66E+08 |    NaN   |    NaN   | 1.0E+00 | 1.2E+09 |   NaN   | NaN |1
2023-02-17 16:05:27 fides(INFO)   141| +1.38E+02 | -9.1E-05 | +9.9E-01 | 1.3E-02 | 6.1E-02 | 2.7E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    10| +2.05E+02 | -1.4E+01 | +6.8E-01 | 2.5E-01 | 5.0E+01 | 5.6E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)     1| +4.07E+04 | -1.9E+08 | +9.8E-02 | 1.0E+00 | 9.0E+08 | 2.7E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)     1| +2.73E+05 | -2.7E+08 | +1.0E-01 | 1.0E+00 | 1.2E+09 | 2.6E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    42| +1.48E+02 | -4.0E-05 | +9.3E-01 | 2.2E-02 | 1.9E-01 | 5.0E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    66| +1.48E+02 | -8.2E-06 | +3.1E-01 | 6.8E-03 | 6.1E-02 | 9.2E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    20| +2.15E+02 | -8.7E-02 | +1.1E+00 | 9.4E-02 | 1.9E+00 | 2.3E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    33| +1.48E+02 | -4.0E-05 | +2.0E-02 | 7.3E-02 | 2.0E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)   142| +1.38E+02 | -1.8E-04 | +9.8E-01 | 2.7E-02 | 6.5E-02 | 5.2E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     2| +4.40E+04 | -2.3E+05 | +9.0E-01 | 2.5E-01 | 1.2E+06 | 6.4E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)     2| +7.17E+03 | -3.4E+04 | +9.0E-01 | 2.5E-01 | 1.8E+05 | 6.7E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    43| +1.48E+02 | -5.0E-05 | +9.1E-01 | 4.4E-02 | 1.7E-01 | 9.9E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    34| +1.48E+02 | -1.0E-03 | +3.6E-01 | 1.8E-02 | 5.7E-01 | 1.6E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    67| +1.48E+02 | -1.5E-05 | +4.3E-01 | 6.8E-03 | 1.6E-01 | 3.3E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     3| +7.74E+03 | -3.6E+04 | +9.0E-01 | 5.0E-01 | 2.0E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    11| +2.01E+02 | -5.0E+00 | +7.0E-01 | 2.5E-01 | 4.0E+01 | 4.9E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)   143| +1.38E+02 | +2.2E-04 | -6.8E-01 | 5.3E-02 | 6.5E-02 | 1.1E-02 |  2d |0
2023-02-17 16:05:27 fides(INFO)     3| +1.60E+03 | -5.6E+03 | +9.1E-01 | 5.0E-01 | 2.9E+04 | 1.4E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    21| +2.15E+02 | +4.3E-01 | -3.7E+00 | 1.9E-01 | 1.0E+01 | 4.4E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)     4| +1.72E+03 | -6.0E+03 | +9.1E-01 | 1.0E+00 | 3.1E+04 | 6.8E-01 | trr |1
2023-02-17 16:05:27 fides(INFO)    44| +1.48E+02 | -5.3E-06 | +7.9E-02 | 8.9E-02 | 1.1E-01 | 1.6E-02 |  2d |1
2023-02-17 16:05:27 fides(INFO)    35| +1.48E+02 | -2.9E-04 | +5.8E-01 | 1.8E-02 | 1.2E+00 | 4.5E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    68| +1.48E+02 | +9.2E-06 | -2.6E-01 | 6.8E-03 | 6.7E-02 | 1.0E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)     4| +1.60E+03 | +3.5E+04 | -8.3E+01 | 1.0E+00 | 5.0E+03 | 2.7E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)     5| +4.61E+02 | -1.3E+03 | +9.0E-01 | 1.0E+00 | 5.3E+03 | 2.5E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    45| +1.48E+02 | +2.0E-04 | -7.1E-01 | 2.2E-02 | 1.1E-01 | 9.5E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)   144| +1.38E+02 | -6.1E-05 | +5.7E-01 | 1.3E-02 | 6.5E-02 | 2.7E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    36| +1.48E+02 | -9.1E-05 | +5.8E-01 | 1.8E-02 | 2.9E-01 | 6.2E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    69| +1.48E+02 | -4.2E-06 | +3.3E-01 | 1.7E-03 | 6.7E-02 | 3.4E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)     6| +2.62E+02 | -2.0E+02 | +9.0E-01 | 2.0E+00 | 8.5E+02 | 3.9E+00 | trr |1
2023-02-17 16:05:27 fides(INFO)    46| +1.48E+02 | -3.2E-05 | +3.6E-01 | 5.5E-03 | 1.1E-01 | 2.5E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    12| +1.93E+02 | -7.4E+00 | +1.1E+00 | 2.5E-01 | 3.8E+01 | 6.6E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    37| +1.48E+02 | -7.0E-05 | +7.1E-01 | 1.8E-02 | 3.1E-01 | 3.3E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    22| +2.15E+02 | -6.4E-02 | +1.1E+00 | 4.7E-02 | 1.0E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)     5| +5.17E+02 | -1.1E+03 | +9.1E-01 | 2.5E-01 | 5.0E+03 | 5.6E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    70| +1.48E+02 | -4.4E-06 | +8.2E-01 | 1.7E-03 | 1.8E-01 | 3.6E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)     7| +2.38E+02 | -2.4E+01 | +1.0E+00 | 4.0E+00 | 1.1E+02 | 2.5E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)   145| +1.38E+02 | +7.2E-05 | -2.9E-01 | 1.3E-02 | 1.4E-01 | 3.7E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)    47| +1.48E+02 | -1.6E-05 | +9.2E-01 | 5.5E-03 | 3.7E-01 | 6.5E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)     6| +3.08E+02 | -2.1E+02 | +6.8E-01 | 5.0E-01 | 1.0E+03 | 1.2E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    38| +1.48E+02 | -5.1E-05 | +7.0E-01 | 1.8E-02 | 2.8E-01 | 4.8E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    71| +1.48E+02 | -6.4E-06 | +1.8E+00 | 3.4E-03 | 2.1E-02 | 6.6E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)     8| +2.38E+02 | +3.4E+01 | -6.3E+00 | 4.0E+00 | 2.4E+01 | 5.0E+00 | trr |0
2023-02-17 16:05:27 fides(INFO)    48| +1.48E+02 | -6.9E-07 | +3.5E-01 | 1.1E-02 | 3.3E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:27 fides(WARNING) Stopping as function difference 6.90E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:27 fides(INFO)   146| +1.38E+02 | -4.5E-05 | +6.7E-01 | 3.3E-03 | 1.4E-01 | 9.2E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)     7| +2.51E+02 | -5.7E+01 | +8.4E-01 | 5.0E-01 | 2.8E+02 | 1.1E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    23| +2.15E+02 | -1.2E-01 | +7.2E-01 | 9.4E-02 | 6.2E+00 | 2.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)     9| +2.38E+02 | +1.6E+00 | -3.9E-01 | 6.9E-01 | 2.4E+01 | 2.0E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)    39| +1.48E+02 | -4.4E-05 | +7.4E-01 | 1.8E-02 | 2.0E-01 | 2.9E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    13| +1.81E+02 | -1.2E+01 | +8.0E-01 | 5.0E-01 | 3.3E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    72| +1.48E+02 | -4.6E-06 | +7.9E-01 | 6.8E-03 | 5.6E-02 | 1.6E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     8| +2.50E+02 | -1.1E+00 | +3.8E-01 | 1.0E+00 | 2.6E+01 | 2.4E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    40| +1.48E+02 | -2.9E-05 | +5.3E-01 | 1.8E-02 | 2.7E-01 | 4.5E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    73| +1.48E+02 | +6.7E-07 | -7.7E-02 | 1.4E-02 | 2.2E-02 | 1.5E-03 |  2d |0
2023-02-17 16:05:27 fides(INFO)   147| +1.38E+02 | -2.1E-05 | +9.9E-01 | 3.3E-03 | 7.8E-02 | 6.0E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:27 fides(INFO)    10| +2.38E+02 | +1.3E+00 | -3.2E-01 | 1.7E-01 | 2.4E+01 | 4.3E-01 |  2d |0
2023-02-17 16:05:27 fides(INFO)    24| +2.15E+02 | -1.6E-01 | +7.4E-01 | 9.4E-02 | 2.9E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    41| +1.48E+02 | -1.4E-05 | +2.8E-01 | 1.8E-02 | 1.4E-01 | 2.6E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)   148| +1.38E+02 | -4.1E-05 | +1.0E+00 | 6.7E-03 | 5.9E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)    74| +1.48E+02 | -3.8E-06 | +1.3E+00 | 3.4E-03 | 2.2E-02 | 3.8E-04 |  2d |1
2023-02-17 16:05:27 fides(INFO)    11| +2.36E+02 | -1.9E+00 | +8.7E-01 | 4.3E-02 | 2.4E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:27 fides(INFO)    14| +1.81E+02 | -6.7E-01 | -5.0E-01 | 1.0E+00 | 1.5E+02 | 1.5E+00 |  2d |0
2023-02-17 16:05:27 fides(INFO)    42| +1.48E+02 | -4.4E-06 | +5.4E-02 | 1.8E-02 | 2.5E-01 | 5.2E-03 |  2d |1
2023-02-17 16:05:27 fides(INFO)     9| +2.50E+02 | -2.9E-01 | +2.9E-02 | 1.0E+00 | 1.2E+01 | 2.2E+00 |  2d |1
2023-02-17 16:05:27 fides(INFO)    75| +1.48E+02 | +1.6E-06 | -3.0E-01 | 6.8E-03 | 6.5E-02 | 1.6E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)   149| +1.38E+02 | -7.9E-05 | +9.9E-01 | 1.3E-02 | 6.8E-02 | 2.4E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    25| +2.15E+02 | -1.7E-01 | +9.8E-01 | 9.4E-02 | 3.2E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    12| +2.34E+02 | -2.2E+00 | +9.0E-01 | 8.6E-02 | 1.9E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)     0| +1.64E+11 |    NaN   |    NaN   | 1.0E+00 | 7.4E+11 |   NaN   | NaN |1
2023-02-17 16:05:28 fides(INFO)    43| +1.48E+02 | -1.9E-05 | +3.6E-01 | 4.6E-03 | 1.3E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    76| +1.48E+02 | +1.3E-06 | -7.2E-01 | 1.7E-03 | 6.5E-02 | 4.1E-04 |  2d |0
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)   150| +1.38E+02 | -1.5E-04 | +1.0E+00 | 2.7E-02 | 5.9E-02 | 4.6E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    10| +2.49E+02 | -8.7E-01 | +5.1E-01 | 2.5E-01 | 1.7E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    13| +2.30E+02 | -3.6E+00 | +9.8E-01 | 1.7E-01 | 2.4E+01 | 3.5E-01 |  2d |1
2023-02-17 16:05:28.049 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.543 and h = 3.35461e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:28.049 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.543: AMICI failed to integrate the forward problem
2023-02-17 16:05:28 fides(INFO)    44| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.6E-03 | 3.8E-01 | 7.2E-04 |  2d |0
2023-02-17 16:05:28 fides(INFO)    26| +2.15E+02 | -1.5E-01 | +3.9E-01 | 1.9E-01 | 1.9E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     1| +3.11E+09 | -1.6E+11 | +8.7E-02 | 1.0E+00 | 7.4E+11 | 3.0E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    77| +1.48E+02 | +1.7E-06 | -2.1E+00 | 4.3E-04 | 6.5E-02 | 1.0E-04 |  2d |0
2023-02-17 16:05:28 fides(INFO)    15| +1.69E+02 | -1.2E+01 | +9.8E-01 | 2.5E-01 | 1.5E+02 | 3.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   151| +1.38E+02 | -2.5E-04 | +8.5E-01 | 5.3E-02 | 6.2E-02 | 8.7E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    45| +1.48E+02 | -1.7E-05 | +9.9E-01 | 1.1E-03 | 3.8E-01 | 2.0E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    14| +2.28E+02 | -2.3E+00 | +2.9E-01 | 3.4E-01 | 2.2E+01 | 9.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    78| +1.48E+02 | -2.3E-06 | +3.9E+00 | 1.1E-04 | 6.5E-02 | 3.0E-05 |  2d |1
2023-02-17 16:05:28 fides(INFO)     2| +4.64E+08 | -2.6E+09 | +8.9E-01 | 2.5E-01 | 1.4E+10 | 6.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    15| +2.18E+02 | -9.5E+00 | +8.3E-01 | 3.4E-01 | 5.4E+01 | 8.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    46| +1.48E+02 | -3.4E-06 | +1.0E+00 | 2.3E-03 | 4.0E-02 | 3.6E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    11| +2.48E+02 | -6.8E-01 | +4.8E-01 | 2.5E-01 | 1.0E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   152| +1.38E+02 | +3.9E-02 | -1.9E+01 | 1.1E-01 | 9.7E-02 | 3.4E-02 |  2d |0
2023-02-17 16:05:28 fides(INFO)    27| +2.15E+02 | -1.9E-01 | +1.1E+00 | 1.9E-01 | 3.5E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    16| +1.69E+02 | +8.9E+00 | -1.6E+00 | 5.0E-01 | 4.4E+01 | 1.0E+00 |  2d |0
2023-02-17 16:05:28 fides(INFO)    79| +1.48E+02 | +4.9E-06 | -2.7E+01 | 2.1E-04 | 6.9E-03 | 5.2E-05 |  2d |0
2023-02-17 16:05:28 fides(INFO)    16| +1.99E+02 | -1.9E+01 | +4.2E-01 | 6.9E-01 | 2.5E+01 | 1.7E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    47| +1.48E+02 | -6.6E-06 | +2.6E+00 | 4.6E-03 | 1.0E-01 | 6.3E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)     3| +6.92E+07 | -3.9E+08 | +8.9E-01 | 5.0E-01 | 2.1E+09 | 8.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   153| +1.38E+02 | +1.9E-03 | -3.0E+00 | 2.7E-02 | 9.7E-02 | 8.6E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    80| +1.48E+02 | +5.6E-06 | -7.7E+01 | 5.3E-05 | 6.9E-03 | 1.8E-05 |  2d |0
2023-02-17 16:05:28 fides(INFO)    12| +2.47E+02 | -1.4E+00 | +7.4E-01 | 2.5E-01 | 1.5E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    17| +1.99E+02 | +3.2E+01 | -2.2E+00 | 6.9E-01 | 1.5E+02 | 1.1E+00 |  2d |0
2023-02-17 16:05:28 fides(INFO)    48| +1.48E+02 | +2.7E-06 | -7.8E-01 | 9.2E-03 | 2.6E-02 | 1.2E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)    28| +2.14E+02 | -1.7E-01 | +1.4E-01 | 3.8E-01 | 1.4E+01 | 5.7E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   154| +1.38E+02 | +5.5E-07 | -6.5E-03 | 6.7E-03 | 9.7E-02 | 2.2E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)     4| +1.04E+07 | -5.9E+07 | +8.9E-01 | 5.0E-01 | 3.2E+08 | 8.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    81| +1.48E+02 | +3.1E-06 | -6.9E+01 | 1.3E-05 | 6.9E-03 | 1.2E-05 |  2d |0
2023-02-17 16:05:28 fides(INFO)    17| +1.65E+02 | -3.7E+00 | +8.2E-01 | 1.2E-01 | 4.4E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    18| +1.77E+02 | -2.1E+01 | +9.9E-01 | 1.7E-01 | 1.5E+02 | 2.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    49| +1.48E+02 | +1.4E-06 | -6.6E-01 | 2.3E-03 | 2.6E-02 | 3.3E-04 |  2d |0
2023-02-17 16:05:28 fides(INFO)    13| +2.46E+02 | -1.4E+00 | +6.1E-01 | 2.5E-01 | 1.2E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    82| +1.48E+02 | +3.2E-07 | -1.0E+01 | 3.3E-06 | 6.9E-03 | 7.3E-06 |  2d |0
2023-02-17 16:05:28 fides(INFO)   155| +1.38E+02 | -3.3E-05 | +7.0E-01 | 1.7E-03 | 9.7E-02 | 6.3E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)     5| +1.56E+06 | -8.8E+06 | +8.9E-01 | 5.0E-01 | 4.8E+07 | 9.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    29| +2.14E+02 | -9.0E-02 | +1.1E+00 | 9.4E-02 | 3.2E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    50| +1.48E+02 | -1.0E-06 | +5.9E-01 | 5.7E-04 | 2.6E-02 | 1.7E-04 |  2d |1
2023-02-17 16:05:28 fides(WARNING) Stopping as function difference 1.02E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:28 fides(INFO)    19| +1.59E+02 | -1.9E+01 | +6.8E-01 | 3.4E-01 | 5.9E+01 | 6.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    14| +2.43E+02 | -2.7E+00 | +7.9E-01 | 2.5E-01 | 2.1E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     6| +2.38E+05 | -1.3E+06 | +8.9E-01 | 5.0E-01 | 7.2E+06 | 9.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   156| +1.38E+02 | -1.4E-05 | +9.4E-01 | 1.7E-03 | 2.4E-01 | 2.8E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    83| +1.48E+02 | -4.8E-08 | +4.5E+00 | 8.3E-07 | 6.9E-03 | 1.8E-06 |  2d |1
2023-02-17 16:05:28 fides(WARNING) Stopping as function difference 4.76E-08 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:28 fides(INFO)    18| +1.55E+02 | -9.5E+00 | +1.1E+00 | 2.5E-01 | 8.3E+01 | 5.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    20| +1.59E+02 | +4.1E+01 | -3.7E+00 | 3.4E-01 | 1.8E+02 | 5.7E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)     7| +3.68E+04 | -2.0E+05 | +8.9E-01 | 5.0E-01 | 1.1E+06 | 9.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    15| +2.38E+02 | -4.9E+00 | +6.5E-01 | 5.0E-01 | 1.9E+01 | 8.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    30| +2.14E+02 | -9.2E-02 | +9.5E-01 | 1.9E-01 | 3.3E+00 | 2.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   157| +1.38E+02 | -1.6E-05 | +9.6E-01 | 3.3E-03 | 6.0E-02 | 4.9E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)     8| +5.70E+03 | -3.1E+04 | +9.0E-01 | 5.0E-01 | 1.7E+05 | 9.0E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    21| +1.51E+02 | -8.1E+00 | +8.9E-01 | 7.6E-02 | 1.8E+02 | 1.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    19| +1.55E+02 | -2.7E-01 | -1.1E-02 | 5.0E-01 | 5.1E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    16| +2.29E+02 | -9.2E+00 | +9.1E-01 | 5.0E-01 | 4.7E+01 | 7.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   158| +1.38E+02 | -3.1E-05 | +1.0E+00 | 6.7E-03 | 6.2E-02 | 9.3E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)     9| +9.75E+02 | -4.7E+03 | +9.1E-01 | 5.0E-01 | 2.6E+04 | 8.0E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    22| +1.49E+02 | -2.0E+00 | +9.2E-01 | 1.5E-01 | 5.5E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    31| +2.14E+02 | -1.3E-01 | +7.0E-01 | 3.8E-01 | 5.3E+00 | 4.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    17| +2.29E+02 | +2.5E+01 | -3.2E+00 | 1.0E+00 | 2.9E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)     0| +2.62E+11 |    NaN   |    NaN   | 1.0E+00 | 9.5E+11 |   NaN   | NaN |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    10| +7.50E+02 | -2.2E+02 | +9.7E-02 | 5.0E-01 | 3.8E+03 | 1.2E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)   159| +1.38E+02 | -5.8E-05 | +9.6E-01 | 1.3E-02 | 5.8E-02 | 1.8E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    23| +1.49E+02 | +1.6E+00 | -1.6E+00 | 3.0E-01 | 3.7E+01 | 4.1E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)     0| +1.18E+11 |    NaN   |    NaN   | 1.0E+00 | 5.4E+11 |   NaN   | NaN |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    20| +1.55E+02 | -9.1E-01 | +9.5E-01 | 9.3E-02 | 5.1E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    18| +2.29E+02 | -1.8E-01 | -1.2E-01 | 2.5E-01 | 2.9E+01 | 5.9E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    32| +2.14E+02 | -1.0E-01 | +1.2E+00 | 3.8E-01 | 1.3E+01 | 3.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    11| +2.94E+02 | -4.6E+02 | +9.2E-01 | 1.2E-01 | 3.6E+03 | 2.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    24| +1.48E+02 | -3.3E-01 | +7.0E-01 | 7.6E-02 | 3.7E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     1| +1.03E+09 | -2.6E+11 | +1.1E-01 | 1.0E+00 | 9.5E+11 | 3.0E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)     1| +2.17E+08 | -1.2E+11 | +9.2E-02 | 1.0E+00 | 5.4E+11 | 2.9E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)   160| +1.38E+02 | -3.8E-05 | +2.4E-01 | 2.7E-02 | 6.0E-02 | 3.8E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    12| +1.83E+02 | -1.1E+02 | +8.5E-01 | 2.5E-01 | 9.1E+02 | 5.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    19| +2.26E+02 | -3.1E+00 | +8.9E-01 | 6.2E-02 | 2.9E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    25| +1.48E+02 | -3.2E-01 | +5.8E-01 | 7.6E-02 | 2.8E+01 | 7.0E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    21| +1.54E+02 | -2.6E-01 | +8.2E-01 | 1.9E-01 | 1.3E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     2| +1.56E+08 | -8.7E+08 | +8.9E-01 | 2.5E-01 | 4.7E+09 | 6.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    33| +2.14E+02 | -1.2E-01 | +5.8E-01 | 7.5E-01 | 7.1E+00 | 4.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     2| +3.32E+07 | -1.8E+08 | +8.9E-01 | 2.5E-01 | 1.0E+09 | 6.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    13| +1.72E+02 | -1.1E+01 | +7.6E-01 | 5.0E-01 | 1.5E+02 | 1.1E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)   161| +1.38E+02 | +8.5E-05 | -2.1E-01 | 6.7E-03 | 1.5E-01 | 3.5E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    20| +2.20E+02 | -5.6E+00 | +1.1E+00 | 1.2E-01 | 2.9E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     3| +2.38E+07 | -1.3E+08 | +8.9E-01 | 5.0E-01 | 7.2E+08 | 1.3E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)     3| +5.10E+06 | -2.8E+07 | +8.9E-01 | 5.0E-01 | 1.5E+08 | 1.2E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    26| +1.48E+02 | -6.1E-02 | +1.6E-01 | 7.6E-02 | 1.6E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    22| +1.54E+02 | -1.4E-01 | +8.6E-01 | 3.7E-01 | 2.2E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    34| +2.14E+02 | -5.4E-02 | +1.4E+00 | 7.5E-01 | 1.1E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    14| +1.71E+02 | -6.7E-01 | +6.7E-01 | 1.0E+00 | 1.3E+01 | 2.0E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)   162| +1.38E+02 | -7.4E-05 | +6.9E-01 | 1.7E-03 | 1.5E-01 | 9.0E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    21| +2.09E+02 | -1.1E+01 | +1.2E+00 | 2.5E-01 | 3.0E+01 | 4.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     4| +3.66E+06 | -2.0E+07 | +8.9E-01 | 1.0E+00 | 1.1E+08 | 9.7E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    27| +1.48E+02 | -1.1E-01 | +8.0E-01 | 1.9E-02 | 2.2E+01 | 2.5E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)     4| +7.91E+05 | -4.3E+06 | +8.9E-01 | 1.0E+00 | 2.3E+07 | 2.3E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    23| +1.54E+02 | -1.2E-02 | +5.1E-01 | 7.4E-01 | 3.6E+00 | 8.7E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     5| +5.66E+05 | -3.1E+06 | +9.0E-01 | 1.0E+00 | 1.7E+07 | 9.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    22| +2.09E+02 | -1.8E+00 | -5.4E-01 | 5.0E-01 | 3.1E+01 | 1.0E+00 |  2d |0
2023-02-17 16:05:28 fides(INFO)    28| +1.48E+02 | -7.0E-02 | +6.5E-01 | 3.8E-02 | 1.4E+01 | 2.8E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)     5| +1.24E+05 | -6.7E+05 | +9.0E-01 | 2.0E+00 | 3.6E+06 | 3.9E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)   163| +1.38E+02 | -1.7E-05 | +8.1E-01 | 1.7E-03 | 2.0E-01 | 3.5E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    35| +2.14E+02 | -7.3E-02 | +7.5E-01 | 7.5E-01 | 3.2E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    15| +1.71E+02 | -1.3E-01 | +6.7E-01 | 1.0E+00 | 1.1E+01 | 1.7E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)     6| +8.84E+04 | -4.8E+05 | +9.0E-01 | 1.0E+00 | 2.6E+06 | 8.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     6| +1.96E+04 | -1.0E+05 | +9.0E-01 | 4.0E+00 | 5.6E+05 | 1.6E+00 | trr |1
2023-02-17 16:05:28 fides(INFO)   164| +1.38E+02 | -1.4E-05 | +8.9E-01 | 3.3E-03 | 6.0E-02 | 4.5E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    29| +1.48E+02 | -3.8E-02 | +5.8E-01 | 3.8E-02 | 1.0E+01 | 5.0E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    23| +2.03E+02 | -6.0E+00 | +9.5E-01 | 1.2E-01 | 3.1E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    24| +1.54E+02 | +1.5E-01 | -5.1E+00 | 7.4E-01 | 1.8E+00 | 3.3E-01 | trr |0
2023-02-17 16:05:28 fides(INFO)     7| +1.40E+04 | -7.4E+04 | +9.0E-01 | 1.0E+00 | 4.0E+05 | 8.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     7| +3.28E+03 | -1.6E+04 | +9.0E-01 | 4.0E+00 | 8.8E+04 | 1.1E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    16| +1.71E+02 | -2.8E-02 | +8.1E-01 | 1.0E+00 | 4.7E+00 | 1.3E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    36| +2.14E+02 | -1.6E-02 | +1.4E+00 | 7.5E-01 | 4.7E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    30| +1.48E+02 | -3.1E-02 | +6.4E-01 | 3.8E-02 | 1.1E+01 | 1.9E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    24| +1.89E+02 | -1.5E+01 | +1.1E+00 | 2.5E-01 | 4.0E+01 | 4.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     8| +2.35E+03 | -1.2E+04 | +9.1E-01 | 1.0E+00 | 6.3E+04 | 8.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)     8| +7.03E+02 | -2.6E+03 | +9.0E-01 | 4.0E+00 | 1.4E+04 | 1.2E+00 | trr |1
2023-02-17 16:05:28 fides(INFO)    25| +1.54E+02 | -4.9E-03 | +8.4E-01 | 9.0E-02 | 1.8E+00 | 6.6E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    31| +1.48E+02 | -1.9E-02 | +3.9E-01 | 3.8E-02 | 5.1E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)   165| +1.38E+02 | -2.5E-05 | +9.2E-01 | 6.7E-03 | 6.2E-02 | 8.1E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)     9| +5.18E+02 | -1.8E+03 | +9.2E-01 | 1.0E+00 | 9.9E+03 | 9.0E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    17| +1.71E+02 | -3.2E-03 | +5.4E-01 | 2.0E+00 | 1.8E+00 | 1.1E+00 | trr |1
2023-02-17 16:05:28 fides(INFO)    25| +1.89E+02 | -5.0E+00 | -3.4E-01 | 5.0E-01 | 4.5E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:28 fides(INFO)    37| +2.14E+02 | -1.0E-02 | +1.0E+00 | 7.5E-01 | 2.2E+00 | 7.6E-03 | trr |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)     9| +3.02E+02 | -4.0E+02 | +9.1E-01 | 4.0E+00 | 2.2E+03 | 1.5E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    10| +2.23E+02 | -3.0E+02 | +1.0E+00 | 1.0E+00 | 1.4E+03 | 1.0E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    32| +1.48E+02 | -6.2E-03 | +1.7E-01 | 3.8E-02 | 3.7E+00 | 4.4E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    26| +1.54E+02 | -4.2E-03 | +6.5E-01 | 1.8E-01 | 1.8E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    26| +1.79E+02 | -9.6E+00 | +1.0E+00 | 1.2E-01 | 4.5E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   166| +1.38E+02 | -4.1E-05 | +7.2E-01 | 1.3E-02 | 5.9E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    18| +1.71E+02 | -1.2E-04 | +4.8E-02 | 2.0E+00 | 1.5E+00 | 1.4E-02 | trr |1
2023-02-17 16:05:28 fides(INFO)    11| +1.99E+02 | -2.4E+01 | +9.8E-01 | 1.0E+00 | 1.4E+02 | 8.3E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    10| +2.21E+02 | -8.1E+01 | +1.2E+00 | 4.0E+00 | 3.3E+02 | 2.6E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    38| +2.14E+02 | -3.0E-04 | +9.4E-01 | 7.5E-01 | 2.2E+00 | 1.4E-03 | trr |1
2023-02-17 16:05:28 fides(INFO)    33| +1.48E+02 | -5.0E-03 | +7.4E-01 | 9.5E-03 | 1.3E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    27| +1.59E+02 | -2.0E+01 | +1.0E+00 | 2.5E-01 | 5.8E+01 | 4.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   167| +1.38E+02 | +3.5E-04 | -1.9E+00 | 1.3E-02 | 7.7E-02 | 3.8E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)    27| +1.54E+02 | -1.4E-03 | +3.8E-01 | 1.8E-01 | 7.8E-01 | 1.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    19| +1.71E+02 | -7.2E-06 | +2.1E-03 | 3.0E-02 | 1.1E+00 | 1.4E-02 | trr |1
2023-02-17 16:05:28 fides(INFO)    12| +1.99E+02 | +4.4E+02 | -2.4E+01 | 2.0E+00 | 3.8E+01 | 5.9E+00 |  2d |0
2023-02-17 16:05:28 fides(INFO)    34| +1.48E+02 | -2.3E-03 | +7.8E-01 | 9.5E-03 | 2.1E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    28| +1.59E+02 | +3.0E+01 | -2.1E+00 | 5.0E-01 | 7.3E+01 | 8.5E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    11| +2.21E+02 | +1.1E+03 | -3.7E+01 | 4.0E+00 | 2.9E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    39| +2.14E+02 | -4.6E-06 | +1.7E-01 | 7.5E-01 | 2.1E+00 | 5.5E-04 | trr |1
2023-02-17 16:05:28 fides(INFO)    28| +1.54E+02 | +2.0E-04 | -6.0E-02 | 1.8E-01 | 8.8E-01 | 9.4E-02 |  2d |0
2023-02-17 16:05:28 fides(INFO)   168| +1.38E+02 | +1.7E-05 | -3.1E-01 | 3.3E-03 | 7.7E-02 | 1.3E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    20| +1.71E+02 | -5.6E-04 | +2.6E-01 | 5.2E-03 | 1.1E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    12| +2.21E+02 | +7.1E+00 | -1.2E+00 | 1.0E+00 | 2.9E+01 | 2.9E+00 |  2d |0
2023-02-17 16:05:28 fides(INFO)    13| +1.94E+02 | -4.5E+00 | +2.2E-01 | 5.0E-01 | 3.8E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:28 fides(INFO)    35| +1.48E+02 | -9.7E-04 | +5.6E-01 | 1.9E-02 | 5.3E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    29| +1.53E+02 | -6.7E+00 | +8.1E-01 | 1.2E-01 | 7.3E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   169| +1.38E+02 | -9.1E-08 | +2.9E-03 | 8.3E-04 | 7.7E-02 | 7.0E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    13| +2.21E+02 | +3.5E+00 | -4.7E-01 | 2.5E-01 | 2.9E+01 | 6.5E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    36| +1.48E+02 | -8.1E-04 | +5.1E-01 | 1.9E-02 | 1.0E+00 | 5.7E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    40| +2.14E+02 | +1.2E-07 | -1.1E-02 | 3.8E-04 | 2.1E+00 | 5.3E-04 | trr |0
2023-02-17 16:05:28 fides(INFO)    29| +1.54E+02 | -1.0E-03 | +8.0E-01 | 4.5E-02 | 8.8E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    30| +1.50E+02 | -2.8E+00 | +9.0E-01 | 2.5E-01 | 7.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    14| +1.85E+02 | -9.2E+00 | +8.7E-01 | 1.2E-01 | 8.4E+01 | 3.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    21| +1.71E+02 | -3.1E-04 | +3.0E-01 | 5.2E-03 | 9.2E-01 | 7.4E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    37| +1.48E+02 | -4.7E-04 | +3.1E-01 | 1.9E-02 | 5.6E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)   170| +1.38E+02 | -1.2E-05 | +9.8E-01 | 2.1E-04 | 3.7E-01 | 6.8E-05 |  2d |1
2023-02-17 16:05:28 fides(INFO)    31| +1.50E+02 | +4.9E+00 | -1.6E+00 | 5.0E-01 | 4.5E+01 | 5.3E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    14| +2.18E+02 | -3.3E+00 | +8.5E-01 | 6.2E-02 | 2.9E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    15| +1.75E+02 | -1.0E+01 | +1.3E+00 | 2.5E-01 | 3.6E+01 | 5.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    30| +1.54E+02 | -6.0E-04 | +8.2E-01 | 9.0E-02 | 4.2E-01 | 4.0E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    22| +1.71E+02 | -7.9E-06 | +1.7E-02 | 5.2E-03 | 6.1E-01 | 5.8E-03 | trr |1
2023-02-17 16:05:28 fides(INFO)    15| +2.16E+02 | -1.6E+00 | +5.3E-01 | 1.2E-01 | 1.8E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    38| +1.48E+02 | +2.2E-04 | -1.2E-01 | 1.9E-02 | 5.9E-01 | 6.9E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)    41| +2.14E+02 | -4.4E-06 | +8.1E-01 | 6.5E-05 | 2.1E+00 | 1.4E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    32| +1.49E+02 | -1.2E+00 | +7.2E-01 | 1.2E-01 | 4.5E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    16| +1.75E+02 | +1.1E+01 | -1.4E+00 | 5.0E-01 | 2.4E+01 | 9.2E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)   171| +1.38E+02 | -3.4E-06 | +1.1E+00 | 4.2E-04 | 6.3E-02 | 1.0E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    31| +1.54E+02 | -8.5E-04 | +1.1E+00 | 1.8E-01 | 3.8E-01 | 7.1E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    16| +2.14E+02 | -2.7E+00 | +7.2E-01 | 1.2E-01 | 2.9E+01 | 2.7E-01 | trr |1
2023-02-17 16:05:28 fides(INFO)    39| +1.48E+02 | -3.9E-04 | +6.1E-01 | 4.8E-03 | 5.9E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    23| +1.71E+02 | -1.4E-04 | +7.8E-01 | 5.8E-04 | 5.0E-01 | 9.7E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    33| +1.48E+02 | -4.1E-01 | +5.5E-01 | 1.2E-01 | 4.4E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    17| +1.69E+02 | -6.2E+00 | +1.0E+00 | 1.2E-01 | 2.4E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    42| +2.14E+02 | -5.0E-07 | +1.8E-01 | 1.3E-04 | 2.1E+00 | 2.4E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    17| +2.11E+02 | -2.5E+00 | +6.5E-01 | 1.2E-01 | 1.8E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   172| +1.38E+02 | -3.1E-06 | +8.8E-01 | 8.3E-04 | 6.2E-02 | 1.0E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    32| +1.54E+02 | +6.3E-04 | -7.2E-01 | 3.6E-01 | 3.1E-01 | 8.3E-02 | trr |0
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    40| +1.48E+02 | -2.2E-04 | +9.6E-01 | 4.8E-03 | 1.0E+00 | 2.4E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    24| +1.71E+02 | -7.0E-05 | +5.8E-01 | 1.2E-03 | 3.1E-01 | 3.2E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    34| +1.48E+02 | -3.8E-01 | +3.7E-01 | 1.2E-01 | 2.5E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    18| +1.60E+02 | -8.5E+00 | +8.5E-01 | 2.5E-01 | 5.6E+01 | 4.3E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    18| +2.08E+02 | -3.3E+00 | +7.6E-01 | 1.2E-01 | 2.7E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)   173| +1.38E+02 | -3.5E-06 | +5.5E-01 | 1.7E-03 | 6.6E-02 | 1.9E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    41| +1.48E+02 | -3.0E-04 | +7.9E-01 | 9.5E-03 | 2.6E-01 | 5.0E-03 |  2d |1
2023-02-17 16:05:28 fides(INFO)    33| +1.54E+02 | -3.0E-04 | +8.0E-01 | 6.8E-02 | 3.1E-01 | 2.0E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    43| +2.14E+02 | -9.1E-07 | +8.2E-01 | 3.2E-05 | 2.1E+00 | 7.5E-05 |  2d |1
2023-02-17 16:05:28 fides(WARNING) Stopping as function difference 9.13E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:28 fides(INFO)    25| +1.71E+02 | -1.7E-06 | +5.8E-02 | 1.2E-03 | 1.4E-01 | 1.7E-03 | trr |1
2023-02-17 16:05:28 fides(INFO)    35| +1.48E+02 | +7.8E-02 | -1.1E-01 | 1.2E-01 | 1.2E+01 | 1.9E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    19| +2.07E+02 | -5.6E-01 | +4.8E-02 | 2.5E-01 | 1.8E+01 | 6.8E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    19| +1.55E+02 | -4.8E+00 | +7.9E-01 | 5.0E-01 | 7.0E+01 | 1.1E+00 | trr |1
2023-02-17 16:05:28 fides(INFO)   174| +1.38E+02 | -8.5E-06 | +1.4E+00 | 1.7E-03 | 6.0E-02 | 1.9E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    42| +1.48E+02 | -9.6E-05 | +1.7E-01 | 1.9E-02 | 6.1E-01 | 1.5E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    20| +2.03E+02 | -4.2E+00 | +8.2E-01 | 6.2E-02 | 5.4E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:28 fides(INFO)    26| +1.71E+02 | -8.6E-06 | +6.6E-01 | 1.6E-04 | 1.2E-01 | 2.8E-04 |  2d |1
2023-02-17 16:05:28 fides(INFO)    36| +1.48E+02 | -2.3E-01 | +7.6E-01 | 3.1E-02 | 1.2E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)    34| +1.54E+02 | -4.5E-04 | +9.8E-01 | 1.4E-01 | 1.6E-01 | 3.5E-02 |  2d |1
2023-02-17 16:05:28 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:28 fides(INFO)    20| +1.55E+02 | +9.5E+01 | -1.1E+01 | 5.0E-01 | 1.0E+02 | 8.3E-01 |  2d |0
2023-02-17 16:05:28 fides(INFO)    43| +1.48E+02 | +8.2E-05 | -1.4E-01 | 4.8E-03 | 3.2E-01 | 3.7E-03 |  2d |0
2023-02-17 16:05:28 fides(INFO)    21| +2.01E+02 | -2.5E+00 | +8.8E-01 | 1.2E-01 | 2.0E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    37| +1.48E+02 | -7.8E-02 | +3.5E-01 | 6.2E-02 | 8.4E+00 | 8.2E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)   175| +1.38E+02 | -1.2E-05 | +9.7E-01 | 3.3E-03 | 6.1E-02 | 3.7E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    35| +1.54E+02 | +2.2E-03 | -2.9E+00 | 2.7E-01 | 1.7E-01 | 4.6E-02 | trr |0
2023-02-17 16:05:29 fides(INFO)    21| +1.50E+02 | -5.4E+00 | +7.7E-01 | 1.2E-01 | 1.0E+02 | 2.1E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    27| +1.71E+02 | -3.9E-06 | +7.3E-01 | 1.6E-04 | 8.2E-02 | 4.3E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    22| +1.91E+02 | -9.1E+00 | +1.5E+00 | 2.5E-01 | 1.5E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    44| +1.48E+02 | -7.1E-05 | +1.9E-01 | 1.2E-03 | 3.2E-01 | 2.1E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    38| +1.48E+02 | -3.2E-02 | +7.9E-01 | 6.2E-02 | 8.4E+00 | 4.3E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    36| +1.54E+02 | -1.8E-04 | +5.5E-01 | 4.0E-02 | 1.7E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    22| +1.48E+02 | -1.6E+00 | +9.7E-01 | 2.3E-01 | 6.7E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)   176| +1.38E+02 | -2.4E-05 | +9.9E-01 | 6.7E-03 | 6.0E-02 | 7.3E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    28| +1.71E+02 | +3.9E-07 | -4.3E+00 | 1.6E-04 | 1.2E-02 | 8.0E-05 | trr |0
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)     0| +6.60E+09 |    NaN   |    NaN   | 1.0E+00 | 3.1E+10 |   NaN   | NaN |1
2023-02-17 16:05:29 fides(INFO)    45| +1.48E+02 | -2.1E-04 | +9.7E-01 | 3.0E-04 | 1.4E+00 | 3.5E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    23| +1.83E+02 | -9.0E+00 | +3.6E-01 | 5.0E-01 | 4.0E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    39| +1.48E+02 | -3.0E-02 | +8.4E-01 | 1.2E-01 | 3.2E+00 | 8.6E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    23| +1.48E+02 | +4.3E+00 | -2.3E+00 | 4.7E-01 | 2.0E+01 | 5.9E-01 |  2d |0
2023-02-17 16:05:29 fides(INFO)   177| +1.38E+02 | -4.6E-05 | +1.0E+00 | 1.3E-02 | 5.9E-02 | 1.4E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    46| +1.48E+02 | -8.0E-06 | +8.6E-01 | 6.0E-04 | 1.0E-01 | 3.1E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    37| +1.54E+02 | -1.1E-04 | +7.1E-01 | 4.0E-02 | 2.1E-01 | 7.8E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    29| +1.71E+02 | -8.7E-07 | +1.4E+01 | 7.2E-06 | 1.2E-02 | 2.0E-05 |  2d |1
2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 8.74E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    40| +1.48E+02 | -1.8E-02 | +9.1E-01 | 2.5E-01 | 7.6E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)     1| +1.51E+04 | -6.6E+09 | +9.3E-02 | 1.0E+00 | 3.1E+10 | 2.8E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    24| +1.68E+02 | -1.5E+01 | +4.4E-01 | 5.0E-01 | 1.5E+02 | 7.1E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    24| +1.48E+02 | -2.4E-01 | +1.5E-01 | 1.2E-01 | 2.0E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    47| +1.48E+02 | -1.1E-05 | +9.5E-01 | 1.2E-03 | 1.2E-01 | 5.8E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    38| +1.54E+02 | -1.7E-04 | +1.0E+00 | 4.0E-02 | 7.8E-02 | 7.6E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    41| +1.48E+02 | +3.3E-02 | -4.0E+00 | 5.0E-01 | 1.2E+00 | 2.3E-01 | trr |0
2023-02-17 16:05:29 fides(INFO)   178| +1.38E+02 | -8.5E-05 | +9.6E-01 | 2.7E-02 | 6.0E-02 | 2.7E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    25| +1.53E+02 | -1.4E+01 | +9.8E-01 | 5.0E-01 | 2.3E+02 | 1.4E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    25| +1.48E+02 | -5.3E-01 | +9.5E-01 | 2.9E-02 | 7.0E+01 | 3.5E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     2| +2.53E+03 | -1.3E+04 | +9.0E-01 | 2.5E-01 | 6.9E+04 | 6.3E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    48| +1.48E+02 | -1.8E-05 | +9.1E-01 | 2.4E-03 | 5.7E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    42| +1.48E+02 | -1.2E-03 | +3.0E-01 | 1.1E-01 | 1.2E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    39| +1.54E+02 | +1.2E-04 | -6.4E-01 | 7.9E-02 | 2.0E-01 | 1.5E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)   179| +1.38E+02 | +1.3E-03 | -6.4E+00 | 5.3E-02 | 6.0E-02 | 7.7E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    26| +1.53E+02 | +3.2E+02 | -3.1E+01 | 1.0E+00 | 6.2E+01 | 1.5E+00 |  2d |0
2023-02-17 16:05:29 fides(INFO)    26| +1.48E+02 | -3.4E-02 | +5.9E-01 | 5.9E-02 | 5.9E+00 | 6.7E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    49| +1.48E+02 | -3.0E-05 | +1.0E+00 | 4.8E-03 | 1.1E-01 | 2.0E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    43| +1.48E+02 | +9.5E-03 | -8.5E-01 | 1.1E-01 | 1.2E+00 | 5.1E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)     3| +6.21E+02 | -1.9E+03 | +8.4E-01 | 5.0E-01 | 1.1E+04 | 1.3E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    40| +1.54E+02 | -5.4E-05 | +7.3E-01 | 2.0E-02 | 2.0E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    27| +1.52E+02 | -1.1E+00 | +8.3E-02 | 2.5E-01 | 6.2E+01 | 3.9E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    27| +1.48E+02 | -2.3E-02 | +9.6E-01 | 5.9E-02 | 1.1E+01 | 6.0E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)   180| +1.38E+02 | +3.9E-05 | -6.4E-01 | 1.3E-02 | 6.0E-02 | 2.0E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    50| +1.48E+02 | -4.5E-05 | +9.5E-01 | 9.5E-03 | 5.2E-02 | 3.2E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    44| +1.48E+02 | -2.0E-03 | +5.8E-01 | 2.7E-02 | 1.2E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     4| +2.36E+02 | -3.8E+02 | +9.2E-01 | 1.0E+00 | 1.8E+03 | 1.6E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)     0| +5.61E+08 |    NaN   |    NaN   | 1.0E+00 | 2.6E+09 |   NaN   | NaN |1
2023-02-17 16:05:29 fides(INFO)    28| +1.50E+02 | -2.1E+00 | +9.6E-01 | 6.2E-02 | 1.1E+02 | 5.4E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    28| +1.48E+02 | -1.8E-02 | +9.0E-01 | 1.2E-01 | 3.7E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    51| +1.48E+02 | -5.8E-05 | +8.2E-01 | 1.9E-02 | 1.5E-01 | 6.8E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    41| +1.54E+02 | -3.1E-05 | +9.9E-01 | 2.0E-02 | 1.2E-01 | 2.1E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    45| +1.48E+02 | -4.5E-04 | +9.8E-01 | 2.7E-02 | 1.0E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)   181| +1.38E+02 | -7.5E-06 | +4.3E-01 | 3.3E-03 | 6.0E-02 | 5.3E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    29| +1.49E+02 | -1.3E+00 | +6.3E-01 | 1.2E-01 | 5.7E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    29| +1.48E+02 | -8.7E-03 | +3.6E-01 | 2.3E-01 | 6.4E+00 | 2.2E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    42| +1.54E+02 | -4.7E-05 | +1.1E+00 | 4.0E-02 | 7.7E-02 | 3.6E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)     5| +1.91E+02 | -4.6E+01 | +9.0E-01 | 1.0E+00 | 2.2E+02 | 2.4E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    52| +1.48E+02 | +2.7E-04 | -2.1E+00 | 3.8E-02 | 7.7E-02 | 4.2E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    46| +1.48E+02 | -5.9E-04 | +9.7E-01 | 5.4E-02 | 5.5E-01 | 2.1E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)   182| +1.38E+02 | -1.4E-05 | +7.1E-01 | 3.3E-03 | 1.1E-01 | 5.2E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    30| +1.48E+02 | -7.0E-01 | +9.6E-01 | 1.2E-01 | 6.6E+01 | 8.7E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     1| +3.31E+06 | -5.6E+08 | +9.3E-02 | 1.0E+00 | 2.6E+09 | 2.8E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    30| +1.48E+02 | +1.2E-01 | -1.8E+00 | 2.3E-01 | 2.7E+00 | 2.0E-01 |  2d |0
2023-02-17 16:05:29 fides(INFO)     6| +1.91E+02 | +2.4E+03 | -1.7E+02 | 2.0E+00 | 8.4E+01 | 2.3E+00 |  2d |0
2023-02-17 16:05:29 fides(INFO)    53| +1.48E+02 | -1.1E-05 | +2.4E-01 | 9.5E-03 | 7.7E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    47| +1.48E+02 | -7.4E-04 | +9.4E-01 | 1.1E-01 | 6.0E-01 | 3.7E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    43| +1.54E+02 | -2.6E-05 | +6.6E-01 | 7.9E-02 | 3.3E-02 | 5.6E-03 | trr |1
2023-02-17 16:05:29 fides(INFO)    31| +1.48E+02 | -2.1E-01 | +6.2E-01 | 2.5E-01 | 2.2E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)   183| +1.38E+02 | -9.0E-06 | +5.6E-01 | 3.3E-03 | 6.0E-02 | 4.8E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    31| +1.48E+02 | +2.1E-02 | -5.5E-01 | 5.9E-02 | 2.7E+00 | 5.7E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)    54| +1.48E+02 | -2.1E-05 | +8.9E-01 | 2.4E-03 | 1.9E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)     7| +1.82E+02 | -8.3E+00 | +4.1E-01 | 3.4E-01 | 8.4E+01 | 5.7E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    48| +1.48E+02 | +2.9E-03 | -3.3E+00 | 2.2E-01 | 3.3E-01 | 7.3E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)    44| +1.54E+02 | +7.6E-04 | -3.9E+00 | 7.9E-02 | 4.7E-02 | 2.2E-02 | trr |0
2023-02-17 16:05:29 fides(INFO)    32| +1.48E+02 | +9.3E-01 | -1.5E+00 | 2.5E-01 | 1.4E+01 | 3.5E-01 |  2d |0
2023-02-17 16:05:29 fides(INFO)     2| +5.08E+05 | -2.8E+06 | +8.9E-01 | 2.5E-01 | 1.5E+07 | 6.8E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    32| +1.48E+02 | +5.0E-03 | -1.8E-01 | 1.5E-02 | 2.7E+00 | 2.6E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)    55| +1.48E+02 | -5.0E-06 | +4.1E-01 | 4.8E-03 | 3.3E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)   184| +1.38E+02 | -1.1E-05 | +7.4E-01 | 3.3E-03 | 6.7E-02 | 4.5E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    49| +1.48E+02 | -9.9E-05 | +2.9E-01 | 5.4E-02 | 3.3E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    45| +1.54E+02 | -2.4E-05 | +2.8E-01 | 2.6E-03 | 4.7E-02 | 5.4E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)     8| +1.76E+02 | -6.8E+00 | +9.1E-01 | 3.4E-01 | 1.4E+02 | 6.9E-01 | trr |1
2023-02-17 16:05:29 fides(INFO)    33| +1.48E+02 | -9.9E-02 | +5.2E-01 | 6.2E-02 | 1.4E+01 | 8.7E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    56| +1.48E+02 | -8.0E-06 | +1.0E+00 | 4.8E-03 | 2.4E-02 | 9.2E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    50| +1.48E+02 | +6.2E-04 | -6.9E-01 | 5.4E-02 | 3.7E-01 | 1.5E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)    33| +1.48E+02 | -1.1E-02 | +7.8E-01 | 3.7E-03 | 2.7E+00 | 7.6E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)   185| +1.38E+02 | -1.0E-05 | +7.5E-01 | 3.3E-03 | 5.9E-02 | 4.3E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    46| +1.54E+02 | +7.5E-06 | -1.5E-01 | 2.6E-03 | 3.9E-02 | 5.2E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    34| +1.48E+02 | -2.1E-02 | +9.4E-01 | 6.2E-02 | 6.9E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    51| +1.48E+02 | -1.5E-04 | +5.0E-01 | 1.3E-02 | 3.7E-01 | 3.9E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    57| +1.48E+02 | -5.0E-06 | +2.9E-01 | 9.5E-03 | 1.2E-01 | 2.9E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    34| +1.48E+02 | -1.4E-03 | +9.6E-01 | 7.3E-03 | 2.8E+00 | 6.0E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)     9| +1.74E+02 | -1.6E+00 | +7.8E-01 | 3.4E-01 | 5.5E+01 | 8.6E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)     3| +7.83E+04 | -4.3E+05 | +9.0E-01 | 5.0E-01 | 2.4E+06 | 1.4E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)   186| +1.38E+02 | -1.1E-05 | +3.9E-01 | 6.7E-03 | 6.3E-02 | 8.3E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    35| +1.48E+02 | -8.4E-03 | +5.5E-01 | 1.2E-01 | 6.1E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    47| +1.54E+02 | -1.1E-05 | +7.6E-01 | 6.5E-04 | 3.9E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    35| +1.48E+02 | -2.5E-03 | +6.0E-01 | 1.5E-02 | 1.2E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:29.462 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.596 and h = 3.12958e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.463 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.596: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)    52| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.3E-02 | 6.4E-01 | 3.5E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    58| +1.48E+02 | +1.8E-04 | -3.9E+00 | 9.5E-03 | 4.7E-02 | 2.1E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    10| +1.73E+02 | -7.7E-01 | +9.5E-01 | 6.9E-01 | 4.2E+01 | 1.9E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)   187| +1.38E+02 | +5.3E-05 | -6.2E-01 | 6.7E-03 | 7.1E-02 | 1.9E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    36| +1.48E+02 | -2.4E-03 | +9.5E-01 | 1.5E-02 | 4.4E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    36| +1.48E+02 | +6.4E-02 | -1.6E+00 | 1.2E-01 | 2.7E+00 | 1.4E-01 |  2d |0
2023-02-17 16:05:29 fides(INFO)    48| +1.54E+02 | -5.0E-06 | +4.5E-01 | 1.3E-03 | 3.3E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    59| +1.48E+02 | +1.4E-04 | -3.5E+00 | 2.4E-03 | 4.7E-02 | 1.7E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    53| +1.48E+02 | -5.8E-05 | +1.0E+00 | 3.4E-03 | 6.4E-01 | 9.0E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)     4| +1.05E+04 | -6.8E+04 | +9.2E-01 | 1.0E+00 | 3.6E+05 | 1.1E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    11| +1.73E+02 | +1.0E+00 | -1.1E+01 | 1.4E+00 | 3.5E+01 | 4.2E+00 | trr |0
2023-02-17 16:05:29 fides(INFO)    37| +1.48E+02 | -9.3E-04 | +9.9E-01 | 2.9E-02 | 5.3E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    37| +1.48E+02 | -2.3E-03 | +1.3E-01 | 3.1E-02 | 2.7E+00 | 3.5E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)   188| +1.38E+02 | -1.2E-05 | +5.2E-01 | 1.7E-03 | 7.1E-02 | 4.9E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    60| +1.48E+02 | +7.4E-05 | -2.1E+00 | 6.0E-04 | 4.7E-02 | 1.4E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    49| +1.54E+02 | -3.5E-06 | +2.4E-01 | 1.3E-03 | 1.9E-02 | 2.4E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    54| +1.48E+02 | -6.1E-05 | +8.6E-01 | 6.7E-03 | 1.6E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    38| +1.48E+02 | -1.1E-03 | +8.8E-01 | 5.9E-02 | 1.4E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    12| +1.73E+02 | -3.5E-01 | +8.9E-01 | 3.4E-01 | 3.5E+01 | 3.5E-01 | trr |1
2023-02-17 16:05:29 fides(INFO)    38| +1.48E+02 | -5.6E-03 | +8.4E-01 | 7.8E-03 | 5.9E+00 | 1.0E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    61| +1.48E+02 | -9.7E-06 | +7.4E-01 | 1.5E-04 | 4.7E-02 | 3.4E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    55| +1.48E+02 | -3.7E-05 | +1.0E+00 | 1.3E-02 | 3.6E-01 | 3.4E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    50| +1.54E+02 | -3.9E-06 | +8.2E-01 | 3.2E-04 | 3.4E-02 | 6.5E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)   189| +1.38E+02 | -6.8E-06 | +1.4E+00 | 1.7E-03 | 1.0E-01 | 1.4E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)     5| +1.58E+03 | -8.9E+03 | +9.1E-01 | 1.0E+00 | 5.1E+04 | 9.4E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    39| +1.48E+02 | -1.4E-03 | +7.7E-01 | 1.2E-01 | 3.9E-01 | 8.9E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    62| +1.48E+02 | -1.4E-06 | +2.5E+00 | 1.5E-04 | 4.0E-02 | 4.1E-05 |  2d |1
2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 1.39E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:29 fides(INFO)    39| +1.48E+02 | -6.2E-04 | +5.2E-01 | 1.6E-02 | 9.1E-01 | 7.7E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    13| +1.72E+02 | -5.0E-01 | +9.4E-01 | 3.4E-01 | 3.3E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    56| +1.48E+02 | -3.2E-05 | +8.2E-01 | 2.7E-02 | 8.1E-02 | 6.2E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    51| +1.54E+02 | -2.7E-06 | +5.6E-01 | 6.5E-04 | 1.7E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)   190| +1.38E+02 | -8.2E-06 | +9.3E-01 | 3.3E-03 | 5.6E-02 | 2.7E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    40| +1.48E+02 | +4.2E-03 | -8.8E-01 | 2.3E-01 | 1.3E+00 | 1.7E-01 |  2d |0
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    40| +1.48E+02 | -2.9E-04 | +8.9E-01 | 1.6E-02 | 1.1E+00 | 5.5E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    57| +1.48E+02 | -2.9E-06 | +4.1E-02 | 5.4E-02 | 2.0E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     6| +3.68E+02 | -1.2E+03 | +9.1E-01 | 1.0E+00 | 7.7E+03 | 8.1E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    14| +1.72E+02 | -5.4E-01 | +8.9E-01 | 6.9E-01 | 2.5E+01 | 2.3E-01 | trr |1
2023-02-17 16:05:29.645 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2931 and h = 1.46524e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.646 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2931: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)   191| +1.38E+02 | -1.7E-05 | +9.7E-01 | 6.7E-03 | 5.7E-02 | 5.4E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    41| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.1E-02 | 5.5E-01 | 6.7E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    41| +1.48E+02 | -9.1E-04 | +5.9E-01 | 5.9E-02 | 1.3E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    52| +1.54E+02 | -3.4E-06 | +7.2E-01 | 6.5E-04 | 1.3E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    58| +1.48E+02 | +1.1E-04 | -6.7E-01 | 1.3E-02 | 1.3E-01 | 3.6E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    42| +1.48E+02 | -2.0E-04 | +9.3E-01 | 7.8E-03 | 5.5E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    42| +1.48E+02 | -4.5E-04 | +7.8E-01 | 5.9E-02 | 3.3E-01 | 3.9E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    15| +1.71E+02 | -4.7E-01 | +6.5E-01 | 6.9E-01 | 3.4E+01 | 4.7E-01 | trr |1
2023-02-17 16:05:29 fides(INFO)   192| +1.38E+02 | -3.2E-05 | +9.5E-01 | 1.3E-02 | 5.6E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    53| +1.54E+02 | -1.3E-06 | +3.1E-01 | 6.5E-04 | 3.5E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    59| +1.48E+02 | +3.1E-05 | -3.2E-01 | 3.4E-03 | 1.3E-01 | 1.6E-03 |  2d |0
2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 1.26E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:29 fides(INFO)     7| +1.81E+02 | -1.9E+02 | +1.1E+00 | 1.0E+00 | 1.1E+03 | 9.8E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)     0| +4.31E+02 |    NaN   |    NaN   | 1.0E+00 | 6.4E+01 |   NaN   | NaN |1
2023-02-17 16:05:29 fides(INFO)    43| +1.48E+02 | -6.0E-04 | +7.4E-01 | 1.2E-01 | 5.4E-01 | 7.6E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    16| +1.71E+02 | -8.5E-02 | +3.1E-01 | 6.9E-01 | 2.2E+01 | 1.6E-01 | trr |1
2023-02-17 16:05:29 fides(INFO)    43| +1.48E+02 | -1.5E-04 | +9.8E-01 | 1.6E-02 | 9.1E-01 | 3.3E-03 |  2d |1
2023-02-17 16:05:29.722 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.674 and h = 2.5308e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.722 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.674: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    60| +1.48E+02 | +0.0E+00 | +0.0E+00 | 8.4E-04 | 1.3E-01 | 1.3E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)   193| +1.38E+02 | -5.4E-05 | +8.1E-01 | 2.7E-02 | 5.6E-02 | 2.0E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)     1| +2.68E+02 | -1.6E+02 | +8.8E-01 | 1.0E+00 | 6.4E+01 | 2.9E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    44| +1.48E+02 | +1.2E-04 | -1.3E-01 | 1.2E-01 | 2.9E-01 | 6.7E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)    44| +1.48E+02 | -9.5E-05 | +9.2E-01 | 3.1E-02 | 3.0E-01 | 6.9E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    61| +1.48E+02 | -3.1E-05 | +6.7E-01 | 2.1E-04 | 1.3E-01 | 4.5E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)     2| +2.68E+02 | +6.4E+00 | -4.0E-01 | 2.0E+00 | 6.9E+01 | 5.3E+00 |  2d |0
2023-02-17 16:05:29 fides(INFO)    17| +1.71E+02 | -6.9E-03 | +3.4E-02 | 6.9E-01 | 8.4E+00 | 2.1E-01 | trr |1
2023-02-17 16:05:29 fides(INFO)   194| +1.38E+02 | +1.7E-02 | -2.5E+01 | 5.3E-02 | 7.3E-02 | 2.0E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)    45| +1.48E+02 | -1.5E-04 | +4.0E-01 | 2.9E-02 | 2.9E-01 | 1.7E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     3| +2.56E+02 | -1.2E+01 | +3.6E-01 | 5.0E-01 | 6.9E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    45| +1.48E+02 | -4.2E-05 | +4.1E-01 | 6.2E-02 | 3.9E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    62| +1.48E+02 | -7.6E-06 | +1.0E+00 | 2.1E-04 | 2.4E-01 | 7.2E-05 |  2d |1
2023-02-17 16:05:29 fides(INFO)    18| +1.71E+02 | -6.8E-02 | +6.9E-01 | 5.3E-02 | 1.1E+01 | 8.4E-02 |  2d |1
2023-02-17 16:05:29.791 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.178 and h = 3.56278e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.792 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.178: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)    46| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.9E-02 | 1.0E+00 | 1.7E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)     4| +2.56E+02 | -7.5E-01 | -8.6E-03 | 5.0E-01 | 5.0E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:29 fides(INFO)   195| +1.38E+02 | +9.0E-04 | -3.9E+00 | 1.3E-02 | 7.3E-02 | 5.1E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)    63| +1.48E+02 | -1.3E-06 | +7.7E-02 | 4.2E-04 | 6.3E-02 | 5.6E-04 |  2d |1
2023-02-17 16:05:29.809 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.2503 and h = 4.35246e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.810 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.2503: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)    46| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 1.7E-01 | 2.7E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)     0| +1.96E+13 |    NaN   |    NaN   | 1.0E+00 | 9.0E+13 |   NaN   | NaN |1
2023-02-17 16:05:29 fides(INFO)    19| +1.71E+02 | -6.8E-03 | +8.7E-01 | 5.3E-02 | 4.4E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     5| +2.50E+02 | -6.6E+00 | +7.1E-01 | 1.2E-01 | 5.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    47| +1.48E+02 | -1.6E-04 | +9.5E-01 | 7.3E-03 | 1.0E+00 | 4.2E-03 |  2d |1
2023-02-17 16:05:29.840 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.3921 and h = 2.28356e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.840 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.3921: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)    47| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 1.7E-01 | 7.1E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)   196| +1.38E+02 | +1.2E-05 | -2.0E-01 | 3.3E-03 | 7.3E-02 | 1.3E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)     1| +6.60E+10 | -2.0E+13 | +8.5E-02 | 1.0E+00 | 9.0E+13 | 3.1E+00 |  2d |1
2023-02-17 16:05:29 fides(INFO)    64| +1.48E+02 | -1.3E-05 | +8.6E-01 | 1.1E-04 | 3.5E-01 | 8.5E-05 |  2d |1
2023-02-17 16:05:29 fides(INFO)     6| +2.50E+02 | +9.0E-03 | -1.0E-01 | 1.2E-01 | 3.9E+00 | 3.1E-01 |  2d |0
2023-02-17 16:05:29 fides(INFO)    48| +1.48E+02 | -6.7E-05 | +9.9E-01 | 1.5E-02 | 8.9E-02 | 8.3E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    20| +1.71E+02 | -7.8E-05 | +1.6E-01 | 1.1E-01 | 3.3E-01 | 2.2E-02 | trr |1
2023-02-17 16:05:29 fides(INFO)    48| +1.48E+02 | +7.9E-05 | -5.5E-01 | 3.9E-03 | 1.7E-01 | 2.5E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)   197| +1.38E+02 | -1.0E-05 | +6.2E-01 | 8.3E-04 | 7.3E-02 | 3.5E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)     8| +1.81E+02 | +1.4E+03 | -5.6E+01 | 1.0E+00 | 6.2E+01 | 2.3E+00 |  2d |0
2023-02-17 16:05:29 fides(INFO)    65| +1.48E+02 | +6.1E-07 | -2.6E+00 | 2.1E-04 | 2.3E-02 | 4.3E-05 |  2d |0
2023-02-17 16:05:29 fides(INFO)     7| +2.50E+02 | +9.1E-03 | -1.1E-01 | 3.1E-02 | 3.9E+00 | 7.9E-02 |  2d |0
2023-02-17 16:05:29 fides(INFO)     2| +9.84E+09 | -5.6E+10 | +8.9E-01 | 2.5E-01 | 3.0E+11 | 6.9E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    49| +1.48E+02 | -1.0E-04 | +9.3E-01 | 2.9E-02 | 1.1E-01 | 1.6E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)    49| +1.48E+02 | +3.9E-05 | -3.4E-01 | 9.8E-04 | 1.7E-01 | 1.6E-03 |  2d |0
2023-02-17 16:05:29 fides(INFO)     8| +2.50E+02 | -4.4E-02 | +7.3E-01 | 7.8E-03 | 3.9E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:29.904 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.594 and h = 2.06348e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.904 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.594: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)    66| +1.48E+02 | +0.0E+00 | +0.0E+00 | 5.3E-05 | 2.3E-02 | 1.4E-05 |  2d |0
2023-02-17 16:05:29 fides(INFO)   198| +1.38E+02 | -3.1E-06 | +8.4E-01 | 8.3E-04 | 1.1E-01 | 1.1E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    21| +1.71E+02 | -7.4E-06 | +1.8E-02 | 7.8E-03 | 2.4E-01 | 1.5E-02 | trr |1
2023-02-17 16:05:29 fides(INFO)     3| +1.47E+09 | -8.4E+09 | +8.9E-01 | 5.0E-01 | 4.5E+10 | 7.7E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    50| +1.48E+02 | -1.7E-04 | +9.9E-01 | 5.9E-02 | 1.1E-01 | 3.1E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     9| +2.50E+02 | -1.5E-05 | +2.5E-03 | 7.8E-03 | 8.8E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    50| +1.48E+02 | -4.0E-05 | +7.2E-01 | 2.4E-04 | 1.7E-01 | 5.0E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    67| +1.48E+02 | -8.0E-07 | +7.1E+00 | 1.3E-05 | 2.3E-02 | 9.6E-06 |  2d |1
2023-02-17 16:05:29 fides(WARNING) Stopping as function difference 7.96E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:29.943 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 142.796 and h = 9.16043e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:29.943 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 142.796: AMICI failed to integrate the forward problem
2023-02-17 16:05:29 fides(INFO)     9| +1.81E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 6.2E+01 | 5.9E-01 |  2d |0
2023-02-17 16:05:29 fides(INFO)   199| +1.38E+02 | -3.5E-06 | +9.6E-01 | 1.7E-03 | 5.6E-02 | 1.2E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    22| +1.71E+02 | -1.0E-04 | +8.5E-01 | 1.4E-03 | 2.6E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)    10| +2.50E+02 | -2.0E-03 | +7.4E-01 | 2.0E-03 | 8.8E-01 | 4.0E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)    51| +1.48E+02 | -2.4E-04 | +9.6E-01 | 1.2E-01 | 1.6E-01 | 5.9E-02 |  2d |1
2023-02-17 16:05:29 fides(INFO)     4| +2.21E+08 | -1.3E+09 | +8.9E-01 | 5.0E-01 | 6.8E+09 | 8.1E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    51| +1.48E+02 | -3.7E-06 | +1.4E+00 | 2.4E-04 | 1.2E-01 | 7.4E-05 |  2d |1
2023-02-17 16:05:29 fides(INFO)    11| +2.50E+02 | -4.5E-06 | +7.9E-03 | 2.0E-03 | 3.0E-01 | 3.6E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:29 fides(INFO)   200| +1.38E+02 | -6.0E-06 | +8.9E-01 | 3.3E-03 | 5.7E-02 | 2.1E-04 |  2d |1
2023-02-17 16:05:29 fides(INFO)    23| +1.71E+02 | -8.5E-05 | +7.9E-01 | 2.8E-03 | 2.5E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:29 fides(INFO)     5| +3.34E+07 | -1.9E+08 | +8.9E-01 | 5.0E-01 | 1.0E+09 | 8.0E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    52| +1.48E+02 | -1.7E-04 | +6.7E-01 | 2.3E-01 | 1.1E-01 | 1.0E-01 |  2d |1
2023-02-17 16:05:29 fides(INFO)    52| +1.48E+02 | -4.6E-06 | +7.7E-01 | 4.9E-04 | 5.9E-02 | 2.5E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +2.50E+02 | -2.4E-04 | +7.8E-01 | 4.9E-04 | 3.0E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:30 fides(INFO)    53| +1.48E+02 | +6.6E-03 | -7.8E+00 | 2.3E-01 | 1.1E-01 | 8.2E-02 |  2d |0
2023-02-17 16:05:30 fides(INFO)   201| +1.38E+02 | -1.2E-05 | +9.3E-01 | 6.7E-03 | 5.6E-02 | 4.4E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    53| +1.48E+02 | -3.2E-06 | +7.1E-01 | 9.8E-04 | 1.7E-01 | 2.1E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)     6| +5.07E+06 | -2.8E+07 | +8.9E-01 | 5.0E-01 | 1.5E+08 | 8.0E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    13| +2.50E+02 | +7.8E-08 | -1.9E-03 | 9.8E-04 | 8.6E-02 | 2.5E-03 |  2d |0
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +1.74E+02 | -6.7E+00 | +1.0E+00 | 6.2E-02 | 6.2E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    24| +1.71E+02 | +2.2E-07 | -2.3E-02 | 5.6E-03 | 5.8E-02 | 2.9E-03 | trr |0
2023-02-17 16:05:30 fides(INFO)    54| +1.48E+02 | +1.6E-04 | -5.2E-01 | 5.9E-02 | 1.1E-01 | 2.0E-02 |  2d |0
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)     0| +2.28E+12 |    NaN   |    NaN   | 1.0E+00 | 1.0E+13 |   NaN   | NaN |1
2023-02-17 16:05:30 fides(INFO)    14| +2.50E+02 | -2.0E-05 | +5.5E-01 | 2.4E-04 | 8.6E-02 | 6.3E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    54| +1.48E+02 | -1.5E-06 | +3.4E-01 | 9.8E-04 | 2.9E-02 | 4.2E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)     7| +7.72E+05 | -4.3E+06 | +8.9E-01 | 5.0E-01 | 2.3E+07 | 7.9E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)   202| +1.38E+02 | +8.6E-05 | -2.1E+00 | 1.3E-02 | 5.8E-02 | 1.9E-03 |  2d |0
2023-02-17 16:05:30 fides(INFO)    25| +1.71E+02 | -2.5E-06 | +5.2E-01 | 5.4E-04 | 5.8E-02 | 7.3E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    55| +1.48E+02 | -5.5E-05 | +6.3E-01 | 1.5E-02 | 1.1E-01 | 5.1E-03 |  2d |1
2023-02-17 16:05:30 fides(INFO)    15| +2.50E+02 | -1.5E-09 | +5.4E-04 | 2.4E-04 | 2.1E-02 | 5.7E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)     1| +1.65E+06 | -2.3E+12 | +8.4E-02 | 1.0E+00 | 1.0E+13 | 3.1E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    55| +1.48E+02 | -2.0E-06 | +2.7E+00 | 9.8E-04 | 1.6E-02 | 1.7E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)     8| +1.17E+05 | -6.5E+05 | +9.0E-01 | 5.0E-01 | 3.5E+06 | 7.8E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)   203| +1.38E+02 | -3.9E-07 | +2.2E-02 | 3.3E-03 | 5.8E-02 | 5.5E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    26| +1.71E+02 | -1.8E-06 | +1.2E+00 | 5.4E-04 | 2.4E-02 | 7.2E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    16| +2.50E+02 | -1.2E-06 | +5.3E-01 | 6.1E-05 | 2.1E-02 | 1.6E-04 |  2d |1
2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 1.18E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:30 fides(INFO)    56| +1.48E+02 | -9.7E-06 | +9.7E-01 | 1.5E-02 | 1.6E-01 | 4.4E-03 |  2d |1
2023-02-17 16:05:30 fides(INFO)     2| +2.54E+05 | -1.4E+06 | +8.9E-01 | 2.5E-01 | 7.6E+06 | 6.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    56| +1.48E+02 | -1.7E-06 | +1.4E+00 | 2.0E-03 | 3.8E-02 | 3.2E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    11| +1.64E+02 | -1.1E+01 | +1.0E+00 | 1.2E-01 | 7.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     9| +1.73E+04 | -1.0E+05 | +9.0E-01 | 5.0E-01 | 5.4E+05 | 7.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     3| +4.01E+04 | -2.1E+05 | +9.0E-01 | 5.0E-01 | 1.2E+06 | 1.3E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)   204| +1.38E+02 | -8.3E-06 | +7.3E-01 | 8.3E-04 | 1.1E-01 | 2.8E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    57| +1.48E+02 | -7.1E-06 | +8.7E-01 | 2.9E-02 | 2.3E-02 | 8.4E-03 |  2d |1
2023-02-17 16:05:30 fides(INFO)    57| +1.48E+02 | +1.9E-06 | -1.0E+00 | 3.9E-03 | 1.5E-02 | 6.1E-04 |  2d |0
2023-02-17 16:05:30 fides(INFO)    27| +1.71E+02 | -1.8E-07 | +2.2E+00 | 1.1E-03 | 7.0E-03 | 1.4E-04 | trr |1
2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 1.82E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:30 fides(INFO)    58| +1.48E+02 | -1.0E-05 | +8.7E-01 | 5.9E-02 | 5.2E-02 | 1.6E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)     4| +6.41E+03 | -3.4E+04 | +9.0E-01 | 1.0E+00 | 1.8E+05 | 1.2E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +2.55E+03 | -1.5E+04 | +9.1E-01 | 5.0E-01 | 7.9E+04 | 6.3E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    58| +1.48E+02 | -6.8E-07 | +1.3E+00 | 9.8E-04 | 1.5E-02 | 1.5E-04 |  2d |1
2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 6.84E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:30 fides(INFO)   205| +1.38E+02 | +2.7E-07 | -1.3E-01 | 8.3E-04 | 5.9E-02 | 9.0E-05 |  2d |0
2023-02-17 16:05:30 fides(INFO)    59| +1.48E+02 | -7.1E-07 | +4.5E-02 | 1.2E-01 | 1.8E-02 | 2.8E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)     5| +1.18E+03 | -5.2E+03 | +9.0E-01 | 1.0E+00 | 2.8E+04 | 1.4E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)     0| +1.58E+05 |    NaN   |    NaN   | 1.0E+00 | 7.3E+05 |   NaN   | NaN |1
2023-02-17 16:05:30 fides(INFO)    11| +4.97E+02 | -2.1E+03 | +9.2E-01 | 5.0E-01 | 1.1E+04 | 5.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)   206| +1.38E+02 | -4.1E-07 | +6.9E-01 | 2.1E-04 | 5.9E-02 | 2.4E-05 |  2d |1
2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 4.10E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:30 fides(INFO)     6| +3.76E+02 | -8.1E+02 | +9.0E-01 | 1.0E+00 | 4.5E+03 | 1.9E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    60| +1.48E+02 | +3.6E-05 | -6.2E-01 | 2.9E-02 | 6.8E-02 | 5.8E-03 |  2d |0
2023-02-17 16:05:30 fides(INFO)     1| +4.19E+02 | -1.6E+05 | +1.2E-01 | 1.0E+00 | 7.3E+05 | 2.3E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     7| +2.56E+02 | -1.2E+02 | +8.9E-01 | 2.0E+00 | 6.9E+02 | 2.8E+00 | trr |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)     0| +2.21E+05 |    NaN   |    NaN   | 1.0E+00 | 1.0E+06 |   NaN   | NaN |1
2023-02-17 16:05:30 fides(INFO)    61| +1.48E+02 | +2.9E-06 | -1.4E-01 | 7.3E-03 | 6.8E-02 | 1.5E-03 |  2d |0
2023-02-17 16:05:30 fides(INFO)     8| +2.27E+02 | -2.9E+01 | +1.5E+00 | 2.0E+00 | 8.4E+01 | 2.0E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +1.56E+02 | -7.7E+00 | +9.1E-01 | 2.5E-01 | 4.1E+01 | 3.7E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     2| +3.80E+02 | -3.9E+01 | +9.6E-01 | 2.5E-01 | 5.6E+01 | 7.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     1| +6.40E+02 | -2.2E+05 | +1.2E-01 | 1.0E+00 | 1.0E+06 | 2.3E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +2.28E+02 | -2.7E+02 | +9.4E-01 | 5.0E-01 | 1.7E+03 | 4.7E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    62| +1.48E+02 | -2.5E-06 | +2.5E-01 | 1.8E-03 | 6.8E-02 | 4.4E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)     0| +3.65E+13 |    NaN   |    NaN   | 1.0E+00 | 1.7E+14 |   NaN   | NaN |1
2023-02-17 16:05:30 fides(INFO)     3| +3.05E+02 | -7.6E+01 | +1.0E+00 | 5.0E-01 | 5.3E+01 | 1.5E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     2| +2.99E+02 | -3.4E+02 | +9.0E-01 | 2.5E-01 | 1.9E+03 | 6.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     9| +2.27E+02 | +1.7E+02 | -1.3E+01 | 2.0E+00 | 2.9E+01 | 5.1E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     1| +2.37E+07 | -3.7E+13 | +8.4E-02 | 1.0E+00 | 1.7E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:30.345 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.1296 and h = 1.64695e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:30.345 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.1296: AMICI failed to integrate the forward problem
2023-02-17 16:05:30 fides(INFO)    63| +1.48E+02 | +0.0E+00 | +0.0E+00 | 4.6E-04 | 2.1E-01 | 9.3E-05 |  2d |0
2023-02-17 16:05:30 fides(INFO)     2| +3.64E+06 | -2.0E+07 | +8.9E-01 | 2.5E-01 | 1.1E+08 | 7.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     3| +2.52E+02 | -4.6E+01 | +8.5E-01 | 5.0E-01 | 2.9E+02 | 1.4E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +2.27E+02 | +9.6E+00 | -1.1E+00 | 5.0E-01 | 2.9E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     4| +3.05E+02 | +1.3E+03 | -2.5E+01 | 1.0E+00 | 5.2E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    64| +1.48E+02 | -9.4E-06 | +1.7E+00 | 1.1E-04 | 2.1E-01 | 5.4E-05 |  2d |1
2023-02-17 16:05:30 fides(INFO)     3| +5.63E+05 | -3.1E+06 | +9.0E-01 | 5.0E-01 | 1.7E+07 | 1.4E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     4| +2.50E+02 | -1.8E+00 | +4.6E-01 | 1.0E+00 | 3.3E+01 | 2.3E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    13| +1.90E+02 | -3.8E+01 | +1.1E+00 | 5.0E-01 | 3.0E+02 | 6.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    11| +2.24E+02 | -3.8E+00 | +5.5E-01 | 1.2E-01 | 2.9E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     4| +8.80E+04 | -4.7E+05 | +9.0E-01 | 1.0E+00 | 2.6E+06 | 2.7E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     5| +2.71E+02 | -3.4E+01 | +9.7E-01 | 2.5E-01 | 5.2E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    65| +1.48E+02 | -1.7E-06 | +1.0E+00 | 2.3E-04 | 2.7E-02 | 1.3E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)     5| +2.49E+02 | -8.0E-01 | +3.2E-01 | 1.0E+00 | 1.2E+01 | 2.4E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +2.21E+02 | -2.6E+00 | +7.8E-01 | 1.2E-01 | 2.8E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)     0| +3.47E+09 |    NaN   |    NaN   | 1.0E+00 | 1.6E+10 |   NaN   | NaN |1
2023-02-17 16:05:30 fides(INFO)     5| +1.40E+04 | -7.4E+04 | +9.0E-01 | 2.0E+00 | 4.0E+05 | 4.4E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     6| +2.41E+03 | -1.2E+04 | +9.0E-01 | 4.0E+00 | 6.4E+04 | 1.6E+00 | trr |1
2023-02-17 16:05:30 fides(INFO)    13| +2.20E+02 | -1.0E+00 | +1.8E-01 | 2.5E-01 | 2.0E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     6| +2.71E+02 | +6.3E+01 | -2.0E+00 | 5.0E-01 | 4.7E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     6| +2.31E+02 | -1.8E+01 | +3.1E+00 | 1.0E+00 | 1.8E+01 | 2.2E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    66| +1.48E+02 | +6.5E-07 | -4.6E-01 | 4.6E-04 | 1.1E-01 | 8.1E-05 |  2d |0
2023-02-17 16:05:30 fides(INFO)     1| +9.62E+04 | -3.5E+09 | +9.3E-02 | 1.0E+00 | 1.6E+10 | 2.8E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     7| +5.71E+02 | -1.8E+03 | +9.0E-01 | 4.0E+00 | 1.0E+04 | 1.3E+00 | trr |1
2023-02-17 16:05:30 fides(INFO)    13| +1.52E+02 | -4.1E+00 | +8.1E-01 | 5.0E-01 | 6.9E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    14| +1.83E+02 | -7.2E+00 | +1.3E-01 | 1.0E+00 | 6.8E+01 | 3.1E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     7| +2.57E+02 | -1.4E+01 | +9.3E-01 | 1.2E-01 | 4.7E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    67| +1.48E+02 | -1.1E-06 | +7.9E-01 | 1.1E-04 | 1.1E-01 | 3.2E-05 |  2d |1
2023-02-17 16:05:30 fides(WARNING) Stopping as function difference 1.10E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:30 fides(INFO)    14| +2.17E+02 | -3.4E+00 | +8.3E-01 | 6.2E-02 | 4.6E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     8| +2.87E+02 | -2.8E+02 | +9.0E-01 | 4.0E+00 | 1.6E+03 | 1.7E+00 | trr |1
2023-02-17 16:05:30 fides(INFO)     7| +2.31E+02 | +4.8E+02 | -2.3E+01 | 2.0E+00 | 4.2E+01 | 3.3E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     2| +2.00E+04 | -7.6E+04 | +9.0E-01 | 2.5E-01 | 4.1E+05 | 6.7E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    15| +2.14E+02 | -2.4E+00 | +8.0E-01 | 1.2E-01 | 2.2E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     8| +2.57E+02 | +4.1E+00 | -3.7E-01 | 2.5E-01 | 3.5E+01 | 6.5E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)     9| +2.36E+02 | -5.1E+01 | +1.0E+00 | 4.0E+00 | 2.4E+02 | 3.6E+00 | trr |1
2023-02-17 16:05:30 fides(INFO)    14| +1.51E+02 | -7.1E-01 | +9.7E-01 | 1.0E+00 | 3.9E+01 | 3.0E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     8| +2.31E+02 | +4.3E+01 | -2.0E+00 | 5.0E-01 | 4.2E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    16| +2.13E+02 | -1.5E+00 | +2.6E-01 | 2.5E-01 | 1.9E+01 | 5.8E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     3| +4.16E+03 | -1.6E+04 | +9.1E-01 | 5.0E-01 | 7.0E+04 | 1.4E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     9| +2.52E+02 | -4.9E+00 | +9.1E-01 | 6.2E-02 | 3.5E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +2.36E+02 | +1.2E+02 | -1.1E+01 | 4.0E+00 | 2.7E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    17| +2.06E+02 | -6.8E+00 | +7.3E-01 | 2.5E-01 | 4.5E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     9| +2.21E+02 | -9.8E+00 | +8.4E-01 | 1.2E-01 | 4.2E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    15| +1.51E+02 | +2.3E+02 | -1.3E+02 | 2.0E+00 | 2.1E+01 | 5.0E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     4| +4.16E+03 | +2.1E+04 | -1.9E+01 | 1.0E+00 | 1.3E+04 | 2.7E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    18| +2.02E+02 | -3.6E+00 | +4.2E-01 | 2.5E-01 | 2.3E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    11| +2.36E+02 | +1.1E+01 | -1.6E+00 | 1.0E+00 | 2.7E+01 | 3.0E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    15| +1.74E+02 | -9.1E+00 | +1.1E+00 | 2.5E-01 | 1.1E+02 | 3.9E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +2.51E+02 | -5.6E-01 | +8.0E-02 | 1.2E-01 | 2.4E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)     0| +4.48E+11 |    NaN   |    NaN   | 1.0E+00 | 2.1E+12 |   NaN   | NaN |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +2.08E+02 | -1.3E+01 | +9.7E-01 | 2.5E-01 | 3.5E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     1| +6.61E+05 | -4.5E+11 | +9.0E-02 | 1.0E+00 | 2.1E+12 | 2.9E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    16| +1.51E+02 | +2.5E+00 | -7.2E+00 | 5.0E-01 | 2.1E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     2| +1.04E+05 | -5.6E+05 | +9.0E-01 | 2.5E-01 | 3.0E+06 | 6.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    19| +1.91E+02 | -1.1E+01 | +9.8E-01 | 2.5E-01 | 5.1E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     5| +9.03E+02 | -3.3E+03 | +8.9E-01 | 2.5E-01 | 1.3E+04 | 5.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +2.36E+02 | +1.2E+01 | -1.7E+00 | 2.5E-01 | 2.7E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    11| +2.50E+02 | -1.3E+00 | +8.7E-01 | 3.1E-02 | 2.9E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)    11| +1.96E+02 | -1.2E+01 | +1.1E+00 | 5.0E-01 | 4.4E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    17| +1.51E+02 | -2.6E-01 | +1.1E+00 | 1.2E-01 | 2.1E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     3| +1.66E+04 | -8.7E+04 | +9.0E-01 | 5.0E-01 | 4.8E+05 | 1.2E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    20| +1.60E+02 | -3.1E+01 | +1.1E+00 | 5.0E-01 | 3.8E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     4| +2.84E+03 | -1.4E+04 | +9.0E-01 | 1.0E+00 | 7.5E+04 | 2.2E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    13| +2.33E+02 | -3.0E+00 | +8.3E-01 | 6.2E-02 | 2.7E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +2.49E+02 | -5.2E-01 | +5.0E-01 | 6.2E-02 | 1.5E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     6| +3.44E+02 | -5.6E+02 | +8.3E-01 | 5.0E-01 | 2.3E+03 | 1.3E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +1.96E+02 | +5.5E+02 | -3.7E+01 | 1.0E+00 | 2.8E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     5| +6.37E+02 | -2.2E+03 | +9.0E-01 | 2.0E+00 | 1.2E+04 | 3.6E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    21| +1.60E+02 | +1.1E+01 | -1.4E+00 | 1.0E+00 | 7.4E+01 | 1.4E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)     6| +2.97E+02 | -3.4E+02 | +9.0E-01 | 4.0E+00 | 1.9E+03 | 1.2E+00 | trr |1
2023-02-17 16:05:30 fides(INFO)    14| +2.31E+02 | -1.5E+00 | +5.1E-01 | 1.2E-01 | 1.7E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    18| +1.51E+02 | -3.1E-01 | +4.8E-01 | 2.5E-01 | 2.3E+01 | 5.9E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    13| +2.49E+02 | -8.7E-02 | +3.0E-01 | 6.2E-02 | 5.5E+00 | 1.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     7| +2.51E+02 | -4.5E+01 | +8.5E-01 | 4.0E+00 | 3.0E+02 | 1.9E+00 | trr |1
2023-02-17 16:05:30 fides(INFO)     7| +2.52E+02 | -9.2E+01 | +8.4E-01 | 1.0E+00 | 3.8E+02 | 2.6E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    13| +1.90E+02 | -6.9E+00 | +7.1E-01 | 2.5E-01 | 2.8E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    22| +1.53E+02 | -6.1E+00 | +8.1E-01 | 2.1E-01 | 7.4E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     8| +2.36E+02 | -1.5E+01 | +2.5E+00 | 4.0E+00 | 3.1E+01 | 2.5E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    15| +2.29E+02 | -2.5E+00 | +6.4E-01 | 1.2E-01 | 3.3E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)     8| +2.50E+02 | -1.7E+00 | +4.4E-01 | 2.0E+00 | 3.2E+01 | 4.8E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    14| +2.49E+02 | -1.5E-01 | +5.0E-01 | 6.2E-02 | 6.3E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    19| +1.50E+02 | -5.3E-01 | +6.8E-01 | 2.5E-01 | 3.6E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    16| +1.61E+02 | -1.3E+01 | +7.9E-01 | 5.0E-01 | 1.8E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)     9| +2.50E+02 | +1.4E-01 | -6.4E-01 | 2.0E+00 | 1.3E+01 | 4.5E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    14| +1.78E+02 | -1.2E+01 | +7.8E-01 | 2.5E-01 | 4.4E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    23| +1.49E+02 | -4.1E+00 | +1.0E+00 | 4.1E-01 | 8.8E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    16| +2.29E+02 | -6.7E-03 | -6.1E-02 | 1.2E-01 | 1.9E+01 | 2.9E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)     9| +2.36E+02 | +5.5E+02 | -2.5E+01 | 4.0E+00 | 4.0E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +2.50E+02 | +4.2E-01 | -3.8E-01 | 5.0E-01 | 1.3E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    24| +1.49E+02 | +4.1E+00 | -2.1E+00 | 8.2E-01 | 3.2E+01 | 5.9E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    15| +2.49E+02 | -1.2E-01 | +4.8E-01 | 6.2E-02 | 4.7E+00 | 1.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    17| +2.28E+02 | -9.9E-01 | +8.9E-01 | 3.1E-02 | 1.9E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    20| +1.50E+02 | -2.7E-01 | +8.7E-01 | 2.5E-01 | 2.2E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    10| +2.36E+02 | +1.1E+02 | -5.7E+00 | 1.0E+00 | 4.0E+01 | 3.0E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    11| +2.50E+02 | +4.2E-01 | -3.8E-01 | 1.2E-01 | 1.3E+01 | 3.0E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    15| +1.78E+02 | +1.8E+01 | -1.4E+00 | 5.0E-01 | 1.4E+02 | 1.0E+00 |  2d |0
2023-02-17 16:05:30 fides(INFO)    25| +1.49E+02 | -7.4E-01 | +7.0E-01 | 1.3E-01 | 3.2E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    11| +2.35E+02 | -1.8E+00 | +3.1E-02 | 2.5E-01 | 4.0E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    18| +2.26E+02 | -1.3E+00 | +9.6E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    16| +2.49E+02 | -1.6E-01 | +5.9E-01 | 6.2E-02 | 5.5E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +2.50E+02 | -5.6E-01 | +6.9E-01 | 3.1E-02 | 1.3E+01 | 8.1E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)    21| +1.50E+02 | -1.7E-01 | +8.5E-01 | 5.0E-01 | 1.8E+01 | 8.7E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    16| +1.65E+02 | -1.2E+01 | +9.1E-01 | 1.2E-01 | 1.4E+02 | 2.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    12| +2.28E+02 | -6.2E+00 | +8.7E-01 | 6.2E-02 | 7.4E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    26| +1.49E+02 | +1.0E+00 | -1.1E+00 | 1.3E-01 | 2.6E+01 | 2.1E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    19| +2.24E+02 | -2.0E+00 | +1.0E+00 | 1.2E-01 | 1.7E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    13| +2.50E+02 | +1.7E-04 | -3.3E-02 | 3.1E-02 | 9.4E-01 | 7.1E-02 |  2d |0
2023-02-17 16:05:30 fides(INFO)    17| +2.49E+02 | -1.4E-01 | +5.4E-01 | 6.2E-02 | 4.6E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    13| +2.25E+02 | -3.4E+00 | +6.6E-01 | 1.2E-01 | 3.9E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    27| +1.48E+02 | -2.0E-01 | +6.3E-01 | 3.4E-02 | 2.6E+01 | 5.4E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)    22| +1.50E+02 | -2.2E-02 | +6.3E-01 | 1.0E+00 | 7.7E+00 | 1.3E+00 |  2d |1
2023-02-17 16:05:30 fides(INFO)    17| +1.59E+02 | -1.6E+00 | +1.2E-01 | 1.0E+00 | 9.8E+01 | 7.3E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    17| +1.58E+02 | -7.5E+00 | +6.2E-01 | 2.5E-01 | 4.3E+01 | 5.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    20| +2.24E+02 | +7.3E-01 | -3.6E-01 | 2.5E-01 | 1.8E+01 | 7.2E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    14| +2.50E+02 | +1.7E-04 | -3.3E-02 | 7.8E-03 | 9.4E-01 | 1.8E-02 |  2d |0
2023-02-17 16:05:30 fides(INFO)    14| +2.25E+02 | -5.0E-02 | -4.1E-02 | 1.2E-01 | 1.9E+01 | 2.9E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    18| +2.49E+02 | -1.8E-01 | +6.1E-01 | 6.2E-02 | 5.9E+00 | 1.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    15| +2.50E+02 | -2.6E-03 | +7.2E-01 | 2.0E-03 | 9.4E-01 | 4.9E-03 |  2d |1
2023-02-17 16:05:30 fides(INFO)    28| +1.48E+02 | -2.4E-01 | +9.2E-01 | 3.4E-02 | 1.9E+01 | 3.7E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)    15| +2.24E+02 | -9.3E-01 | +8.8E-01 | 3.1E-02 | 1.9E+01 | 7.1E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)    21| +2.23E+02 | -1.1E+00 | +6.2E-01 | 6.2E-02 | 1.8E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    23| +1.50E+02 | +3.1E-01 | -5.5E+00 | 1.0E+00 | 8.4E-01 | 6.0E-01 | trr |0
2023-02-17 16:05:30 fides(INFO)    16| +2.50E+02 | +3.7E-07 | -4.0E-03 | 2.0E-03 | 1.3E-01 | 4.5E-03 |  2d |0
2023-02-17 16:05:30 fides(INFO)    16| +2.23E+02 | -1.5E+00 | +1.0E+00 | 6.2E-02 | 1.7E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    29| +1.48E+02 | -1.7E-01 | +8.2E-01 | 6.7E-02 | 2.4E+01 | 6.5E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)    18| +1.54E+02 | -4.1E+00 | +8.4E-01 | 2.5E-01 | 1.0E+02 | 5.1E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    22| +2.22E+02 | -1.1E+00 | +8.6E-01 | 6.2E-02 | 1.7E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    19| +2.48E+02 | -1.6E-01 | +5.0E-01 | 6.2E-02 | 5.4E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    17| +2.50E+02 | -3.4E-05 | +3.6E-01 | 4.9E-04 | 1.3E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:30 fides(INFO)    17| +2.20E+02 | -2.5E+00 | +1.1E+00 | 1.2E-01 | 1.8E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    24| +1.50E+02 | -9.6E-03 | +7.0E-01 | 1.5E-01 | 8.4E-01 | 1.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    23| +2.22E+02 | -4.0E-01 | +2.1E-01 | 1.2E-01 | 1.3E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    30| +1.48E+02 | -1.7E-01 | +5.7E-01 | 1.3E-01 | 8.5E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    18| +2.20E+02 | +3.6E-01 | -2.5E-01 | 2.5E-01 | 1.7E+01 | 7.3E-01 |  2d |0
2023-02-17 16:05:30 fides(INFO)    18| +2.50E+02 | -1.3E-07 | +3.4E-03 | 4.9E-04 | 7.7E-02 | 9.5E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    19| +1.53E+02 | -9.0E-01 | +1.1E+00 | 5.0E-01 | 2.3E+01 | 7.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    18| +1.57E+02 | -2.5E+00 | +9.3E-01 | 1.0E-01 | 9.0E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:30 fides(INFO)    20| +2.48E+02 | -2.3E-01 | +5.8E-01 | 6.2E-02 | 7.3E+00 | 1.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    24| +2.21E+02 | -1.2E+00 | +8.7E-01 | 3.1E-02 | 2.9E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:30 fides(INFO)    19| +2.50E+02 | -1.6E-05 | +8.0E-01 | 1.2E-04 | 7.7E-02 | 3.1E-04 |  2d |1
2023-02-17 16:05:30 fides(INFO)    19| +2.19E+02 | -9.3E-01 | +6.1E-01 | 6.2E-02 | 1.7E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    25| +1.50E+02 | -1.6E-03 | +6.7E-01 | 1.5E-01 | 1.6E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:30 fides(INFO)    31| +1.48E+02 | +7.5E-01 | -1.3E+00 | 1.3E-01 | 1.8E+01 | 2.0E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    20| +2.50E+02 | +1.2E-09 | -3.8E-04 | 2.4E-04 | 2.5E-02 | 5.7E-04 |  2d |0
2023-02-17 16:05:31 fides(INFO)    25| +2.20E+02 | -8.9E-01 | +7.1E-01 | 6.2E-02 | 1.7E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    20| +2.18E+02 | -1.1E+00 | +8.1E-01 | 6.2E-02 | 2.0E+01 | 9.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    20| +1.52E+02 | -4.3E-01 | +9.7E-01 | 1.0E+00 | 1.7E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    32| +1.48E+02 | -1.1E-01 | +5.7E-01 | 3.4E-02 | 1.8E+01 | 5.0E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    21| +2.48E+02 | -1.7E-01 | +4.1E-01 | 6.2E-02 | 6.5E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    26| +1.50E+02 | -5.0E-04 | +1.0E+00 | 1.5E-01 | 6.9E-01 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    21| +2.50E+02 | -1.9E-06 | +6.5E-01 | 6.1E-05 | 2.5E-02 | 1.5E-04 |  2d |1
2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 1.86E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:31 fides(INFO)    21| +2.18E+02 | -1.1E-01 | -1.6E-02 | 1.2E-01 | 1.4E+01 | 2.7E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    26| +2.19E+02 | -4.6E-01 | +4.8E-01 | 6.2E-02 | 1.2E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    21| +1.52E+02 | +1.4E+02 | -2.2E+02 | 2.0E+00 | 1.4E+01 | 5.2E+00 |  2d |0
2023-02-17 16:05:31 fides(INFO)    33| +1.48E+02 | -3.9E-02 | +9.1E-01 | 3.4E-02 | 4.2E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    27| +1.50E+02 | -6.0E-04 | +1.1E+00 | 2.9E-01 | 4.8E-01 | 2.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    22| +2.18E+02 | -5.6E-01 | +8.8E-01 | 3.1E-02 | 1.4E+01 | 6.2E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    19| +1.55E+02 | -1.4E+00 | +9.8E-01 | 2.0E-01 | 8.1E+01 | 3.9E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    27| +2.19E+02 | -7.9E-01 | +6.5E-01 | 6.2E-02 | 1.7E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    22| +1.52E+02 | -1.5E-01 | +3.0E-01 | 5.0E-01 | 1.4E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    22| +2.48E+02 | -3.1E-01 | +5.6E-01 | 6.2E-02 | 9.4E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    23| +2.16E+02 | -1.1E+00 | +1.0E+00 | 6.2E-02 | 1.4E+01 | 8.2E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    34| +1.48E+02 | -4.8E-02 | +8.4E-01 | 6.7E-02 | 1.0E+01 | 5.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    28| +1.50E+02 | -1.5E-04 | +8.2E-01 | 5.9E-01 | 2.9E-01 | 2.6E-01 | trr |1
2023-02-17 16:05:31 fides(INFO)    23| +1.52E+02 | -6.4E-01 | +5.2E-01 | 5.0E-01 | 2.3E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    28| +2.18E+02 | -3.0E-01 | +3.4E-01 | 6.2E-02 | 1.1E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    24| +2.16E+02 | -3.9E-01 | +2.1E-01 | 1.2E-01 | 1.3E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    35| +1.48E+02 | -4.7E-02 | +6.4E-01 | 1.3E-01 | 2.3E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    29| +1.50E+02 | +4.7E-04 | -3.2E+00 | 5.9E-01 | 3.3E-01 | 1.5E-02 | trr |0
2023-02-17 16:05:31 fides(INFO)    23| +2.48E+02 | -1.9E-01 | +3.4E-01 | 6.2E-02 | 7.7E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    29| +2.17E+02 | -7.2E-01 | +6.0E-01 | 6.2E-02 | 1.7E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    25| +2.15E+02 | -1.1E+00 | +8.5E-01 | 3.1E-02 | 2.8E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    24| +1.51E+02 | -1.1E+00 | +8.7E-01 | 5.0E-01 | 2.0E+01 | 8.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    20| +1.55E+02 | +4.0E-01 | -7.4E-01 | 4.0E-01 | 2.1E+01 | 8.1E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)     0| +2.59E+04 |    NaN   |    NaN   | 1.0E+00 | 9.1E+04 |   NaN   | NaN |1
2023-02-17 16:05:31 fides(INFO)    36| +1.48E+02 | +1.9E-01 | -1.3E+00 | 1.3E-01 | 3.7E+00 | 1.6E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    30| +2.17E+02 | -1.7E-01 | +2.0E-01 | 6.2E-02 | 1.0E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    26| +2.14E+02 | -5.0E-01 | +5.4E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    30| +1.50E+02 | -3.1E-05 | +4.5E-01 | 1.9E-02 | 3.3E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    24| +2.47E+02 | -4.2E-01 | +5.7E-01 | 6.2E-02 | 1.2E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    25| +1.51E+02 | +2.8E+00 | -1.7E+00 | 1.0E+00 | 9.0E+00 | 1.7E+00 |  2d |0
2023-02-17 16:05:31 fides(INFO)    31| +2.17E+02 | -3.9E-01 | +9.0E-01 | 1.6E-02 | 1.7E+01 | 3.0E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    37| +1.48E+02 | -2.1E-02 | +5.1E-01 | 3.4E-02 | 3.7E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    27| +2.14E+02 | +3.1E-03 | -3.1E-02 | 6.2E-02 | 1.1E+01 | 1.5E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)     1| +3.75E+02 | -2.6E+04 | +1.6E-01 | 1.0E+00 | 9.1E+04 | 2.2E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    31| +1.50E+02 | -6.2E-06 | +2.9E-01 | 1.9E-02 | 8.7E-02 | 2.5E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    26| +1.50E+02 | -4.1E-01 | +6.1E-01 | 2.5E-01 | 9.0E+00 | 4.2E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    32| +2.17E+02 | -3.9E-01 | +7.9E-01 | 3.1E-02 | 1.2E+01 | 5.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    28| +2.14E+02 | -2.7E-01 | +8.7E-01 | 1.6E-02 | 1.1E+01 | 3.6E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    38| +1.48E+02 | -9.7E-03 | +9.2E-01 | 3.4E-02 | 1.6E+00 | 2.1E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     2| +2.83E+02 | -9.2E+01 | +8.9E-01 | 2.5E-01 | 5.4E+02 | 5.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    25| +2.47E+02 | -2.2E-01 | +3.1E-01 | 6.2E-02 | 9.0E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    21| +1.55E+02 | -5.6E-01 | +8.6E-01 | 1.0E-01 | 2.1E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    29| +2.14E+02 | -2.7E-01 | +7.9E-01 | 3.1E-02 | 9.4E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    33| +2.16E+02 | -5.8E-01 | +8.9E-01 | 6.2E-02 | 7.8E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    32| +1.50E+02 | +4.8E-08 | -4.0E-03 | 1.9E-02 | 5.6E-02 | 2.3E-03 |  2d |0
2023-02-17 16:05:31 fides(INFO)     3| +2.58E+02 | -2.5E+01 | +7.7E-01 | 5.0E-01 | 8.1E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    39| +1.48E+02 | -1.4E-02 | +9.3E-01 | 6.7E-02 | 2.1E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    27| +1.50E+02 | -1.8E-01 | +7.7E-01 | 2.5E-01 | 1.2E+01 | 3.6E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    34| +2.16E+02 | -3.3E-01 | +5.0E-01 | 1.2E-01 | 9.8E+00 | 3.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    30| +2.14E+02 | -3.0E-01 | +5.8E-01 | 6.2E-02 | 1.1E+01 | 9.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    26| +2.46E+02 | -5.9E-01 | +6.0E-01 | 6.2E-02 | 1.5E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     4| +2.58E+02 | +1.1E+02 | -6.5E+00 | 1.0E+00 | 4.0E+01 | 2.3E+00 |  2d |0
2023-02-17 16:05:31 fides(INFO)    35| +2.16E+02 | +1.9E-01 | -2.3E-01 | 1.2E-01 | 1.1E+01 | 3.5E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    33| +1.50E+02 | -3.2E-06 | +7.8E-01 | 4.7E-03 | 5.6E-02 | 5.8E-04 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    40| +1.48E+02 | -1.6E-02 | +7.7E-01 | 1.3E-01 | 1.0E+00 | 7.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    28| +1.50E+02 | -2.1E-01 | +6.2E-01 | 5.0E-01 | 4.7E+00 | 6.9E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    31| +2.14E+02 | +1.2E-01 | -1.9E-01 | 6.2E-02 | 1.1E+01 | 1.5E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    22| +1.54E+02 | -4.5E-01 | +6.0E-01 | 2.0E-01 | 4.9E+01 | 4.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    36| +2.15E+02 | -4.1E-01 | +6.8E-01 | 3.1E-02 | 1.1E+01 | 7.5E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     5| +2.57E+02 | -1.5E+00 | +1.0E-02 | 2.5E-01 | 4.0E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    41| +1.48E+02 | +3.6E-01 | -7.2E+00 | 2.7E-01 | 1.4E+00 | 2.6E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    32| +2.13E+02 | -2.7E-01 | +8.5E-01 | 1.6E-02 | 1.1E+01 | 3.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    34| +1.50E+02 | -7.5E-07 | +3.3E-01 | 9.5E-03 | 1.0E-02 | 7.5E-04 |  2d |1
2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 7.48E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:31 fides(INFO)    27| +2.46E+02 | -3.1E-01 | +3.6E-01 | 6.2E-02 | 1.0E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    29| +1.50E+02 | -1.2E-01 | +6.6E-01 | 5.0E-01 | 4.0E+00 | 6.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    37| +2.15E+02 | -2.6E-01 | +9.4E-01 | 3.1E-02 | 6.6E+00 | 5.0E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     6| +2.52E+02 | -5.5E+00 | +8.5E-01 | 6.2E-02 | 6.6E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    33| +2.13E+02 | -1.5E-01 | +5.5E-01 | 3.1E-02 | 7.8E+00 | 6.3E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    42| +1.48E+02 | +6.2E-03 | -3.4E-01 | 6.7E-02 | 1.4E+00 | 6.6E-02 |  2d |0
2023-02-17 16:05:31 fides(INFO)    23| +1.54E+02 | -2.0E-01 | +8.9E-01 | 2.0E-01 | 2.7E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    38| +2.15E+02 | -1.4E-01 | +3.4E-01 | 6.2E-02 | 6.1E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     7| +2.50E+02 | -1.2E+00 | +4.0E-01 | 1.2E-01 | 2.8E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    30| +1.50E+02 | -6.3E-02 | +7.3E-01 | 5.0E-01 | 7.0E+00 | 6.9E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    34| +2.13E+02 | -2.0E-01 | +6.4E-01 | 3.1E-02 | 9.9E+00 | 5.3E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    43| +1.48E+02 | -3.6E-03 | +6.9E-01 | 1.7E-02 | 1.4E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    28| +2.45E+02 | -7.9E-01 | +6.6E-01 | 6.2E-02 | 1.8E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    39| +2.15E+02 | -3.2E-01 | +4.3E-01 | 6.2E-02 | 1.3E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    35| +2.13E+02 | -9.1E-02 | +3.8E-01 | 3.1E-02 | 7.1E+00 | 6.5E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     8| +2.50E+02 | +3.4E-01 | -3.3E-01 | 1.2E-01 | 1.3E+01 | 2.8E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    24| +1.54E+02 | -2.9E-02 | +9.1E-01 | 4.0E-01 | 5.9E+00 | 5.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    44| +1.48E+02 | -1.3E-03 | +9.1E-01 | 1.7E-02 | 5.8E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    40| +2.15E+02 | +1.3E-02 | -5.0E-02 | 6.2E-02 | 8.2E+00 | 1.6E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    31| +1.50E+02 | -1.4E-02 | +7.5E-01 | 5.0E-01 | 2.7E+00 | 7.7E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    36| +2.13E+02 | -1.7E-01 | +5.7E-01 | 3.1E-02 | 9.8E+00 | 5.6E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)     0| +1.98E+12 |    NaN   |    NaN   | 1.0E+00 | 9.2E+12 |   NaN   | NaN |1
2023-02-17 16:05:31 fides(INFO)    29| +2.45E+02 | -5.1E-01 | +5.1E-01 | 6.2E-02 | 1.2E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     9| +2.50E+02 | -5.2E-01 | +6.9E-01 | 3.1E-02 | 1.3E+01 | 7.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    41| +2.14E+02 | -2.0E-01 | +8.1E-01 | 1.6E-02 | 8.2E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    45| +1.48E+02 | -2.2E-03 | +9.8E-01 | 3.4E-02 | 7.0E-01 | 1.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    37| +2.13E+02 | -4.2E-02 | +1.9E-01 | 3.1E-02 | 6.4E+00 | 6.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    25| +1.54E+02 | -7.2E-03 | +5.1E-01 | 8.0E-01 | 4.4E+00 | 9.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     1| +1.26E+06 | -2.0E+12 | +8.4E-02 | 1.0E+00 | 9.2E+12 | 3.1E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    32| +1.50E+02 | -3.6E-03 | +7.3E-01 | 1.0E+00 | 1.0E+00 | 1.4E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    10| +2.50E+02 | -3.9E-03 | +9.2E-02 | 3.1E-02 | 2.7E+00 | 6.2E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    42| +2.14E+02 | -1.4E-01 | +7.0E-01 | 3.1E-02 | 5.2E+00 | 6.0E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    38| +2.13E+02 | -1.0E-01 | +9.1E-01 | 7.8E-03 | 9.6E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    46| +1.48E+02 | -3.1E-03 | +9.4E-01 | 6.7E-02 | 5.8E-01 | 3.6E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    30| +2.44E+02 | -9.4E-01 | +7.3E-01 | 6.2E-02 | 2.0E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     2| +1.83E+05 | -1.1E+06 | +9.0E-01 | 2.5E-01 | 6.0E+06 | 5.6E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    39| +2.12E+02 | -9.9E-02 | +7.8E-01 | 1.6E-02 | 7.3E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    43| +2.14E+02 | -1.5E-01 | +5.9E-01 | 3.1E-02 | 7.3E+00 | 5.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    26| +1.54E+02 | +3.7E-01 | -1.2E+01 | 8.0E-01 | 1.1E+00 | 5.0E-01 | trr |0
2023-02-17 16:05:31 fides(INFO)    33| +1.50E+02 | +1.0E-04 | -2.0E-01 | 1.0E+00 | 5.6E-01 | 7.4E-01 | trr |0
2023-02-17 16:05:31 fides(INFO)    11| +2.50E+02 | -1.3E-02 | +4.3E-01 | 7.8E-03 | 2.3E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     3| +2.56E+04 | -1.6E+05 | +9.0E-01 | 5.0E-01 | 9.0E+05 | 7.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    47| +1.48E+02 | -2.5E-03 | +8.0E-01 | 1.3E-01 | 5.2E-01 | 5.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    40| +2.12E+02 | -1.4E-01 | +8.8E-01 | 3.1E-02 | 5.2E+00 | 4.3E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    44| +2.14E+02 | -7.0E-02 | +3.1E-01 | 3.1E-02 | 5.7E+00 | 7.3E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    31| +2.43E+02 | -7.3E-01 | +6.4E-01 | 6.2E-02 | 1.3E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    27| +1.54E+02 | -5.4E-03 | +7.0E-01 | 1.3E-01 | 1.1E+00 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    12| +2.50E+02 | -3.1E-04 | +4.0E-02 | 7.8E-03 | 1.1E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     4| +3.89E+03 | -2.2E+04 | +9.0E-01 | 5.0E-01 | 1.4E+05 | 5.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    48| +1.48E+02 | +8.2E-02 | -1.4E+01 | 2.7E-01 | 2.9E-01 | 1.4E-01 | trr |0
2023-02-17 16:05:31 fides(INFO)    41| +2.12E+02 | -4.7E-02 | +3.2E-01 | 6.2E-02 | 5.9E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    45| +2.14E+02 | -1.6E-01 | +5.6E-01 | 3.1E-02 | 8.2E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    34| +1.50E+02 | -2.0E-04 | +7.7E-01 | 2.2E-01 | 5.6E-01 | 1.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     5| +7.42E+02 | -3.1E+03 | +9.0E-01 | 5.0E-01 | 2.2E+04 | 4.2E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    13| +2.50E+02 | -3.1E-03 | +7.4E-01 | 2.0E-03 | 1.0E+00 | 5.1E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    49| +1.48E+02 | +3.1E-03 | -1.1E+00 | 3.9E-02 | 2.9E-01 | 3.4E-02 |  2d |0
2023-02-17 16:05:31 fides(INFO)    46| +2.14E+02 | -5.6E-02 | +2.8E-01 | 3.1E-02 | 5.3E+00 | 7.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    32| +2.42E+02 | -9.5E-01 | +7.7E-01 | 6.2E-02 | 2.0E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    42| +2.12E+02 | +3.4E-02 | -1.5E-01 | 6.2E-02 | 6.3E+00 | 1.8E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    28| +1.54E+02 | -5.8E-04 | +6.8E-01 | 1.3E-01 | 3.7E-01 | 9.3E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    35| +1.50E+02 | -7.7E-05 | +9.2E-01 | 4.3E-01 | 2.5E-01 | 3.2E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     6| +2.75E+02 | -4.7E+02 | +9.0E-01 | 5.0E-01 | 3.5E+03 | 4.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    14| +2.50E+02 | +1.1E-06 | -6.0E-03 | 2.0E-03 | 1.8E-01 | 4.2E-03 |  2d |0
2023-02-17 16:05:31 fides(INFO)    47| +2.14E+02 | -1.5E-01 | +5.3E-01 | 3.1E-02 | 8.0E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    43| +2.12E+02 | -1.2E-01 | +6.9E-01 | 1.6E-02 | 6.3E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    50| +1.48E+02 | -3.3E-04 | +4.1E-01 | 9.8E-03 | 2.9E-01 | 8.7E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)     7| +2.05E+02 | -7.0E+01 | +9.3E-01 | 5.0E-01 | 5.4E+02 | 6.7E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    29| +1.54E+02 | -2.3E-04 | +1.1E+00 | 1.3E-01 | 4.2E-01 | 8.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    33| +2.41E+02 | -8.7E-01 | +4.6E-01 | 1.2E-01 | 1.3E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    15| +2.50E+02 | -9.7E-05 | +5.8E-01 | 4.9E-04 | 1.8E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    44| +2.12E+02 | -6.4E-02 | +9.8E-01 | 1.6E-02 | 4.1E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    48| +2.14E+02 | -4.6E-02 | +2.4E-01 | 3.1E-02 | 5.2E+00 | 7.6E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    36| +1.50E+02 | -2.2E-05 | +8.7E-01 | 8.7E-01 | 1.9E-01 | 2.4E-01 | trr |1
2023-02-17 16:05:31 fides(INFO)    51| +1.48E+02 | -1.3E-04 | +8.5E-01 | 9.8E-03 | 8.1E-01 | 1.7E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    45| +2.12E+02 | -6.6E-02 | +6.7E-01 | 3.1E-02 | 3.7E+00 | 4.5E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    16| +2.50E+02 | -8.5E-09 | +1.2E-03 | 4.9E-04 | 3.3E-02 | 9.8E-04 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    49| +2.13E+02 | -8.7E-02 | +9.0E-01 | 7.8E-03 | 7.8E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    30| +1.54E+02 | -3.4E-04 | +1.1E+00 | 2.5E-01 | 1.7E-01 | 1.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    37| +1.50E+02 | +6.1E-06 | -4.5E-01 | 8.7E-01 | 5.5E-02 | 6.1E-03 | trr |0
2023-02-17 16:05:31 fides(INFO)     8| +2.05E+02 | +1.8E+02 | -1.8E+01 | 1.0E+00 | 9.1E+01 | 2.9E+00 |  2d |0
2023-02-17 16:05:31 fides(INFO)    34| +2.39E+02 | -1.9E+00 | +9.3E-01 | 1.2E-01 | 1.2E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    52| +1.48E+02 | -8.1E-05 | +8.2E-01 | 2.0E-02 | 1.1E-01 | 6.6E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    46| +2.12E+02 | -2.9E-02 | +2.3E-01 | 3.1E-02 | 5.5E+00 | 7.5E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    50| +2.13E+02 | -8.5E-02 | +7.7E-01 | 1.6E-02 | 5.5E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     9| +1.94E+02 | -1.0E+01 | +1.1E+00 | 2.5E-01 | 9.1E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    17| +2.50E+02 | -1.7E-06 | +2.8E-01 | 1.2E-04 | 3.2E-02 | 3.2E-04 |  2d |1
2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 1.72E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:31 fides(INFO)    38| +1.50E+02 | -5.2E-06 | +8.5E-01 | 1.9E-02 | 5.5E-02 | 1.5E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    53| +1.48E+02 | +6.9E-05 | -3.9E-01 | 3.9E-02 | 1.6E-01 | 5.4E-03 |  2d |0
2023-02-17 16:05:31 fides(INFO)    31| +1.54E+02 | -5.0E-04 | +1.6E+00 | 5.1E-01 | 1.7E-01 | 2.1E-01 | trr |1
2023-02-17 16:05:31 fides(INFO)    47| +2.12E+02 | -5.5E-02 | +8.1E-01 | 7.8E-03 | 4.7E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    51| +2.13E+02 | -1.0E-01 | +7.1E-01 | 3.1E-02 | 3.9E+00 | 5.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    10| +1.94E+02 | +1.3E+01 | -2.6E+00 | 5.0E-01 | 3.1E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:31 fides(INFO)    39| +1.50E+02 | -1.3E-06 | +6.0E-01 | 3.7E-02 | 2.5E-02 | 2.5E-03 |  2d |1
2023-02-17 16:05:31 fides(WARNING) Stopping as function difference 1.28E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:31 fides(INFO)    54| +1.48E+02 | -3.9E-05 | +7.0E-01 | 9.8E-03 | 1.6E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    48| +2.12E+02 | -1.1E-02 | +2.9E-01 | 1.6E-02 | 3.0E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    35| +2.39E+02 | +2.7E+00 | -6.9E-01 | 2.5E-01 | 1.2E+01 | 6.0E-01 |  2d |0
2023-02-17 16:05:31 fides(INFO)    32| +1.54E+02 | -1.9E-04 | +1.5E+00 | 5.1E-01 | 1.0E-01 | 5.0E-03 | trr |1
2023-02-17 16:05:31 fides(INFO)    52| +2.13E+02 | -7.9E-02 | +4.2E-01 | 3.1E-02 | 6.2E+00 | 6.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    11| +1.89E+02 | -5.4E+00 | +1.0E+00 | 1.2E-01 | 3.1E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    55| +1.48E+02 | -2.8E-05 | +7.7E-01 | 9.8E-03 | 1.4E-01 | 3.1E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    49| +2.12E+02 | -3.4E-02 | +4.8E-01 | 1.6E-02 | 4.5E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    53| +2.13E+02 | -2.6E-02 | +1.3E-01 | 3.1E-02 | 5.3E+00 | 7.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    36| +2.38E+02 | -9.4E-01 | +7.2E-01 | 6.2E-02 | 1.2E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    33| +1.54E+02 | +3.4E-04 | -2.4E+00 | 5.1E-01 | 7.8E-02 | 1.6E-02 | trr |0
2023-02-17 16:05:31 fides(INFO)    12| +1.76E+02 | -1.3E+01 | +1.4E+00 | 2.5E-01 | 1.9E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    50| +2.12E+02 | -4.7E-03 | +1.0E-01 | 1.6E-02 | 3.1E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)     0| +1.57E+13 |    NaN   |    NaN   | 1.0E+00 | 5.8E+13 |   NaN   | NaN |1
2023-02-17 16:05:31 fides(INFO)    56| +1.48E+02 | -3.1E-05 | +6.2E-01 | 2.0E-02 | 8.4E-02 | 3.1E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    54| +2.13E+02 | -8.6E-02 | +8.9E-01 | 7.8E-03 | 7.6E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     1| +4.16E+10 | -1.6E+13 | +1.0E-01 | 1.0E+00 | 5.8E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    51| +2.12E+02 | -2.2E-02 | +9.0E-01 | 3.9E-03 | 4.3E+00 | 7.4E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    13| +1.63E+02 | -1.2E+01 | +4.7E-01 | 5.0E-01 | 6.1E+01 | 1.1E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    57| +1.48E+02 | +4.0E-05 | -4.4E-01 | 2.0E-02 | 1.7E-01 | 7.6E-03 |  2d |0
2023-02-17 16:05:31 fides(INFO)    55| +2.13E+02 | -7.2E-02 | +7.1E-01 | 1.6E-02 | 5.2E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    34| +1.54E+02 | -3.3E-05 | +5.3E-01 | 1.8E-03 | 7.8E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    37| +2.37E+02 | -9.8E-01 | +8.0E-01 | 6.2E-02 | 1.6E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     2| +6.23E+09 | -3.5E+10 | +8.9E-01 | 2.5E-01 | 1.9E+11 | 6.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    52| +2.12E+02 | -2.0E-02 | +7.2E-01 | 7.8E-03 | 3.2E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     0| +6.30E+11 |    NaN   |    NaN   | 1.0E+00 | 2.6E+12 |   NaN   | NaN |1
2023-02-17 16:05:31 fides(INFO)    56| +2.13E+02 | -5.4E-02 | +7.6E-01 | 1.6E-02 | 3.5E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     3| +9.33E+08 | -5.3E+09 | +8.9E-01 | 5.0E-01 | 2.9E+10 | 1.0E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    14| +1.63E+02 | -2.2E+00 | -6.9E-02 | 5.0E-01 | 1.4E+02 | 1.0E+00 |  2d |0
2023-02-17 16:05:31 fides(INFO)    58| +1.48E+02 | -1.9E-05 | +6.9E-01 | 4.9E-03 | 1.7E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)     4| +1.41E+08 | -7.9E+08 | +8.9E-01 | 5.0E-01 | 4.3E+09 | 1.0E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    35| +1.54E+02 | -2.2E-05 | +4.6E-01 | 1.8E-03 | 4.6E-02 | 3.8E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    53| +2.12E+02 | -1.5E-02 | +8.3E-01 | 7.8E-03 | 2.4E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     1| +9.99E+09 | -6.2E+11 | +9.9E-02 | 1.0E+00 | 2.6E+12 | 2.9E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    38| +2.35E+02 | -2.1E+00 | +1.0E+00 | 1.2E-01 | 1.5E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     5| +2.13E+07 | -1.2E+08 | +8.9E-01 | 5.0E-01 | 6.4E+08 | 9.9E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    57| +2.13E+02 | -4.7E-02 | +4.1E-01 | 3.1E-02 | 4.3E+00 | 6.3E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    15| +1.58E+02 | -4.9E+00 | +9.8E-01 | 1.2E-01 | 1.4E+02 | 2.6E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    59| +1.48E+02 | -7.7E-06 | +1.2E+00 | 4.9E-03 | 4.8E-02 | 8.9E-04 |  2d |1
2023-02-17 16:05:31 fides(INFO)     2| +1.49E+09 | -8.5E+09 | +8.9E-01 | 2.5E-01 | 4.6E+10 | 7.5E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    54| +2.12E+02 | -1.2E-02 | +4.2E-01 | 1.6E-02 | 2.6E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     6| +3.24E+06 | -1.8E+07 | +8.9E-01 | 5.0E-01 | 9.7E+07 | 9.9E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    58| +2.13E+02 | +1.6E-02 | -1.0E-01 | 3.1E-02 | 5.3E+00 | 7.5E-02 | trr |0
2023-02-17 16:05:31 fides(INFO)    36| +1.54E+02 | -2.1E-05 | +4.1E-01 | 1.8E-03 | 5.1E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    16| +1.57E+02 | -1.5E+00 | +3.8E-01 | 2.5E-01 | 6.9E+01 | 5.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     7| +4.97E+05 | -2.7E+06 | +8.9E-01 | 5.0E-01 | 1.5E+07 | 9.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     3| +2.25E+08 | -1.3E+09 | +8.9E-01 | 5.0E-01 | 6.9E+09 | 1.5E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    60| +1.48E+02 | -9.4E-06 | +9.5E-01 | 9.8E-03 | 6.0E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    55| +2.12E+02 | -2.9E-03 | +5.7E-02 | 1.6E-02 | 2.9E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    59| +2.13E+02 | -7.0E-02 | +8.5E-01 | 7.8E-03 | 5.3E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     8| +7.70E+04 | -4.2E+05 | +9.0E-01 | 5.0E-01 | 2.3E+06 | 9.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)     4| +3.41E+07 | -1.9E+08 | +8.9E-01 | 1.0E+00 | 1.0E+09 | 2.7E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    17| +1.52E+02 | -4.8E+00 | +8.1E-01 | 2.5E-01 | 7.9E+01 | 5.4E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    39| +2.34E+02 | -1.3E+00 | +2.5E-01 | 2.5E-01 | 1.3E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    37| +1.54E+02 | -1.1E-05 | +2.7E-01 | 1.8E-03 | 3.5E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    61| +1.48E+02 | -1.1E-05 | +8.1E-01 | 2.0E-02 | 3.6E-02 | 2.8E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    56| +2.12E+02 | -2.0E-02 | +8.9E-01 | 3.9E-03 | 3.8E+00 | 7.6E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)     9| +1.21E+04 | -6.5E+04 | +9.0E-01 | 5.0E-01 | 3.5E+05 | 9.8E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    60| +2.13E+02 | -3.8E-02 | +5.5E-01 | 1.6E-02 | 3.5E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)     5| +5.17E+06 | -2.9E+07 | +8.9E-01 | 2.0E+00 | 1.6E+08 | 8.0E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:31 fides(INFO)    10| +2.08E+03 | -1.0E+04 | +9.0E-01 | 1.0E+00 | 5.5E+04 | 1.0E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    57| +2.12E+02 | -1.4E-02 | +6.3E-01 | 7.8E-03 | 2.7E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    38| +1.54E+02 | -1.4E-05 | +3.0E-01 | 1.8E-03 | 4.1E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:31 fides(INFO)    18| +1.50E+02 | -2.0E+00 | +7.7E-01 | 5.0E-01 | 3.8E+01 | 1.0E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)    62| +1.48E+02 | +2.3E-05 | -1.4E+00 | 3.9E-02 | 4.1E-02 | 7.0E-03 |  2d |0
2023-02-17 16:05:31 fides(INFO)    11| +5.14E+02 | -1.6E+03 | +9.0E-01 | 1.0E+00 | 8.6E+03 | 1.4E+00 |  2d |1
2023-02-17 16:05:31 fides(INFO)     6| +7.88E+05 | -4.4E+06 | +8.9E-01 | 2.0E+00 | 2.4E+07 | 7.9E-01 |  2d |1
2023-02-17 16:05:31 fides(INFO)    61| +2.13E+02 | -5.5E-02 | +6.7E-01 | 1.6E-02 | 4.4E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:31 fides(INFO)    58| +2.12E+02 | -6.6E-03 | +4.9E-01 | 7.8E-03 | 1.9E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    12| +2.76E+02 | -2.4E+02 | +9.0E-01 | 2.0E+00 | 1.3E+03 | 1.6E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    40| +2.29E+02 | -4.7E+00 | +9.8E-01 | 2.5E-01 | 3.4E+01 | 4.5E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    63| +1.48E+02 | -6.0E-06 | +1.1E+00 | 9.8E-03 | 4.1E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)     7| +1.21E+05 | -6.7E+05 | +9.0E-01 | 2.0E+00 | 3.6E+06 | 7.7E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    62| +2.13E+02 | -3.4E-02 | +5.3E-01 | 1.6E-02 | 3.3E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    39| +1.54E+02 | -5.5E-06 | +1.5E-01 | 1.8E-03 | 2.8E-02 | 3.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    59| +2.12E+02 | -1.1E-02 | +5.8E-01 | 7.8E-03 | 2.4E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    13| +2.29E+02 | -4.7E+01 | +1.2E+00 | 2.0E+00 | 1.9E+02 | 2.4E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    19| +1.50E+02 | -2.3E-01 | +2.2E-01 | 1.0E+00 | 3.0E+01 | 8.3E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)     8| +1.88E+04 | -1.0E+05 | +9.0E-01 | 2.0E+00 | 5.5E+05 | 7.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    64| +1.48E+02 | +2.3E-05 | -1.7E+00 | 2.0E-02 | 3.1E-02 | 1.3E-03 |  2d |0
2023-02-17 16:05:32 fides(INFO)    63| +2.13E+02 | -5.2E-02 | +6.4E-01 | 1.6E-02 | 4.4E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    41| +2.23E+02 | -6.6E+00 | +7.2E-01 | 5.0E-01 | 2.8E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    60| +2.12E+02 | -4.4E-03 | +3.3E-01 | 7.8E-03 | 1.9E+00 | 1.7E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)     9| +3.09E+03 | -1.6E+04 | +9.0E-01 | 2.0E+00 | 8.5E+04 | 6.9E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    40| +1.54E+02 | -9.6E-06 | +8.3E-01 | 4.5E-04 | 3.4E-02 | 9.8E-04 |  2d |1
2023-02-17 16:05:32 fides(INFO)    64| +2.13E+02 | -2.9E-02 | +4.7E-01 | 1.6E-02 | 3.2E+00 | 3.3E-02 | trr |1
2023-02-17 16:05:32 fides(INFO)    65| +1.48E+02 | -1.8E-07 | +3.5E-02 | 4.9E-03 | 3.1E-02 | 3.8E-04 |  2d |1
2023-02-17 16:05:32 fides(INFO)    14| +2.29E+02 | +1.4E+02 | -1.6E+01 | 2.0E+00 | 3.1E+01 | 6.1E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    61| +2.12E+02 | -1.0E-02 | +5.5E-01 | 7.8E-03 | 2.4E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    20| +1.50E+02 | -1.9E-01 | +5.3E-01 | 1.1E-01 | 6.9E+00 | 1.9E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    10| +6.63E+02 | -2.4E+03 | +9.0E-01 | 2.0E+00 | 1.3E+04 | 5.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    42| +2.23E+02 | +8.6E+01 | -6.9E+00 | 5.0E-01 | 3.5E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    15| +2.29E+02 | +1.4E+01 | -1.6E+00 | 5.0E-01 | 3.1E+01 | 1.5E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    41| +1.54E+02 | -6.5E-06 | +4.4E-01 | 9.0E-04 | 2.3E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    65| +2.13E+02 | -5.0E-02 | +6.2E-01 | 1.6E-02 | 4.4E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    62| +2.12E+02 | -3.3E-03 | +2.7E-01 | 7.8E-03 | 1.7E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    11| +2.93E+02 | -3.7E+02 | +9.0E-01 | 2.0E+00 | 2.1E+03 | 9.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    66| +1.48E+02 | -5.5E-06 | +2.3E+00 | 1.2E-03 | 1.0E-01 | 2.7E-04 |  2d |1
2023-02-17 16:05:32 fides(INFO)    66| +2.13E+02 | -2.5E-02 | +4.2E-01 | 1.6E-02 | 3.1E+00 | 3.4E-02 | trr |1
2023-02-17 16:05:32 fides(INFO)    16| +2.25E+02 | -3.9E+00 | +5.3E-01 | 1.2E-01 | 3.1E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    43| +2.23E+02 | +2.0E+00 | -3.7E-01 | 1.2E-01 | 3.5E+01 | 2.7E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)    12| +2.43E+02 | -5.0E+01 | +8.8E-01 | 2.0E+00 | 3.1E+02 | 5.0E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    42| +1.54E+02 | -4.7E-06 | +4.2E-01 | 9.0E-04 | 1.7E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    17| +2.23E+02 | -2.1E+00 | +7.1E-01 | 1.2E-01 | 2.6E+01 | 2.2E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    67| +1.48E+02 | +3.7E-06 | -3.2E+00 | 2.4E-03 | 1.2E-02 | 4.0E-04 |  2d |0
2023-02-17 16:05:32 fides(INFO)    63| +2.12E+02 | -9.0E-03 | +5.1E-01 | 7.8E-03 | 2.3E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    67| +2.12E+02 | -5.1E-02 | +6.3E-01 | 1.6E-02 | 4.4E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    18| +2.23E+02 | +1.0E-01 | -8.0E-02 | 1.2E-01 | 2.1E+01 | 3.0E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)    68| +1.48E+02 | +3.3E-06 | -9.3E+00 | 6.1E-04 | 1.2E-02 | 1.0E-04 |  2d |0
2023-02-17 16:05:32 fides(INFO)    43| +1.54E+02 | -3.0E-06 | +2.6E-01 | 9.0E-04 | 2.0E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    64| +2.12E+02 | -2.6E-03 | +2.3E-01 | 7.8E-03 | 1.6E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    68| +2.12E+02 | -2.2E-02 | +3.9E-01 | 1.6E-02 | 3.0E+00 | 3.4E-02 | trr |1
2023-02-17 16:05:32 fides(INFO)    21| +1.50E+02 | -1.3E-01 | +8.2E-01 | 1.1E-01 | 1.7E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    44| +2.21E+02 | -1.6E+00 | +8.1E-01 | 3.1E-02 | 3.5E+01 | 6.8E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    13| +2.38E+02 | -5.3E+00 | +7.2E-01 | 4.0E+00 | 3.5E+01 | 4.4E+00 | trr |1
2023-02-17 16:05:32 fides(INFO)    19| +2.22E+02 | -1.1E+00 | +8.8E-01 | 3.1E-02 | 2.1E+01 | 7.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    65| +2.12E+02 | -5.3E-03 | +9.0E-01 | 2.0E-03 | 2.1E+00 | 3.7E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    69| +1.48E+02 | +4.7E-06 | -3.2E+01 | 1.5E-04 | 1.2E-02 | 3.0E-05 |  2d |0
2023-02-17 16:05:32 fides(INFO)    69| +2.12E+02 | -5.1E-02 | +6.3E-01 | 1.6E-02 | 4.3E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    44| +1.54E+02 | -3.8E-06 | +3.3E-01 | 9.0E-04 | 1.4E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    14| +2.38E+02 | +7.8E+01 | -6.4E+00 | 4.0E+00 | 2.2E+01 | 9.9E+00 | trr |0
2023-02-17 16:05:32 fides(INFO)    66| +2.12E+02 | -5.2E-03 | +7.6E-01 | 3.9E-03 | 1.7E+00 | 6.6E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    20| +2.20E+02 | -1.2E+00 | +8.6E-01 | 6.2E-02 | 1.7E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    45| +2.18E+02 | -2.6E+00 | +7.3E-01 | 6.2E-02 | 4.6E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    22| +1.50E+02 | -5.4E-02 | +5.6E-01 | 2.2E-01 | 5.4E+00 | 3.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    70| +1.48E+02 | +5.5E-06 | -5.8E+01 | 3.8E-05 | 1.2E-02 | 1.6E-05 |  2d |0
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    70| +2.12E+02 | -2.0E-02 | +3.8E-01 | 1.6E-02 | 2.8E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    67| +2.12E+02 | -6.3E-03 | +7.2E-01 | 7.8E-03 | 1.3E+00 | 1.2E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    21| +2.19E+02 | -1.8E+00 | +8.4E-01 | 1.2E-01 | 2.0E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    45| +1.54E+02 | -4.9E-07 | +5.4E-02 | 9.0E-04 | 1.6E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    46| +2.16E+02 | -1.9E+00 | +8.6E-01 | 6.2E-02 | 4.8E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    71| +2.12E+02 | -5.0E-02 | +6.2E-01 | 1.6E-02 | 4.3E+00 | 3.2E-02 |  2d |1
2023-02-17 16:05:32.264 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.574 and h = 2.93244e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:32.264 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.574: AMICI failed to integrate the forward problem
2023-02-17 16:05:32 fides(INFO)    71| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.6E-06 | 1.2E-02 | 1.4E-05 |  2d |0
2023-02-17 16:05:32 fides(INFO)    68| +2.12E+02 | -3.9E-03 | +3.5E-01 | 7.8E-03 | 1.7E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    22| +2.19E+02 | +8.3E-01 | -3.6E-01 | 2.5E-01 | 1.9E+01 | 7.2E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)    23| +1.50E+02 | -1.1E-02 | +8.8E-01 | 2.2E-01 | 4.1E+00 | 3.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    46| +1.54E+02 | -2.9E-06 | +8.7E-01 | 2.2E-04 | 1.1E-02 | 4.9E-04 |  2d |1
2023-02-17 16:05:32 fides(INFO)    72| +2.12E+02 | -2.8E-02 | +5.4E-01 | 1.6E-02 | 2.8E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    15| +2.38E+02 | +2.5E+01 | -5.3E+00 | 9.2E-01 | 2.2E+01 | 2.5E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    69| +2.12E+02 | -2.3E-03 | +1.9E-01 | 7.8E-03 | 1.6E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    23| +2.17E+02 | -1.2E+00 | +6.1E-01 | 6.2E-02 | 1.9E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    47| +2.14E+02 | -2.2E+00 | +9.6E-01 | 1.2E-01 | 3.1E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    72| +1.48E+02 | +2.8E-06 | -6.0E+01 | 2.4E-06 | 1.2E-02 | 5.2E-06 |  2d |0
2023-02-17 16:05:32 fides(INFO)    73| +2.12E+02 | -4.1E-02 | +6.2E-01 | 1.6E-02 | 3.7E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    24| +1.50E+02 | -8.9E-03 | +9.2E-01 | 4.5E-01 | 3.6E+00 | 5.6E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    47| +1.54E+02 | -2.3E-06 | +5.4E-01 | 4.5E-04 | 2.7E-02 | 9.7E-04 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    24| +2.16E+02 | -1.0E+00 | +8.6E-01 | 6.2E-02 | 1.8E+01 | 9.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    70| +2.12E+02 | -4.8E-03 | +8.9E-01 | 2.0E-03 | 1.9E+00 | 3.8E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    48| +2.11E+02 | -3.0E+00 | +8.7E-01 | 2.5E-01 | 3.3E+01 | 6.2E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    73| +1.48E+02 | +6.7E-06 | -4.9E+02 | 6.0E-07 | 1.2E-02 | 1.3E-06 |  2d |0
2023-02-17 16:05:32 fides(INFO)    74| +2.12E+02 | -2.8E-02 | +5.2E-01 | 1.6E-02 | 2.8E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    16| +2.38E+02 | +3.1E+00 | -8.3E-01 | 2.3E-01 | 2.2E+01 | 5.6E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)    25| +2.16E+02 | -1.4E-01 | +3.3E-02 | 1.2E-01 | 1.4E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    71| +2.12E+02 | -3.8E-03 | +6.9E-01 | 3.9E-03 | 1.4E+00 | 6.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    25| +1.50E+02 | -3.7E-03 | +5.2E-01 | 9.0E-01 | 7.0E-01 | 9.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    48| +1.54E+02 | -1.2E-06 | +4.9E-01 | 4.5E-04 | 9.6E-03 | 9.5E-04 |  2d |1
2023-02-17 16:05:32 fides(WARNING) Stopping as function difference 1.19E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:32 fides(INFO)    75| +2.12E+02 | -4.0E-02 | +6.2E-01 | 1.6E-02 | 3.6E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    74| +1.48E+02 | +1.4E-05 | -4.0E+03 | 1.5E-07 | 1.2E-02 | 3.2E-07 |  2d |0
2023-02-17 16:05:32 fides(INFO)    49| +2.11E+02 | +1.6E+01 | -5.2E+00 | 5.0E-01 | 4.0E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    26| +2.15E+02 | -1.2E+00 | +8.7E-01 | 3.1E-02 | 3.1E+01 | 5.8E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    72| +2.12E+02 | -2.6E-03 | +6.5E-01 | 3.9E-03 | 1.1E+00 | 7.4E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    17| +2.36E+02 | -1.9E+00 | +8.2E-01 | 5.8E-02 | 2.2E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    76| +2.12E+02 | -2.7E-02 | +5.2E-01 | 1.6E-02 | 2.7E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    26| +1.50E+02 | +8.2E-03 | -2.7E+00 | 9.0E-01 | 1.5E+00 | 1.2E-01 | trr |0
2023-02-17 16:05:32 fides(INFO)    73| +2.12E+02 | -3.2E-03 | +6.7E-01 | 3.9E-03 | 1.3E+00 | 6.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    27| +2.14E+02 | -8.0E-01 | +6.6E-01 | 6.2E-02 | 1.9E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    75| +1.48E+02 | +1.5E-05 | -1.6E+04 | 3.7E-08 | 1.2E-02 | 8.1E-08 |  2d |0
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    50| +2.09E+02 | -1.9E+00 | +1.1E+00 | 1.2E-01 | 4.0E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    77| +2.12E+02 | -3.9E-02 | +6.2E-01 | 1.6E-02 | 3.5E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    28| +2.14E+02 | -2.5E-01 | +2.8E-01 | 6.2E-02 | 1.2E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    74| +2.12E+02 | -2.0E-03 | +5.4E-01 | 3.9E-03 | 1.0E+00 | 8.1E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    18| +2.33E+02 | -2.9E+00 | +1.2E+00 | 1.2E-01 | 1.6E+01 | 1.9E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    76| +1.48E+02 | +8.1E-06 | -3.6E+04 | 9.3E-09 | 1.2E-02 | 2.0E-08 |  2d |0
2023-02-17 16:05:32 fides(INFO)    27| +1.50E+02 | -8.3E-04 | +5.5E-01 | 7.9E-02 | 1.5E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    51| +2.05E+02 | -4.8E+00 | +8.5E-01 | 2.5E-01 | 3.2E+01 | 5.8E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    78| +2.12E+02 | -2.8E-02 | +5.3E-01 | 1.6E-02 | 2.7E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    75| +2.12E+02 | -3.0E-03 | +6.3E-01 | 3.9E-03 | 1.2E+00 | 7.2E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    29| +2.13E+02 | -7.1E-01 | +5.8E-01 | 6.2E-02 | 1.9E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    79| +2.12E+02 | -3.9E-02 | +6.3E-01 | 1.6E-02 | 3.4E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    77| +1.48E+02 | +4.7E-06 | -8.4E+04 | 2.3E-09 | 1.2E-02 | 5.0E-09 |  2d |0
2023-02-17 16:05:32 fides(INFO)    28| +1.50E+02 | -1.7E-04 | +3.6E-01 | 7.9E-02 | 4.4E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    52| +1.90E+02 | -1.5E+01 | +6.2E-01 | 5.0E-01 | 1.1E+02 | 1.2E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    30| +2.13E+02 | -6.8E-02 | +6.2E-02 | 6.2E-02 | 1.1E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    76| +2.12E+02 | -1.7E-03 | +4.8E-01 | 3.9E-03 | 9.9E-01 | 8.5E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)     0| +7.90E+12 |    NaN   |    NaN   | 1.0E+00 | 3.6E+13 |   NaN   | NaN |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    80| +2.12E+02 | -2.8E-02 | +5.5E-01 | 1.6E-02 | 2.6E+00 | 4.0E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    78| +1.48E+02 | +7.0E-06 | -5.0E+05 | 5.8E-10 | 1.2E-02 | 1.3E-09 |  2d |0
2023-02-17 16:05:32 fides(INFO)    31| +2.13E+02 | -4.1E-01 | +9.0E-01 | 1.6E-02 | 2.0E+01 | 2.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    19| +2.30E+02 | -2.6E+00 | +9.5E-01 | 2.3E-01 | 1.6E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    29| +1.50E+02 | -2.5E-05 | +8.4E-02 | 7.9E-02 | 4.0E-01 | 2.1E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    77| +2.12E+02 | -2.7E-03 | +6.0E-01 | 3.9E-03 | 1.2E+00 | 7.4E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    53| +1.90E+02 | +6.1E+01 | -4.4E+00 | 5.0E-01 | 5.1E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    81| +2.12E+02 | -5.6E-02 | +1.0E+00 | 1.6E-02 | 3.3E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    32| +2.12E+02 | -3.7E-01 | +7.5E-01 | 3.1E-02 | 1.4E+01 | 5.3E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)     1| +3.35E+08 | -7.9E+12 | +8.5E-02 | 1.0E+00 | 3.6E+13 | 3.0E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    79| +1.48E+02 | +3.2E-06 | -9.2E+05 | 1.5E-10 | 1.2E-02 | 3.2E-10 |  2d |0
2023-02-17 16:05:32 fides(INFO)    78| +2.12E+02 | -1.5E-03 | +4.4E-01 | 3.9E-03 | 9.3E-01 | 8.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    30| +1.50E+02 | -8.0E-05 | +7.1E-01 | 2.0E-02 | 9.9E-02 | 4.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    54| +1.87E+02 | -2.3E+00 | +3.4E-01 | 1.2E-01 | 5.1E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    82| +2.12E+02 | -8.3E-02 | +7.8E-01 | 3.1E-02 | 2.2E+00 | 6.6E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    33| +2.12E+02 | -4.2E-01 | +7.5E-01 | 6.2E-02 | 8.8E+00 | 1.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    20| +2.25E+02 | -5.8E+00 | +1.0E+00 | 4.6E-01 | 2.8E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    79| +2.12E+02 | -2.5E-03 | +5.7E-01 | 3.9E-03 | 1.1E+00 | 7.5E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)     2| +5.08E+07 | -2.8E+08 | +8.9E-01 | 2.5E-01 | 1.5E+09 | 6.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    34| +2.12E+02 | -2.1E-01 | +3.8E-01 | 6.2E-02 | 1.3E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    83| +2.12E+02 | -1.8E-01 | +1.0E+00 | 6.2E-02 | 3.2E+00 | 1.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    31| +1.50E+02 | -1.2E-05 | +7.5E-01 | 2.0E-02 | 1.7E-01 | 3.7E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    55| +1.85E+02 | -2.3E+00 | +6.9E-01 | 1.2E-01 | 3.8E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    80| +1.48E+02 | +3.5E-06 | -4.0E+06 | 3.6E-11 | 1.2E-02 | 7.9E-11 |  2d |0
2023-02-17 16:05:32 fides(INFO)    80| +2.12E+02 | -1.3E-03 | +4.1E-01 | 3.9E-03 | 8.9E-01 | 9.3E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)     3| +7.21E+06 | -4.4E+07 | +9.0E-01 | 5.0E-01 | 2.3E+08 | 7.7E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    21| +2.20E+02 | -4.1E+00 | +2.9E-01 | 9.2E-01 | 2.3E+01 | 2.1E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    35| +2.12E+02 | +1.1E-01 | -2.1E-01 | 6.2E-02 | 9.5E+00 | 1.5E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)    84| +2.11E+02 | -2.7E-01 | +9.6E-01 | 1.2E-01 | 2.2E+00 | 2.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    32| +1.50E+02 | -2.2E-06 | +8.6E-01 | 2.0E-02 | 3.6E-02 | 3.4E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    81| +2.12E+02 | -2.2E-03 | +5.4E-01 | 3.9E-03 | 1.1E+00 | 7.7E-03 |  2d |1
2023-02-17 16:05:32.617 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.317 and h = 3.91293e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:32.617 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.317: AMICI failed to integrate the forward problem
2023-02-17 16:05:32 fides(INFO)    81| +1.48E+02 | +0.0E+00 | +0.0E+00 | 9.1E-12 | 1.2E-02 | 2.0E-11 |  2d |0
2023-02-17 16:05:32 fides(INFO)    56| +1.77E+02 | -8.4E+00 | +6.6E-01 | 1.2E-01 | 5.5E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    36| +2.12E+02 | -2.3E-01 | +8.4E-01 | 1.6E-02 | 9.5E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    85| +2.10E+02 | -1.2E+00 | +1.4E+00 | 2.5E-01 | 4.8E+00 | 5.3E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    82| +2.12E+02 | -1.2E-03 | +3.9E-01 | 3.9E-03 | 8.5E-01 | 9.6E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)     4| +1.01E+06 | -6.2E+06 | +9.0E-01 | 5.0E-01 | 3.3E+07 | 7.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    22| +2.20E+02 | -5.1E+00 | -4.0E-01 | 9.2E-01 | 6.9E+01 | 1.7E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    33| +1.50E+02 | -1.8E-06 | +8.9E-01 | 3.9E-02 | 4.4E-02 | 6.3E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    82| +1.48E+02 | +5.5E-06 | -1.0E+08 | 2.3E-12 | 1.2E-02 | 4.9E-12 |  2d |0
2023-02-17 16:05:32 fides(INFO)    37| +2.11E+02 | -1.4E-01 | +5.8E-01 | 3.1E-02 | 7.1E+00 | 5.9E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    57| +1.73E+02 | -3.1E+00 | +5.8E-01 | 1.2E-01 | 4.6E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    86| +2.10E+02 | +2.5E+01 | -1.0E+01 | 5.0E-01 | 8.4E+00 | 1.2E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    83| +2.12E+02 | -2.0E-03 | +5.2E-01 | 3.9E-03 | 1.0E+00 | 7.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    38| +2.11E+02 | -1.6E-01 | +5.7E-01 | 3.1E-02 | 9.6E+00 | 5.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)     5| +1.44E+05 | -8.7E+05 | +9.0E-01 | 5.0E-01 | 4.9E+06 | 6.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    87| +2.10E+02 | -6.9E-01 | +8.2E-01 | 1.2E-01 | 8.4E+00 | 3.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    34| +1.50E+02 | -1.8E-06 | +1.1E+00 | 7.9E-02 | 3.4E-02 | 1.1E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    84| +2.12E+02 | -1.1E-03 | +3.8E-01 | 3.9E-03 | 8.2E-01 | 9.8E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    58| +1.71E+02 | -2.9E+00 | +4.1E-01 | 1.2E-01 | 4.3E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    23| +2.07E+02 | -1.3E+01 | +8.3E-01 | 2.3E-01 | 6.9E+01 | 4.5E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    39| +2.11E+02 | -6.7E-02 | +2.8E-01 | 3.1E-02 | 6.8E+00 | 6.8E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    83| +1.48E+02 | +1.4E-05 | -9.9E+08 | 5.7E-13 | 1.2E-02 | 1.2E-12 |  2d |0
2023-02-17 16:05:32 fides(INFO)    85| +2.12E+02 | -1.8E-03 | +5.0E-01 | 3.9E-03 | 9.7E-01 | 8.1E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    88| +2.10E+02 | +8.6E+00 | -4.0E+00 | 2.5E-01 | 6.7E+00 | 4.7E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    59| +1.71E+02 | +2.7E+01 | -2.7E+00 | 1.2E-01 | 4.9E+01 | 3.3E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)     6| +2.12E+04 | -1.2E+05 | +9.0E-01 | 5.0E-01 | 7.5E+05 | 6.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    35| +1.50E+02 | +2.5E-06 | -2.2E+00 | 1.6E-01 | 1.5E-02 | 8.4E-03 | trr |0
2023-02-17 16:05:32 fides(INFO)    40| +2.11E+02 | -1.6E-01 | +5.3E-01 | 3.1E-02 | 9.8E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    86| +2.12E+02 | -1.1E-03 | +3.7E-01 | 3.9E-03 | 7.8E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    24| +1.83E+02 | -2.4E+01 | +1.0E+00 | 4.6E-01 | 3.3E+01 | 9.6E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    89| +2.10E+02 | +3.0E-01 | -4.3E-01 | 6.2E-02 | 6.7E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)    84| +1.48E+02 | +5.3E-06 | -1.6E+09 | 1.4E-13 | 1.2E-02 | 3.1E-13 |  2d |0
2023-02-17 16:05:32 fides(INFO)    87| +2.12E+02 | -1.7E-03 | +4.8E-01 | 3.9E-03 | 9.2E-01 | 8.3E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    41| +2.11E+02 | -3.4E-02 | +1.6E-01 | 3.1E-02 | 6.2E+00 | 7.0E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    60| +1.70E+02 | -3.8E-01 | +1.0E-01 | 3.1E-02 | 4.9E+01 | 8.5E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)     7| +3.31E+03 | -1.8E+04 | +9.0E-01 | 5.0E-01 | 1.2E+05 | 5.9E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    90| +2.09E+02 | -1.3E-01 | +6.3E-01 | 1.6E-02 | 6.7E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    36| +1.50E+02 | -1.7E-07 | +3.1E-01 | 2.3E-02 | 1.5E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:32 fides(WARNING) Stopping as function difference 1.68E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:32 fides(INFO)    25| +1.83E+02 | +3.9E+02 | -1.7E+01 | 9.2E-01 | 1.2E+02 | 1.8E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    85| +1.48E+02 | +4.3E-06 | -5.0E+09 | 3.6E-14 | 1.2E-02 | 7.7E-14 |  2d |0
2023-02-17 16:05:32 fides(INFO)    88| +2.12E+02 | -1.0E-03 | +3.7E-01 | 3.9E-03 | 7.5E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    42| +2.11E+02 | -9.6E-02 | +9.0E-01 | 7.8E-03 | 9.5E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    91| +2.09E+02 | -5.5E-02 | +1.0E+00 | 1.6E-02 | 1.9E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    61| +1.69E+02 | -8.6E-01 | +1.0E+00 | 7.8E-03 | 6.9E+01 | 1.5E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)     8| +6.40E+02 | -2.7E+03 | +9.0E-01 | 5.0E-01 | 1.9E+04 | 6.0E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    89| +2.12E+02 | -1.5E-03 | +4.7E-01 | 3.9E-03 | 8.8E-01 | 8.6E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    26| +1.70E+02 | -1.3E+01 | +8.7E-01 | 2.3E-01 | 1.2E+02 | 4.3E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    86| +1.48E+02 | +2.5E-06 | -1.1E+10 | 8.9E-15 | 1.2E-02 | 1.9E-14 |  2d |0
2023-02-17 16:05:32 fides(INFO)    43| +2.11E+02 | -9.0E-02 | +7.5E-01 | 1.6E-02 | 7.2E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    92| +2.09E+02 | -1.1E-01 | +1.1E+00 | 3.1E-02 | 1.4E+00 | 8.8E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    62| +1.68E+02 | -1.1E+00 | +1.0E+00 | 1.6E-02 | 5.1E+01 | 3.1E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    27| +1.56E+02 | -1.4E+01 | +1.0E+00 | 4.6E-01 | 8.3E+01 | 7.3E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    44| +2.11E+02 | -1.1E-01 | +7.6E-01 | 3.1E-02 | 5.0E+00 | 4.6E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)     9| +2.48E+02 | -3.9E+02 | +8.9E-01 | 5.0E-01 | 3.0E+03 | 5.3E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    90| +2.12E+02 | -1.0E-03 | +3.8E-01 | 3.9E-03 | 7.3E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    93| +2.09E+02 | -2.0E-01 | +1.1E+00 | 6.2E-02 | 1.6E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    45| +2.11E+02 | -6.0E-02 | +3.5E-01 | 6.2E-02 | 6.6E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)     0| +6.35E+09 |    NaN   |    NaN   | 1.0E+00 | 2.9E+10 |   NaN   | NaN |1
2023-02-17 16:05:32 fides(INFO)    87| +1.48E+02 | +1.1E-05 | -2.0E+11 | 2.2E-15 | 1.2E-02 | 4.8E-15 |  2d |0
2023-02-17 16:05:32 fides(INFO)    91| +2.12E+02 | -1.4E-03 | +4.6E-01 | 3.9E-03 | 8.4E-01 | 8.8E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    28| +1.56E+02 | +1.8E+01 | -2.7E+00 | 9.2E-01 | 9.3E+01 | 1.1E+00 |  2d |0
2023-02-17 16:05:32 fides(INFO)    63| +1.67E+02 | -1.1E+00 | +9.9E-01 | 3.1E-02 | 2.6E+01 | 6.1E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    94| +2.09E+02 | -5.6E-01 | +1.3E+00 | 1.2E-01 | 3.5E+00 | 3.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    10| +1.84E+02 | -6.4E+01 | +9.0E-01 | 5.0E-01 | 5.2E+02 | 6.5E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)     1| +1.83E+04 | -6.4E+09 | +9.6E-02 | 1.0E+00 | 2.9E+10 | 2.8E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    46| +2.11E+02 | +4.8E-03 | -3.8E-02 | 6.2E-02 | 6.0E+00 | 1.8E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)    92| +2.12E+02 | -2.2E-03 | +1.0E+00 | 3.9E-03 | 7.0E-01 | 6.9E-03 |  2d |1
2023-02-17 16:05:32 fides(INFO)    88| +1.48E+02 | +6.8E-06 | -5.1E+11 | 5.6E-16 | 1.2E-02 | 1.2E-15 |  2d |0
2023-02-17 16:05:32 fides(WARNING) Stopping as trust region radius 1.39E-16 is smaller than machine precision.
2023-02-17 16:05:32 fides(INFO)     2| +3.15E+03 | -1.5E+04 | +9.0E-01 | 2.5E-01 | 8.3E+04 | 4.6E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    29| +1.51E+02 | -4.4E+00 | +8.7E-01 | 2.1E-01 | 9.3E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    95| +2.06E+02 | -2.5E+00 | +1.9E+00 | 2.5E-01 | 7.4E+00 | 6.5E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    64| +1.66E+02 | -1.5E+00 | +9.8E-01 | 6.2E-02 | 2.8E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    47| +2.11E+02 | -1.0E-01 | +6.7E-01 | 1.6E-02 | 6.0E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    93| +2.12E+02 | -3.6E-03 | +9.0E-01 | 7.8E-03 | 5.2E-01 | 1.4E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)     3| +7.50E+02 | -2.4E+03 | +9.0E-01 | 5.0E-01 | 1.3E+04 | 1.3E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    11| +1.69E+02 | -1.5E+01 | +1.0E+00 | 5.0E-01 | 2.0E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    96| +1.98E+02 | -8.5E+00 | +6.2E-01 | 5.0E-01 | 1.4E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:32 fides(INFO)    30| +1.51E+02 | +4.7E-01 | -1.9E-01 | 4.2E-01 | 5.9E+01 | 5.4E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)     4| +3.61E+02 | -3.9E+02 | +9.0E-01 | 1.0E+00 | 2.1E+03 | 2.7E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    48| +2.11E+02 | -6.1E-02 | +9.3E-01 | 1.6E-02 | 4.3E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    94| +2.12E+02 | -1.3E-03 | +5.8E-01 | 1.6E-02 | 6.0E-01 | 8.8E-03 | trr |1
2023-02-17 16:05:32 fides(INFO)    65| +1.62E+02 | -3.3E+00 | +7.9E-01 | 1.2E-01 | 2.3E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    97| +1.98E+02 | +5.1E-01 | -1.2E-01 | 5.0E-01 | 6.8E+01 | 9.2E-01 |  2d |0
2023-02-17 16:05:32 fides(INFO)     5| +2.64E+02 | -9.7E+01 | +9.2E-01 | 2.0E+00 | 3.3E+02 | 4.8E+00 |  2d |1
2023-02-17 16:05:32 fides(INFO)    49| +2.10E+02 | -2.6E-02 | +3.1E-01 | 3.1E-02 | 3.8E+00 | 6.7E-02 |  2d |1
2023-02-17 16:05:32 fides(INFO)    31| +1.50E+02 | -1.1E+00 | +8.4E-01 | 1.1E-01 | 5.9E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:32 fides(INFO)    95| +2.12E+02 | -3.1E-03 | +8.9E-01 | 1.6E-02 | 7.0E-01 | 1.4E-02 | trr |1
2023-02-17 16:05:32 fides(INFO)    66| +1.60E+02 | -2.1E+00 | +1.2E-01 | 2.5E-01 | 5.4E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)     6| +2.64E+02 | +1.6E+03 | -1.1E+02 | 4.0E+00 | 4.8E+01 | 9.8E+00 | trr |0
2023-02-17 16:05:33.009 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 193.843 and h = 3.10514e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:33 fides(INFO)    12| +1.66E+02 | -3.1E+00 | +6.3E-01 | 1.0E+00 | 5.1E+01 | 4.0E-01 | trr |1
2023-02-17 16:05:33.009 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 193.843: AMICI failed to integrate the forward problem
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    50| +2.10E+02 | -5.4E-02 | +3.1E-01 | 3.1E-02 | 6.7E+00 | 7.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    98| +1.98E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 6.8E+01 | 2.4E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    32| +1.49E+02 | -1.1E+00 | +6.4E-01 | 2.1E-01 | 4.0E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)     0| +3.27E+09 |    NaN   |    NaN   | 1.0E+00 | 1.5E+10 |   NaN   | NaN |1
2023-02-17 16:05:33 fides(INFO)     7| +2.64E+02 | +1.7E+02 | -8.1E+00 | 1.0E+00 | 4.8E+01 | 2.4E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)    96| +2.12E+02 | -3.0E-03 | +8.3E-01 | 1.6E-02 | 6.4E-01 | 1.7E-02 | trr |1
2023-02-17 16:05:33 fides(INFO)    67| +1.57E+02 | -3.6E+00 | +7.7E-01 | 6.2E-02 | 1.2E+02 | 1.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)     8| +2.52E+02 | -1.2E+01 | +5.7E-01 | 2.5E-01 | 4.8E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    51| +2.10E+02 | -5.6E-03 | +2.7E-02 | 3.1E-02 | 4.9E+00 | 8.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    99| +1.94E+02 | -3.6E+00 | +1.0E+00 | 3.1E-02 | 6.8E+01 | 6.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)     1| +1.38E+04 | -3.3E+09 | +9.8E-02 | 1.0E+00 | 1.5E+10 | 2.7E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    33| +1.49E+02 | +2.8E-01 | -2.0E-01 | 2.1E-01 | 5.9E+01 | 2.8E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    97| +2.12E+02 | -3.2E-03 | +9.8E-01 | 1.6E-02 | 7.1E-01 | 1.5E-02 | trr |1
2023-02-17 16:05:33 fides(INFO)     9| +2.51E+02 | -5.9E-01 | +1.5E-01 | 2.5E-01 | 2.7E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    68| +1.57E+02 | +2.0E-01 | -2.9E-01 | 1.2E-01 | 2.8E+01 | 2.2E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    52| +2.10E+02 | -7.1E-02 | +8.6E-01 | 7.8E-03 | 6.9E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:33.067 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 57.1283 and h = 7.30369e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:33.067 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 57.1283: AMICI failed to integrate the forward problem
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)   100| +1.94E+02 | +0.0E+00 | +0.0E+00 | 6.2E-02 | 6.4E+01 | 1.2E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    98| +2.12E+02 | -2.4E-03 | +8.6E-01 | 1.6E-02 | 4.5E-01 | 2.3E-02 | trr |1
2023-02-17 16:05:33 fides(INFO)    10| +2.50E+02 | -1.2E+00 | +6.1E-01 | 6.2E-02 | 2.2E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)     2| +2.98E+03 | -1.1E+04 | +8.9E-01 | 2.5E-01 | 5.4E+04 | 5.6E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    13| +1.59E+02 | -6.5E+00 | +1.0E+00 | 1.0E+00 | 1.5E+02 | 1.3E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    34| +1.48E+02 | -6.5E-01 | +8.4E-01 | 5.3E-02 | 5.9E+01 | 7.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    11| +2.50E+02 | -1.4E-02 | +1.5E-01 | 6.2E-02 | 4.0E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    53| +2.10E+02 | -3.3E-02 | +5.1E-01 | 1.6E-02 | 4.4E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   101| +1.92E+02 | -1.7E+00 | +1.0E+00 | 1.6E-02 | 6.4E+01 | 3.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    99| +2.12E+02 | -3.5E-03 | +8.7E-01 | 3.1E-02 | 6.8E-01 | 2.9E-02 | trr |1
2023-02-17 16:05:33 fides(INFO)    69| +1.56E+02 | -3.2E-01 | +7.2E-01 | 3.1E-02 | 2.8E+01 | 5.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    12| +2.50E+02 | +9.1E-05 | -7.4E-03 | 1.6E-02 | 3.2E+00 | 3.9E-02 |  2d |0
2023-02-17 16:05:33 fides(INFO)    35| +1.48E+02 | -2.7E-01 | +7.1E-01 | 1.1E-01 | 1.7E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)     3| +6.53E+02 | -2.3E+03 | +9.0E-01 | 5.0E-01 | 9.7E+03 | 1.1E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    54| +2.10E+02 | -1.5E-02 | +2.9E-01 | 1.6E-02 | 3.3E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    13| +2.50E+02 | -2.4E-02 | +8.6E-01 | 3.9E-03 | 3.2E+00 | 9.8E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)   102| +1.89E+02 | -3.4E+00 | +9.9E-01 | 3.1E-02 | 6.3E+01 | 6.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)   100| +2.12E+02 | -2.3E-03 | +6.3E-01 | 3.1E-02 | 7.1E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    36| +1.48E+02 | -2.0E-01 | +8.9E-01 | 1.1E-01 | 2.2E+01 | 9.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    70| +1.56E+02 | -2.7E-01 | +7.6E-01 | 3.1E-02 | 1.5E+01 | 5.5E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    55| +2.10E+02 | -3.2E-02 | +4.9E-01 | 1.6E-02 | 4.4E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   101| +2.12E+02 | -7.8E-05 | +1.3E-02 | 3.1E-02 | 4.8E-01 | 2.4E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    14| +2.50E+02 | -9.3E-04 | +5.2E-02 | 7.8E-03 | 1.7E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)     4| +2.90E+02 | -3.6E+02 | +8.9E-01 | 1.0E+00 | 1.6E+03 | 1.6E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)   103| +1.82E+02 | -6.4E+00 | +9.9E-01 | 6.2E-02 | 6.0E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    15| +2.50E+02 | -4.8E-03 | +8.9E-01 | 2.0E-03 | 1.6E+00 | 3.8E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    37| +1.48E+02 | -1.6E-01 | +8.1E-01 | 2.1E-01 | 5.7E+00 | 1.9E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)     5| +2.49E+02 | -4.1E+01 | +8.3E-01 | 1.0E+00 | 2.3E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    56| +2.10E+02 | -1.3E-02 | +2.7E-01 | 1.6E-02 | 3.1E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   102| +2.12E+02 | -4.0E-03 | +8.9E-01 | 7.8E-03 | 1.1E+00 | 9.2E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    71| +1.56E+02 | +1.4E-01 | -5.0E-01 | 6.2E-02 | 6.1E+00 | 1.3E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    16| +2.50E+02 | -2.4E-03 | +5.0E-01 | 3.9E-03 | 9.6E-01 | 7.5E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)   104| +1.72E+02 | -1.0E+01 | +1.0E+00 | 1.2E-01 | 5.4E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    17| +2.50E+02 | -1.6E-04 | +2.1E-01 | 3.9E-03 | 3.2E-01 | 9.2E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)     6| +2.35E+02 | -1.5E+01 | +3.9E+00 | 2.0E+00 | 1.2E+01 | 3.9E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    57| +2.10E+02 | -2.7E-02 | +4.5E-01 | 1.6E-02 | 4.1E+00 | 3.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   103| +2.12E+02 | -4.4E-03 | +8.0E-01 | 1.6E-02 | 3.7E-01 | 3.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    38| +1.48E+02 | +4.2E+00 | -8.7E+00 | 4.2E-01 | 3.2E+00 | 4.8E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    72| +1.56E+02 | -1.1E-01 | +8.6E-01 | 1.6E-02 | 6.1E+00 | 3.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    18| +2.50E+02 | -3.1E-04 | +6.8E-01 | 9.8E-04 | 3.2E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)   105| +1.65E+02 | -7.2E+00 | +4.9E-01 | 2.5E-01 | 4.9E+01 | 4.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   104| +2.12E+02 | -8.0E-03 | +1.1E+00 | 3.1E-02 | 5.8E-01 | 4.5E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    58| +2.10E+02 | -1.2E-02 | +2.6E-01 | 1.6E-02 | 3.0E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    19| +2.50E+02 | -6.7E-05 | +9.8E-01 | 9.8E-04 | 3.0E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    14| +1.59E+02 | -1.8E+00 | -4.6E-01 | 2.0E+00 | 3.8E+01 | 2.5E+00 | trr |0
2023-02-17 16:05:33 fides(INFO)    39| +1.48E+02 | +5.4E-02 | -3.5E-01 | 1.1E-01 | 3.2E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    73| +1.56E+02 | -5.4E-02 | +6.5E-01 | 3.1E-02 | 3.4E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)     7| +2.35E+02 | +4.0E+02 | -1.8E+01 | 4.0E+00 | 3.5E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:33.259 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 68.9213 and h = 1.14762e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:33.259 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 68.9213: AMICI failed to integrate the forward problem
2023-02-17 16:05:33 fides(INFO)   106| +1.65E+02 | +0.0E+00 | +0.0E+00 | 2.5E-01 | 1.3E+02 | 5.9E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    20| +2.50E+02 | -7.7E-05 | +8.7E-01 | 2.0E-03 | 4.1E-02 | 4.6E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)   105| +2.12E+02 | -2.0E-02 | +1.1E+00 | 6.2E-02 | 3.6E-01 | 1.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    59| +2.10E+02 | -2.4E-02 | +4.3E-01 | 1.6E-02 | 3.9E+00 | 3.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)     8| +2.35E+02 | +3.4E+01 | -3.0E+00 | 1.0E+00 | 3.5E+01 | 2.8E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)    21| +2.50E+02 | -1.6E-04 | +8.3E-01 | 3.9E-03 | 6.9E-02 | 9.1E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    40| +1.48E+02 | -3.1E-02 | +6.8E-01 | 2.6E-02 | 3.2E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   106| +2.12E+02 | -7.4E-02 | +1.4E+00 | 1.2E-01 | 6.9E-01 | 2.8E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    60| +2.10E+02 | -1.1E-02 | +2.6E-01 | 1.6E-02 | 2.9E+00 | 4.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    22| +2.50E+02 | -3.1E-04 | +8.6E-01 | 7.8E-03 | 9.6E-02 | 1.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    74| +1.56E+02 | -8.2E-02 | +1.1E+00 | 3.1E-02 | 3.8E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   107| +1.61E+02 | -4.2E+00 | +3.4E-01 | 6.2E-02 | 1.3E+02 | 1.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)     9| +2.35E+02 | +5.7E+00 | -5.3E-01 | 2.5E-01 | 3.5E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    41| +1.48E+02 | -1.2E-02 | +9.6E-01 | 2.6E-02 | 3.4E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    23| +2.50E+02 | -6.5E-04 | +9.2E-01 | 1.6E-02 | 1.1E-01 | 3.7E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   107| +2.11E+02 | -4.3E-01 | +2.1E+00 | 2.5E-01 | 1.7E+00 | 6.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    10| +2.30E+02 | -4.4E+00 | +8.8E-01 | 6.2E-02 | 3.5E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    61| +2.10E+02 | -2.1E-02 | +4.2E-01 | 1.6E-02 | 3.6E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    24| +2.50E+02 | -1.4E-03 | +9.8E-01 | 3.1E-02 | 1.3E-01 | 7.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   108| +1.54E+02 | -7.0E+00 | +9.0E-01 | 6.2E-02 | 1.5E+02 | 1.2E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    75| +1.56E+02 | -1.7E-01 | +1.2E+00 | 6.2E-02 | 2.6E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    42| +1.48E+02 | -1.9E-02 | +9.5E-01 | 5.3E-02 | 1.5E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   108| +2.11E+02 | +8.4E+00 | -8.0E+00 | 5.0E-01 | 4.3E+00 | 1.4E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)    25| +2.50E+02 | -3.2E-03 | +1.1E+00 | 6.2E-02 | 1.4E-01 | 1.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    11| +2.29E+02 | -1.1E+00 | +2.1E-01 | 1.2E-01 | 2.3E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    62| +2.10E+02 | -1.1E-02 | +2.7E-01 | 1.6E-02 | 2.7E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   109| +1.52E+02 | -2.0E+00 | +3.1E-01 | 1.2E-01 | 5.2E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    26| +2.50E+02 | -8.3E-03 | +1.2E+00 | 1.2E-01 | 1.6E-01 | 2.9E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    12| +2.28E+02 | -1.7E+00 | +9.2E-01 | 3.1E-02 | 3.9E+01 | 5.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    76| +1.55E+02 | -3.3E-01 | +1.0E+00 | 1.2E-01 | 5.5E+00 | 2.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   109| +2.11E+02 | -6.0E-01 | +1.4E+00 | 1.2E-01 | 4.3E+00 | 3.4E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    63| +2.10E+02 | -1.9E-02 | +4.1E-01 | 1.6E-02 | 3.4E+00 | 3.5E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    43| +1.48E+02 | -3.2E-02 | +9.6E-01 | 1.1E-01 | 2.1E+00 | 7.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    15| +1.56E+02 | -3.0E+00 | +1.0E+00 | 5.0E-01 | 3.8E+01 | 5.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    27| +2.50E+02 | -2.8E-02 | +1.4E+00 | 2.5E-01 | 1.8E-01 | 5.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    13| +2.26E+02 | -1.9E+00 | +8.6E-01 | 6.2E-02 | 2.7E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)   110| +1.52E+02 | +9.5E-01 | -2.4E-01 | 1.2E-01 | 7.2E+01 | 2.8E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)   110| +2.11E+02 | +1.5E+00 | -1.5E+00 | 2.5E-01 | 3.6E+00 | 6.7E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    28| +2.50E+02 | -1.6E-01 | +2.0E+00 | 5.0E-01 | 2.7E-01 | 1.1E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    64| +2.10E+02 | -1.1E-02 | +2.9E-01 | 1.6E-02 | 2.6E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    44| +1.48E+02 | -3.8E-02 | +8.5E-01 | 2.1E-01 | 1.1E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    14| +2.23E+02 | -3.2E+00 | +1.1E+00 | 1.2E-01 | 1.8E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    77| +1.55E+02 | -5.7E-01 | +6.7E-01 | 2.5E-01 | 2.2E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    29| +2.47E+02 | -2.1E+00 | +3.2E+00 | 1.0E+00 | 5.1E-01 | 2.1E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)   111| +1.50E+02 | -1.5E+00 | +5.5E-01 | 3.1E-02 | 7.2E+01 | 6.4E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    65| +2.10E+02 | -1.8E-02 | +4.2E-01 | 1.6E-02 | 3.2E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   111| +2.10E+02 | -3.6E-01 | +1.0E+00 | 6.2E-02 | 3.6E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    45| +1.48E+02 | +2.0E-01 | -3.7E+00 | 4.2E-01 | 1.7E+00 | 2.2E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    15| +2.20E+02 | -3.0E+00 | +1.0E+00 | 2.5E-01 | 1.9E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    30| +2.29E+02 | -1.8E+01 | +3.6E+00 | 2.0E+00 | 6.4E+00 | 3.7E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)   112| +2.10E+02 | +2.5E-01 | -5.3E-01 | 1.2E-01 | 2.0E+00 | 3.3E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    66| +2.10E+02 | -1.2E-02 | +3.2E-01 | 1.6E-02 | 2.4E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   112| +1.49E+02 | -1.0E+00 | +5.1E-01 | 3.1E-02 | 7.3E+01 | 7.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    46| +1.48E+02 | -6.6E-03 | +2.8E-01 | 1.1E-01 | 1.7E+00 | 5.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    16| +2.19E+02 | -9.4E-01 | +1.1E-04 | 5.0E-01 | 2.0E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    78| +1.54E+02 | -9.4E-01 | +1.4E+00 | 2.5E-01 | 3.1E+01 | 4.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    31| +2.29E+02 | +1.9E+02 | -1.3E+01 | 4.0E+00 | 2.7E+01 | 1.2E+01 |  2d |0
2023-02-17 16:05:33 fides(INFO)   113| +2.10E+02 | -1.2E-01 | +8.6E-01 | 3.1E-02 | 2.0E+00 | 8.4E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    17| +2.12E+02 | -6.7E+00 | +7.7E-01 | 1.2E-01 | 6.3E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    67| +2.10E+02 | -1.7E-02 | +4.3E-01 | 1.6E-02 | 3.0E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    47| +1.48E+02 | +4.7E-02 | -7.8E-01 | 1.1E-01 | 2.3E+00 | 1.1E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)   113| +1.49E+02 | -4.6E-01 | +6.7E-01 | 3.1E-02 | 3.7E+01 | 6.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    32| +2.29E+02 | +5.4E+00 | -1.3E+00 | 1.0E+00 | 2.7E+01 | 2.9E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)   114| +2.10E+02 | +1.7E-01 | -1.4E+00 | 6.2E-02 | 1.2E+00 | 1.5E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    18| +2.03E+02 | -8.4E+00 | +1.3E+00 | 2.5E-01 | 1.6E+01 | 6.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    68| +2.10E+02 | -1.2E-02 | +3.6E-01 | 1.6E-02 | 2.3E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   114| +1.48E+02 | -2.7E-01 | +6.1E-01 | 3.1E-02 | 2.5E+01 | 7.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    33| +2.29E+02 | +6.5E+00 | -9.9E-01 | 2.5E-01 | 2.7E+01 | 6.5E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    48| +1.48E+02 | -9.9E-03 | +5.8E-01 | 2.6E-02 | 2.3E+00 | 2.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   115| +2.10E+02 | -3.1E-02 | +7.8E-01 | 1.6E-02 | 1.2E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    69| +2.10E+02 | -1.7E-02 | +4.6E-01 | 1.6E-02 | 2.8E+00 | 3.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    19| +1.77E+02 | -2.6E+01 | +8.4E-01 | 5.0E-01 | 3.1E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    34| +2.26E+02 | -2.9E+00 | +8.2E-01 | 6.2E-02 | 2.7E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    16| +1.52E+02 | -4.3E+00 | +9.0E-01 | 1.0E+00 | 6.9E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)   115| +1.48E+02 | -2.6E-01 | +4.1E-01 | 3.1E-02 | 2.4E+01 | 6.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    49| +1.48E+02 | -2.2E-03 | +9.7E-01 | 2.6E-02 | 1.0E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   116| +2.10E+02 | -3.2E-03 | +5.8E-02 | 3.1E-02 | 1.4E+00 | 7.7E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    35| +2.25E+02 | -1.6E+00 | +5.6E-01 | 1.2E-01 | 1.8E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    79| +1.52E+02 | -2.0E+00 | +1.2E+00 | 2.5E-01 | 4.5E+01 | 5.9E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    20| +1.77E+02 | +1.3E+02 | -6.6E+00 | 1.0E+00 | 1.2E+02 | 1.7E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    70| +2.10E+02 | -1.3E-02 | +4.0E-01 | 1.6E-02 | 2.1E+00 | 4.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    50| +1.48E+02 | -3.6E-03 | +9.6E-01 | 5.3E-02 | 4.1E-01 | 3.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   116| +1.48E+02 | -1.2E-01 | +3.0E-01 | 3.1E-02 | 2.0E+01 | 8.5E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    36| +2.22E+02 | -2.3E+00 | +6.6E-01 | 1.2E-01 | 3.3E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    17| +1.52E+02 | +1.8E+02 | -7.2E+02 | 2.0E+00 | 3.9E+01 | 5.7E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)   117| +2.10E+02 | -3.4E-02 | +1.0E+00 | 7.8E-03 | 3.4E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    21| +1.61E+02 | -1.6E+01 | +8.7E-01 | 2.5E-01 | 1.2E+02 | 4.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    71| +2.10E+02 | -1.6E-02 | +5.0E-01 | 1.6E-02 | 2.5E+00 | 4.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   117| +1.48E+02 | -1.9E-01 | +4.4E-01 | 3.1E-02 | 3.2E+01 | 8.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    37| +2.22E+02 | -2.2E-01 | +6.1E-03 | 1.2E-01 | 1.8E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   118| +2.10E+02 | -1.7E-02 | +1.1E+00 | 1.6E-02 | 9.4E-01 | 4.4E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    51| +1.48E+02 | -5.1E-03 | +9.5E-01 | 1.1E-01 | 7.8E-01 | 5.5E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    72| +2.10E+02 | -1.3E-02 | +4.6E-01 | 1.6E-02 | 2.0E+00 | 4.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    38| +2.20E+02 | -1.7E+00 | +8.8E-01 | 3.1E-02 | 4.1E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   119| +2.10E+02 | -3.2E-02 | +1.1E+00 | 3.1E-02 | 4.9E-01 | 8.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    22| +1.58E+02 | -3.4E+00 | +9.4E-01 | 5.0E-01 | 8.1E+01 | 2.5E-01 | trr |1
2023-02-17 16:05:33 fides(INFO)   118| +1.48E+02 | -1.5E-01 | +6.8E-01 | 3.1E-02 | 2.3E+01 | 8.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    52| +1.48E+02 | -4.2E-03 | +8.8E-01 | 2.1E-01 | 2.5E-01 | 9.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    73| +2.10E+02 | -1.7E-02 | +5.4E-01 | 1.6E-02 | 2.3E+00 | 4.1E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    39| +2.19E+02 | -1.4E+00 | +7.6E-01 | 6.2E-02 | 2.6E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)   120| +2.10E+02 | -7.6E-02 | +1.2E+00 | 6.2E-02 | 7.9E-01 | 1.8E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    23| +1.58E+02 | +2.3E+01 | -2.0E+00 | 5.0E-01 | 6.3E+01 | 9.2E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)   119| +1.48E+02 | -1.3E-02 | +9.6E-02 | 3.1E-02 | 9.5E+00 | 7.6E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    74| +2.10E+02 | -2.2E-02 | +8.2E-01 | 1.6E-02 | 1.8E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    53| +1.48E+02 | +5.1E-03 | -5.4E+00 | 4.2E-01 | 6.0E-01 | 3.2E-02 | trr |0
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    40| +2.18E+02 | -1.3E+00 | +6.3E-01 | 1.2E-01 | 1.5E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    80| +1.52E+02 | +2.0E+00 | -2.0E+00 | 5.0E-01 | 1.3E+01 | 4.0E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)   121| +2.10E+02 | -2.1E-01 | +1.4E+00 | 1.2E-01 | 1.5E+00 | 3.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    18| +1.51E+02 | -2.5E-01 | +1.0E+00 | 5.0E-01 | 3.9E+01 | 1.4E+00 |  2d |1
2023-02-17 16:05:33 fides(INFO)    75| +2.10E+02 | +5.0E-04 | -1.5E-02 | 3.1E-02 | 1.8E+00 | 8.5E-02 |  2d |0
2023-02-17 16:05:33 fides(INFO)    24| +1.53E+02 | -5.5E+00 | +7.9E-01 | 1.2E-01 | 6.3E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)   120| +1.48E+02 | -5.1E-02 | +7.8E-01 | 7.8E-03 | 1.5E+01 | 1.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    41| +2.16E+02 | -1.4E+00 | +5.9E-01 | 1.2E-01 | 2.7E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    54| +1.48E+02 | -3.6E-05 | +8.2E-02 | 4.3E-02 | 6.0E-01 | 8.1E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)   122| +2.10E+02 | -1.2E-01 | +9.6E-02 | 2.5E-01 | 2.9E+00 | 6.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    76| +2.10E+02 | -1.2E-02 | +6.1E-01 | 7.8E-03 | 1.8E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    25| +1.49E+02 | -3.1E+00 | +9.8E-01 | 2.5E-01 | 7.7E+01 | 2.9E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    42| +2.16E+02 | +1.5E-01 | -1.5E-01 | 1.2E-01 | 1.4E+01 | 3.2E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)    19| +1.51E+02 | +3.2E+00 | -2.2E+01 | 1.0E+00 | 3.2E+01 | 1.8E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)   123| +2.09E+02 | -7.1E-01 | +1.0E+00 | 6.2E-02 | 6.6E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   121| +1.48E+02 | -1.2E-02 | +4.5E-01 | 1.6E-02 | 3.9E+00 | 4.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    55| +1.48E+02 | -2.5E-04 | +5.2E-01 | 1.1E-02 | 2.8E-01 | 7.2E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    77| +2.10E+02 | -9.6E-03 | +1.0E+00 | 7.8E-03 | 1.4E+00 | 2.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    43| +2.16E+02 | -6.4E-01 | +8.1E-01 | 3.1E-02 | 1.4E+01 | 7.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    26| +1.49E+02 | +1.0E+01 | -3.8E+00 | 5.0E-01 | 4.1E+01 | 5.4E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)   124| +2.08E+02 | -6.2E-01 | +1.2E+00 | 1.2E-01 | 4.4E+00 | 3.0E-01 | trr |1
2023-02-17 16:05:33 fides(INFO)   122| +1.48E+02 | +2.6E-03 | -4.2E-01 | 1.6E-02 | 4.5E+00 | 2.2E-02 |  2d |0
2023-02-17 16:05:33 fides(INFO)    56| +1.48E+02 | -3.8E-05 | +9.3E-01 | 1.1E-02 | 2.9E-01 | 2.3E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    81| +1.51E+02 | -3.0E-01 | +5.1E-01 | 4.2E-02 | 1.3E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    78| +2.10E+02 | -1.9E-02 | +9.2E-01 | 1.6E-02 | 1.2E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    44| +2.15E+02 | -9.0E-01 | +1.0E+00 | 6.2E-02 | 1.2E+01 | 9.3E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    27| +1.49E+02 | -9.2E-01 | +6.2E-01 | 1.2E-01 | 4.1E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   125| +2.07E+02 | -7.8E-01 | +4.3E-01 | 2.5E-01 | 5.8E+00 | 6.8E-01 |  2d |1
2023-02-17 16:05:33.825 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.2839 and h = 1.60631e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:33.825 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.2839: AMICI failed to integrate the forward problem
2023-02-17 16:05:33 fides(INFO)   123| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.0E-03 | 4.5E+00 | 5.4E-03 |  2d |0
2023-02-17 16:05:33 fides(INFO)    79| +2.10E+02 | -4.0E-02 | +1.0E+00 | 3.1E-02 | 1.3E+00 | 8.9E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    57| +1.48E+02 | -5.9E-05 | +1.1E+00 | 2.1E-02 | 8.0E-02 | 4.9E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    20| +1.51E+02 | -3.6E-01 | +1.0E+00 | 2.5E-01 | 3.2E+01 | 4.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    45| +2.14E+02 | -9.4E-01 | +8.3E-01 | 1.2E-01 | 1.2E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:33.840 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.3559 and h = 3.61223e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:33.840 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.3559: AMICI failed to integrate the forward problem
2023-02-17 16:05:33 fides(INFO)    28| +1.49E+02 | +0.0E+00 | +0.0E+00 | 1.2E-01 | 4.1E+01 | 1.5E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    80| +2.10E+02 | -8.6E-02 | +1.1E+00 | 6.2E-02 | 1.2E+00 | 1.8E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    46| +2.14E+02 | -3.7E-01 | +1.4E-01 | 2.5E-01 | 1.3E+01 | 7.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   126| +2.05E+02 | -2.3E+00 | +8.8E-01 | 2.5E-01 | 3.5E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   124| +1.48E+02 | -2.3E-03 | +7.2E-01 | 4.9E-04 | 4.5E+00 | 1.3E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    21| +1.51E+02 | +8.5E-01 | -3.0E+00 | 5.0E-01 | 3.0E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)    29| +1.48E+02 | -3.0E-01 | +8.8E-01 | 3.1E-02 | 4.1E+01 | 4.0E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)    81| +2.10E+02 | -2.1E-01 | +1.2E+00 | 1.2E-01 | 1.5E+00 | 3.6E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    47| +2.12E+02 | -1.5E+00 | +6.9E-01 | 6.2E-02 | 2.8E+01 | 1.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   127| +2.05E+02 | +4.3E+00 | -5.9E-01 | 5.0E-01 | 3.1E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:33 fides(INFO)   125| +1.48E+02 | -4.1E-04 | +9.8E-01 | 4.9E-04 | 1.2E+00 | 1.2E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    48| +2.11E+02 | -5.6E-01 | +9.0E-01 | 6.2E-02 | 7.2E+00 | 1.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    82| +2.09E+02 | -5.2E-01 | +1.1E+00 | 2.5E-01 | 2.9E+00 | 7.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    82| +1.51E+02 | -3.2E-01 | +8.7E-01 | 4.2E-02 | 1.6E+01 | 9.5E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    30| +1.48E+02 | -2.3E-01 | +8.7E-01 | 6.2E-02 | 2.4E+01 | 6.4E-02 |  2d |1
2023-02-17 16:05:33 fides(INFO)   128| +2.04E+02 | -1.4E+00 | +2.6E-01 | 1.2E-01 | 3.1E+01 | 2.6E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    49| +2.10E+02 | -1.2E+00 | +1.0E+00 | 1.2E-01 | 1.0E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   126| +1.48E+02 | -4.1E-04 | +9.0E-01 | 9.8E-04 | 7.5E-01 | 2.8E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    22| +1.51E+02 | -2.5E-01 | +1.1E+00 | 1.2E-01 | 3.0E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    83| +2.09E+02 | +1.6E+00 | -4.9E+00 | 5.0E-01 | 7.9E+00 | 8.8E-01 |  2d |0
2023-02-17 16:05:33 fides(INFO)   129| +2.01E+02 | -2.9E+00 | +1.4E+00 | 1.2E-01 | 2.3E+01 | 3.5E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    31| +1.48E+02 | -2.1E-01 | +9.6E-01 | 1.2E-01 | 2.6E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)   127| +1.48E+02 | -5.3E-04 | +1.0E+00 | 2.0E-03 | 8.9E-01 | 5.6E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)    50| +2.06E+02 | -4.3E+00 | +1.3E+00 | 2.5E-01 | 9.8E+00 | 6.6E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    84| +2.09E+02 | -3.8E-01 | +1.3E+00 | 1.2E-01 | 7.9E+00 | 2.2E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:33 fides(INFO)   130| +1.93E+02 | -7.4E+00 | +1.2E+00 | 2.5E-01 | 1.8E+01 | 6.7E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    58| +1.48E+02 | -5.7E-05 | +8.0E-01 | 4.3E-02 | 1.2E-01 | 8.0E-03 |  2d |1
2023-02-17 16:05:33 fides(INFO)    23| +1.50E+02 | -6.3E-01 | +1.3E+00 | 2.5E-01 | 1.6E+01 | 6.0E-01 |  2d |1
2023-02-17 16:05:33 fides(INFO)    32| +1.48E+02 | -1.6E-01 | +8.7E-01 | 2.5E-01 | 1.3E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:33.989 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 90.0831 and h = 2.15215e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:33.989 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 90.0831: AMICI failed to integrate the forward problem
2023-02-17 16:05:33 fides(INFO)   128| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 5.3E-01 | 1.1E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)    85| +2.09E+02 | +5.0E+00 | -2.1E+00 | 2.5E-01 | 6.4E+00 | 6.7E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    51| +1.84E+02 | -2.2E+01 | +1.4E+00 | 5.0E-01 | 2.4E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)    59| +1.48E+02 | +2.4E-04 | -3.0E+00 | 8.5E-02 | 4.8E-02 | 1.9E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)    83| +1.51E+02 | -2.7E-01 | +1.1E+00 | 8.5E-02 | 2.0E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   131| +1.93E+02 | +9.2E+01 | -6.7E+00 | 5.0E-01 | 5.0E+01 | 1.3E+00 | trr |0
2023-02-17 16:05:34 fides(INFO)   129| +1.48E+02 | -2.6E-04 | +1.0E+00 | 9.8E-04 | 5.3E-01 | 2.8E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    33| +1.48E+02 | +8.8E-01 | -5.0E+00 | 5.0E-01 | 8.7E+00 | 2.7E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    86| +2.08E+02 | -3.4E-01 | +3.6E-01 | 6.2E-02 | 6.4E+00 | 1.7E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    24| +1.50E+02 | +4.2E-01 | -1.1E+00 | 5.0E-01 | 2.0E+01 | 9.8E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    52| +1.84E+02 | +3.1E+02 | -1.3E+01 | 1.0E+00 | 3.1E+01 | 2.6E+00 |  2d |0
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    60| +1.48E+02 | -1.5E-05 | +4.8E-01 | 2.1E-02 | 4.8E-02 | 4.8E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   130| +1.48E+02 | -4.7E-04 | +1.0E+00 | 2.0E-03 | 4.8E-01 | 5.6E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    34| +1.48E+02 | -2.2E-02 | +2.7E-01 | 1.2E-01 | 8.7E+00 | 6.9E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    87| +2.08E+02 | -7.9E-01 | +1.3E+00 | 6.2E-02 | 1.0E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   132| +1.88E+02 | -4.9E+00 | +8.5E-01 | 1.2E-01 | 5.0E+01 | 3.3E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    53| +1.68E+02 | -1.6E+01 | +1.3E+00 | 2.5E-01 | 3.1E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    61| +1.48E+02 | +4.6E-05 | -6.0E-01 | 2.1E-02 | 9.3E-02 | 3.1E-03 |  2d |0
2023-02-17 16:05:34 fides(INFO)    88| +2.06E+02 | -1.5E+00 | +1.0E+00 | 1.2E-01 | 5.4E+00 | 3.5E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    25| +1.50E+02 | -1.9E-01 | +8.9E-01 | 1.2E-01 | 2.0E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   131| +1.48E+02 | -6.7E-04 | +1.0E+00 | 3.9E-03 | 4.8E-01 | 1.1E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   133| +1.77E+02 | -1.1E+01 | +5.5E-01 | 2.5E-01 | 7.0E+01 | 4.6E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    35| +1.48E+02 | +1.5E-01 | -8.7E-01 | 1.2E-01 | 4.8E+00 | 1.5E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    84| +1.51E+02 | +5.3E-03 | -8.8E-02 | 1.7E-01 | 4.7E+00 | 1.1E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    89| +2.03E+02 | -3.1E+00 | +1.0E+00 | 2.5E-01 | 1.2E+01 | 6.8E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    54| +1.68E+02 | +1.4E+01 | -1.4E+00 | 5.0E-01 | 4.5E+01 | 1.3E+00 |  2d |0
2023-02-17 16:05:34 fides(INFO)    62| +1.48E+02 | -1.5E-05 | +6.2E-01 | 5.3E-03 | 9.3E-02 | 8.1E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)   132| +1.48E+02 | -1.2E-03 | +7.6E-01 | 7.8E-03 | 3.1E-01 | 2.3E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   134| +1.71E+02 | -6.0E+00 | +4.0E-01 | 2.5E-01 | 7.0E+01 | 3.7E-01 | trr |1
2023-02-17 16:05:34 fides(INFO)    36| +1.48E+02 | -2.7E-02 | +5.4E-01 | 2.9E-02 | 4.8E+00 | 3.7E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    26| +1.50E+02 | -1.8E-01 | +6.7E-01 | 2.5E-01 | 1.3E+01 | 4.7E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    90| +2.03E+02 | +2.6E+01 | -5.3E+00 | 5.0E-01 | 4.2E+01 | 1.2E+00 |  2d |0
2023-02-17 16:05:34 fides(INFO)    55| +1.59E+02 | -8.5E+00 | +1.0E+00 | 1.2E-01 | 4.5E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    63| +1.48E+02 | -3.2E-06 | +6.1E-01 | 5.3E-03 | 1.4E-01 | 7.5E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)    37| +1.48E+02 | -9.3E-03 | +9.8E-01 | 2.9E-02 | 7.3E+00 | 1.8E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   135| +1.58E+02 | -1.3E+01 | +1.1E+00 | 2.5E-01 | 1.1E+02 | 3.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   133| +1.48E+02 | -2.4E-03 | +1.1E+00 | 1.6E-02 | 1.6E+00 | 4.5E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    91| +2.01E+02 | -1.8E+00 | +1.1E+00 | 1.2E-01 | 4.2E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    64| +1.48E+02 | -4.0E-06 | +1.0E+00 | 5.3E-03 | 2.9E-02 | 6.8E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)    27| +1.50E+02 | -1.6E-01 | +8.2E-01 | 2.5E-01 | 1.8E+01 | 4.2E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    38| +1.48E+02 | -8.7E-03 | +9.5E-01 | 5.9E-02 | 3.6E+00 | 3.4E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   134| +1.48E+02 | -2.7E-03 | +9.5E-01 | 3.1E-02 | 6.9E-01 | 9.1E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    56| +1.52E+02 | -7.3E+00 | +4.1E-01 | 2.5E-01 | 7.5E+01 | 5.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   136| +1.58E+02 | +3.0E+02 | -1.7E+01 | 5.0E-01 | 5.6E+01 | 1.3E+00 | trr |0
2023-02-17 16:05:34 fides(INFO)    85| +1.51E+02 | -5.1E-02 | +9.5E-01 | 1.1E-02 | 4.7E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    92| +2.01E+02 | +4.2E-01 | -1.6E-01 | 2.5E-01 | 5.3E+01 | 6.7E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    65| +1.48E+02 | -6.0E-06 | +1.2E+00 | 1.1E-02 | 8.5E-02 | 1.5E-03 |  2d |1
2023-02-17 16:05:34.214 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.9354 and h = 3.13883e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.215 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.9354: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)   135| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.3E-02 | 3.9E-01 | 2.4E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)    39| +1.48E+02 | -1.1E-02 | +9.2E-01 | 1.2E-01 | 3.9E+00 | 5.8E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    57| +1.49E+02 | -3.2E+00 | +9.6E-01 | 2.5E-01 | 1.8E+02 | 3.3E-01 | trr |1
2023-02-17 16:05:34 fides(INFO)   137| +1.51E+02 | -7.0E+00 | +8.7E-01 | 1.2E-01 | 5.6E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:34.229 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 171.577 and h = 4.79171e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.229 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 171.577: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)    28| +1.50E+02 | +0.0E+00 | +0.0E+00 | 5.0E-01 | 1.3E+01 | 7.9E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    66| +1.48E+02 | -2.5E-06 | +3.6E-01 | 2.1E-02 | 2.2E-02 | 2.1E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    93| +1.98E+02 | -3.1E+00 | +1.4E+00 | 6.2E-02 | 5.3E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:34.243 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.485 and h = 3.02269e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.243 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.485: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)   136| +1.48E+02 | +0.0E+00 | +0.0E+00 | 2.0E-03 | 3.9E-01 | 5.9E-03 |  2d |0
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    40| +1.48E+02 | +3.8E-02 | -2.4E+00 | 2.4E-01 | 2.1E+00 | 1.5E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    58| +1.49E+02 | +2.5E-02 | -6.7E-02 | 2.5E-01 | 3.6E+01 | 2.6E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)   138| +1.51E+02 | +2.6E+01 | -4.4E+00 | 2.5E-01 | 2.9E+01 | 5.4E-01 | trr |0
2023-02-17 16:05:34 fides(INFO)   137| +1.48E+02 | -2.2E-04 | +1.3E+00 | 5.1E-04 | 3.9E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    94| +1.85E+02 | -1.3E+01 | +8.7E-01 | 1.2E-01 | 5.3E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    41| +1.48E+02 | -2.2E-03 | +3.7E-01 | 5.9E-02 | 2.1E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    67| +1.48E+02 | +2.4E-05 | -1.2E+00 | 2.1E-02 | 6.1E-02 | 4.2E-03 |  2d |0
2023-02-17 16:05:34 fides(INFO)    59| +1.48E+02 | -9.4E-01 | +6.2E-01 | 6.2E-02 | 3.6E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   139| +1.51E+02 | +2.2E+00 | -7.1E-01 | 6.2E-02 | 2.9E+01 | 1.6E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    29| +1.50E+02 | -4.7E-02 | +1.1E+00 | 1.2E-01 | 1.3E+01 | 2.0E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   138| +1.48E+02 | -1.4E-04 | +9.0E-01 | 1.0E-03 | 3.1E-01 | 2.9E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    42| +1.48E+02 | +7.8E-04 | -8.4E-02 | 5.9E-02 | 2.1E+00 | 2.5E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)    68| +1.48E+02 | -5.0E-06 | +8.5E-01 | 5.3E-03 | 6.1E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    95| +1.85E+02 | +1.1E+01 | -5.7E-01 | 2.5E-01 | 4.4E+01 | 6.4E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   140| +1.50E+02 | -7.8E-01 | +7.2E-01 | 1.6E-02 | 2.9E+01 | 4.2E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    60| +1.48E+02 | -1.2E-01 | +5.3E-01 | 6.2E-02 | 2.1E+01 | 8.0E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    86| +1.51E+02 | -3.4E-02 | +8.2E-01 | 2.2E-02 | 4.0E+00 | 4.7E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   139| +1.48E+02 | -1.4E-04 | +9.4E-01 | 2.0E-03 | 6.3E-01 | 5.9E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    43| +1.48E+02 | -2.4E-03 | +6.7E-01 | 1.5E-02 | 2.1E+00 | 6.8E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    69| +1.48E+02 | +2.7E-06 | -1.5E+00 | 1.1E-02 | 2.0E-02 | 8.0E-04 |  2d |0
2023-02-17 16:05:34 fides(INFO)    96| +1.78E+02 | -6.7E+00 | +9.9E-01 | 6.2E-02 | 4.4E+01 | 1.6E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   141| +1.49E+02 | -6.6E-01 | +7.9E-01 | 1.6E-02 | 3.9E+01 | 3.2E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    61| +1.48E+02 | -4.4E-02 | +3.7E-01 | 6.2E-02 | 4.7E+00 | 6.5E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    30| +1.50E+02 | -8.0E-02 | +1.1E+00 | 2.5E-01 | 9.0E+00 | 3.8E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   140| +1.48E+02 | -7.6E-05 | +9.2E-01 | 4.1E-03 | 1.6E-01 | 8.2E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    70| +1.48E+02 | -1.8E-07 | +3.3E-01 | 2.7E-03 | 2.0E-02 | 2.0E-04 |  2d |1
2023-02-17 16:05:34 fides(WARNING) Stopping as function difference 1.75E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:34 fides(INFO)    44| +1.48E+02 | -1.3E-03 | +9.7E-01 | 1.5E-02 | 2.6E+00 | 5.7E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    97| +1.68E+02 | -1.0E+01 | +7.8E-01 | 1.2E-01 | 4.6E+01 | 3.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    62| +1.48E+02 | -2.8E-02 | +6.4E-01 | 6.2E-02 | 9.5E+00 | 5.6E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   142| +1.49E+02 | -5.3E-01 | +8.5E-01 | 3.1E-02 | 2.9E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   141| +1.48E+02 | -2.0E-06 | +2.8E-01 | 4.1E-03 | 4.6E-02 | 2.5E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    31| +1.50E+02 | -9.7E-03 | +8.3E-01 | 5.0E-01 | 1.7E+00 | 7.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    98| +1.68E+02 | +5.6E+00 | -6.0E-01 | 2.5E-01 | 8.1E+01 | 5.1E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    45| +1.48E+02 | -1.4E-03 | +9.5E-01 | 2.9E-02 | 1.2E+00 | 1.1E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   143| +1.48E+02 | -4.9E-01 | +5.0E-01 | 6.2E-02 | 2.6E+01 | 8.1E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    63| +1.48E+02 | -1.1E-02 | +8.1E-01 | 6.2E-02 | 3.5E+00 | 4.2E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   142| +1.48E+02 | -3.4E-06 | +1.7E+00 | 4.1E-03 | 2.9E-02 | 2.3E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)    32| +1.50E+02 | -3.3E-03 | +8.7E-01 | 1.0E+00 | 1.4E+00 | 1.1E+00 | trr |1
2023-02-17 16:05:34 fides(INFO)    46| +1.48E+02 | -1.2E-03 | +7.6E-01 | 5.9E-02 | 1.8E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    87| +1.51E+02 | +3.9E-03 | -4.8E-01 | 4.4E-02 | 5.0E+00 | 1.6E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)    99| +1.63E+02 | -4.6E+00 | +9.4E-01 | 6.2E-02 | 8.1E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   144| +1.48E+02 | -2.2E-02 | +1.2E-02 | 6.2E-02 | 5.3E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    64| +1.48E+02 | -1.2E-02 | +8.5E-01 | 1.2E-01 | 4.7E+00 | 8.5E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   143| +1.48E+02 | +4.7E-07 | -8.7E+00 | 4.1E-03 | 5.6E-03 | 4.0E-04 |  2d |0
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   100| +1.59E+02 | -4.3E+00 | +6.8E-01 | 1.2E-01 | 5.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)     0| +3.57E+10 |    NaN   |    NaN   | 1.0E+00 | 1.6E+11 |   NaN   | NaN |1
2023-02-17 16:05:34 fides(INFO)    33| +1.50E+02 | -3.0E-04 | +2.6E-01 | 2.0E+00 | 1.8E+00 | 2.2E-01 | trr |1
2023-02-17 16:05:34 fides(INFO)    47| +1.48E+02 | +4.6E-03 | -1.6E+00 | 1.2E-01 | 7.2E-01 | 3.2E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)    65| +1.48E+02 | +4.4E-03 | -3.2E-01 | 2.5E-01 | 1.6E+00 | 1.4E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)   145| +1.48E+02 | -2.3E-01 | +7.6E-01 | 1.6E-02 | 2.7E+01 | 2.3E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   144| +1.48E+02 | -2.7E-06 | +1.0E+02 | 3.5E-05 | 5.6E-03 | 9.9E-05 |  2d |1
2023-02-17 16:05:34 fides(INFO)     1| +9.25E+07 | -3.6E+10 | +9.0E-02 | 1.0E+00 | 1.6E+11 | 2.9E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)    48| +1.48E+02 | -3.9E-04 | +3.5E-01 | 2.9E-02 | 7.2E-01 | 8.2E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   101| +1.54E+02 | -5.0E+00 | +6.0E-01 | 1.2E-01 | 7.3E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    34| +1.50E+02 | -2.1E-05 | +2.1E-02 | 2.0E+00 | 6.3E-01 | 7.8E-03 | trr |1
2023-02-17 16:05:34 fides(INFO)    66| +1.48E+02 | -3.3E-03 | +6.8E-01 | 6.2E-02 | 1.6E+00 | 3.6E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   146| +1.48E+02 | -2.9E-01 | +7.0E-01 | 3.1E-02 | 2.6E+01 | 3.3E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)     2| +1.42E+07 | -7.8E+07 | +8.9E-01 | 2.5E-01 | 4.3E+08 | 7.3E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   145| +1.48E+02 | +4.4E-06 | -2.5E+02 | 7.0E-05 | 2.1E-03 | 1.9E-04 |  2d |0
2023-02-17 16:05:34 fides(INFO)     3| +2.21E+06 | -1.2E+07 | +8.9E-01 | 5.0E-01 | 6.5E+07 | 1.5E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)    49| +1.48E+02 | -4.3E-04 | +3.5E-01 | 2.9E-02 | 1.3E+00 | 1.6E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    88| +1.51E+02 | -3.1E-03 | +5.4E-01 | 2.1E-03 | 5.0E+00 | 4.0E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    67| +1.48E+02 | -2.3E-03 | +7.4E-01 | 6.2E-02 | 2.1E+00 | 3.8E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   102| +1.54E+02 | +3.8E+01 | -3.4E+00 | 1.2E-01 | 6.3E+01 | 2.3E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)    35| +1.50E+02 | +1.6E-05 | -1.7E-02 | 1.7E-02 | 1.0E+00 | 6.4E-03 | trr |0
2023-02-17 16:05:34 fides(INFO)   146| +1.48E+02 | +2.9E-06 | -3.8E+02 | 1.7E-05 | 2.1E-03 | 4.7E-05 |  2d |0
2023-02-17 16:05:34 fides(INFO)   147| +1.48E+02 | +2.9E-02 | -1.3E-01 | 3.1E-02 | 1.9E+01 | 3.7E-02 | trr |0
2023-02-17 16:05:34 fides(INFO)    68| +1.48E+02 | -1.4E-03 | +6.5E-01 | 6.2E-02 | 8.2E-01 | 3.2E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)     4| +3.72E+05 | -1.8E+06 | +8.7E-01 | 1.0E+00 | 1.0E+07 | 2.8E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)   103| +1.53E+02 | -5.3E-01 | +1.6E-01 | 3.1E-02 | 6.3E+01 | 5.9E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    50| +1.48E+02 | +1.6E-05 | -1.7E-02 | 2.9E-02 | 5.0E-01 | 8.3E-03 |  2d |0
2023-02-17 16:05:34 fides(INFO)    36| +1.50E+02 | -3.8E-04 | +7.9E-01 | 1.9E-03 | 1.0E+00 | 1.7E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   148| +1.48E+02 | -5.6E-02 | +6.9E-01 | 7.2E-03 | 1.9E+01 | 7.9E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   147| +1.48E+02 | +4.4E-06 | -1.7E+03 | 4.4E-06 | 2.1E-03 | 1.2E-05 |  2d |0
2023-02-17 16:05:34 fides(INFO)     5| +5.76E+04 | -3.1E+05 | +9.0E-01 | 2.0E+00 | 1.6E+06 | 1.2E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)    69| +1.48E+02 | -1.1E-03 | +5.8E-01 | 6.2E-02 | 1.5E+00 | 3.5E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    51| +1.48E+02 | -2.3E-04 | +5.3E-01 | 7.3E-03 | 5.0E-01 | 2.6E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   104| +1.52E+02 | -1.0E+00 | +9.8E-01 | 7.8E-03 | 7.3E+01 | 2.0E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    37| +1.50E+02 | -8.4E-05 | +7.0E-01 | 3.7E-03 | 4.0E-01 | 1.1E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   148| +1.48E+02 | +3.9E-06 | -3.1E+03 | 1.1E-06 | 2.1E-03 | 2.9E-06 |  2d |0
2023-02-17 16:05:34 fides(INFO)   149| +1.48E+02 | -3.8E-02 | +9.5E-01 | 7.2E-03 | 1.3E+01 | 5.2E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)     6| +8.73E+03 | -4.9E+04 | +9.1E-01 | 2.0E+00 | 2.4E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)     7| +1.35E+03 | -7.4E+03 | +9.2E-01 | 2.0E+00 | 3.6E+04 | 9.0E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    52| +1.48E+02 | -2.0E-04 | +9.5E-01 | 7.3E-03 | 1.2E+00 | 2.2E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    70| +1.48E+02 | +2.4E-04 | -1.2E-01 | 6.2E-02 | 5.1E-01 | 2.8E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)    89| +1.51E+02 | -1.1E-03 | +9.9E-01 | 2.1E-03 | 2.5E+00 | 5.1E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   150| +1.48E+02 | -4.4E-02 | +7.2E-01 | 1.4E-02 | 9.4E+00 | 1.5E-02 | trr |1
2023-02-17 16:05:34 fides(INFO)   105| +1.52E+02 | -5.8E-01 | +9.3E-01 | 1.6E-02 | 3.5E+01 | 3.0E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   149| +1.48E+02 | +1.5E-06 | -1.8E+03 | 2.7E-07 | 2.1E-03 | 7.0E-07 |  2d |0
2023-02-17 16:05:34 fides(INFO)    38| +1.50E+02 | -6.5E-07 | +9.2E-02 | 3.7E-03 | 1.4E-01 | 8.8E-04 | trr |1
2023-02-17 16:05:34 fides(INFO)     8| +3.49E+02 | -1.0E+03 | +9.2E-01 | 2.0E+00 | 5.1E+03 | 9.8E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    53| +1.48E+02 | -1.6E-04 | +9.0E-01 | 1.5E-02 | 2.1E-01 | 4.3E-03 |  2d |1
2023-02-17 16:05:34.687 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.782 and h = 3.80467e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.687 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.782: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)    71| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 5.1E-01 | 7.7E-03 |  2d |0
2023-02-17 16:05:34 fides(INFO)   151| +1.48E+02 | -5.6E-02 | +8.8E-01 | 1.4E-02 | 2.0E+01 | 6.5E-03 | trr |1
2023-02-17 16:05:34 fides(INFO)   106| +1.51E+02 | -9.8E-01 | +8.8E-01 | 3.1E-02 | 3.1E+01 | 6.2E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)     9| +2.27E+02 | -1.2E+02 | +9.2E-01 | 2.0E+00 | 7.5E+02 | 1.9E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   150| +1.48E+02 | +3.1E-06 | -9.7E+03 | 6.8E-08 | 2.1E-03 | 1.7E-07 |  2d |0
2023-02-17 16:05:34 fides(INFO)    39| +1.50E+02 | +1.8E-06 | -2.3E-01 | 9.3E-04 | 3.1E-02 | 1.2E-03 | trr |0
2023-02-17 16:05:34 fides(INFO)    54| +1.48E+02 | -9.1E-05 | +5.3E-01 | 2.9E-02 | 4.0E-01 | 9.7E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    72| +1.48E+02 | -1.6E-04 | +2.2E-01 | 3.9E-03 | 5.1E-01 | 3.5E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    10| +2.27E+02 | +5.9E+01 | -4.5E+00 | 2.0E+00 | 1.2E+02 | 3.0E+00 |  2d |0
2023-02-17 16:05:34 fides(INFO)   152| +1.48E+02 | -2.0E-02 | +9.5E-01 | 1.4E-02 | 7.9E+00 | 6.2E-03 | trr |1
2023-02-17 16:05:34.726 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.665 and h = 2.87681e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.726 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.665: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)   151| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.7E-08 | 2.1E-03 | 4.3E-08 |  2d |0
2023-02-17 16:05:34 fides(INFO)   107| +1.51E+02 | -8.2E-02 | +4.8E-02 | 6.2E-02 | 3.8E+01 | 1.2E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    40| +1.50E+02 | -3.0E-06 | +7.7E-01 | 1.6E-04 | 3.1E-02 | 3.1E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)    11| +2.00E+02 | -2.7E+01 | +1.0E+00 | 5.0E-01 | 1.2E+02 | 7.9E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    55| +1.48E+02 | +5.0E-05 | -2.5E-01 | 2.9E-02 | 1.6E-01 | 6.0E-03 |  2d |0
2023-02-17 16:05:34 fides(INFO)    73| +1.48E+02 | -4.7E-04 | +9.6E-01 | 9.8E-04 | 2.0E+00 | 6.7E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)   153| +1.48E+02 | -1.9E-02 | +9.3E-01 | 1.4E-02 | 9.5E+00 | 5.4E-03 | trr |1
2023-02-17 16:05:34 fides(INFO)   152| +1.48E+02 | +5.5E-06 | -2.4E+05 | 4.3E-09 | 2.1E-03 | 1.1E-08 |  2d |0
2023-02-17 16:05:34 fides(INFO)    12| +2.00E+02 | +7.4E+02 | -2.4E+01 | 1.0E+00 | 5.5E+01 | 2.0E+00 |  2d |0
2023-02-17 16:05:34 fides(INFO)   108| +1.50E+02 | -5.9E-01 | +9.1E-01 | 1.6E-02 | 4.8E+01 | 2.4E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    41| +1.50E+02 | -6.4E-08 | +5.8E-02 | 3.1E-04 | 6.1E-02 | 4.8E-04 | trr |1
2023-02-17 16:05:34 fides(INFO)    56| +1.48E+02 | -1.9E-05 | +2.0E-01 | 7.3E-03 | 1.6E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    74| +1.48E+02 | -4.6E-05 | +1.0E+00 | 2.0E-03 | 2.3E-01 | 9.9E-04 |  2d |1
2023-02-17 16:05:34.794 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 81.0378 and h = 4.97343e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.794 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 81.0378: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)   154| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.4E-02 | 7.2E+00 | 7.4E-03 | trr |0
2023-02-17 16:05:34 fides(INFO)    13| +1.81E+02 | -1.9E+01 | +8.5E-01 | 2.5E-01 | 5.5E+01 | 5.3E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   153| +1.48E+02 | +3.0E-06 | -5.3E+05 | 1.1E-09 | 2.1E-03 | 2.7E-09 |  2d |0
2023-02-17 16:05:34 fides(INFO)   109| +1.49E+02 | -7.0E-01 | +6.7E-01 | 3.1E-02 | 3.2E+01 | 5.2E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    90| +1.51E+02 | -8.2E-04 | +1.4E+00 | 4.3E-03 | 3.5E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    42| +1.50E+02 | -2.9E-07 | +5.0E-01 | 7.8E-05 | 6.1E-03 | 1.7E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)    57| +1.48E+02 | -4.8E-05 | +1.0E+00 | 1.8E-03 | 5.9E-01 | 5.7E-04 |  2d |1
2023-02-17 16:05:34 fides(WARNING) Stopping as function difference 2.88E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:34.819 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.558 and h = 2.71512e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.819 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.558: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)    75| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.9E-03 | 2.5E-01 | 1.9E-03 |  2d |0
2023-02-17 16:05:34 fides(INFO)   155| +1.48E+02 | -8.0E-03 | +9.9E-01 | 1.0E-03 | 7.2E+00 | 1.8E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    14| +1.70E+02 | -1.2E+01 | +7.0E-02 | 5.0E-01 | 5.3E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)   154| +1.48E+02 | +4.5E-06 | -3.2E+06 | 2.7E-10 | 2.1E-03 | 6.7E-10 |  2d |0
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   110| +1.49E+02 | -8.1E-02 | +8.5E-02 | 3.1E-02 | 3.5E+01 | 4.7E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    15| +1.53E+02 | -1.7E+01 | +7.8E-01 | 1.2E-01 | 3.3E+02 | 2.7E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    76| +1.48E+02 | -2.6E-05 | +9.5E-01 | 9.8E-04 | 2.5E-01 | 5.0E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)    58| +1.48E+02 | -1.4E-05 | +1.2E+00 | 3.7E-03 | 4.6E-02 | 1.0E-03 |  2d |1
2023-02-17 16:05:34.854 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0766 and h = 1.15392e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.854 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0766: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)   155| +1.48E+02 | +0.0E+00 | +0.0E+00 | 6.7E-11 | 2.1E-03 | 1.7E-10 |  2d |0
2023-02-17 16:05:34 fides(INFO)   156| +1.48E+02 | -8.1E-03 | +9.7E-01 | 2.0E-03 | 4.3E+00 | 3.7E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   111| +1.49E+02 | -4.0E-01 | +8.0E-01 | 7.8E-03 | 5.3E+01 | 1.9E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)    16| +1.51E+02 | -2.4E+00 | +4.9E-01 | 2.5E-01 | 1.2E+02 | 4.3E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    77| +1.48E+02 | -3.2E-05 | +9.4E-01 | 2.0E-03 | 2.0E-01 | 9.7E-04 |  2d |1
2023-02-17 16:05:34 fides(INFO)    59| +1.48E+02 | -1.3E-05 | +7.5E-01 | 7.3E-03 | 5.0E-02 | 1.9E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   156| +1.48E+02 | +1.5E-06 | -1.7E+07 | 1.7E-11 | 2.1E-03 | 4.2E-11 |  2d |0
2023-02-17 16:05:34.885 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 224.204 and h = 2.042e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:34.885 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 224.204: AMICI failed to integrate the forward problem
2023-02-17 16:05:34 fides(INFO)    91| +1.51E+02 | +0.0E+00 | +0.0E+00 | 8.6E-03 | 3.0E-01 | 2.0E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)   157| +1.48E+02 | -1.0E-02 | +9.7E-01 | 4.1E-03 | 7.7E+00 | 2.8E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)    17| +1.49E+02 | -1.7E+00 | +6.7E-01 | 2.5E-01 | 4.6E+01 | 5.0E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    78| +1.48E+02 | -5.7E-05 | +9.2E-01 | 3.9E-03 | 1.5E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   112| +1.49E+02 | -2.4E-01 | +8.9E-01 | 1.6E-02 | 1.2E+01 | 3.5E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    60| +1.48E+02 | -2.2E-05 | +9.2E-01 | 1.5E-02 | 3.7E-02 | 3.4E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   157| +1.48E+02 | +5.0E-06 | -2.3E+08 | 4.2E-12 | 2.1E-03 | 1.1E-11 |  2d |0
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)     0| +8.21E+10 |    NaN   |    NaN   | 1.0E+00 | 3.8E+11 |   NaN   | NaN |1
2023-02-17 16:05:34 fides(INFO)    18| +1.49E+02 | -4.0E-01 | +4.2E-01 | 2.5E-01 | 3.5E+01 | 3.5E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)   158| +1.48E+02 | -6.8E-03 | +9.8E-01 | 8.1E-03 | 4.1E+00 | 4.9E-03 | trr |1
2023-02-17 16:05:34 fides(INFO)    79| +1.48E+02 | -9.5E-05 | +9.7E-01 | 7.8E-03 | 2.4E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   113| +1.49E+02 | -1.6E-01 | +6.4E-01 | 3.1E-02 | 1.7E+01 | 4.8E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)     1| +1.49E+05 | -8.2E+10 | +9.2E-02 | 1.0E+00 | 3.8E+11 | 2.9E+00 |  2d |1
2023-02-17 16:05:34 fides(INFO)    19| +1.49E+02 | +5.7E-01 | -4.4E-01 | 2.5E-01 | 2.0E+01 | 4.3E-01 |  2d |0
2023-02-17 16:05:34 fides(INFO)   158| +1.48E+02 | +2.6E-06 | -4.8E+08 | 1.0E-12 | 2.1E-03 | 2.6E-12 |  2d |0
2023-02-17 16:05:34 fides(INFO)    61| +1.48E+02 | -3.6E-05 | +1.0E+00 | 2.9E-02 | 7.3E-02 | 6.2E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   159| +1.48E+02 | -9.2E-03 | +9.8E-01 | 8.1E-03 | 6.5E+00 | 4.6E-03 | trr |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    20| +1.48E+02 | -3.8E-01 | +7.3E-01 | 6.2E-02 | 2.0E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)     2| +2.36E+04 | -1.2E+05 | +9.0E-01 | 2.5E-01 | 6.8E+05 | 6.8E-01 |  2d |1
2023-02-17 16:05:34 fides(INFO)    62| +1.48E+02 | -4.2E-05 | +9.5E-01 | 5.9E-02 | 4.2E-02 | 1.1E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)   114| +1.49E+02 | +4.0E+00 | -6.2E+00 | 3.1E-02 | 9.9E+00 | 8.1E-02 |  2d |0
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)    80| +1.48E+02 | -1.6E-04 | +9.7E-01 | 1.6E-02 | 1.1E-01 | 7.3E-03 |  2d |1
2023-02-17 16:05:34 fides(INFO)   159| +1.48E+02 | +5.8E-06 | -4.2E+09 | 2.6E-13 | 2.1E-03 | 6.6E-13 |  2d |0
2023-02-17 16:05:34 fides(INFO)    21| +1.48E+02 | -1.1E-01 | +7.5E-01 | 6.2E-02 | 1.8E+01 | 8.4E-02 |  2d |1
2023-02-17 16:05:34 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:34 fides(INFO)   160| +1.48E+02 | -6.5E-03 | +9.9E-01 | 8.1E-03 | 4.8E+00 | 5.4E-03 | trr |1
2023-02-17 16:05:35 fides(INFO)     3| +3.99E+03 | -2.0E+04 | +9.0E-01 | 5.0E-01 | 1.1E+05 | 1.4E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    63| +1.48E+02 | +3.0E-04 | -5.9E+00 | 1.2E-01 | 3.1E-02 | 2.2E-02 |  2d |0
2023-02-17 16:05:35 fides(INFO)    22| +1.48E+02 | -6.1E-02 | +8.7E-01 | 6.2E-02 | 1.2E+01 | 7.6E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   115| +1.49E+02 | +9.3E-02 | -5.0E-01 | 7.8E-03 | 9.9E+00 | 2.1E-02 |  2d |0
2023-02-17 16:05:35 fides(INFO)    81| +1.48E+02 | -2.5E-04 | +9.5E-01 | 3.1E-02 | 2.6E-01 | 1.4E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    92| +1.51E+02 | -3.7E-04 | +1.0E+00 | 2.1E-03 | 3.0E-01 | 5.0E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)     4| +8.79E+02 | -3.1E+03 | +9.0E-01 | 1.0E+00 | 1.7E+04 | 2.1E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)   161| +1.48E+02 | -8.2E-03 | +9.9E-01 | 8.1E-03 | 4.9E+00 | 7.2E-03 | trr |1
2023-02-17 16:05:35 fides(INFO)    23| +1.48E+02 | -1.1E-01 | +9.5E-01 | 1.2E-01 | 1.1E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    64| +1.48E+02 | +2.6E-06 | -1.2E-01 | 2.9E-02 | 3.1E-02 | 5.4E-03 |  2d |0
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)   160| +1.48E+02 | +1.3E-06 | -3.9E+09 | 6.5E-14 | 2.1E-03 | 1.6E-13 |  2d |0
2023-02-17 16:05:35 fides(INFO)     5| +3.46E+02 | -5.3E+02 | +9.2E-01 | 2.0E+00 | 2.7E+03 | 1.9E+00 | trr |1
2023-02-17 16:05:35 fides(INFO)    82| +1.48E+02 | -3.9E-04 | +9.3E-01 | 6.2E-02 | 1.5E-01 | 2.6E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   162| +1.48E+02 | -8.6E-03 | +1.0E+00 | 8.1E-03 | 5.3E+00 | 9.9E-03 | trr |1
2023-02-17 16:05:35 fides(INFO)   116| +1.49E+02 | -3.1E-02 | +6.4E-01 | 2.0E-03 | 9.9E+00 | 5.2E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    24| +1.48E+02 | -9.6E-02 | +6.6E-01 | 2.5E-01 | 1.0E+01 | 2.8E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)     6| +2.60E+02 | -8.6E+01 | +8.9E-01 | 2.0E+00 | 4.0E+02 | 5.5E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    65| +1.48E+02 | -2.7E-06 | +4.7E-01 | 7.3E-03 | 3.1E-02 | 1.3E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   161| +1.48E+02 | +2.2E-06 | -2.6E+10 | 1.6E-14 | 2.1E-03 | 4.1E-14 |  2d |0
2023-02-17 16:05:35 fides(INFO)    83| +1.48E+02 | -1.5E-04 | +2.1E-01 | 1.2E-01 | 4.3E-01 | 5.2E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    25| +1.48E+02 | +2.4E-01 | -7.0E-01 | 2.5E-01 | 7.1E+00 | 2.9E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)   163| +1.48E+02 | -8.3E-03 | +1.0E+00 | 8.1E-03 | 4.7E+00 | 8.9E-03 | trr |1
2023-02-17 16:05:35 fides(INFO)   117| +1.49E+02 | -3.0E-02 | +9.2E-01 | 2.0E-03 | 9.7E+00 | 4.1E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)     7| +2.25E+02 | -3.5E+01 | +5.1E-01 | 4.0E+00 | 5.5E+01 | 8.5E+00 | trr |1
2023-02-17 16:05:35 fides(INFO)    66| +1.48E+02 | -6.6E-07 | +2.7E-01 | 7.3E-03 | 2.2E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 6.59E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:35 fides(INFO)    84| +1.48E+02 | +6.5E-04 | -4.5E-01 | 3.1E-02 | 4.0E-01 | 1.3E-02 |  2d |0
2023-02-17 16:05:35 fides(INFO)    26| +1.48E+02 | -6.0E-02 | +3.7E-01 | 6.2E-02 | 7.1E+00 | 7.7E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   162| +1.48E+02 | +1.3E-06 | -5.8E+10 | 4.1E-15 | 2.1E-03 | 1.0E-14 |  2d |0
2023-02-17 16:05:35 fides(INFO)     8| +2.25E+02 | +4.9E+02 | -3.4E+01 | 4.0E+00 | 3.9E+01 | 9.4E+00 | trr |0
2023-02-17 16:05:35 fides(INFO)   164| +1.48E+02 | -1.6E-02 | +1.0E+00 | 1.6E-02 | 3.1E+00 | 3.0E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)    27| +1.48E+02 | -7.2E-02 | +8.4E-01 | 6.2E-02 | 1.9E+01 | 6.1E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   118| +1.48E+02 | -4.0E-02 | +8.7E-01 | 3.9E-03 | 7.1E+00 | 8.9E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    85| +1.48E+02 | -2.2E-06 | +8.4E-04 | 7.8E-03 | 4.0E-01 | 4.3E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   163| +1.48E+02 | +1.7E-06 | -3.1E+11 | 1.0E-15 | 2.1E-03 | 2.6E-15 |  2d |0
2023-02-17 16:05:35 fides(INFO)    28| +1.48E+02 | -7.0E-02 | +1.0E+00 | 1.2E-01 | 3.1E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    93| +1.51E+02 | -6.9E-04 | +1.0E+00 | 4.3E-03 | 3.7E-01 | 1.0E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     9| +2.25E+02 | +1.9E+01 | -1.7E+00 | 8.0E-01 | 3.9E+01 | 1.9E+00 | trr |0
2023-02-17 16:05:35 fides(INFO)   165| +1.48E+02 | -1.1E-02 | +9.8E-01 | 3.3E-02 | 2.5E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   119| +1.48E+02 | -5.0E-02 | +9.3E-01 | 7.8E-03 | 1.0E+01 | 1.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    86| +1.48E+02 | -4.2E-04 | +9.5E-01 | 2.0E-03 | 1.9E+00 | 8.7E-04 |  2d |1
2023-02-17 16:05:35 fides(INFO)    29| +1.47E+02 | -1.6E-01 | +1.2E+00 | 2.5E-01 | 7.0E+00 | 2.2E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)   164| +1.48E+02 | +1.6E-07 | -1.2E+11 | 2.5E-16 | 2.1E-03 | 6.4E-16 |  2d |0
2023-02-17 16:05:35 fides(WARNING) Stopping as trust region radius 6.35E-17 is smaller than machine precision.
2023-02-17 16:05:35 fides(INFO)   166| +1.48E+02 | -1.7E-02 | +9.4E-01 | 6.5E-02 | 2.3E+00 | 8.8E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    10| +2.21E+02 | -4.6E+00 | +3.4E-01 | 2.0E-01 | 3.9E+01 | 4.8E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    87| +1.48E+02 | -2.9E-05 | +8.6E-01 | 3.9E-03 | 1.6E-01 | 1.4E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    30| +1.47E+02 | +2.7E-02 | -1.4E-01 | 5.0E-01 | 4.2E+00 | 3.8E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)   120| +1.48E+02 | -5.9E-02 | +8.5E-01 | 1.6E-02 | 6.9E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   167| +1.48E+02 | +1.5E-02 | -1.8E+00 | 1.3E-01 | 9.2E-01 | 7.1E-02 |  2d |0
2023-02-17 16:05:35 fides(INFO)    31| +1.47E+02 | -8.3E-02 | +7.9E-01 | 1.2E-01 | 4.2E+00 | 9.5E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)     0| +1.15E+13 |    NaN   |    NaN   | 1.0E+00 | 5.3E+13 |   NaN   | NaN |1
2023-02-17 16:05:35 fides(INFO)    11| +2.18E+02 | -2.9E+00 | +4.8E-01 | 2.0E-01 | 3.4E+01 | 5.2E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    88| +1.48E+02 | -3.2E-05 | +8.7E-01 | 7.8E-03 | 1.9E-01 | 2.7E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   121| +1.48E+02 | -1.8E-01 | +8.8E-01 | 3.1E-02 | 7.7E+00 | 5.1E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    32| +1.47E+02 | -1.2E-01 | +3.1E-01 | 2.5E-01 | 7.4E+00 | 2.2E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)   168| +1.48E+02 | -1.9E-03 | +5.3E-01 | 2.2E-02 | 9.2E-01 | 1.8E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     1| +6.42E+06 | -1.2E+13 | +8.3E-02 | 1.0E+00 | 5.3E+13 | 3.1E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    12| +2.18E+02 | -2.4E-01 | +1.8E-02 | 2.0E-01 | 2.2E+01 | 5.4E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    94| +1.51E+02 | -1.7E-03 | +1.1E+00 | 8.6E-03 | 2.1E-01 | 2.0E-02 |  2d |1
2023-02-17 16:05:35.268 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 145.52 and h = 3.50065e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:35.268 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 145.52: AMICI failed to integrate the forward problem
2023-02-17 16:05:35 fides(INFO)    89| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.6E-02 | 7.9E-02 | 4.9E-03 |  2d |0
2023-02-17 16:05:35 fides(INFO)    33| +1.47E+02 | +8.0E+00 | -4.5E+00 | 2.5E-01 | 1.8E+01 | 3.5E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)   122| +1.48E+02 | -3.2E-02 | +1.0E-01 | 6.2E-02 | 4.7E+00 | 1.0E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    13| +2.15E+02 | -2.4E+00 | +8.3E-01 | 5.0E-02 | 3.4E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)   169| +1.48E+02 | -9.4E-04 | +7.6E-01 | 2.2E-02 | 1.2E+00 | 2.4E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     2| +9.82E+05 | -5.4E+06 | +8.9E-01 | 2.5E-01 | 3.0E+07 | 7.3E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    34| +1.47E+02 | -1.5E-01 | +2.6E-01 | 6.2E-02 | 1.8E+01 | 8.8E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    90| +1.48E+02 | -8.6E-06 | +8.2E-01 | 3.9E-03 | 7.9E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   123| +1.48E+02 | -2.3E-01 | +9.9E-01 | 1.6E-02 | 4.0E+01 | 2.5E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    14| +2.15E+02 | -6.2E-01 | +4.3E-01 | 1.0E-01 | 1.4E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    35| +1.47E+02 | -1.4E-01 | +7.0E-01 | 6.2E-02 | 9.2E+00 | 6.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     3| +1.52E+05 | -8.3E+05 | +8.9E-01 | 5.0E-01 | 4.5E+06 | 1.5E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)   170| +1.48E+02 | +1.6E-03 | -1.8E+00 | 4.4E-02 | 2.6E-01 | 3.0E-02 | trr |0
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)     0| +6.05E+13 |    NaN   |    NaN   | 1.0E+00 | 2.8E+14 |   NaN   | NaN |1
2023-02-17 16:05:35 fides(INFO)    91| +1.48E+02 | -1.4E-05 | +9.9E-01 | 7.8E-03 | 1.0E-01 | 2.4E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   124| +1.48E+02 | -9.1E-02 | +9.3E-01 | 3.1E-02 | 3.9E+00 | 4.8E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    36| +1.47E+02 | -1.2E-01 | +8.4E-01 | 6.2E-02 | 1.3E+01 | 4.1E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    15| +2.15E+02 | -8.5E-02 | +3.3E-02 | 1.0E-01 | 1.6E+01 | 2.5E-01 | trr |1
2023-02-17 16:05:35 fides(INFO)     4| +3.14E+04 | -1.2E+05 | +7.2E-01 | 1.0E+00 | 7.0E+05 | 2.8E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)     1| +3.62E+07 | -6.0E+13 | +8.3E-02 | 1.0E+00 | 2.8E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)   171| +1.48E+02 | +7.3E-05 | -1.6E-01 | 7.2E-03 | 2.6E-01 | 6.3E-03 |  2d |0
2023-02-17 16:05:35 fides(INFO)    37| +1.47E+02 | -2.2E-01 | +9.7E-01 | 1.2E-01 | 9.1E+00 | 9.2E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    92| +1.48E+02 | -2.2E-05 | +1.1E+00 | 1.6E-02 | 5.0E-02 | 4.6E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   125| +1.48E+02 | -1.1E-01 | +8.6E-01 | 6.2E-02 | 4.3E+00 | 9.4E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     2| +5.55E+06 | -3.1E+07 | +8.9E-01 | 2.5E-01 | 1.7E+08 | 5.9E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    16| +2.14E+02 | -7.3E-01 | +8.6E-01 | 2.5E-02 | 2.0E+01 | 5.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     5| +5.08E+03 | -2.6E+04 | +9.0E-01 | 1.0E+00 | 1.1E+05 | 1.0E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)   172| +1.48E+02 | +4.1E-05 | -1.4E-01 | 1.8E-03 | 2.6E-01 | 2.3E-03 |  2d |0
2023-02-17 16:05:35 fides(INFO)    38| +1.47E+02 | +3.5E+00 | -5.9E+00 | 2.5E-01 | 7.2E+00 | 2.4E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)     6| +9.65E+02 | -4.1E+03 | +9.0E-01 | 1.0E+00 | 1.8E+04 | 1.0E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    17| +2.14E+02 | -2.7E-01 | +4.7E-01 | 5.0E-02 | 1.0E+01 | 1.1E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)   126| +1.48E+02 | -1.7E-02 | +7.5E-02 | 1.2E-01 | 4.0E+00 | 1.9E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)     3| +8.57E+05 | -4.7E+06 | +9.0E-01 | 5.0E-01 | 2.6E+07 | 1.1E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    93| +1.48E+02 | -2.7E-05 | +8.9E-01 | 3.1E-02 | 9.1E-02 | 8.9E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    39| +1.47E+02 | -9.7E-02 | +3.6E-01 | 6.2E-02 | 7.2E+00 | 7.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     7| +3.34E+02 | -6.3E+02 | +9.0E-01 | 1.0E+00 | 2.8E+03 | 1.6E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)   173| +1.48E+02 | -9.0E-05 | +4.9E-01 | 4.5E-04 | 2.6E-01 | 9.8E-04 |  2d |1
2023-02-17 16:05:35 fides(INFO)     4| +1.34E+05 | -7.2E+05 | +9.0E-01 | 1.0E+00 | 3.9E+06 | 2.0E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    18| +2.14E+02 | -8.5E-02 | +1.9E-01 | 5.0E-02 | 8.3E+00 | 1.2E-01 | trr |1
2023-02-17 16:05:35 fides(INFO)   127| +1.48E+02 | -8.9E-02 | +8.5E-01 | 3.1E-02 | 6.1E+00 | 4.6E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    95| +1.51E+02 | -3.0E-03 | +1.0E+00 | 1.7E-02 | 5.7E-01 | 4.0E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    40| +1.46E+02 | -1.7E-01 | +4.8E-01 | 6.2E-02 | 1.4E+01 | 7.7E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    94| +1.48E+02 | -4.4E-05 | +1.0E+00 | 6.2E-02 | 4.6E-02 | 1.6E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     5| +1.34E+05 | +1.0E+09 | -7.0E+04 | 2.0E+00 | 6.1E+05 | 5.5E+00 |  2d |0
2023-02-17 16:05:35 fides(INFO)     8| +2.52E+02 | -8.2E+01 | +8.6E-01 | 1.0E+00 | 4.3E+02 | 2.1E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    41| +1.46E+02 | -9.1E-02 | +5.9E-01 | 6.2E-02 | 1.5E+01 | 4.4E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    19| +2.13E+02 | -1.9E-01 | +8.8E-01 | 1.3E-02 | 9.9E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   174| +1.48E+02 | -5.7E-05 | +7.7E-01 | 4.5E-04 | 7.2E-01 | 5.3E-04 |  2d |1
2023-02-17 16:05:35 fides(INFO)     6| +2.12E+04 | -1.1E+05 | +9.0E-01 | 5.0E-01 | 6.1E+05 | 1.4E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)   128| +1.48E+02 | -4.6E-02 | +9.8E-01 | 6.2E-02 | 9.7E+00 | 6.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    42| +1.46E+02 | -6.1E-02 | +2.8E-01 | 6.2E-02 | 6.9E+00 | 7.8E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    95| +1.48E+02 | +3.0E-05 | -5.7E-01 | 1.2E-01 | 6.7E-02 | 3.0E-02 |  2d |0
2023-02-17 16:05:35 fides(INFO)     9| +2.29E+02 | -2.4E+01 | +2.0E+00 | 2.0E+00 | 4.6E+01 | 4.7E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    20| +2.13E+02 | -1.5E-01 | +6.9E-01 | 2.5E-02 | 6.1E+00 | 4.9E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     7| +3.53E+03 | -1.8E+04 | +9.0E-01 | 1.0E+00 | 9.7E+04 | 1.6E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)   129| +1.48E+02 | -9.9E-03 | +1.1E+00 | 6.2E-02 | 1.1E+00 | 6.0E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   175| +1.48E+02 | -3.2E-05 | +1.4E+00 | 8.9E-04 | 1.3E-01 | 1.1E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    43| +1.46E+02 | +2.9E-01 | -8.8E-01 | 6.2E-02 | 7.6E+00 | 1.1E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)     8| +7.48E+02 | -2.8E+03 | +9.0E-01 | 2.0E+00 | 1.5E+04 | 4.3E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    96| +1.48E+02 | -9.6E-06 | +5.5E-01 | 3.1E-02 | 6.7E-02 | 7.4E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    21| +2.13E+02 | -9.9E-02 | +6.4E-01 | 2.5E-02 | 4.7E+00 | 5.1E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    10| +2.29E+02 | +6.1E+03 | -1.7E+02 | 4.0E+00 | 4.3E+01 | 1.1E+01 | trr |0
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)   130| +1.48E+02 | -3.1E-03 | +3.2E-01 | 6.2E-02 | 1.1E+00 | 8.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    44| +1.46E+02 | -9.1E-02 | +7.1E-01 | 1.6E-02 | 7.6E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     9| +3.13E+02 | -4.3E+02 | +9.0E-01 | 2.0E+00 | 2.4E+03 | 1.9E+00 | trr |1
2023-02-17 16:05:35 fides(INFO)   176| +1.48E+02 | -3.3E-05 | +9.8E-01 | 1.8E-03 | 1.0E-01 | 2.2E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    22| +2.13E+02 | -1.1E-01 | +6.0E-01 | 2.5E-02 | 5.2E+00 | 5.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    97| +1.48E+02 | -1.9E-06 | +1.1E-01 | 3.1E-02 | 4.4E-02 | 6.5E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    11| +2.29E+02 | +8.1E+01 | -4.2E+00 | 1.0E+00 | 4.3E+01 | 2.7E+00 |  2d |0
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    10| +2.53E+02 | -6.0E+01 | +8.6E-01 | 2.0E+00 | 3.8E+02 | 3.7E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    45| +1.46E+02 | -4.7E-02 | +9.3E-01 | 1.6E-02 | 1.6E+01 | 1.1E-02 |  2d |1
2023-02-17 16:05:35.557 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.0211 and h = 1.41573e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:35.558 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.0211: AMICI failed to integrate the forward problem
2023-02-17 16:05:35 fides(INFO)   131| +1.48E+02 | -5.1E-03 | +1.0E+00 | 6.2E-02 | 3.1E+00 | 2.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   177| +1.48E+02 | +0.0E+00 | +0.0E+00 | 3.6E-03 | 8.1E-02 | 4.6E-03 |  2d |0
2023-02-17 16:05:35 fides(INFO)    11| +2.50E+02 | -2.9E+00 | +5.6E-01 | 2.0E+00 | 4.4E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    12| +2.21E+02 | -7.8E+00 | +3.3E-01 | 2.5E-01 | 4.3E+01 | 6.4E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    23| +2.13E+02 | -8.3E-02 | +5.3E-01 | 2.5E-02 | 5.2E+00 | 5.1E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)    98| +1.48E+02 | -9.3E-06 | +8.2E-01 | 7.8E-03 | 1.3E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    96| +1.51E+02 | -5.7E-03 | +1.0E+00 | 3.4E-02 | 4.4E-01 | 7.9E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    46| +1.46E+02 | -7.3E-02 | +1.0E+00 | 3.1E-02 | 4.9E+00 | 2.6E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   132| +1.48E+02 | -4.2E-04 | +9.5E-01 | 6.2E-02 | 3.6E-01 | 9.4E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    12| +2.50E+02 | +2.0E-02 | -4.4E-02 | 2.0E+00 | 1.3E+01 | 1.4E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)   178| +1.48E+02 | -1.5E-05 | +1.0E+00 | 8.9E-04 | 8.1E-02 | 1.2E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    24| +2.13E+02 | -8.0E-02 | +4.7E-01 | 2.5E-02 | 5.0E+00 | 5.5E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)    13| +2.15E+02 | -6.1E+00 | +6.8E-01 | 2.5E-01 | 4.7E+01 | 6.3E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    47| +1.46E+02 | -8.9E-02 | +1.0E+00 | 6.2E-02 | 1.4E+01 | 3.7E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    99| +1.48E+02 | -4.1E-06 | +8.8E-01 | 1.6E-02 | 2.3E-02 | 3.1E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    13| +2.50E+02 | -3.3E-01 | +8.5E-01 | 1.7E-02 | 1.3E+01 | 3.7E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   133| +1.48E+02 | -7.9E-05 | +1.2E+00 | 6.2E-02 | 1.1E-01 | 9.7E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    48| +1.46E+02 | -8.9E-02 | +8.7E-01 | 1.2E-01 | 3.2E+00 | 8.5E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    25| +2.13E+02 | -8.4E-02 | +5.0E-01 | 2.5E-02 | 5.6E+00 | 5.1E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)    14| +2.10E+02 | -4.9E+00 | +9.9E-01 | 2.5E-01 | 1.6E+01 | 6.8E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    14| +2.50E+02 | -5.2E-02 | +2.2E-01 | 3.3E-02 | 6.6E+00 | 6.5E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   179| +1.48E+02 | -2.1E-05 | +9.1E-01 | 1.8E-03 | 5.1E-02 | 2.3E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)   100| +1.48E+02 | -3.7E-06 | +6.9E-01 | 3.1E-02 | 1.7E-02 | 5.7E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    49| +1.46E+02 | +2.2E+01 | -5.4E+01 | 2.5E-01 | 3.0E+00 | 4.8E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)    15| +2.50E+02 | -5.9E-02 | +7.9E-01 | 8.3E-03 | 4.8E+00 | 1.9E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   134| +1.48E+02 | -1.3E-05 | +1.3E+00 | 6.2E-02 | 2.3E-02 | 5.2E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    15| +1.91E+02 | -1.9E+01 | +1.2E+00 | 5.0E-01 | 2.3E+01 | 1.3E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    26| +2.13E+02 | -5.5E-02 | +3.6E-01 | 2.5E-02 | 4.7E+00 | 5.7E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)   180| +1.48E+02 | -3.3E-05 | +1.0E+00 | 3.6E-03 | 4.0E-02 | 4.5E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    16| +2.50E+02 | -9.4E-04 | +4.7E-02 | 1.7E-02 | 1.8E+00 | 2.0E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    50| +1.46E+02 | +4.5E-01 | -2.9E+00 | 6.2E-02 | 3.0E+00 | 1.2E-01 |  2d |0
2023-02-17 16:05:35 fides(INFO)   101| +1.48E+02 | +4.8E-06 | -9.0E-01 | 3.1E-02 | 4.7E-02 | 5.3E-03 |  2d |0
2023-02-17 16:05:35 fides(INFO)   135| +1.48E+02 | +2.4E-06 | -2.5E+01 | 6.2E-02 | 7.1E-03 | 3.0E-04 |  2d |0
2023-02-17 16:05:35 fides(INFO)    27| +2.13E+02 | -9.0E-02 | +5.1E-01 | 2.5E-02 | 6.0E+00 | 5.1E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)    17| +2.50E+02 | -7.3E-03 | +7.9E-01 | 2.7E-03 | 1.7E+00 | 6.7E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    16| +1.91E+02 | +4.3E+03 | -9.5E+01 | 1.0E+00 | 5.8E+01 | 2.4E+00 |  2d |0
2023-02-17 16:05:35 fides(INFO)    51| +1.46E+02 | -1.0E-02 | +2.3E-01 | 1.6E-02 | 3.0E+00 | 3.0E-02 |  2d |1
2023-02-17 16:05:35.696 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 87.9877 and h = 3.2767e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:35.696 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 87.9877: AMICI failed to integrate the forward problem
2023-02-17 16:05:35 fides(INFO)   181| +1.48E+02 | -1.5E-05 | +5.8E-01 | 7.2E-03 | 3.6E-02 | 8.6E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   102| +1.48E+02 | +0.0E+00 | +0.0E+00 | 7.8E-03 | 4.7E-02 | 1.3E-03 |  2d |0
2023-02-17 16:05:35 fides(INFO)    97| +1.51E+02 | -9.5E-03 | +1.1E+00 | 6.8E-02 | 4.7E-01 | 1.6E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    18| +2.50E+02 | -4.5E-06 | +9.3E-04 | 5.4E-03 | 6.0E-01 | 7.1E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   136| +1.48E+02 | +1.8E-06 | -3.7E+01 | 5.8E-05 | 7.1E-03 | 7.4E-05 |  2d |0
2023-02-17 16:05:35 fides(INFO)    28| +2.13E+02 | -4.0E-02 | +2.9E-01 | 2.5E-02 | 4.3E+00 | 5.9E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)    52| +1.46E+02 | -5.1E-03 | +8.4E-01 | 3.9E-03 | 3.3E+00 | 5.4E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    17| +1.68E+02 | -2.3E+01 | +9.4E-01 | 2.5E-01 | 5.8E+01 | 5.8E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)   103| +1.48E+02 | -9.8E-07 | +1.6E+00 | 2.0E-03 | 4.7E-02 | 3.3E-04 |  2d |1
2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 9.82E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:35 fides(INFO)    19| +2.50E+02 | -8.2E-04 | +8.3E-01 | 8.6E-04 | 6.0E-01 | 2.0E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   182| +1.48E+02 | -2.8E-07 | +2.0E-02 | 7.2E-03 | 5.3E-02 | 2.6E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    29| +2.13E+02 | -9.0E-02 | +5.0E-01 | 2.5E-02 | 6.1E+00 | 5.1E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    53| +1.46E+02 | -4.9E-03 | +8.0E-01 | 7.8E-03 | 3.3E+00 | 8.0E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   137| +1.48E+02 | +9.8E-07 | -4.8E+01 | 1.4E-05 | 7.1E-03 | 1.9E-05 |  2d |0
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    20| +2.50E+02 | -4.6E-05 | +9.2E-02 | 1.7E-03 | 2.9E-01 | 3.3E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   183| +1.48E+02 | -6.0E-06 | +8.3E-01 | 1.2E-03 | 5.0E-02 | 1.7E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    18| +1.68E+02 | +1.1E+00 | -2.2E-01 | 5.0E-01 | 5.4E+01 | 8.6E-01 | trr |0
2023-02-17 16:05:35 fides(INFO)    54| +1.46E+02 | -7.7E-03 | +9.1E-01 | 1.6E-02 | 2.2E+00 | 7.6E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    30| +2.13E+02 | -2.3E-02 | +1.6E-01 | 2.5E-02 | 4.2E+00 | 5.9E-02 | trr |1
2023-02-17 16:05:35 fides(INFO)    21| +2.50E+02 | -1.8E-04 | +7.9E-01 | 4.3E-04 | 2.6E-01 | 1.1E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)   138| +1.48E+02 | +7.6E-07 | -6.1E+01 | 3.6E-06 | 7.1E-03 | 5.3E-06 |  2d |0
2023-02-17 16:05:35 fides(INFO)    22| +2.50E+02 | -5.3E-08 | +8.2E-04 | 8.6E-04 | 9.4E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    55| +1.46E+02 | -1.1E-03 | +7.2E-02 | 3.1E-02 | 3.7E+00 | 2.7E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)   184| +1.48E+02 | -3.7E-06 | +3.3E+00 | 2.4E-03 | 4.0E-02 | 1.1E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)    19| +1.64E+02 | -4.1E+00 | +8.8E-01 | 7.5E-02 | 5.4E+01 | 2.1E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    31| +2.12E+02 | -6.4E-02 | +9.1E-01 | 6.3E-03 | 6.5E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    98| +1.51E+02 | -1.1E-02 | +1.4E+00 | 1.4E-01 | 6.9E-01 | 2.4E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    23| +2.50E+02 | -2.1E-05 | +8.2E-01 | 1.4E-04 | 9.4E-02 | 3.3E-04 |  2d |1
2023-02-17 16:05:35 fides(INFO)   139| +1.48E+02 | -6.1E-07 | +7.1E+01 | 9.0E-07 | 7.1E-03 | 1.8E-06 |  2d |1
2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 6.06E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:35 fides(INFO)    56| +1.46E+02 | -8.6E-03 | +5.1E-01 | 7.8E-03 | 2.0E+00 | 1.5E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    32| +2.12E+02 | -6.5E-02 | +7.8E-01 | 1.3E-02 | 4.6E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    24| +2.50E+02 | -1.0E-08 | +8.5E-04 | 2.8E-04 | 4.2E-02 | 5.0E-04 |  2d |1
2023-02-17 16:05:35 fides(INFO)   185| +1.48E+02 | +2.3E-06 | -1.4E+01 | 2.4E-03 | 7.6E-03 | 1.1E-04 |  2d |0
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    20| +1.54E+02 | -9.2E+00 | +7.7E-01 | 1.5E-01 | 7.6E+01 | 3.0E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    57| +1.46E+02 | -2.8E-03 | +9.7E-01 | 7.8E-03 | 2.7E+00 | 3.0E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)     0| +2.95E+13 |    NaN   |    NaN   | 1.0E+00 | 1.4E+14 |   NaN   | NaN |1
2023-02-17 16:05:35 fides(INFO)    33| +2.12E+02 | -1.1E-01 | +9.3E-01 | 2.5E-02 | 2.9E+00 | 5.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    25| +2.50E+02 | -4.4E-06 | +8.1E-01 | 6.4E-05 | 4.2E-02 | 1.6E-04 |  2d |1
2023-02-17 16:05:35 fides(INFO)   186| +1.48E+02 | +2.4E-06 | -2.7E+01 | 1.2E-04 | 7.6E-03 | 3.1E-05 |  2d |0
2023-02-17 16:05:35 fides(INFO)    58| +1.46E+02 | -3.5E-03 | +9.5E-01 | 1.6E-02 | 1.5E+00 | 7.2E-03 |  2d |1
2023-02-17 16:05:35.868 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 143.128 and h = 1.38416e-05, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:35.868 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 143.128: AMICI failed to integrate the forward problem
2023-02-17 16:05:35 fides(INFO)    21| +1.54E+02 | +0.0E+00 | +0.0E+00 | 3.0E-01 | 8.2E+01 | 3.2E-01 | trr |0
2023-02-17 16:05:35 fides(INFO)    26| +2.50E+02 | -3.3E-10 | +1.6E-04 | 1.3E-04 | 1.7E-02 | 2.0E-04 |  2d |1
2023-02-17 16:05:35 fides(INFO)    59| +1.46E+02 | +8.1E-03 | -1.1E+00 | 3.1E-02 | 1.3E+00 | 2.0E-02 |  2d |0
2023-02-17 16:05:35 fides(INFO)    34| +2.12E+02 | -2.6E-02 | +1.9E-01 | 5.0E-02 | 3.7E+00 | 1.2E-01 | trr |1
2023-02-17 16:05:35 fides(INFO)   187| +1.48E+02 | -1.4E-06 | +2.7E+01 | 2.9E-05 | 7.6E-03 | 1.3E-05 |  2d |1
2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 1.37E-06 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:35 fides(INFO)    27| +2.50E+02 | -6.9E-07 | +8.2E-01 | 2.5E-05 | 1.7E-02 | 6.0E-05 |  2d |1
2023-02-17 16:05:35 fides(WARNING) Stopping as function difference 6.87E-07 was smaller than specified tolerances (atol=1.00E-08, rtol=1.00E-08)
2023-02-17 16:05:35 fides(INFO)    22| +1.53E+02 | -1.9E+00 | +9.5E-01 | 2.6E-02 | 8.2E+01 | 7.4E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)    60| +1.46E+02 | -1.4E-03 | +6.0E-01 | 7.8E-03 | 1.3E+00 | 5.2E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)     1| +2.16E+07 | -2.9E+13 | +8.5E-02 | 1.0E+00 | 1.4E+14 | 3.1E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    35| +2.12E+02 | -1.3E-01 | +8.2E-01 | 1.2E-02 | 6.7E+00 | 2.9E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    61| +1.46E+02 | -1.0E-03 | +3.6E-01 | 7.8E-03 | 1.7E+00 | 8.6E-03 |  2d |1
2023-02-17 16:05:35 fides(INFO)     2| +3.33E+06 | -1.8E+07 | +8.9E-01 | 2.5E-01 | 9.9E+07 | 7.2E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    23| +1.50E+02 | -2.1E+00 | +8.4E-01 | 5.2E-02 | 4.6E+01 | 9.9E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    36| +2.12E+02 | -3.0E-02 | +2.9E-01 | 2.4E-02 | 3.3E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    62| +1.46E+02 | -2.5E-03 | +3.8E-01 | 7.8E-03 | 9.7E-01 | 1.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    99| +1.51E+02 | -9.1E-03 | +1.6E+00 | 1.4E-01 | 1.2E+00 | 2.0E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:35 fides(INFO)     0| +5.21E+07 |    NaN   |    NaN   | 1.0E+00 | 2.4E+08 |   NaN   | NaN |1
2023-02-17 16:05:35 fides(INFO)     3| +5.18E+05 | -2.8E+06 | +9.0E-01 | 5.0E-01 | 1.5E+07 | 1.5E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)    24| +1.49E+02 | -1.3E+00 | +9.6E-01 | 1.0E-01 | 4.8E+01 | 1.0E-01 |  2d |1
2023-02-17 16:05:35 fides(INFO)    37| +2.12E+02 | -1.1E-01 | +6.0E-01 | 2.4E-02 | 6.1E+00 | 5.3E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)    63| +1.46E+02 | -1.2E-03 | +1.7E-01 | 7.8E-03 | 1.9E+00 | 1.4E-02 |  2d |1
2023-02-17 16:05:35 fides(INFO)     1| +2.41E+04 | -5.2E+07 | +1.1E-01 | 1.0E+00 | 2.4E+08 | 2.6E+00 |  2d |1
2023-02-17 16:05:35 fides(INFO)     4| +8.27E+04 | -4.4E+05 | +8.9E-01 | 1.0E+00 | 2.4E+06 | 2.7E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    64| +1.46E+02 | -1.1E-03 | +7.3E-01 | 2.0E-03 | 8.2E-01 | 3.3E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)     0| +2.15E+10 |    NaN   |    NaN   | 1.0E+00 | 9.9E+10 |   NaN   | NaN |1
2023-02-17 16:05:36 fides(INFO)    25| +1.49E+02 | -1.1E-01 | -3.1E-02 | 2.1E-01 | 3.0E+01 | 2.3E-01 |  2d |0
2023-02-17 16:05:36 fides(INFO)     5| +1.32E+04 | -6.9E+04 | +9.0E-01 | 2.0E+00 | 3.7E+05 | 1.3E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    38| +2.12E+02 | -5.4E-02 | +4.5E-01 | 2.4E-02 | 3.5E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)     2| +4.83E+03 | -1.9E+04 | +8.9E-01 | 2.5E-01 | 1.0E+05 | 5.8E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    65| +1.46E+02 | -3.9E-04 | +7.8E-01 | 2.0E-03 | 9.7E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)     1| +3.42E+04 | -2.2E+10 | +9.0E-02 | 1.0E+00 | 9.9E+10 | 2.9E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     6| +2.26E+03 | -1.1E+04 | +9.0E-01 | 2.0E+00 | 5.9E+04 | 1.3E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     3| +9.58E+02 | -3.9E+03 | +8.9E-01 | 5.0E-01 | 1.7E+04 | 1.2E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    39| +2.12E+02 | -1.1E-01 | +6.4E-01 | 2.4E-02 | 5.5E+00 | 5.5E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    26| +1.49E+02 | -6.0E-01 | +7.5E-01 | 5.2E-02 | 3.0E+01 | 6.8E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)     2| +5.57E+03 | -2.9E+04 | +9.0E-01 | 2.5E-01 | 1.6E+05 | 6.7E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    66| +1.46E+02 | -2.4E-04 | +8.1E-01 | 3.9E-03 | 4.6E-01 | 1.3E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)     7| +5.46E+02 | -1.7E+03 | +9.0E-01 | 2.0E+00 | 9.4E+03 | 1.6E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     4| +3.30E+02 | -6.3E+02 | +8.9E-01 | 1.0E+00 | 2.7E+03 | 1.6E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)     0| +2.85E+08 |    NaN   |    NaN   | 1.0E+00 | 1.2E+09 |   NaN   | NaN |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)    40| +2.12E+02 | -8.0E-02 | +6.0E-01 | 2.4E-02 | 3.6E+00 | 5.9E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)     3| +1.06E+03 | -4.5E+03 | +9.0E-01 | 5.0E-01 | 2.4E+04 | 1.4E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     8| +2.84E+02 | -2.6E+02 | +9.0E-01 | 2.0E+00 | 1.5E+03 | 1.7E+00 | trr |1
2023-02-17 16:05:36 fides(INFO)    67| +1.46E+02 | -3.6E-04 | +7.3E-01 | 7.8E-03 | 4.5E-01 | 3.2E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)    27| +1.48E+02 | -3.5E-01 | +9.6E-01 | 5.2E-02 | 4.2E+01 | 4.4E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)     5| +2.53E+02 | -7.7E+01 | +8.5E-01 | 1.0E+00 | 4.0E+02 | 2.2E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     1| +6.78E+06 | -2.8E+08 | +1.1E-01 | 1.0E+00 | 1.2E+09 | 2.6E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     4| +3.57E+02 | -7.0E+02 | +9.0E-01 | 1.0E+00 | 3.9E+03 | 2.2E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    41| +2.12E+02 | -1.2E-01 | +7.1E-01 | 2.4E-02 | 5.0E+00 | 5.7E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    68| +1.46E+02 | +6.4E-05 | -8.7E-02 | 7.8E-03 | 5.6E-01 | 4.7E-03 |  2d |0
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)   100| +1.51E+02 | -1.5E-02 | +1.4E+00 | 1.4E-01 | 1.2E+00 | 2.9E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)     6| +2.42E+02 | -1.1E+01 | +9.0E-01 | 2.0E+00 | 4.3E+01 | 4.0E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     9| +2.48E+02 | -3.5E+01 | +8.7E-01 | 2.0E+00 | 2.3E+02 | 2.5E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    28| +1.48E+02 | -3.3E-01 | +8.4E-01 | 1.0E-01 | 1.9E+01 | 8.7E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)     5| +2.57E+02 | -9.9E+01 | +8.8E-01 | 1.0E+00 | 6.0E+02 | 2.6E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    42| +2.12E+02 | -1.1E-01 | +7.0E-01 | 2.4E-02 | 3.7E+00 | 6.1E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)     2| +1.04E+06 | -5.7E+06 | +8.9E-01 | 2.5E-01 | 3.1E+07 | 6.8E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    69| +1.46E+02 | -1.6E-04 | +7.5E-01 | 2.0E-03 | 5.6E-01 | 1.2E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)    10| +2.29E+02 | -1.9E+01 | +3.0E+00 | 2.0E+00 | 1.6E+01 | 3.4E+00 | trr |1
2023-02-17 16:05:36 fides(INFO)     7| +2.42E+02 | +3.2E+01 | -6.3E+00 | 4.0E+00 | 2.8E+01 | 9.0E+00 | trr |0
2023-02-17 16:05:36 fides(INFO)     6| +2.47E+02 | -1.1E+01 | +7.1E-01 | 2.0E+00 | 7.7E+01 | 4.3E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    29| +1.48E+02 | -1.6E-01 | +5.6E-01 | 2.1E-01 | 3.0E+01 | 1.7E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    43| +2.11E+02 | -1.4E-01 | +7.8E-01 | 2.4E-02 | 4.9E+00 | 5.9E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)     8| +2.42E+02 | +9.1E+00 | -1.2E+00 | 8.5E-01 | 2.8E+01 | 2.3E+00 |  2d |0
2023-02-17 16:05:36 fides(INFO)    70| +1.46E+02 | -1.9E-04 | +9.7E-01 | 3.9E-03 | 3.4E-01 | 9.2E-04 |  2d |1
2023-02-17 16:05:36 fides(INFO)     3| +1.61E+05 | -8.8E+05 | +8.9E-01 | 5.0E-01 | 4.8E+06 | 1.3E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     7| +2.35E+02 | -1.1E+01 | +1.6E+00 | 2.0E+00 | 1.2E+01 | 3.1E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    71| +1.46E+02 | -2.9E-04 | +1.0E+00 | 7.8E-03 | 5.7E-01 | 1.7E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)    44| +2.11E+02 | -2.1E-01 | +7.2E-01 | 4.8E-02 | 3.9E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)     9| +2.42E+02 | +7.0E+00 | -1.0E+00 | 2.1E-01 | 2.8E+01 | 5.4E-01 |  2d |0
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)    30| +1.48E+02 | +4.6E-01 | -1.0E+00 | 2.1E-01 | 9.8E+00 | 2.1E-01 |  2d |0
2023-02-17 16:05:36 fides(INFO)     4| +2.51E+04 | -1.4E+05 | +9.0E-01 | 1.0E+00 | 7.4E+05 | 9.7E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    45| +2.11E+02 | -3.2E-01 | +6.7E-01 | 4.8E-02 | 7.9E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)    10| +2.40E+02 | -2.8E+00 | +8.5E-01 | 5.3E-02 | 2.8E+01 | 1.4E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    11| +2.29E+02 | +1.7E+02 | -2.0E+01 | 2.0E+00 | 3.1E+01 | 6.1E+00 |  2d |0
2023-02-17 16:05:36 fides(INFO)     8| +2.35E+02 | +2.0E+01 | -3.9E+00 | 4.0E+00 | 1.9E+01 | 6.9E+00 | trr |0
2023-02-17 16:05:36 fides(INFO)    72| +1.46E+02 | -4.4E-04 | +8.1E-01 | 1.6E-02 | 2.4E-01 | 3.8E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)   101| +1.51E+02 | -1.8E-02 | +1.3E+00 | 2.7E-01 | 7.5E-01 | 4.8E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    11| +2.39E+02 | -5.3E-01 | +1.9E-01 | 1.1E-01 | 1.6E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    73| +1.46E+02 | +1.8E-02 | -8.2E+00 | 3.1E-02 | 9.4E-01 | 2.8E-02 |  2d |0
2023-02-17 16:05:36 fides(INFO)    31| +1.48E+02 | -9.8E-02 | +3.4E-01 | 5.2E-02 | 9.8E+00 | 7.6E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    12| +2.29E+02 | +1.6E+01 | -1.7E+00 | 5.0E-01 | 3.1E+01 | 1.4E+00 |  2d |0
2023-02-17 16:05:36 fides(INFO)    46| +2.11E+02 | -3.0E-01 | +5.8E-01 | 4.8E-02 | 6.4E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)     9| +2.30E+02 | -5.3E+00 | +1.3E+00 | 5.8E-01 | 1.9E+01 | 1.7E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)     5| +4.09E+03 | -2.1E+04 | +9.0E-01 | 1.0E+00 | 1.1E+05 | 9.3E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    12| +2.38E+02 | -1.3E+00 | +9.3E-01 | 2.7E-02 | 3.3E+01 | 4.9E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    74| +1.46E+02 | +5.1E-04 | -6.9E-01 | 7.8E-03 | 9.4E-01 | 7.0E-03 |  2d |0
2023-02-17 16:05:36 fides(INFO)    13| +2.25E+02 | -4.0E+00 | +5.4E-01 | 1.2E-01 | 3.1E+01 | 3.2E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    32| +1.48E+02 | -8.1E-02 | +5.7E-01 | 5.2E-02 | 1.4E+01 | 6.5E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    47| +2.10E+02 | -4.7E-01 | +7.3E-01 | 4.8E-02 | 9.3E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    13| +2.36E+02 | -1.6E+00 | +8.8E-01 | 5.3E-02 | 2.4E+01 | 9.5E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)    10| +2.30E+02 | +1.0E+02 | -1.0E+01 | 1.2E+00 | 2.6E+01 | 3.2E+00 |  2d |0
2023-02-17 16:05:36 fides(INFO)    75| +1.46E+02 | -1.7E-04 | +6.9E-01 | 2.0E-03 | 9.4E-01 | 1.8E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)    14| +2.22E+02 | -2.3E+00 | +7.6E-01 | 1.2E-01 | 2.6E+01 | 2.3E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)     6| +8.23E+02 | -3.3E+03 | +9.0E-01 | 1.0E+00 | 1.8E+04 | 8.8E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    14| +2.33E+02 | -2.9E+00 | +1.2E+00 | 1.1E-01 | 1.6E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    48| +2.10E+02 | -4.7E-01 | +7.2E-01 | 4.8E-02 | 7.1E+00 | 1.3E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    33| +1.48E+02 | -5.8E-03 | +9.3E-01 | 5.2E-02 | 3.2E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    76| +1.46E+02 | -3.1E-05 | +9.7E-01 | 2.0E-03 | 1.2E-01 | 3.6E-04 |  2d |1
2023-02-17 16:05:36 fides(INFO)    15| +2.22E+02 | -5.6E-02 | -5.7E-02 | 2.5E-01 | 2.0E+01 | 7.0E-01 |  2d |0
2023-02-17 16:05:36 fides(INFO)    11| +2.30E+02 | +2.6E+00 | -4.7E-01 | 2.9E-01 | 2.6E+01 | 7.4E-01 |  2d |0
2023-02-17 16:05:36 fides(INFO)    15| +2.30E+02 | -3.5E+00 | +8.4E-01 | 2.1E-01 | 1.7E+01 | 4.1E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    77| +1.46E+02 | -4.6E-05 | +9.4E-01 | 3.9E-03 | 2.3E-01 | 6.8E-04 |  2d |1
2023-02-17 16:05:36 fides(INFO)    49| +2.09E+02 | -5.9E-01 | +8.2E-01 | 4.8E-02 | 9.3E+00 | 1.2E-01 |  2d |1
2023-02-17 16:05:36.303 - amici.swig_wrappers - DEBUG - [model1_data1][CVODES:CVode:ERR_FAILURE] AMICI ERROR: in module CVODES in function CVode : At t = 89.9015 and h = 7.61275e-06, the error test failed repeatedly or with |h| = hmin.
2023-02-17 16:05:36.304 - amici.swig_wrappers - ERROR - [model1_data1][FORWARD_FAILURE] AMICI forward simulation failed at t = 89.9015: AMICI failed to integrate the forward problem
2023-02-17 16:05:36 fides(INFO)    34| +1.48E+02 | +0.0E+00 | +0.0E+00 | 1.0E-01 | 1.7E+00 | 5.2E-02 |  2d |0
2023-02-17 16:05:36 fides(INFO)    16| +2.21E+02 | -1.4E+00 | +6.8E-01 | 6.2E-02 | 2.0E+01 | 1.5E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    12| +2.27E+02 | -2.9E+00 | +7.8E-01 | 7.2E-02 | 2.6E+01 | 1.8E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)     7| +3.14E+02 | -5.1E+02 | +9.1E-01 | 1.0E+00 | 2.8E+03 | 9.9E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    16| +2.25E+02 | -4.4E+00 | +7.3E-01 | 4.3E-01 | 3.9E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    78| +1.46E+02 | -6.6E-05 | +8.2E-01 | 7.8E-03 | 1.3E-01 | 9.8E-04 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)    50| +2.08E+02 | -6.4E-01 | +6.0E-01 | 9.6E-02 | 7.2E+00 | 2.4E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    17| +2.20E+02 | -1.4E+00 | +9.6E-01 | 6.2E-02 | 2.0E+01 | 9.5E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)   102| +1.51E+02 | -2.4E-03 | +1.0E+00 | 2.7E-01 | 5.9E-01 | 2.4E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    35| +1.48E+02 | -4.0E-03 | +9.1E-01 | 2.6E-02 | 1.7E+00 | 1.3E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    13| +2.23E+02 | -4.2E+00 | +1.2E+00 | 1.4E-01 | 2.0E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    79| +1.46E+02 | +9.6E-04 | -3.1E+00 | 1.6E-02 | 1.3E-01 | 7.5E-03 |  2d |0
2023-02-17 16:05:36 fides(INFO)    17| +2.22E+02 | -3.2E+00 | +3.5E-01 | 4.3E-01 | 2.3E+01 | 1.2E+00 |  2d |1
2023-02-17 16:05:36 fides(INFO)    18| +2.18E+02 | -1.7E+00 | +7.2E-01 | 1.2E-01 | 1.6E+01 | 2.4E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    51| +2.07E+02 | -1.0E+00 | +7.3E-01 | 9.6E-02 | 1.4E+01 | 2.5E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)  iter|    fval   |   fdiff  | tr ratio |tr radius|  ||g||  | ||step||| step|acc
2023-02-17 16:05:36 fides(INFO)    80| +1.46E+02 | -7.0E-06 | +7.6E-02 | 3.9E-03 | 1.3E-01 | 1.9E-03 |  2d |1
2023-02-17 16:05:36 fides(INFO)    36| +1.48E+02 | -3.5E-03 | +9.6E-01 | 5.2E-02 | 3.8E+00 | 2.5E-02 |  2d |1
2023-02-17 16:05:36 fides(INFO)    14| +2.17E+02 | -5.5E+00 | +1.1E+00 | 2.9E-01 | 1.9E+01 | 6.9E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    18| +2.14E+02 | -8.1E+00 | +7.4E-01 | 4.3E-01 | 5.5E+01 | 7.1E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)    19| +2.16E+02 | -1.6E+00 | +5.9E-01 | 1.2E-01 | 2.6E+01 | 2.7E-01 |  2d |1
2023-02-17 16:05:36 fides(INFO)